IN166416B - - Google Patents

Info

Publication number
IN166416B
IN166416B IN740/DEL/86A IN740DE1986A IN166416B IN 166416 B IN166416 B IN 166416B IN 740DE1986 A IN740DE1986 A IN 740DE1986A IN 166416 B IN166416 B IN 166416B
Authority
IN
India
Application number
IN740/DEL/86A
Other languages
English (en)
Inventor
Martin Raymond Jefson
Paul Robert Mcguirk
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IN166416B publication Critical patent/IN166416B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IN740/DEL/86A 1985-09-18 1986-08-18 IN166416B (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77747185A 1985-09-18 1985-09-18

Publications (1)

Publication Number Publication Date
IN166416B true IN166416B (enExample) 1990-05-05

Family

ID=25110350

Family Applications (1)

Application Number Title Priority Date Filing Date
IN740/DEL/86A IN166416B (enExample) 1985-09-18 1986-08-18

Country Status (42)

Country Link
US (3) US4775668A (enExample)
EP (1) EP0215650B1 (enExample)
JP (1) JPH0798819B2 (enExample)
KR (1) KR870000961B1 (enExample)
CN (1) CN1014789B (enExample)
AT (1) ATE72245T1 (enExample)
AU (1) AU576302B2 (enExample)
BG (2) BG49275A3 (enExample)
CA (1) CA1340734C (enExample)
CY (1) CY1774A (enExample)
CZ (1) CZ277825B6 (enExample)
DD (1) DD259190A5 (enExample)
DE (2) DE19675019I2 (enExample)
DK (1) DK171276B1 (enExample)
EG (1) EG18184A (enExample)
ES (1) ES2001428A6 (enExample)
FI (1) FI87565C (enExample)
GR (1) GR862363B (enExample)
HK (1) HK132795A (enExample)
HU (1) HU200462B (enExample)
IE (1) IE58966B1 (enExample)
IL (1) IL80033A (enExample)
IN (1) IN166416B (enExample)
LU (1) LU90356I2 (enExample)
MA (1) MA20770A1 (enExample)
MW (1) MW5886A1 (enExample)
MX (1) MX173358B (enExample)
MY (1) MY102518A (enExample)
NO (1) NO170335C (enExample)
NZ (1) NZ217614A (enExample)
OA (1) OA08410A (enExample)
PH (2) PH24048A (enExample)
PL (1) PL149987B1 (enExample)
PT (1) PT83388B (enExample)
SG (1) SG28094G (enExample)
SK (1) SK667886A3 (enExample)
SU (1) SU1482531A3 (enExample)
UA (1) UA6340A1 (enExample)
YU (1) YU45024B (enExample)
ZA (1) ZA867063B (enExample)
ZM (1) ZM8586A1 (enExample)
ZW (1) ZW19386A1 (enExample)

Families Citing this family (61)

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IN166416B (enExample) * 1985-09-18 1990-05-05 Pfizer
DE3601567A1 (de) * 1986-01-21 1987-07-23 Bayer Ag 7-(azabicycloalkyl)-chinoloncarbonsaeure- und -naphthyridon-carbonsaeure-derivate
EP0251308B1 (de) * 1986-07-04 1990-11-22 Chemie Linz Gesellschaft m.b.H. 4-Chinolon-3-carbonsäurederivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
US4965273A (en) * 1986-10-08 1990-10-23 Bristol-Myers Company Certain 1-tertiary-butyl-naphthyridone carboxylic acid derivatives anti-bacterial agents
WO1989000158A1 (en) * 1987-07-02 1989-01-12 Pfizer Inc. Bridged-diazabicycloalkyl quinolone carboxylic acids and esters
US4968799A (en) * 1987-07-31 1990-11-06 Warner-Lambert Company Antibacterial agents
US4923879A (en) * 1987-07-31 1990-05-08 Warner-Lambert Company 1,8-Naphthyridines and their use as antibacterial agents
US4992546A (en) * 1987-07-31 1991-02-12 Warner-Lambert Company Process for preparing 6,8-diazabicyclo[3.2.2]nonane derivatives
US4933335A (en) * 1987-08-07 1990-06-12 Warner-Lambert Company Quinolones as antibacterial agents
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
DE3902079A1 (de) * 1988-04-15 1989-10-26 Bayer Ag I.m. injektionsformen von gyrase-inhibitoren
WO1990002123A1 (en) * 1988-08-23 1990-03-08 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
US5147873A (en) * 1988-08-23 1992-09-15 Pfizer Inc. Amino-substituted bridged azabicyclic quinolone carboxylic acids and esters
US4895943A (en) * 1988-10-25 1990-01-23 Pfizer Inc. Preparation of 1,4-diazabicyclo(3.2.2)nonane
US5036153A (en) * 1989-05-11 1991-07-30 Braish Tamim F Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
US5214051A (en) * 1989-08-01 1993-05-25 Pfizer Inc. Thiazolyl and oxazolyl[5,4-c]piperidyl-substituted quinolone-carboxylic acid and related analogs thereof having antibacterial properties are disclosed
US5013839A (en) * 1989-09-25 1991-05-07 Pfizer Inc. Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1) heptanes
US5095121A (en) * 1989-09-25 1992-03-10 Pfizer Inc Process for optically active 2-alkyl-2,5-diazabicyclo(2.2.1)heptanes
US5157125A (en) * 1989-09-25 1992-10-20 Pfizer Inc. Optically active 2-alkyl-2,5-diazabicyclo[2.2.1]heptanes
FI921475L (fi) * 1989-10-06 1992-04-03 Pfizer 1,4-dihydro-4-oxo-3-kinolinderivat som selektivt toxiska antibakteriella aemenn hos daeggdjur.
US5385913A (en) * 1989-10-06 1995-01-31 Pfizer Inc. 1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
US4992449A (en) * 1990-02-01 1991-02-12 American Cyanamid Company 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
US5580872A (en) * 1990-05-02 1996-12-03 Abbott Laboratories Quinolizinone type compounds
ES2065175T3 (es) * 1991-03-01 1995-02-01 Pfizer Derivados de 1-azabiciclo(3.2.2)nonan-3-amina.
US5235054A (en) * 1992-07-15 1993-08-10 Pfizer Inc. 3-carboxaldehyde substituted quinolines and naphthyridines
GB2291421A (en) * 1994-07-16 1996-01-24 Pfizer A process for preparing a quinoline carboxylic acid
ES2092963B1 (es) * 1995-04-12 1997-12-16 Sint Quimica Sa Procedimiento para la preparacion del acido 1-ciclopropil-6-fluoro-1, 4-dihidro-7-(1s,4s)-5-metil-2,5-diazabiciclo(2.2.1) hept-2-il)-4-oxo-3-quinolincarboxilico y sus sales.
US5929086A (en) * 1996-05-10 1999-07-27 Pharmacia & Upjohn Company Topical administration of antimicrobial agents for the treatment of systemic bacterial diseases
US6056436A (en) * 1997-02-20 2000-05-02 University Of Maryland Simultaneous measurement of temperature and strain using optical sensors
US6114531A (en) * 1998-07-28 2000-09-05 Pfizer Inc. Process for preparing quinolone and naphthyridone carboxylic acids
NZ513575A (en) * 1999-05-04 2003-07-25 Neurosearch As Heteroaryl diazabicycloalkanes useful for treating or preventing a disease or a disorder responsive to the activity of nAChR modulators
FR2809731B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo-[3.2.2] nonane-pheylisoxazole, leur preparation et leur application en therapeutique
FR2809732B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo DERIVES DE 4(-2-PHENYLTHIAZOL-5-yl)-1,4-DIAZABICYCLO-[3.2.2] NONANE, LEUR PREPARATION ET LEUR APPLICATION ENTHERAPEUTIQUE
FR2809730B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique
CN1331864C (zh) * 2001-03-02 2007-08-15 神经研究公司 新型2,5－二氮杂二环[2.2.1]庚烷衍生物
WO2004024729A1 (en) * 2002-09-10 2004-03-25 Pfizer Products Inc. Diazabicyclic compounds useful in the treatment of cns and other disorders
AU2003276919B2 (en) * 2002-09-25 2013-05-16 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE602004010299T2 (de) * 2003-12-22 2008-09-18 Memory Pharmaceuticals Corp. Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen
RU2417225C2 (ru) 2004-03-25 2011-04-27 Мемори Фармасьютиклз Корпорейшн Индазолы, бензотиазолы, бензоизотиазолы, бензизоксазолы и их получение и применение
JP2007534692A (ja) * 2004-04-22 2007-11-29 メモリー・ファーマシューティカルズ・コーポレイション インドール、１ｈ−インダゾール、１，２−ベンズイソキサゾール、１，２−ベンゾイソチアゾール、ならびにその調製および使用
JP2007538011A (ja) * 2004-05-07 2007-12-27 メモリー・ファーマシューティカルズ・コーポレイション １ｈ−インダゾール、ベンゾチアゾール、１，２−ベンゾイソキサゾール、１，２−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
BRPI0517494A (pt) * 2004-12-22 2008-10-14 Memory Pharm Corp composto, composição farmacêutica, método de ativação/estimulação seletiva de receptores nicotìnicos de a-7 em um paciente em que tal ativação/estimulação tem um efeito terapêutico, método de tratamento de um paciente que sofre de uma doença psicótica, uma doença neurodegenerativa que envolve uma disfunção do sistema colinérgico, e/ou uma condição de debilitação da memória e/ou da cognição, método de tratamento de um paciente que sofre de demência e/ou uma outra condição com perda da memória, método de tratamento de um paciente que sofre de debilitação da memória devido à debilitação cognitiva suave devido ao envelhecimento, mal de alzheimer, esquizofrenia, mal de parkinson, mal de huntington, mal de pick, mal de creutzfeldt-jakob, depressão, envelhecimento, trauma na cabeça, acidente vascular cerebral, hipoxia do snc, senilidade cerebral, demência de multiinfarto, hiv e/ou doença cardiovascular, método de tratamento e/ou prevenção da demência em um paciente com o mal de alzheimer, método de tratamento de um paciente para cortar o vìcio do álcool ou o tratamento de um paciente com a terapia anti-intoxicação, método de tratamento de um paciente para propiciar neuroproteção contra os danos associados com acidentes vasculares cerebrais e isquemia e excitotoxicidade induzida por glutamatos, método de tratamento de um paciente que sofre do vìcio da nicotina, dor, tontura do fuso horário, obesidade e/ou diabetes, método de indução do ato de parar fumar em um paciente, método de tratamento de um paciente que sofre de debilitação cognitiva suave (mci), demência vascular (vad), declìnio cognitivo associado com a idade (aacd), amnésia associada com a cirurgia com o coração aberto, parada cardìaca, anestesia geral, deficiências da memória devido à exposição a agentes anestésicos, debilitação cognitiva induzida pela privação do sono, sìndrome de fadiga crÈnica, narcolepsia, demência relacionada com a aids, debilitação cognitiva relacionada com a epilepsia, sìndrome de down, demência relacionada ao alcoolismo, debilitações da memória induzidas por drogas/substáncias, demência pugilìstica (sìndrome do boxeador), ou demência animal, método para o tratamento da perda da memória, método para o tratamento de um paciente que sofre de debilitação da memória, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da disfunção da transmissão do receptor nicotìnico de acetilcolina em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante de receptores nicotìnicos de acetilcolina defeituosos ou funcionando mal em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da transmissão suprimida do receptor nicotìnico de acetilcolina em um paciente, método para o tratamento ou a profilaxia de uma doença ou de uma condição resultante da perda de sinapses colinérgicas em um paciente, método para a proteção dos neurÈnios em um paciente com neurotoxicidade induzi
US8106066B2 (en) * 2005-09-23 2012-01-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof
AU2007213669A1 (en) 2006-02-10 2007-08-16 Neurosearch A/S 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
EP1984366B1 (en) 2006-02-10 2010-12-15 NeuroSearch A/S 3, 9-diazabicyclo ý3.3. 1¨nonane derivatives and their use as monoamine?neurotransmitter re-uptake inhibitors
US7687523B2 (en) 2006-02-10 2010-03-30 Neurosearch A/S 3-heteroaryl-3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102007026550A1 (de) 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
DE102007055341A1 (de) * 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
WO2009111680A1 (en) * 2008-03-07 2009-09-11 Smithline Beecham Corporation Trpv4 antagonists
KR101748891B1 (ko) * 2009-03-11 2017-06-19 교린 세이야꾸 가부시키 가이샤 Ｇｓｋ-3 억제제로서의 7-시클로알킬아미노퀴놀론
WO2012049156A1 (en) 2010-10-12 2012-04-19 Bayer Animal Health Gmbh Non-starch based soft chewables
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MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
JP7752051B2 (ja) 2019-05-24 2025-10-09 デクラ ベテリナリー プロダクツ リミテッド ライアビリティー カンパニー 長時間作用型注射用製剤およびその使用
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Also Published As

Publication number Publication date
DK171276B1 (da) 1996-08-19
AU6276886A (en) 1987-03-19
PT83388A (en) 1986-10-01
CN1014789B (zh) 1991-11-20
HK132795A (en) 1995-09-01
ZA867063B (en) 1988-04-27
ZW19386A1 (en) 1986-12-10
EP0215650A3 (en) 1987-12-02
MY102518A (en) 1992-07-31
NO170335B (no) 1992-06-29
DD259190A5 (de) 1988-08-17
US4775668A (en) 1988-10-04
PL261410A1 (en) 1987-11-16
YU161786A (en) 1987-10-31
IL80033A (en) 1992-05-25
CA1340734C (en) 1999-09-14
SG28094G (en) 1994-10-28
YU45024B (en) 1991-06-30
EP0215650B1 (en) 1992-01-29
GR862363B (en) 1987-01-19
DE19675019I2 (de) 2004-01-29
DE3683711D1 (de) 1992-03-12
HUT43070A (en) 1987-09-28
US4861779A (en) 1989-08-29
NZ217614A (en) 1989-11-28
LU90356I2 (fr) 1999-04-26
MW5886A1 (en) 1987-12-09
NO863718L (no) 1987-03-19
EG18184A (en) 1992-12-30
FI863756A0 (fi) 1986-09-17
JPH0798819B2 (ja) 1995-10-25
MX3751A (es) 1993-09-01
HU200462B (en) 1990-06-28
MA20770A1 (fr) 1987-04-01
FI87565B (fi) 1992-10-15
UA6340A1 (uk) 1994-12-29
SK278605B6 (en) 1997-11-05
FI87565C (fi) 1993-01-25
SU1482531A3 (ru) 1989-05-23
DK445886A (da) 1987-05-27
BG61091B2 (bg) 1996-10-31
ZM8586A1 (en) 1987-03-27
SK667886A3 (en) 1997-11-05
CZ277825B6 (en) 1993-06-16
KR870003106A (ko) 1987-04-15
IE862479L (en) 1987-03-18
CY1774A (en) 1995-10-20
ATE72245T1 (de) 1992-02-15
NO863718D0 (no) 1986-09-17
CN86106385A (zh) 1987-06-03
NO170335C (no) 1992-10-07
PH25338A (en) 1991-04-30
DK445886D0 (da) 1986-09-17
KR870000961B1 (ko) 1987-05-14
ES2001428A6 (es) 1988-05-16
IE58966B1 (en) 1993-12-01
IL80033A0 (en) 1986-12-31
PH24048A (en) 1990-03-05
PT83388B (pt) 1989-05-12
OA08410A (fr) 1988-06-30
PL149987B1 (en) 1990-04-30
US5091383A (en) 1992-02-25
MX173358B (es) 1994-02-23
BG49275A3 (en) 1991-09-16
EP0215650A2 (en) 1987-03-25
AU576302B2 (en) 1988-08-18
JPS62103083A (ja) 1987-05-13
FI863756L (fi) 1987-03-19
CZ667886A3 (en) 1993-02-17

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