AT387980B - Verfahren zur herstellung eines die aufloesung menschlicher zellen bewirkenden faktors - Google Patents

Verfahren zur herstellung eines die aufloesung menschlicher zellen bewirkenden faktors

Info

Publication number
AT387980B
AT387980B AT0283582A AT283582A AT387980B AT 387980 B AT387980 B AT 387980B AT 0283582 A AT0283582 A AT 0283582A AT 283582 A AT283582 A AT 283582A AT 387980 B AT387980 B AT 387980B
Authority
AT
Austria
Prior art keywords
resolution
producing
human cells
factor effecting
effecting
Prior art date
Application number
AT0283582A
Other languages
English (en)
Other versions
ATA283582A (de
Original Assignee
Hayashibara Biochem Lab
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56112914A external-priority patent/JPS5815921A/ja
Priority claimed from JP56112913A external-priority patent/JPS5816687A/ja
Priority claimed from JP56120459A external-priority patent/JPS5821621A/ja
Priority claimed from JP56187627A external-priority patent/JPH0764744B2/ja
Priority claimed from JP56187626A external-priority patent/JPS5889195A/ja
Priority claimed from JP56205115A external-priority patent/JPS6011890B2/ja
Application filed by Hayashibara Biochem Lab, Mochida Pharm Co Ltd filed Critical Hayashibara Biochem Lab
Publication of ATA283582A publication Critical patent/ATA283582A/de
Application granted granted Critical
Publication of AT387980B publication Critical patent/AT387980B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT0283582A 1981-07-21 1982-07-21 Verfahren zur herstellung eines die aufloesung menschlicher zellen bewirkenden faktors AT387980B (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP56112914A JPS5815921A (ja) 1981-07-21 1981-07-21 抗リンホトキシン感受性疾患剤
JP56112913A JPS5816687A (ja) 1981-07-21 1981-07-21 リンホトキシンの製造方法
JP56120459A JPS5821621A (ja) 1981-07-31 1981-07-31 ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤
JP56187627A JPH0764744B2 (ja) 1981-11-21 1981-11-21 標的細胞障害性因子とヒトインタ−フェロンとを有効成分として含有する悪性腫瘍治療剤
JP56187626A JPS5889195A (ja) 1981-11-21 1981-11-21 標的細胞障害性因子の製造方法
JP56205115A JPS6011890B2 (ja) 1981-12-21 1981-12-21 ツモアネクロシスフアクタ−の製造方法

Publications (2)

Publication Number Publication Date
ATA283582A ATA283582A (de) 1988-09-15
AT387980B true AT387980B (de) 1989-04-10

Family

ID=27552385

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0283582A AT387980B (de) 1981-07-21 1982-07-21 Verfahren zur herstellung eines die aufloesung menschlicher zellen bewirkenden faktors

Country Status (9)

Country Link
US (1) US4495282A (de)
AT (1) AT387980B (de)
AU (1) AU560793B2 (de)
CH (1) CH664974A5 (de)
DE (1) DE3227262C3 (de)
FR (1) FR2513124B1 (de)
GB (1) GB2106117B (de)
IT (1) IT1196549B (de)
SE (2) SE8204382L (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5821621A (ja) * 1981-07-31 1983-02-08 Hayashibara Biochem Lab Inc ヒトツモア・ネクロシス・ファクタ−を含有する悪性腫瘍治療剤
US4920196A (en) * 1982-07-30 1990-04-24 Genentech, Inc. Human lymphotoxin
US4806471A (en) * 1982-09-16 1989-02-21 A/S Alfred Benzon Plasmids with conditional uncontrolled replication behavior
IL71954A0 (en) * 1983-06-01 1984-09-30 Genentech Inc Gamma interferon-lymphotoxin synergism
CA1265444A (en) * 1983-06-27 1990-02-06 Lloyd J. Old Effect of human tumor necrosis factor and human interferon on human cancer cells and methods
JPS6019720A (ja) * 1983-07-14 1985-01-31 Yamanouchi Pharmaceut Co Ltd ヒト内来性癌制御因子およびその製造法
JPS60112718A (ja) * 1983-11-21 1985-06-19 Kyorin Pharmaceut Co Ltd 抗腫瘍作用を示す蛋白性物質及びその製造方法
DE3483252D1 (de) * 1983-12-05 1990-10-25 Asahi Chemical Ind Verfahren zur induktion von antitumorimmunozyten, verfahren zur herstellung von antitumorimmunozyten und durch das verfahren hergestellte antitumorimmunozyten.
HU192254B (en) * 1983-12-13 1987-05-28 Egyt Gyogyszervegyeszeti Gyar Process for producing human leucocite and human gamma interferons in consecutive steps
US4758549A (en) * 1983-12-13 1988-07-19 Kabushiki Kaisha Mayashibara Seibutsu Kagaku Kenkyujo Lymphokine, monoclonal antibody specific to the lymphokine and their production and uses
US5288852A (en) * 1984-03-06 1994-02-22 Dainippon Pharmaceutical Co., Ltd. Human tumor necrosis factor polypeptides
US4879226A (en) * 1984-04-06 1989-11-07 Asahi Kasei Kogyo Kabushiki Kaisha Novel human physiologically active polypeptide
JPS60243018A (ja) * 1984-05-17 1985-12-03 Yamanouchi Pharmaceut Co Ltd ヒト内来性癌制御因子
US5683688A (en) 1984-05-31 1997-11-04 Genentech, Inc. Unglycosylated recombinant human lymphotoxin polypeptides and compositions
DE3423234A1 (de) * 1984-06-23 1986-02-06 Boehringer Ingelheim International GmbH, 6507 Ingelheim Synergistische mischungen von interferonen und tumor-nekrose-faktor
US6686455B1 (en) 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
JPS6124520A (ja) * 1984-07-12 1986-02-03 Takeshi Makitsubo 腫瘍壊死因子様物質を抽出する方法
GB2161813B (en) * 1984-07-20 1988-07-13 Michiko Koga Anti-tumor agent
US5840522A (en) * 1984-09-20 1998-11-24 Chiron Corporation Recombinant lectins
US4677064A (en) * 1984-11-09 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4677063A (en) * 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US4752575A (en) * 1984-11-26 1988-06-21 The Regents Of The University Of California Lymphotoxins with antitumor activity and method for producing same
DE3585690D1 (de) * 1984-12-21 1992-04-23 Biogen Inc Reinigung, herstellung und verwendung von tumor-nekrosisfaktoren.
PT81823B (pt) * 1985-01-14 1987-11-30 Yamanouchi Pharma Co Ltd Metodo de preparacao de factores endogenos humanos reguladores de cancro
WO1986005204A1 (en) * 1985-03-04 1986-09-12 Sawai Pharmaceutical Co., Ltd. Novel tumor necrosis factor-inducing substance originating in acid-fast bacteria
US6084073A (en) * 1985-03-25 2000-07-04 Chiron Corporation Recombinant ricin toxin
US4770995A (en) * 1985-08-29 1988-09-13 New York Blood Center, Inc Detection of the sensitivity of cells to the effects of tumor necrosis factor and lymphotoxin
US4870163A (en) * 1985-08-29 1989-09-26 New York Blood Center, Inc. Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor
US4677197A (en) * 1985-10-30 1987-06-30 Cetus Corporation Purification method for tumor necrosis factor
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
US4828830A (en) * 1986-01-24 1989-05-09 Genentech, Inc. Method and composition for prophylaxis and treatment of viral infections
NZ219027A (en) * 1986-01-24 1989-09-27 Genentech Inc Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin
US4822605A (en) * 1986-02-18 1989-04-18 Exovir, Inc. Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like
US4777242A (en) * 1986-10-10 1988-10-11 Phillips Petroleum Company Purification of recombinant tumor necrosis factor
US5213970A (en) * 1987-01-23 1993-05-25 Board Of Regents, The University Of Texas System Method for obtaining soluble antitumor factor
US4975377A (en) * 1987-05-14 1990-12-04 Key Marc E Cell growth chambers and method of use thereof
DE3731255A1 (de) * 1987-09-17 1989-04-06 Boehringer Ingelheim Int Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen
AU630106B2 (en) * 1988-07-15 1992-10-22 Trustees Of Columbia University In The City Of New York, The Tumor necrosis enhancing factor and methods of preparation and use
US6617171B2 (en) * 1998-02-27 2003-09-09 The General Hospital Corporation Methods for diagnosing and treating autoimmune disease
US6599710B1 (en) 1999-03-10 2003-07-29 The General Hospital Corporation Treatment of autoimmune disease
JP4177604B2 (ja) * 2002-03-25 2008-11-05 株式会社林原生物化学研究所 生理活性複合体
US7179891B2 (en) 2002-03-25 2007-02-20 Tadanori Mayumi Physiologically active complex
US7628988B2 (en) * 2002-06-27 2009-12-08 The General Hospital Corporation Methods and compositions for treating type 1 diabetes
US7582313B2 (en) * 2002-06-27 2009-09-01 The General Hospital Corporation Methods of organ regeneration using Hox 11-expressing pluripotent cells
AU2003290948A1 (en) * 2002-11-15 2004-06-15 The General Hospital Corporation Screening methods to identify treatments for autoimmune disease
RU2377253C2 (ru) * 2002-12-02 2009-12-27 Амген Фремонт,Инк. Антитела, специфичные к фактору некроза опухолей, и их применение
US20080102054A1 (en) * 2005-01-18 2008-05-01 Faustman Denise L Compositions Containing Agm Cells And Methods Of Use Thereof
JP6367836B2 (ja) 2013-02-07 2018-08-01 ザ ジェネラル ホスピタル コーポレイション Ｔ制御性細胞の増殖または枯渇方法
US10436680B2 (en) 2013-10-15 2019-10-08 Kianoosh Peyvan Capture, disruption, and extraction apparatus and method
FI3447075T3 (fi) 2015-05-15 2023-11-07 Massachusetts Gen Hospital Antagonistisia anti-tuumorinekroositekijäreseptorin superperheen vasta-aineita
US11266730B2 (en) 2015-09-29 2022-03-08 The General Hospital Corporation Methods of treating and diagnosing disease using biomarkers for BCG therapy
AU2017263833B2 (en) 2016-05-13 2023-08-03 The General Hospital Corporation Antagonistic anti-tumor necrosis factor receptor superfamily antibodies
CN108576399A (zh) * 2018-03-22 2018-09-28 中国农业科学院生物技术研究所 复合干扰素组合物及其制剂和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4266024A (en) * 1978-05-17 1981-05-05 Boehringer Ingelheim Gmbh Process for the production of human interferon
US4276282A (en) * 1978-01-22 1981-06-30 Ken Hayashibara Interferon and preparations containing interferon

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5598118A (en) * 1979-01-18 1980-07-25 Hayashibara Takeshi Preparation of type-2 interferon and drug containing the same
JPS55154919A (en) * 1979-05-24 1980-12-02 Hayashibara Takeshi Preparation of interferon
US4328207A (en) * 1979-12-27 1982-05-04 Ken Hayashibara Process for preparing mouse interferon
JPS586475B2 (ja) * 1980-08-23 1983-02-04 株式会社 林原生物化学研究所 ヒト絨毛性性腺刺激ホルモンの製造方法
JPS6045849B2 (ja) * 1980-08-25 1985-10-12 林原 健 ヒトエリトロポエチンの製造方法
JPS5743696A (en) * 1980-08-27 1982-03-11 Hayashibara Biochem Lab Inc Preparation of human luteinizing hormone
JPS585671B2 (ja) * 1980-08-27 1983-02-01 株式会社 林原生物化学研究所 ヒト卵胞刺激ホルモンの製造方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276282A (en) * 1978-01-22 1981-06-30 Ken Hayashibara Interferon and preparations containing interferon
US4266024A (en) * 1978-05-17 1981-05-05 Boehringer Ingelheim Gmbh Process for the production of human interferon

Also Published As

Publication number Publication date
GB2106117A (en) 1983-04-07
AU8620082A (en) 1983-01-27
DE3227262C3 (de) 1996-03-21
SE9000532D0 (sv) 1990-02-14
CH664974A5 (fr) 1988-04-15
IT1196549B (it) 1988-11-16
DE3227262C2 (de) 1988-11-17
SE8204382D0 (sv) 1982-07-19
SE8204382L (sv) 1983-01-22
ATA283582A (de) 1988-09-15
US4495282A (en) 1985-01-22
DE3227262A1 (de) 1983-03-03
GB2106117B (en) 1985-06-12
FR2513124A1 (fr) 1983-03-25
AU560793B2 (en) 1987-04-16
IT8248855A0 (it) 1982-07-20
SE9000532L (sv) 1991-08-15
FR2513124B1 (fr) 1989-11-17

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