JPWO2019014014A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2019014014A5
JPWO2019014014A5 JP2019561965A JP2019561965A JPWO2019014014A5 JP WO2019014014 A5 JPWO2019014014 A5 JP WO2019014014A5 JP 2019561965 A JP2019561965 A JP 2019561965A JP 2019561965 A JP2019561965 A JP 2019561965A JP WO2019014014 A5 JPWO2019014014 A5 JP WO2019014014A5
Authority
JP
Japan
Prior art keywords
torsion spring
hand
retraction
preload
hub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019561965A
Other languages
English (en)
Other versions
JP7408398B2 (ja
JP2020527373A5 (ja
JP2020527373A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/040671 external-priority patent/WO2019014014A1/en
Publication of JP2020527373A publication Critical patent/JP2020527373A/ja
Publication of JP2020527373A5 publication Critical patent/JP2020527373A5/ja
Publication of JPWO2019014014A5 publication Critical patent/JPWO2019014014A5/ja
Application granted granted Critical
Publication of JP7408398B2 publication Critical patent/JP7408398B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Description

更に別の形態では、右巻きねじりばねと左巻きねじりばねは、単一の２段階ねじりばねへと共に一体化されてもよい。
挿入／後退機構１２は、右巻きねじりばね１３０と左巻きねじりばね１３２とを含む二重ねじりばねシステム１２８を含む。いくつかの構成では、右巻きねじりばね１３０と左巻きねじりばね１３２は、単一の２段階ねじりばねへと共に一体化されている。単一の２段階ねじりばねは、簡単さ、部品点数低減、及び製造コスト低減という利点を提供する。いくつかの構成では、後退ハブ１０２は、外部表面１４４と、外部表面から径方向外側に延びる予荷重切欠部１４６（図３Ａ～図３Ｃに示される）とを含み、（図２Ａ～図２Ｃに示すように）右巻きねじりばね１３０及び左巻きねじりばね１３２のうちの１つは、後退ハブ１０２の予荷重切欠部１４６の遠位側の後退ハブ１０２の外部表面１４４を包囲し、右巻きねじりばね１３０及び左巻きねじりばね１３２のうちのもう一方は、後退ハブ１０２の予荷重切欠部１４６の近位側の後退ハブ１０２の外部表面１４４を包囲する。右巻きねじりばね１３０及び／又は左巻きねじりばね１３２に対する予荷重は、どの予荷重切欠部１４６に右巻きねじりばね１３０及び／又は左巻きねじりばね１３２が接続されるかに応じて変更することができる。二重ねじりばねシステム１２８は、後退ハブ１０２と、挿入ハブ１１０と、挿入／後退機構ハウジング１２４とに動作的に接続されている。起動トリガー１３４は二重ねじりばねシステムに動作的に接続されている。
JP2019561965A 2017-07-14 2018-07-03 二重ねじりばねシステムを有する針挿入後退システム Active JP7408398B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762532868P 2017-07-14 2017-07-14
US62/532,868 2017-07-14
PCT/US2018/040671 WO2019014014A1 (en) 2017-07-14 2018-07-03 NEEDLE INSERTION-RETRACTING SYSTEM HAVING DOUBLE TORSION SPRING SYSTEM

Publications (4)

Publication Number Publication Date
JP2020527373A JP2020527373A (ja) 2020-09-10
JP2020527373A5 JP2020527373A5 (ja) 2021-08-12
JPWO2019014014A5 true JPWO2019014014A5 (ja) 2022-08-15
JP7408398B2 JP7408398B2 (ja) 2024-01-05

Family

ID=63013119

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019561965A Active JP7408398B2 (ja) 2017-07-14 2018-07-03 二重ねじりばねシステムを有する針挿入後退システム

Country Status (6)

Country Link
US (1) US11305056B2 (ja)
EP (1) EP3651832B1 (ja)
JP (1) JP7408398B2 (ja)
IL (1) IL270784B2 (ja)
MA (1) MA49562A (ja)
WO (1) WO2019014014A1 (ja)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005023458D1 (de) 2005-09-12 2010-10-21 Unomedical As Einfürungssystem für ein Infusionsset mit einem ersten und zweiten Federeinheit
US10194938B2 (en) 2011-03-14 2019-02-05 UnoMedical, AS Inserter system with transport protection
CN112292166B (zh) * 2018-09-22 2023-02-21 艾斯曲尔医疗公司 注射器针头插入和缩回组件
FR3093437A1 (fr) * 2019-03-07 2020-09-11 Nemera La Verpilliere Dispositif d’insertion d’une aiguille pour la distribution d’un produit dans un site
AU2020279722A1 (en) 2019-05-20 2021-11-18 Unomedical A/S Rotatable infusion device and methods thereof
US11806505B2 (en) * 2020-12-02 2023-11-07 Medtronic Minimed, Inc. Single-site insertion of multiple medical devices
US11311666B1 (en) 2021-02-18 2022-04-26 Fresenius Kabi Deutschland Gmbh Modular wearable medicament delivery device and method of use thereof
US11464902B1 (en) 2021-02-18 2022-10-11 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with compressible reservoir and method of use thereof
US11872369B1 (en) 2021-02-18 2024-01-16 Fresenius Kabi Deutschland Gmbh Wearable medicament delivery device with leakage and skin contact sensing and method of use thereof
US11497847B1 (en) 2021-02-19 2022-11-15 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive substrate
US11633537B1 (en) 2021-02-19 2023-04-25 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a pre-filled cartridge
US11413394B1 (en) 2021-02-19 2022-08-16 Fresenius Kabi Deutschland Gmbh Display for wearable drug delivery device
US11607505B1 (en) 2021-02-19 2023-03-21 Fresenius Kabi Deutschland Gmbh Wearable injector with sterility sensors
US11406755B1 (en) 2021-02-19 2022-08-09 Fresenius Kabi Deutschland Gmbh Sensing fluid flow irregularities in an on-body injector
US11344682B1 (en) 2021-02-19 2022-05-31 Fresenius Kabi Deutschland Gmbh Drug supply cartridge with visual use indicator and delivery devices that use the same
US11426523B1 (en) 2021-02-19 2022-08-30 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including a removable cartridge
US11351300B1 (en) 2021-04-30 2022-06-07 Fresenius Kabl Deutschland GmbH Drug dispensing system with replaceable drug supply cartridges
US11504470B1 (en) 2021-04-30 2022-11-22 Fresenius Kabi Deutschland Gmbh Deformable drug reservoir for wearable drug delivery device
US11529459B1 (en) 2021-04-30 2022-12-20 Fresenius Kabi Deutschland Gmbh Wearable injector with adhesive module
US11419976B1 (en) 2021-04-30 2022-08-23 Fresenius Kabi Deutschland Gmbh Wearable drug delivery device with pressurized fluid dispensing
US11717608B1 (en) 2021-05-03 2023-08-08 Fresenius Kabi Deutschland Gmbh Drug delivery assembly including an adhesive pad
US11484646B1 (en) 2021-05-04 2022-11-01 Fresenius Kabi Deutschland Gmbh Sealing systems for a reservoir of an on-body injector

Family Cites Families (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1471091A (en) 1922-03-27 1923-10-16 Alfred N Bessesen Fluid-pressure device
GB1017496A (ja) 1961-11-24
US3115133A (en) 1962-05-15 1963-12-24 Morando Emilio Donald Needleless prefilled disposable hypodermic injector
FR2237643B1 (ja) 1973-07-17 1978-03-17 Steiner Maurice
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
KR850004274A (ko) 1983-12-13 1985-07-11 원본미기재 에리트로포이에틴의 제조방법
US4861335A (en) 1985-07-26 1989-08-29 Duoject Medical Systems Inc. Syringe
EP0243249A1 (fr) 1986-04-18 1987-10-28 Maurice Carre Dispositif de distribution, notamment à usage médical, d'un produit suivant des quantités dosées prédéterminées
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4926860A (en) 1988-02-05 1990-05-22 Flexmedics Corporation ARthroscopic instrumentation and method
US5856298A (en) 1989-10-13 1999-01-05 Amgen Inc. Erythropoietin isoforms
KR100263845B1 (ko) 1989-10-13 2000-08-16 스튜어트 엘.왓트 에리트로포이에틴 동형체와 그의 제조방법 및 그를 포함하는제약학적 조성물
US7217689B1 (en) 1989-10-13 2007-05-15 Amgen Inc. Glycosylation analogs of erythropoietin
GB9111600D0 (en) 1991-05-30 1991-07-24 Owen Mumford Ltd Improvements relating to injection devices
CN1057534C (zh) 1993-08-17 2000-10-18 柯瑞英-艾格公司 促红细胞生成素类似物
US6562596B1 (en) 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
US5830851A (en) 1993-11-19 1998-11-03 Affymax Technologies N.V. Methods of administering peptides that bind to the erythropoietin receptor
US5773569A (en) 1993-11-19 1998-06-30 Affymax Technologies N.V. Compounds and peptides that bind to the erythropoietin receptor
US5437640A (en) 1994-01-31 1995-08-01 Schwab; Louis Apparatus and method for inserting hypodermic, tuberculin and other needles and for administering Mantoux tuberculin tests
US5885574A (en) 1994-07-26 1999-03-23 Amgen Inc. Antibodies which activate an erythropoietin receptor
EP0771208B1 (en) 1994-08-12 2005-10-19 Immunomedics, Inc. Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
DE29507987U1 (de) 1995-05-15 1996-09-19 Ferton Holding Ejektionsgerät zur Hochdruckejektion einer Flüssigkeit
US5686292A (en) 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5767078A (en) 1995-06-07 1998-06-16 Johnson; Dana L. Agonist peptide dimers
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US6753165B1 (en) 1999-01-14 2004-06-22 Bolder Biotechnology, Inc. Methods for making proteins containing free cysteine residues
WO1999003887A1 (en) 1997-07-14 1999-01-28 Bolder Biotechnology, Inc. Derivatives of growth hormone and related proteins
US6391633B1 (en) 1997-07-23 2002-05-21 Roche Diagnostics Gmbh Production of erythropoietin by endogenous gene activation
US6030086A (en) 1998-03-02 2000-02-29 Becton, Dickinson And Company Flash tube reflector with arc guide
US6310078B1 (en) 1998-04-20 2001-10-30 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
US20050181482A1 (en) 2004-02-12 2005-08-18 Meade Harry M. Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
DE69933216T2 (de) 1998-06-15 2007-09-20 GTC Biotherapeutics, Inc., Framingham Erythropoietin-analog-menschliches serum-albumin fusionsprotein
CA2346996C (en) 1998-10-23 2013-11-19 Amgen Inc. Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
AR020848A1 (es) 1998-10-23 2002-05-29 Amgen Inc Metodos y composiciones para la prevencion y el tratamiento de anemia
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
DK1721979T3 (da) 1998-11-27 2010-12-13 Ucb Pharma Sa Sammensætninger og fremgangsmåder til forøgelse af knoglemineralisering
EP1006184A1 (en) 1998-12-03 2000-06-07 F. Hoffmann-La Roche Ag IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof
GB9903475D0 (en) 1999-02-17 1999-04-07 Owen Mumford Ltd Improvements relating to injection devices
EP1169352A4 (en) 1999-04-14 2005-05-04 Smithkline Beecham Corp ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR
US7297680B2 (en) 1999-04-15 2007-11-20 Crucell Holland B.V. Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
CZ299516B6 (cs) 1999-07-02 2008-08-20 F. Hoffmann-La Roche Ag Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
JP2003512840A (ja) 1999-10-22 2003-04-08 ミレニアム・ファーマシューティカルズ・インコーポレイテッド ラット脳に由来する核酸分子およびプログラム細胞死モデル
US20050202538A1 (en) 1999-11-12 2005-09-15 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
WO2001036489A2 (en) 1999-11-12 2001-05-25 Merck Patent Gmbh Erythropoietin forms with improved properties
WO2001053505A2 (en) 2000-01-21 2001-07-26 Biovex Limited Herpes virus strains for gene therapy
AUPQ599700A0 (en) 2000-03-03 2000-03-23 Super Internet Site System Pty Ltd On-line geographical directory
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
SI1274728T1 (sl) 2000-04-21 2008-08-31 Amgen Inc Postopek in sestavki za prepreäśevanje in/ali zdravljenje anemije
US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US7530964B2 (en) 2000-06-30 2009-05-12 Elan Pharma International Limited Needle device and method thereof
US7078376B1 (en) 2000-08-11 2006-07-18 Baxter Healthcare S.A. Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
WO2002017996A1 (en) 2000-08-29 2002-03-07 Novo Nordisk A/S Automatic injection device with torsion function for retraction of needle
HUP0303854A2 (hu) 2000-09-08 2004-03-01 Gryhon Therapeutics, Inc. Szintetikus erythropoiesis-stimuláló proteinek
DK1702635T3 (da) 2000-11-09 2008-05-26 Insulet Corp Transkutant afgiverorgan
US7271689B1 (en) 2000-11-22 2007-09-18 Fonar Corporation Magnet structure
EP1345628B1 (en) 2000-12-20 2011-04-13 F. Hoffmann-La Roche AG Conjugates of erythropoietin (epo) with polyethylene glycol (peg)
US6387078B1 (en) 2000-12-21 2002-05-14 Gillespie, Iii Richard D. Automatic mixing and injecting apparatus
ES2344592T3 (es) 2001-01-05 2010-09-01 Pfizer Inc. Anticuerpos frente al receptor del factor de crecimiento similar a la insulina i.
WO2002085940A2 (en) 2001-04-04 2002-10-31 Genodyssee New polynucleotides and polypeptides of the erythropoietin gene
SK288175B6 (sk) 2001-05-11 2014-04-02 Amgen Inc. Látková kompozícia viažuca polypeptid TALL-1, kódujúca DNA, expresný vektor a hostiteľská bunka
NZ547695A (en) 2001-06-26 2008-09-26 Amgen Fremont Inc Antibodies to OPGL
US6900292B2 (en) 2001-08-17 2005-05-31 Lee-Hwei K. Sun Fc fusion proteins of human erythropoietin with increased biological activities
MXPA04001486A (es) 2001-08-23 2004-10-27 Genmab As Anticuerpos humanos especificos para interleucina 15 (il-15).
US7247304B2 (en) 2001-08-23 2007-07-24 Genmab A/S Methods of treating using anti-IL-15 antibodies
US6930086B2 (en) 2001-09-25 2005-08-16 Hoffmann-La Roche Inc. Diglycosylated erythropoietin
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7138370B2 (en) 2001-10-11 2006-11-21 Amgen Inc. Specific binding agents of human angiopoietin-2
US7521053B2 (en) 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
WO2003039634A1 (en) 2001-11-09 2003-05-15 Alza Corporation Pneumatic powered autoinjector
WO2003055526A2 (en) 2001-12-21 2003-07-10 Maxygen Aps Erythropoietin conjugates
US7241444B2 (en) 2002-01-18 2007-07-10 Pierre Fabre Medicament Anti-IGF-IR antibodies and uses thereof
JP4606739B2 (ja) 2002-01-18 2011-01-05 ピエール、ファーブル、メディカマン 新規抗ｉｇｆ−ｉｒ抗体およびその使用
GB0202252D0 (en) 2002-01-31 2002-03-20 Oxford Biomedica Ltd Anemia
EP1470232A1 (en) 2002-01-31 2004-10-27 Oxford Biomedica (UK) Limited Physiologically regulated erythropoietin-expressing vector for the treatment of anaemia
EP1492878B1 (en) 2002-03-26 2007-05-30 Lek Pharmaceutical and Chemical Co. D.D. Process for the preparation of a desired erythropoietin glyco-isoform profile
WO2003083118A1 (fr) 2002-03-29 2003-10-09 Kumiai Chemical Industry Co., Ltd. Genes codant l'acetolactase synthase
AU2003222069A1 (en) 2002-03-29 2003-10-20 Centocor, Inc. Mammalian cdr mimetibodies, compositions, methods and uses
US20050256035A1 (en) 2002-05-13 2005-11-17 Irving Boime Ctp-extended erythropoietin
NZ571508A (en) 2002-05-24 2010-05-28 Schering Corp Neutralizing human anti-IGFR antibody
US7538195B2 (en) 2002-06-14 2009-05-26 Immunogen Inc. Anti-IGF-I receptor antibody
US8034904B2 (en) 2002-06-14 2011-10-11 Immunogen Inc. Anti-IGF-I receptor antibody
MXPA05000202A (es) 2002-06-28 2005-09-30 Johnson & Johnson Cuerpos mimeicos ch1-deletados de epo de mimetica de mamifero.
AU2003280130B2 (en) 2002-06-28 2009-06-11 Centocor, Inc. Mammalian CH1 deleted mimetibodies, compositions, methods and uses
AU2003246486A1 (en) 2002-07-19 2004-02-09 Cangene Corporation Pegylated erythropoietic compounds
WO2004018667A1 (ja) 2002-08-26 2004-03-04 Kirin Beer Kabushiki Kaisha ペプチド及びこれを含む医薬
NZ605429A (en) 2002-09-06 2014-08-29 Amgen Inc Therapeutic human anti-il-1r1 monoclonal antibody
RU2329274C2 (ru) 2002-09-11 2008-07-20 Фрезениус Каби Дойчланд Гмбх Способ получения производных гидроксиалкилкрахмала
US6919426B2 (en) 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
US7396913B2 (en) 2002-10-14 2008-07-08 Abbott Laboratories Erythropoietin receptor binding antibodies
TWI320716B (en) 2002-10-14 2010-02-21 Abbott Lab Erythropoietin receptor binding antibodies
US20040071694A1 (en) 2002-10-14 2004-04-15 Devries Peter J. Erythropoietin receptor binding antibodies
WO2004034988A2 (en) 2002-10-16 2004-04-29 Amgen Inc. Human anti-ifn-ϝ neutralizing antibodies as selective ifn-ϝ pathway inhibitors
US20040091961A1 (en) 2002-11-08 2004-05-13 Evans Glen A. Enhanced variants of erythropoietin and methods of use
EA009056B1 (ru) 2002-12-20 2007-10-26 Амген, Инк. Связывающие агенты, ингибирующие миостатин
EP1603948A1 (en) 2003-03-14 2005-12-14 Pharmacia Corporation Antibodies to igf-i receptor for the treatment of cancers
US7378503B2 (en) 2003-04-02 2008-05-27 Hoffmann-La Roche Inc. Antibodies against insulin-like growth factor 1 receptor and uses thereof
US7220410B2 (en) 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
US7638605B2 (en) 2003-05-01 2009-12-29 ImClone, LLC Fully human antibodies directed against the human insulin-like growth factor-1 receptor
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
CN100441595C (zh) 2003-05-12 2008-12-10 阿费麦克斯公司 结合红细胞生成素受体的新肽
CN1823088B (zh) 2003-05-12 2011-04-13 阿费麦克斯公司 结合红细胞生成素受体的新肽
WO2004101600A2 (en) 2003-05-12 2004-11-25 Affymax, Inc. Novel poly(ethylene glycol) modified compounds and uses thereof
US7074755B2 (en) 2003-05-17 2006-07-11 Centocor, Inc. Erythropoietin conjugate compounds with extended half-lives
US6995245B2 (en) 2003-05-30 2006-02-07 Centocor, Inc. Formation of novel erythropoietin conjugates using transglutaminase
US20050037390A1 (en) 2003-06-04 2005-02-17 Irm Llc, A Delaware Limited Liability Company Methods and compositions for modulating erythropoietin expression
AR046071A1 (es) 2003-07-10 2005-11-23 Hoffmann La Roche Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
RS20100555A (en) 2003-07-15 2011-08-31 Amgen Inc. HUMAN ANTI-NGF NEUTRAL ANTIBODIES AS SELECTIVE NGF SIGNAL ROUTE INHIBITORS
JP5105874B2 (ja) 2003-07-18 2012-12-26 アムジエン・インコーポレーテツド 肝細胞増殖因子に対する特異的結合因子
US20050019914A1 (en) 2003-07-24 2005-01-27 Aventis Pharma Deutschland Gmbh Perfusion process for producing erythropoietin
GB0317511D0 (en) 2003-07-25 2003-08-27 Biovex Ltd Viral vectors
US20050159676A1 (en) 2003-08-13 2005-07-21 Taylor James D. Targeted biopsy delivery system
JP2007512001A (ja) 2003-08-28 2007-05-17 バイオレクシス ファーマシューティカル コーポレイション Ｅｐｏミメティックペプチドおよび融合タンパク質
BRPI0409650A (pt) 2003-09-09 2006-04-25 Warren Pharmaceuticals Inc métodos para regular o nìvel hematócrito e humanos, produtos de eritropoietina artificial, métodos para preparar um produto de eritropoietina e pra tratar anemia em pacientes em risco de dano no tecido, e, composição farmacêutica
WO2005081687A2 (en) 2003-09-30 2005-09-09 Centocor, Inc. Human hinge core mimetibodies, compositions, methods and uses
UA89481C2 (uk) 2003-09-30 2010-02-10 Центокор, Инк. Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
KR101225463B1 (ko) 2003-11-07 2013-01-24 임뮤넥스 코포레이션 인터류킨-4 수용체에 결합하는 항체
PE20050928A1 (es) 2003-11-21 2005-11-08 Schering Corp Combinaciones terapeuticas de anticuerpo anti-igfr1
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
MXPA06005732A (es) 2003-11-24 2006-08-17 Neose Technologies Inc Eritropoyetina glucopegilada.
WO2005058967A2 (en) 2003-12-16 2005-06-30 Pierre Fabre Medicament Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof
EP1548031A1 (en) 2003-12-22 2005-06-29 Dubai Genetics FZ-LLC Nature-identical erythropoietin
AU2004311796A1 (en) 2003-12-31 2005-07-21 Centocor, Inc. Novel recombinant proteins with N-terminal free thiol
AU2004309063B2 (en) 2003-12-31 2010-10-28 Merck Patent Gmbh Fc-erythropoietin fusion protein with improved pharmacokinetics
US7423139B2 (en) 2004-01-20 2008-09-09 Insight Biopharmaceuticals Ltd. High level expression of recombinant human erythropoietin having a modified 5′-UTR
WO2005070451A1 (en) 2004-01-22 2005-08-04 Zafena Aktiebolag Pharmaceutical composition comprising non-glycosylated erythropoietin
WO2005084711A1 (fr) 2004-03-02 2005-09-15 Chengdu Institute Of Biological Products Erythropoietine recombinante pegylee a activite in vivo
EP1758608A2 (en) 2004-03-11 2007-03-07 Fresenius Kabi Deutschland GmbH Conjugates of hydroxyethyl starch and erythropoietin
AU2005229009A1 (en) 2004-03-23 2005-10-13 Amgen, Inc. Monoclonal antibodies specific for human OX40L (CD 134L)
US20050227289A1 (en) 2004-04-09 2005-10-13 Reilly Edward B Antibodies to erythropoietin receptor and uses thereof
AU2005235794A1 (en) 2004-04-23 2005-11-03 Cambridge Antibody Technology Limited Erythropoietin protein variants
CA2572643A1 (en) 2004-07-07 2006-01-12 H. Lundbeck A/S Novel carbamylated epo and method for its production
FR2873699B1 (fr) 2004-07-29 2009-08-21 Pierre Fabre Medicament Sa Nouveaux anticorps anti igf ir rt leurs utilisations
US20060073563A1 (en) 2004-09-02 2006-04-06 Xencor, Inc. Erythropoietin derivatives with altered immunogenicity
AU2005298946B2 (en) 2004-10-21 2011-06-09 Novo Nordisk A/S Injection device with torsion spring and rotatable display
AU2005303887A1 (en) 2004-11-10 2006-05-18 Aplagen Gmbh Molecules which promote hematopoiesis
MY146381A (en) 2004-12-22 2012-08-15 Amgen Inc Compositions and methods relating relating to anti-igf-1 receptor antibodies
CA2589860A1 (en) 2005-01-24 2006-08-03 Amgen Inc. Humanized anti-amyloid antibody
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
DE102005025424A1 (de) 2005-06-02 2006-12-07 Tecpharma Licensing Ag Injektionsvorrichtung mit einem Drehfederantrieb
EP2100618B1 (en) 2005-06-17 2014-02-12 ImClone LLC An anti-PDGFRalpha antibody for use in the treatment of metastatic bone cancer
US8784363B2 (en) 2005-06-27 2014-07-22 3M Innovative Properties Company Microneedle array applicator device and method of array application
WO2007000328A1 (en) 2005-06-27 2007-01-04 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof
CA2614972C (en) 2005-07-18 2014-08-19 Amgen Inc. Human anti-b7rp1 neutralizing antibodies
FR2888850B1 (fr) 2005-07-22 2013-01-11 Pf Medicament Nouveaux anticorps anti-igf-ir et leurs applications
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
GB0603683D0 (en) 2006-02-23 2006-04-05 Novartis Ag Organic compounds
TWI395754B (zh) 2006-04-24 2013-05-11 Amgen Inc 人類化之ｃ-ｋｉｔ抗體
MX2008014744A (es) 2006-05-19 2009-02-10 Glycofi Inc Composiciones de eritrocpoyetina.
CL2007002567A1 (es) 2006-09-08 2008-02-01 Amgen Inc Proteinas aisladas de enlace a activina a humana.
WO2008057458A2 (en) 2006-11-07 2008-05-15 Merck & Co., Inc. Antagonists of pcsk9
CN101636179B (zh) 2006-11-07 2012-10-10 默沙东公司 Pcsk9拮抗剂
WO2008133647A2 (en) 2006-11-07 2008-11-06 Merck & Co., Inc. Antagonists of pcsk9
WO2008057457A2 (en) 2006-11-07 2008-05-15 Merck & Co., Inc. Antagonists of pcsk9
CA2671538A1 (en) 2006-12-14 2008-06-26 Leonard G. Presta Engineered anti-tslp antibody
US20100233177A1 (en) 2007-04-13 2010-09-16 David Langdon Yowe Molecules and methods for modulating proprotein convertase subtilisin/kexin type 9 (pcsk9)
WO2008155365A1 (en) 2007-06-20 2008-12-24 Irm Llc Methods and compositions for treating allergic diseases
US9242044B2 (en) 2007-07-06 2016-01-26 Novo Nordisk A/S Automatic injection device
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
DE102007049446A1 (de) 2007-10-16 2009-04-23 Cequr Aps Katheter-Einführeinrichtung
JP2011501952A (ja) 2007-10-26 2011-01-20 シェーリング コーポレイション 脂質障害およびコレステロール障害を治療するための抗ｐｃｓｋ９および方法
EP2231258A1 (en) 2007-12-21 2010-09-29 Aesthetic Sciences Corporation Self-contained pressurized injection device
AR070316A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9)
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
TWI516501B (zh) 2008-09-12 2016-01-11 禮納特神經系統科學公司 Ｐｃｓｋ９拮抗劑類
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
JO3382B1 (ar) 2008-12-23 2019-03-13 Amgen Inc أجسام مضادة ترتبط مع مستقبل cgrp بشري
DE102009025375A1 (de) 2009-06-18 2010-12-23 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Kolben für einen medizinischen Hohlkörper und medizinischer Hohlkörper
US8882710B2 (en) * 2009-09-02 2014-11-11 Medtronic Minimed, Inc. Insertion device systems and methods
US20120219558A1 (en) 2009-09-25 2012-08-30 Yan Ni Antagonists of pcsk9
WO2011053783A2 (en) 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Ax213 and ax132 pcsk9 antagonists and variants
CA2777698A1 (en) 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. Ax1 and ax189 pcsk9 antagonists and variants
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
CA2789549A1 (en) 2010-02-18 2011-08-25 Sanofi-Aventis Deutschland Gmbh Auto-injector
DK2536455T3 (da) 2010-02-18 2014-06-23 Sanofi Aventis Deutschland Fingerbeskyttelse til en injektionsanordning
CA2789596A1 (en) 2010-02-18 2011-08-25 Sanofi-Aventis Deutschland Gmbh Clutch mechanism
US9636467B2 (en) 2010-02-18 2017-05-02 Sanofi-Aventis Deutschland Gmbh Auto-injector with a torsion spring
EP2708252B1 (en) 2010-03-01 2015-07-29 Eli Lilly and Company Automatic injection device with delay mechanism including dual functioning biasing member
CA2792740A1 (en) 2010-03-11 2011-09-15 Rinat Neuroscience Corporation Antibodies with ph dependent antigen binding
KR20130086600A (ko) 2010-06-07 2013-08-02 암젠 인크 약물 전달 장치
GB201015799D0 (en) 2010-09-21 2010-10-27 Owen Mumford Ltd Autoinjectors
EP2438941A1 (en) 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Auto injector with a torsion spring
EP2438940A1 (en) 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Auto injector with a torsion spring
WO2012054438A1 (en) 2010-10-22 2012-04-26 Schering Corporation Anti-pcsk9
EP2468337A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Back-end device for an auto-injector and auto-injector
EP2468336A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto-injector
EP2468329A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto injector with a torsion spring
EP2468328A1 (en) 2010-12-21 2012-06-27 Sanofi-Aventis Deutschland GmbH Auto-injector
US20120195910A1 (en) 2010-12-22 2012-08-02 Genentech, Inc. Anti-pcsk9 antibodies and methods of use
GB2487235A (en) 2011-01-17 2012-07-18 Owen Mumford Ltd Injection device with pneumatic damping of the drive mechanism
JP5917565B2 (ja) * 2011-01-27 2016-05-18 メドトロニック ミニメド インコーポレイテッド 挿入デバイスシステムおよび方法
DK2668212T3 (en) 2011-01-28 2018-07-02 Saonofi Biotechnology HUMAN ANTIBODIES AGAINST PCSK9 FOR USE IN PROCEDURES FOR TREATING PARTICULAR GROUPS OF PERSONS
CN203724564U (zh) 2011-02-09 2014-07-23 贝克顿·迪金森公司 输注设备
BR112013020402A2 (pt) 2011-02-11 2018-09-25 Irm Llc antagonistas pcsk9
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
EP2734255B1 (en) 2011-08-24 2016-04-27 Unitract Syringe Pty Ltd Auto-injector for retractable prefilled syringe
EP2785395A4 (en) 2011-12-02 2015-11-11 Trendymed Inc MOBILE PERFUSION DEVICE
RU2014128518A (ru) 2011-12-29 2016-02-20 Ново Нордиск А/С Механизм увеличения/уменьшения дозы для взводимого шприца-ручки
US9707357B2 (en) 2012-05-25 2017-07-18 Aptar France Sas Autoinjector
US20140088508A1 (en) 2012-09-24 2014-03-27 Patrick Ryan Drug-delivery devices with integrated needle-insertion mechanism
WO2014099984A1 (en) 2012-12-20 2014-06-26 Amgen Inc. Apj receptor agonists and uses thereof
SG11201507524TA (en) 2013-03-14 2015-10-29 Amgen Inc Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
US20140274874A1 (en) 2013-03-14 2014-09-18 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
WO2014198858A1 (en) 2013-06-14 2014-12-18 Novo Nordisk A/S Drug delivery device with dual layer spring
JP6476188B2 (ja) 2013-09-05 2019-02-27 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 手動でトリガされ、ばね荷重される駆動機構を有する針挿入および後退配置
TWI569841B (zh) 2013-10-10 2017-02-11 卡貝歐洲有限公司 藥物輸送裝置
US10195342B2 (en) * 2014-04-24 2019-02-05 Becton, Dickinson And Company Cannula deployment mechanism
TW201603852A (zh) 2014-07-01 2016-02-01 賽諾菲公司 彈簧裝置及具有該彈簧裝置之藥物傳輸裝置
TW201603847A (zh) 2014-07-01 2016-02-01 賽諾菲公司 注射裝置及組裝方法
WO2016041883A1 (en) 2014-09-15 2016-03-24 Novo Nordisk A/S Torsion spring driven injection device
EP3256189B1 (en) 2015-02-10 2022-10-19 Amgen Inc. Rotationally biased insertion mechanism for a drug delivery pump
EP3463526A1 (en) * 2016-06-02 2019-04-10 West Pharma. Services Il, Ltd. Three position needle retraction

Similar Documents

Publication Publication Date Title
JPWO2019014014A5 (ja)
USD600373S1 (en) Motorcycle front lighting
USD515275S1 (en) Pet treat
JP2020527373A5 (ja)
CA2536847A1 (en) Phacoemulsification tip
USD587637S1 (en) Surface configuration of a front portion of a vehicle, toy, and/or other replicas
USD536040S1 (en) Twirling baton with heart shaped ball and tip
US20130298755A1 (en) Motor assembly for pneumatic tool
USD548563S1 (en) Handle
USD517692S1 (en) Tampon applicator barrel
USD548560S1 (en) Front portions of a combination handle and housing assembly
US10480893B2 (en) Crossbow with stock overlap
JP2002306032A5 (ja)
JP2005087477A (ja) 内痔核吸引輪ゴム結紮器
JP2004529021A5 (ja)
USD511831S1 (en) Tampon applicator barrel
USD512143S1 (en) Tampon applicator barrel
USD511832S1 (en) Tampon applicator barrel
USD517210S1 (en) Tampon applicator plunger
JP4563368B2 (ja) ダーツ
JP2021186319A5 (ja)
TWI353913B (ja)
JP2008532672A5 (ja)
USD522606S1 (en) Fly trap
USD511572S1 (en) Tampon applicator barrel