JPS6254110B2 - - Google Patents
Info
- Publication number
- JPS6254110B2 JPS6254110B2 JP52056978A JP5697877A JPS6254110B2 JP S6254110 B2 JPS6254110 B2 JP S6254110B2 JP 52056978 A JP52056978 A JP 52056978A JP 5697877 A JP5697877 A JP 5697877A JP S6254110 B2 JPS6254110 B2 JP S6254110B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- pyrrolo
- pyrrole
- dihydro
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70485776A | 1976-07-14 | 1976-07-14 | |
| US05/771,283 US4087539A (en) | 1976-07-14 | 1977-02-23 | 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS539789A JPS539789A (en) | 1978-01-28 |
| JPS6254110B2 true JPS6254110B2 (enExample) | 1987-11-13 |
Family
ID=27107392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5697877A Granted JPS539789A (en) | 1976-07-14 | 1977-05-17 | Production of 55*22floyl** * 55*22thenoyl** * 55*33 floyl** and 55*33thenoyl** 1*22dihydroo3hhpyroro * 1*22a*pyrolee11carboxylic acid derivative |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS539789A (enExample) |
| AR (1) | AR218631A1 (enExample) |
| AU (1) | AU513385B2 (enExample) |
| CA (1) | CA1100140A (enExample) |
| CH (2) | CH644861A5 (enExample) |
| CS (1) | CS208724B2 (enExample) |
| DE (1) | DE2731662A1 (enExample) |
| DK (1) | DK152652C (enExample) |
| ES (2) | ES460705A1 (enExample) |
| FI (1) | FI63407C (enExample) |
| FR (1) | FR2361396A1 (enExample) |
| GB (1) | GB1554076A (enExample) |
| GR (1) | GR61607B (enExample) |
| HK (1) | HK17581A (enExample) |
| IE (1) | IE45302B1 (enExample) |
| IL (1) | IL52492A (enExample) |
| IT (1) | IT1117314B (enExample) |
| MY (1) | MY8100371A (enExample) |
| NL (1) | NL7707652A (enExample) |
| NO (1) | NO147563C (enExample) |
| NZ (1) | NZ184611A (enExample) |
| PL (1) | PL111408B1 (enExample) |
| PT (1) | PT66779B (enExample) |
| SE (1) | SE434644B (enExample) |
| SU (2) | SU664566A3 (enExample) |
| YU (2) | YU43156B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4097579A (en) * | 1977-03-31 | 1978-06-27 | Syntex (U.S.A.) Inc. | 5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof |
| US4140698A (en) * | 1977-07-25 | 1979-02-20 | Syntex (Usa) Inc. | 1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles |
| US4353829A (en) * | 1980-11-21 | 1982-10-12 | Syntex (U.S.A.) Inc. | Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters |
| JPS5910589A (ja) * | 1982-06-10 | 1984-01-20 | メルク エンド カムパニー インコーポレーテツド | 抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体 |
| US4511724A (en) * | 1982-06-10 | 1985-04-16 | Merck & Co., Inc. | 5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents |
| HU198927B (en) * | 1987-01-14 | 1989-12-28 | Richter Gedeon Vegyeszet | Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same |
| US4874871A (en) * | 1987-03-25 | 1989-10-17 | Syntex (U.S.A.) Inc. | Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds |
-
1977
- 1977-05-17 JP JP5697877A patent/JPS539789A/ja active Granted
- 1977-07-07 AR AR268357A patent/AR218631A1/es active
- 1977-07-07 DK DK307677A patent/DK152652C/da not_active IP Right Cessation
- 1977-07-07 GR GR53906A patent/GR61607B/el unknown
- 1977-07-08 IL IL52492A patent/IL52492A/xx unknown
- 1977-07-08 IE IE1422/77A patent/IE45302B1/en unknown
- 1977-07-08 PT PT66779A patent/PT66779B/pt unknown
- 1977-07-08 NL NL7707652A patent/NL7707652A/xx not_active Application Discontinuation
- 1977-07-08 CH CH848877A patent/CH644861A5/de not_active IP Right Cessation
- 1977-07-08 CH CH4005/84A patent/CH651045A5/de not_active IP Right Cessation
- 1977-07-11 FI FI772154A patent/FI63407C/fi not_active IP Right Cessation
- 1977-07-11 NZ NZ184611A patent/NZ184611A/xx unknown
- 1977-07-11 GB GB28923/77A patent/GB1554076A/en not_active Expired
- 1977-07-12 CS CS774647A patent/CS208724B2/cs unknown
- 1977-07-12 FR FR7721559A patent/FR2361396A1/fr active Granted
- 1977-07-12 CA CA282,600A patent/CA1100140A/en not_active Expired
- 1977-07-13 AU AU26976/77A patent/AU513385B2/en not_active Expired
- 1977-07-13 PL PL1977199602A patent/PL111408B1/pl unknown
- 1977-07-13 DE DE19772731662 patent/DE2731662A1/de active Granted
- 1977-07-13 IT IT68631/77A patent/IT1117314B/it active
- 1977-07-13 ES ES460705A patent/ES460705A1/es not_active Expired
- 1977-07-13 NO NO772493A patent/NO147563C/no unknown
- 1977-07-13 SE SE7708142A patent/SE434644B/xx not_active IP Right Cessation
- 1977-07-13 SU SU772504151A patent/SU664566A3/ru active
- 1977-12-29 SU SU772558960A patent/SU793400A3/ru active
-
1978
- 1978-05-24 ES ES470213A patent/ES470213A1/es not_active Expired
-
1981
- 1981-04-30 HK HK175/81A patent/HK17581A/xx unknown
- 1981-12-30 MY MY371/81A patent/MY8100371A/xx unknown
-
1983
- 1983-02-28 YU YU475/83A patent/YU43156B/xx unknown
- 1983-02-28 YU YU476/83A patent/YU43157B/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS6254792B2 (enExample) | ||
| US4087539A (en) | 5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof | |
| JPS647997B2 (enExample) | ||
| JPS6254109B2 (enExample) | ||
| IL23152A (en) | Alkanoic acids are converted by aryl groups | |
| JPH0788387B2 (ja) | 新規な４Ｈ―トリアゾロ〔４，３―ａ〕〔１，４〕ベンゾジアゼピン類、それらの製造法及び薬剤としての使用 | |
| KR850000609B1 (ko) | 5-벤조일-6-클로로(또는 브로모)-1,2-디히드로-3H-피롤로[1,2-a]피롤-1-카르복실산 유도체의 제조방법 | |
| JPS6254110B2 (enExample) | ||
| JPH0150698B2 (enExample) | ||
| HU190543B (en) | Process for producing 5-/vynil-or 4-ethinyl-benzoyl/-1,2-dihydro-3h-pyrrolo /1,2-a/pyrrol-1-carboxylic acids and their derivatives | |
| ES2309340T3 (es) | Abridor del canal de k activado por calcio de alta conductancia. | |
| CH648283A5 (fr) | Acides 2-amino-3-(alpha-hydroxybenzyl)-phenylacetiques et sels metalliques, esters et amides, utiles notamment comme agents anti-inflammatoires, et compositions pharmaceutiques les contenant. | |
| US4473583A (en) | Compositions containing certain derivatives of 4-phenyl-4-oxobuten-2-oic acid and methods of treatment using them | |
| WO2019179346A1 (zh) | 苯甲酸类化合物及其制备方法和应用 | |
| JPH0437076B2 (enExample) | ||
| JPH02295984A (ja) | 新規なベンゾチアゾリノン誘導体 | |
| JPS62270558A (ja) | 新規の１−スチレンスルホニル−２−オキソ−５−ヒドロキシピロリジン誘導体、それらの製造方法、それらの製造用中間体、それらの医薬としての使用及びそれらを含有する製薬組成物 | |
| JPS5942385A (ja) | キナゾリノン誘導体 | |
| AT364846B (de) | Verfahren zur herstellung von neuen in stellung 5 substituierten 1,2-dihydro-3h-pyrrolo-(1,2-a) -pyrrol-1-carbonsaeuren und von deren einzelnen 1-saeureisomeren und d-saeureisomeren | |
| JPH0625184B2 (ja) | 新規置換ベンゾチアゾリノン、その製法およびそれを含有する医薬組成物 | |
| CH644862A5 (en) | 5-(2- and 3-furoyl)- and 5-(2- and 3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids and their salts and esters | |
| CN107540672A (zh) | 一种治疗肝硬化的药物及其合成方法 | |
| JPS61106549A (ja) | 不飽和ジフエニルアゾメチン誘導体、その製造法およびそれを含有する医薬組成物 | |
| NO135823B (enExample) | ||
| JPS5865280A (ja) | ５―（アミノアルキル）―１１―フェニル―５Ｈ―ジベンゾ〔ｂ，ｅ〕〔１，４〕ジアゼピン類 |