JPWO2015190452A1 - 清酒酵母含有錠剤 - Google Patents
清酒酵母含有錠剤 Download PDFInfo
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- JPWO2015190452A1 JPWO2015190452A1 JP2016527803A JP2016527803A JPWO2015190452A1 JP WO2015190452 A1 JPWO2015190452 A1 JP WO2015190452A1 JP 2016527803 A JP2016527803 A JP 2016527803A JP 2016527803 A JP2016527803 A JP 2016527803A JP WO2015190452 A1 JPWO2015190452 A1 JP WO2015190452A1
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- Prior art keywords
- tablet
- sake yeast
- mass
- crystalline cellulose
- yeast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
〔1〕 清酒酵母と結晶セルロースとを含有する錠剤において、清酒酵母菌体(A)を錠剤中に15質量%以上含有し、清酒酵母菌体(A)の含有量に対する結晶セルロース(B)の含有量の質量比率(B/A)が1.3以上である、錠剤。
〔2〕 カルボキシメチルセルロースカルシウム(C)を更に含有する、〔1〕に記載の錠剤。
〔3〕 清酒酵母菌体(A)を23質量%以上含有する、〔1〕又は〔2〕に記載の錠剤。
〔4〕 結晶セルロース(B)の嵩密度が0.3g/cm3以下である、〔1〕〜〔3〕のいずれかに記載の錠剤。
〔5〕 結晶セルロース(B)の平均粒子径が100μm以下である、〔1〕〜〔4〕のいずれかに記載の錠剤。
本発明の錠剤は、清酒酵母を含有する。清酒酵母とは、清酒醸造に用いられる酵母である。清酒醸造に用いられる酵母は、主としてサッカロミセス・セレビシエ(S.cerevisiae)に分類される。清酒酵母としては、協会6号酵母(K−6)、協会7号酵母(K−7)、協会9号酵母(K−9)、協会601号酵母(K−601)、協会701号酵母(K−701)、協会901号酵母(K−901)、協会1001号酵母(K−1001)、協会1501号酵母(K−1501)(いずれも公益財団法人日本醸造協会頒布)が例示される。清酒酵母は、生菌体及び死菌体のいずれでもよい。
本発明の錠剤は、結晶セルロース(B)を含有する。結晶セルロース(B)は、結晶構造を有するセルロースであり、微結晶セルロース(微結晶構造を有するセルロース)であってもよい。結晶セルロースの製造条件は特に限定されず、α−セルロースを部分的に解重合して生成したものであってもよいし、パルプ等の原料を加水分解し非結晶部分を除去して製造してもよい。結晶セルロース(B)は、微結晶セルロースと呼ばれているものであってもよい。結晶セルロース(B)としては、例えば、旭化成ケミカルズ株式会社製のUF、KG、PH、FD等のグレードのセオラス(登録商標)が挙げられる。好ましくは、セオラス(登録商標)FD−101、セオラス(登録商標)UF−F702、セオラス(登録商標)UF−F711が挙げられる。
本発明の錠剤において、清酒酵母菌体(A)の含有量に対する結晶セルロース(B)の含有量の質量比率(B/A)が1.3以上であり、2.5以上であることが好ましい。これにより、硬度及び崩壊性の両方に優れた錠剤を得ることができる。
本発明の錠剤は、カルボキシメチルセルロースカルシウム(別名:カルメロースカルシウム)(C)を更に含有することが好ましい。カルボキシメチルセルロースカルシウム(C)を配合することにより、錠剤の崩壊性をさらに向上させることができる。カルボキシメチルセルロースカルシウム(C)の配合量は、0.5質量%以上であることが好ましく、1質量%以上であることがより好ましく、1.5質量%以上であることが更に好ましい。上限は、30質量%以下であることが好ましく、20質量%以下であることが好ましく、10質量%以下であることがより好ましい。カルボキシメチルセルロースカルシウム(C)の含有量は、0.5〜30質量%であることが好ましく、より好ましくは1〜20質量%であり、更に好ましくは1.5〜10質量%である。
清酒酵母(SAMe含有乾燥酵母、三菱ガス化学(株)製、酵母粉末中の菌体量70%)、結晶セルロース、カルボキシメチルセルロースカルシウム(E.C.G−FA、ニチリン化学工業(株)製)を混合した後、ステアリン酸カルシウム(ステアリン酸カルシウム、太平化学産業(株)製)を添加混合し、直打法により5kNで打錠した。なお、結晶セルロースとしてはセオラス(登録商標)FD−101(旭化成ケミカルズ(株)製)を用いた。
硬度が5kgf以上であれば許容と判断した。
☆:8kgf以上
◎:6kgf以上8kgf未満
○:5kgf以上6kgf未満
×:5kgf未満
崩壊時間が60分未満であれば許容と判断した。
◎:40分未満
○:40分以上、60分未満
×:60分以上
※清酒酵母中の清酒酵母菌体(A)としての量(清酒酵母菌体(A)量=清酒酵母量×0.7)〔乾燥質量〕
各成分の含有量の単位:mg/錠
結晶セルロースとして表3に記載された結晶セルロースを用い、打錠圧を4kNとしたほかは、実施例1と同様にして錠剤を作成した。得られた各錠剤の硬度と崩壊時間を実施例1と同様に測定した。各錠剤の成分と評価を表3に示す。なお、微粒二酸化ケイ素としてはカープレックスFPS−500(DSL.ジャパン(株)製)を用い、結晶セルロースとしては、セオラス(登録商標)FD−101、UF−F702、及びUF−F711(いずれも旭化成ケミカルズ(株)製)を用いた。
※清酒酵母中の清酒酵母菌体(A)としての量(清酒酵母菌体(A)量=清酒酵母量×0.7)〔乾燥質量〕
各成分の含有量の単位:mg/錠
Claims (5)
- 清酒酵母と結晶セルロースとを含有する錠剤において、清酒酵母菌体(A)を錠剤中に15質量%以上含有し、清酒酵母菌体(A)の含有量に対する結晶セルロース(B)の含有量の質量比率(B/A)が1.3以上である錠剤。
- カルボキシメチルセルロースカルシウム(C)を更に含有する、請求項1に記載の錠剤。
- 清酒酵母菌体(A)を23質量%以上含有する、請求項1又は2に記載の錠剤。
- 結晶セルロース(B)の嵩密度が0.3g/cm3以下である、請求項1〜3のいずれか1項に記載の錠剤。
- 結晶セルロース(B)の平均粒子径が100μm以下である、請求項1〜4のいずれか1項に記載の錠剤。
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JP2003081880A (ja) * | 2001-09-05 | 2003-03-19 | Kirin Brewery Co Ltd | 固形製剤用崩壊性結合剤 |
JP2012167131A (ja) * | 2012-06-13 | 2012-09-06 | Kimura Sangyo Kk | 生菌剤や消化酵素剤およびその両方を含有する錠剤 |
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