JPS6212760A - １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体 - Google Patents

１−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体

Info

Publication number
JPS6212760A
JPS6212760A JP60280427A JP28042785A JPS6212760A JP S6212760 A JPS6212760 A JP S6212760A JP 60280427 A JP60280427 A JP 60280427A JP 28042785 A JP28042785 A JP 28042785A JP S6212760 A JPS6212760 A JP S6212760A
Authority
JP
Japan
Prior art keywords
compound
carboxylic acid
dihydro
oxoquinoline
fluorocyclopropyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60280427A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0566945B2 (enExample
Inventor
Isao Hayakawa
勇夫 早川
Shogo Shinko
新子　省吾
Shuichi Yokohama
横浜　秀一
Masazumi Imamura
今村　正純
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP60280427A priority Critical patent/JPS6212760A/ja
Publication of JPS6212760A publication Critical patent/JPS6212760A/ja
Publication of JPH0566945B2 publication Critical patent/JPH0566945B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP60280427A 1984-12-14 1985-12-13 １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体 Granted JPS6212760A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP60280427A JPS6212760A (ja) 1984-12-14 1985-12-13 １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP26422184 1984-12-14
JP3700885 1985-02-26
JP60-37008 1985-02-26
JP59-264221 1985-02-26
JP60280427A JPS6212760A (ja) 1984-12-14 1985-12-13 １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体

Related Child Applications (3)

Application Number Title Priority Date Filing Date
JP4248512A Division JP2520549B2 (ja) 1984-12-14 1992-08-05 フルオロシクロプロピルアミノアクリル酸エステル誘導体
JP4248513A Division JP2532192B2 (ja) 1984-12-14 1992-08-05 １−アミノ−２−フルオロシクロプロパン
JP4248511A Division JPH0826002B2 (ja) 1984-12-14 1992-08-05 １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体

Publications (2)

Publication Number Publication Date
JPS6212760A true JPS6212760A (ja) 1987-01-21
JPH0566945B2 JPH0566945B2 (enExample) 1993-09-22

Family

ID=26376111

Family Applications (4)

Application Number Title Priority Date Filing Date
JP60280427A Granted JPS6212760A (ja) 1984-12-14 1985-12-13 １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体
JP4248512A Expired - Lifetime JP2520549B2 (ja) 1984-12-14 1992-08-05 フルオロシクロプロピルアミノアクリル酸エステル誘導体
JP4248511A Expired - Lifetime JPH0826002B2 (ja) 1984-12-14 1992-08-05 １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体
JP4248513A Expired - Lifetime JP2532192B2 (ja) 1984-12-14 1992-08-05 １−アミノ−２−フルオロシクロプロパン

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP4248512A Expired - Lifetime JP2520549B2 (ja) 1984-12-14 1992-08-05 フルオロシクロプロピルアミノアクリル酸エステル誘導体
JP4248511A Expired - Lifetime JPH0826002B2 (ja) 1984-12-14 1992-08-05 １−（２−ハロゲノシクロプロピル）キノリンカルボン酸誘導体
JP4248513A Expired - Lifetime JP2532192B2 (ja) 1984-12-14 1992-08-05 １−アミノ−２−フルオロシクロプロパン

Country Status (4)

Country Link
US (1) US4871852A (enExample)
EP (1) EP0191185B1 (enExample)
JP (4) JPS6212760A (enExample)
DE (1) DE3576335D1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61218575A (ja) * 1985-03-16 1986-09-29 バイエル・アクチエンゲゼルシヤフト ７―アミノ―１―（置換シクロプロピル）―１，４―ジヒドロ―４―オキソ―３―キノリンカルボン酸類
JPH02231475A (ja) * 1988-04-27 1990-09-13 Dai Ichi Seiyaku Co Ltd 光学活性ピリドンカルボン酸誘導体
WO1992021659A1 (fr) * 1991-05-28 1992-12-10 Daiichi Pharmaceutical Co., Ltd. Derive d'acide pyridonecarboxylique
US7056917B2 (en) 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN166416B (enExample) * 1985-09-18 1990-05-05 Pfizer
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
DE3824433A1 (de) * 1988-07-19 1990-01-25 Bayer Ag, 5090 Leverkusen Fluorcyclopropyl-derivate
CA2001203C (en) * 1988-10-24 2001-02-13 Thomas P. Demuth, Jr. Novel antimicrobial dithiocarbamoyl quinolones
EP0997466A1 (en) * 1988-10-24 2000-05-03 PROCTER & GAMBLE PHARMACEUTICALS, INC. Novel antimicrobial lactam-quinolones
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
MY109714A (en) * 1990-10-18 1997-04-30 Daiichi Seiyaku Co Process for preparing 8-chloroquinolone derivatives
DE59310066D1 (de) * 1992-11-04 2000-08-03 Clariant Gmbh Verfahren zur Herstellung fluorierter Benzile
JP3268098B2 (ja) * 1992-12-25 2002-03-25 第一製薬株式会社 二環性環状アミン誘導体
DE19517725A1 (de) * 1995-05-15 1996-11-21 Bayer Ag Verfahren zur Herstellung von 2-Fluorcyclopropylamin-sulfonsäuresalzen und die chemische Verbindung 2-Fluorcyclopropylisocyanat
DE19727890A1 (de) 1997-07-01 1999-01-07 Bayer Ag Verfahren zur Herstellung von 2,4,5-Trifluor-benzonitril
PT1262477E (pt) * 2000-02-09 2008-11-14 Daiichi Sankyo Co Ltd Agentes anti-bacterianos resistentes a ácidos contendo, como princípio activo, ácidos piridinocarboxílicos
WO2007010350A1 (en) * 2005-07-19 2007-01-25 Pfizer Products Inc. Synthesis of therapeutic diphenyl ethers
CN102827075A (zh) * 2011-06-14 2012-12-19 四川科伦药物研究有限公司 一种西他沙星中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61218575A (ja) * 1985-03-16 1986-09-29 バイエル・アクチエンゲゼルシヤフト ７―アミノ―１―（置換シクロプロピル）―１，４―ジヒドロ―４―オキソ―３―キノリンカルボン酸類
JPH05213836A (ja) * 1985-03-16 1993-08-24 Bayer Ag シクロプロピルアミン類
JPH02231475A (ja) * 1988-04-27 1990-09-13 Dai Ichi Seiyaku Co Ltd 光学活性ピリドンカルボン酸誘導体
USRE41149E1 (en) 1988-04-27 2010-02-23 Daiichi Sankyo Company, Limited Optically active pyridonecarboxylic acid derivatives
WO1992021659A1 (fr) * 1991-05-28 1992-12-10 Daiichi Pharmaceutical Co., Ltd. Derive d'acide pyridonecarboxylique
US7056917B2 (en) 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor

Also Published As

Publication number Publication date
JPH07316109A (ja) 1995-12-05
JPH0826002B2 (ja) 1996-03-13
JPH07316104A (ja) 1995-12-05
JP2532192B2 (ja) 1996-09-11
JP2520549B2 (ja) 1996-07-31
US4871852A (en) 1989-10-03
JPH0566945B2 (enExample) 1993-09-22
DE3576335D1 (de) 1990-04-12
JPH07316134A (ja) 1995-12-05
EP0191185B1 (en) 1990-03-07
EP0191185A1 (en) 1986-08-20

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