JPS62195344A - 新規中間体の製法 - Google Patents
新規中間体の製法Info
- Publication number
- JPS62195344A JPS62195344A JP3229587A JP3229587A JPS62195344A JP S62195344 A JPS62195344 A JP S62195344A JP 3229587 A JP3229587 A JP 3229587A JP 3229587 A JP3229587 A JP 3229587A JP S62195344 A JPS62195344 A JP S62195344A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- iii
- carried out
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 238000005903 acid hydrolysis reaction Methods 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 3
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052744 lithium Inorganic materials 0.000 claims description 3
- 229910052783 alkali metal Inorganic materials 0.000 claims description 2
- 150000001340 alkali metals Chemical class 0.000 claims description 2
- 229910052736 halogen Inorganic materials 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 2
- GDZAZDIBXJWVQO-UHFFFAOYSA-N 1-(6-methoxynaphthalen-2-yl)butan-2-one Chemical compound C1=C(OC)C=CC2=CC(CC(=O)CC)=CC=C21 GDZAZDIBXJWVQO-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 150000007857 hydrazones Chemical class 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 238000011065 in-situ storage Methods 0.000 description 2
- 229960004270 nabumetone Drugs 0.000 description 2
- DIIIISSCIXVANO-UHFFFAOYSA-N 1,2-Dimethylhydrazine Chemical compound CNNC DIIIISSCIXVANO-UHFFFAOYSA-N 0.000 description 1
- -1 alkyl compound Chemical class 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/72—Hydrazones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/516—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of nitrogen-containing compounds to >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
- C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868603778A GB8603778D0 (en) | 1986-02-15 | 1986-02-15 | Chemical process |
| GB8603778 | 1986-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS62195344A true JPS62195344A (ja) | 1987-08-28 |
Family
ID=10593134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3229587A Pending JPS62195344A (ja) | 1986-02-15 | 1987-02-14 | 新規中間体の製法 |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS62195344A (da) |
| CH (1) | CH670084A5 (da) |
| DK (1) | DK75487A (da) |
| ES (1) | ES2004879A6 (da) |
| GB (1) | GB8603778D0 (da) |
| GR (1) | GR870258B (da) |
| NL (1) | NL8700358A (da) |
| SE (1) | SE465926B (da) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3829586A1 (de) * | 1988-09-01 | 1990-03-22 | Bayer Ag | Disubstituierte naphthaline, verfahren zur herstellung sowie deren herbizide verwendung |
| US5756851A (en) * | 1996-10-21 | 1998-05-26 | Albemarle Corporation | Production of nabumetone or precursors thereof |
| CU23844B1 (es) * | 2009-04-17 | 2012-10-15 | Ct De Neurociencias De Cuba | Procedimiento de obtención de nuevos derivados de naftaleno para el diagnóstico in vivo de la enfermedad de alzheimer |
-
1986
- 1986-02-15 GB GB868603778A patent/GB8603778D0/en active Pending
-
1987
- 1987-02-13 CH CH53687A patent/CH670084A5/de not_active IP Right Cessation
- 1987-02-13 ES ES8700375A patent/ES2004879A6/es not_active Expired
- 1987-02-13 SE SE8700594A patent/SE465926B/sv unknown
- 1987-02-13 NL NL8700358A patent/NL8700358A/nl not_active Application Discontinuation
- 1987-02-13 GR GR870258A patent/GR870258B/el unknown
- 1987-02-13 DK DK75487A patent/DK75487A/da unknown
- 1987-02-14 JP JP3229587A patent/JPS62195344A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943579A (en) * | 1987-10-06 | 1990-07-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Water soluble prodrugs of camptothecin |
Also Published As
| Publication number | Publication date |
|---|---|
| NL8700358A (nl) | 1987-09-01 |
| DK75487D0 (da) | 1987-02-13 |
| SE465926B (sv) | 1991-11-18 |
| ES2004879A6 (es) | 1989-02-16 |
| SE8700594L (sv) | 1987-08-16 |
| CH670084A5 (en) | 1989-05-12 |
| GR870258B (en) | 1987-06-16 |
| DK75487A (da) | 1987-08-16 |
| SE8700594D0 (sv) | 1987-02-13 |
| GB8603778D0 (en) | 1986-03-19 |
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