JPS6245208B2 - - Google Patents
Info
- Publication number
- JPS6245208B2 JPS6245208B2 JP56120459A JP12045981A JPS6245208B2 JP S6245208 B2 JPS6245208 B2 JP S6245208B2 JP 56120459 A JP56120459 A JP 56120459A JP 12045981 A JP12045981 A JP 12045981A JP S6245208 B2 JPS6245208 B2 JP S6245208B2
- Authority
- JP
- Japan
- Prior art keywords
- human
- cells
- necrosis factor
- htnf
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
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- 208000006552 Lewis Lung Carcinoma Diseases 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241000711408 Murine respirovirus Species 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
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- 102000004142 Trypsin Human genes 0.000 description 1
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- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
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- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
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- 238000001962 electrophoresis Methods 0.000 description 1
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- 210000002257 embryonic structure Anatomy 0.000 description 1
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- 230000001900 immune effect Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
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- 238000001155 isoelectric focusing Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
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- 239000007923 nasal drop Substances 0.000 description 1
- 229940100662 nasal drops Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
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- 229940066842 petrolatum Drugs 0.000 description 1
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- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
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Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56120459A JPS5821621A (ja) | 1981-07-31 | 1981-07-31 | ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤 |
| FR8212541A FR2513124B1 (fr) | 1981-07-21 | 1982-07-19 | Production et applications du facteur de lyse des cellules-cibles |
| SE8204382A SE8204382L (sv) | 1981-07-21 | 1982-07-19 | Sett att framstella malcellysfaktor och anvendning derav |
| IT48855/82A IT1196549B (it) | 1981-07-21 | 1982-07-20 | Procedimento per la produzione del fattore di lisi cellule bersaglio (tclf),prodotto ottenuto a suo impiego in terapia clinica,in particolare come agente citolitico antitumurale |
| CH4420/82A CH664974A5 (fr) | 1981-07-21 | 1982-07-20 | Production du facteur de lyse des cellules-cibles. |
| KR8203215A KR870001433B1 (ko) | 1981-07-21 | 1982-07-20 | 적상적혈구(的狀赤血球) 붕괴인자의 제조 방법 |
| AU86200/82A AU560793B2 (en) | 1981-07-21 | 1982-07-20 | Production of target cell lysis factor |
| DE3227262A DE3227262C3 (de) | 1981-07-21 | 1982-07-21 | Verfahren zur Herstellung von menschlichem Tumor-Nekrose-Faktor und menschlicher Tumor-Nekrose-Faktor |
| GB08221100A GB2106117B (en) | 1981-07-21 | 1982-07-21 | Process for producing target cell lysis factor |
| AT0283582A AT387980B (de) | 1981-07-21 | 1982-07-21 | Verfahren zur herstellung eines die aufloesung menschlicher zellen bewirkenden faktors |
| ES514210A ES8308923A1 (es) | 1981-07-21 | 1982-07-21 | Un procedimiento para la produccion de tclf. |
| US06/400,487 US4495282A (en) | 1981-07-21 | 1982-07-21 | Process for producing target cell lysis factor and uses therewith |
| DE3249946A DE3249946C2 (de) | 1981-07-21 | 1982-07-21 | hTNF-haltiges therapeutisches Mittel gegen maligne Tumoren und dessen Verwendung |
| CA000408532A CA1213544A (en) | 1981-07-31 | 1982-07-30 | Process for producing target cell lysis factor and uses therewith |
| JP62028310A JP2518634B2 (ja) | 1981-07-31 | 1987-02-12 | ヒト ツモア・ネクロシス・フアクタ−の製造方法 |
| JP62028311A JP2518635B2 (ja) | 1981-07-31 | 1987-02-12 | ヒト ツモア・ネクロシス・フアクタ− |
| SE9000532A SE9000532L (sv) | 1981-07-21 | 1990-02-14 | Farmaceutisk tclf-komposition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP56120459A JPS5821621A (ja) | 1981-07-31 | 1981-07-31 | ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62028311A Division JP2518635B2 (ja) | 1981-07-31 | 1987-02-12 | ヒト ツモア・ネクロシス・フアクタ− |
| JP62028310A Division JP2518634B2 (ja) | 1981-07-31 | 1987-02-12 | ヒト ツモア・ネクロシス・フアクタ−の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5821621A JPS5821621A (ja) | 1983-02-08 |
| JPS6245208B2 true JPS6245208B2 (de) | 1987-09-25 |
Family
ID=14786690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP56120459A Granted JPS5821621A (ja) | 1981-07-21 | 1981-07-31 | ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5821621A (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0764744B2 (ja) * | 1981-11-21 | 1995-07-12 | 株式会社林原生物化学研究所 | 標的細胞障害性因子とヒトインタ−フェロンとを有効成分として含有する悪性腫瘍治療剤 |
| US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
| GR851626B (de) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
| JP2675294B2 (ja) * | 1984-10-15 | 1997-11-12 | カイロン コーポレイション | ヒト腫瘍壊死因子 |
| JPS6248634A (ja) * | 1985-07-23 | 1987-03-03 | Mochida Pharmaceut Co Ltd | 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5816687A (ja) * | 1981-07-21 | 1983-01-31 | Hayashibara Biochem Lab Inc | リンホトキシンの製造方法 |
| GB2106117A (en) * | 1981-07-21 | 1983-04-07 | Mochida Pharm Co Ltd | Process for producing target cell lysis factor |
| JPS6011890A (ja) * | 1983-06-30 | 1985-01-22 | 富士通株式会社 | イメ−ジメモリ制御方式 |
-
1981
- 1981-07-31 JP JP56120459A patent/JPS5821621A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5816687A (ja) * | 1981-07-21 | 1983-01-31 | Hayashibara Biochem Lab Inc | リンホトキシンの製造方法 |
| GB2106117A (en) * | 1981-07-21 | 1983-04-07 | Mochida Pharm Co Ltd | Process for producing target cell lysis factor |
| JPS6011890A (ja) * | 1983-06-30 | 1985-01-22 | 富士通株式会社 | イメ−ジメモリ制御方式 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5821621A (ja) | 1983-02-08 |
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