JPS6356881B2 - - Google Patents
Info
- Publication number
- JPS6356881B2 JPS6356881B2 JP58086470A JP8647083A JPS6356881B2 JP S6356881 B2 JPS6356881 B2 JP S6356881B2 JP 58086470 A JP58086470 A JP 58086470A JP 8647083 A JP8647083 A JP 8647083A JP S6356881 B2 JPS6356881 B2 JP S6356881B2
- Authority
- JP
- Japan
- Prior art keywords
- general formula
- proteoglucan
- bonds
- main chain
- branched chains
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 240000001080 Grifola frondosa Species 0.000 claims description 15
- 235000007710 Grifola frondosa Nutrition 0.000 claims description 15
- 235000001674 Agaricus brunnescens Nutrition 0.000 claims description 13
- 229920001503 Glucan Polymers 0.000 claims description 10
- 239000002246 antineoplastic agent Substances 0.000 claims description 10
- 238000006243 chemical reaction Methods 0.000 claims description 9
- 238000003809 water extraction Methods 0.000 claims description 7
- 239000004480 active ingredient Substances 0.000 claims description 5
- RJGDLRCDCYRQOQ-UHFFFAOYSA-N anthrone Chemical compound C1=CC=C2C(=O)C3=CC=CC=C3CC2=C1 RJGDLRCDCYRQOQ-UHFFFAOYSA-N 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 3
- 239000003513 alkali Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 description 18
- 150000004676 glycans Chemical class 0.000 description 14
- 229920001282 polysaccharide Polymers 0.000 description 14
- 239000005017 polysaccharide Substances 0.000 description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 5
- 239000002244 precipitate Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000002054 transplantation Methods 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 230000001093 anti-cancer Effects 0.000 description 3
- 229940041181 antineoplastic drug Drugs 0.000 description 3
- 238000004817 gas chromatography Methods 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000009702 cancer cell proliferation Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000002198 insoluble material Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000002195 soluble material Substances 0.000 description 2
- DBTMGCOVALSLOR-DEVYUCJPSA-N (2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](CO)O[C@H](O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-DEVYUCJPSA-N 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- 101710154757 Exo-beta-1,3-glucanase Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920001543 Laminarin Polymers 0.000 description 1
- 239000005717 Laminarin Substances 0.000 description 1
- 208000006268 Sarcoma 180 Diseases 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- WORJEOGGNQDSOE-UHFFFAOYSA-N chloroform;methanol Chemical compound OC.ClC(Cl)Cl WORJEOGGNQDSOE-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- WJLUBOLDZCQZEV-UHFFFAOYSA-M hexadecyl(trimethyl)azanium;hydroxide Chemical compound [OH-].CCCCCCCCCCCCCCCC[N+](C)(C)C WJLUBOLDZCQZEV-UHFFFAOYSA-M 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000006140 methanolysis reaction Methods 0.000 description 1
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 1
- 229940117969 neopentyl glycol Drugs 0.000 description 1
- FEMOMIGRRWSMCU-UHFFFAOYSA-N ninhydrin Chemical compound C1=CC=C2C(=O)C(O)(O)C(=O)C2=C1 FEMOMIGRRWSMCU-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229910021332 silicide Inorganic materials 0.000 description 1
- FVBUAEGBCNSCDD-UHFFFAOYSA-N silicide(4-) Chemical compound [Si-4] FVBUAEGBCNSCDD-UHFFFAOYSA-N 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58086470A JPS59210901A (ja) | 1983-05-17 | 1983-05-17 | プロテオグルカン及びそれからなる抗ガン剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58086470A JPS59210901A (ja) | 1983-05-17 | 1983-05-17 | プロテオグルカン及びそれからなる抗ガン剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59210901A JPS59210901A (ja) | 1984-11-29 |
| JPS6356881B2 true JPS6356881B2 (ko) | 1988-11-09 |
Family
ID=13887842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58086470A Granted JPS59210901A (ja) | 1983-05-17 | 1983-05-17 | プロテオグルカン及びそれからなる抗ガン剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59210901A (ko) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0500718A1 (en) * | 1989-11-09 | 1992-09-02 | Byron A Donzis | Insoluble yeast extract. |
| WO2009102008A1 (ja) * | 2008-02-14 | 2009-08-20 | Yukiguni Maitake Co., Ltd. | 免疫賦活作用および抗腫瘍作用を有するマイタケ由来の低分子物質 |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6058925A (ja) * | 1983-09-09 | 1985-04-05 | Nippon Beet Sugar Mfg Co Ltd | 抗腫瘍活性物質 |
| JPS60255733A (ja) * | 1984-05-30 | 1985-12-17 | Nippon Beet Sugar Mfg Co Ltd | β−Ｄ−グルカン |
| AU647751B2 (en) * | 1989-09-08 | 1994-03-31 | Alpha-Beta Technology, Inc. | Method for immune system activation |
| EP0490995A1 (en) * | 1989-09-08 | 1992-06-24 | Alpha Beta Technology | Method for producing soluble glucans |
| US5622939A (en) * | 1992-08-21 | 1997-04-22 | Alpha-Beta Technology, Inc. | Glucan preparation |
| US5811542A (en) * | 1989-09-08 | 1998-09-22 | Alpha-Beta Technology, Inc. | Method for producing soluble glucans |
| US5488040A (en) * | 1989-09-08 | 1996-01-30 | Alpha-Beta Technology, Inc. | Use of neutral soluble glucan preparations to stimulate platelet production |
| JP2753935B2 (ja) * | 1993-04-30 | 1998-05-20 | 株式会社雪国まいたけ | 免疫抑制剤の製造方法 |
| JP2732008B2 (ja) * | 1993-04-30 | 1998-03-25 | 株式会社雪国まいたけ | 育毛促進剤の製造方法 |
| JP2689244B2 (ja) * | 1993-04-30 | 1997-12-10 | 株式会社雪国まいたけ | 肝疾患改善剤の製造方法 |
| US5622940A (en) * | 1994-07-14 | 1997-04-22 | Alpha-Beta Technology | Inhibition of infection-stimulated oral tissue destruction by β(1,3)-glucan |
| JPH08119874A (ja) * | 1994-10-24 | 1996-05-14 | Takumi Sogabe | エイズウィルス・癌細胞の抑制剤の製造方法 |
| AUPN166195A0 (en) | 1995-03-13 | 1995-04-06 | Norvet Research Pty Limited | Process for glucan extraction |
| JP2859843B2 (ja) * | 1996-03-08 | 1999-02-24 | 株式会社雪国まいたけ | マイタケから抽出した抗腫瘍物質 |
| US6046323A (en) * | 1997-07-29 | 2000-04-04 | The Collaborative Group, Ltd. | Conformations of PPG-glucan |
| US6616928B1 (en) | 1998-10-20 | 2003-09-09 | Yukiguni Maitake Co., Ltd. | Active oxygen scavenger and cancer chemopreventer from Grifola |
| AU6261999A (en) | 1998-09-25 | 2000-04-17 | Collaborative Group, Ltd., The | Very high molecular weight beta-glucans |
| US6369216B1 (en) | 1998-09-25 | 2002-04-09 | Biopolymer Engineering Pharmaceutical, Inc. | Very high molecular weight β-glucans |
| JP2001097881A (ja) * | 1999-09-28 | 2001-04-10 | Yukiguni Maitake Co Ltd | マイタケ由来の発がん防止剤及び発がん防止用食品又は飼料 |
| JP2005133069A (ja) * | 2003-10-09 | 2005-05-26 | Ichimasa Kamaboko Co Ltd | きのこ由来のβ−グルカン多糖類の取得方法ときのこ由来のβ−グルカン多糖類 |
| JP5153188B2 (ja) * | 2007-03-30 | 2013-02-27 | 小林製薬株式会社 | Ｔｈ１／Ｔｈ２バランス改善剤 |
| JP2011184306A (ja) * | 2010-03-04 | 2011-09-22 | Yukiguni Maitake Co Ltd | マイタケ属キノコ由来の食後過血糖の上昇を抑制する物質 |
| CN103304680B (zh) * | 2012-03-09 | 2017-02-08 | 中国科学院上海药物研究所 | 一种β‑葡聚糖、其提取方法及用途 |
| CN104497161B (zh) * | 2015-01-04 | 2016-09-14 | 华东理工大学 | 一种灰树花多糖的提纯方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5836395A (ja) * | 1981-08-26 | 1983-03-03 | Nippon Beet Sugar Mfg Co Ltd | 多糖類の製造方法 |
-
1983
- 1983-05-17 JP JP58086470A patent/JPS59210901A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5836395A (ja) * | 1981-08-26 | 1983-03-03 | Nippon Beet Sugar Mfg Co Ltd | 多糖類の製造方法 |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0500718A1 (en) * | 1989-11-09 | 1992-09-02 | Byron A Donzis | Insoluble yeast extract. |
| EP0500718A4 (en) * | 1989-11-09 | 1994-09-14 | Byron A Donzis | Insoluble yeast extract |
| WO2009102008A1 (ja) * | 2008-02-14 | 2009-08-20 | Yukiguni Maitake Co., Ltd. | 免疫賦活作用および抗腫瘍作用を有するマイタケ由来の低分子物質 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS59210901A (ja) | 1984-11-29 |
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