CN1014789B - 取代的桥式二氮二环烷基喹诺酮羧酸的制备方法 - Google Patents

取代的桥式二氮二环烷基喹诺酮羧酸的制备方法

Info

Publication number
CN1014789B
CN1014789B CN86106385A CN86106385A CN1014789B CN 1014789 B CN1014789 B CN 1014789B CN 86106385 A CN86106385 A CN 86106385A CN 86106385 A CN86106385 A CN 86106385A CN 1014789 B CN1014789 B CN 1014789B
Authority
CN
China
Prior art keywords
diazabicyclo
compound
methyl
oxo
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CN86106385A
Other languages
English (en)
Chinese (zh)
Other versions
CN86106385A (zh
Inventor
马丁·雷蒙德·杰夫逊
保罗·罗伯特·麦夸克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp SRL
Original Assignee
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp SRL filed Critical Pfizer Corp SRL
Publication of CN86106385A publication Critical patent/CN86106385A/zh
Publication of CN1014789B publication Critical patent/CN1014789B/zh
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Materials For Photolithography (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CN86106385A 1985-09-18 1986-09-17 取代的桥式二氮二环烷基喹诺酮羧酸的制备方法 Expired CN1014789B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77747185A 1985-09-18 1985-09-18
US777,471 1985-09-18

Publications (2)

Publication Number Publication Date
CN86106385A CN86106385A (zh) 1987-06-03
CN1014789B true CN1014789B (zh) 1991-11-20

Family

ID=25110350

Family Applications (1)

Application Number Title Priority Date Filing Date
CN86106385A Expired CN1014789B (zh) 1985-09-18 1986-09-17 取代的桥式二氮二环烷基喹诺酮羧酸的制备方法

Country Status (42)

Country Link
US (3) US4775668A (enExample)
EP (1) EP0215650B1 (enExample)
JP (1) JPH0798819B2 (enExample)
KR (1) KR870000961B1 (enExample)
CN (1) CN1014789B (enExample)
AT (1) ATE72245T1 (enExample)
AU (1) AU576302B2 (enExample)
BG (2) BG49275A3 (enExample)
CA (1) CA1340734C (enExample)
CY (1) CY1774A (enExample)
CZ (1) CZ277825B6 (enExample)
DD (1) DD259190A5 (enExample)
DE (2) DE3683711D1 (enExample)
DK (1) DK171276B1 (enExample)
EG (1) EG18184A (enExample)
ES (1) ES2001428A6 (enExample)
FI (1) FI87565C (enExample)
GR (1) GR862363B (enExample)
HK (1) HK132795A (enExample)
HU (1) HU200462B (enExample)
IE (1) IE58966B1 (enExample)
IL (1) IL80033A (enExample)
IN (1) IN166416B (enExample)
LU (1) LU90356I2 (enExample)
MA (1) MA20770A1 (enExample)
MW (1) MW5886A1 (enExample)
MX (1) MX173358B (enExample)
MY (1) MY102518A (enExample)
NO (1) NO170335C (enExample)
NZ (1) NZ217614A (enExample)
OA (1) OA08410A (enExample)
PH (2) PH24048A (enExample)
PL (1) PL149987B1 (enExample)
PT (1) PT83388B (enExample)
SG (1) SG28094G (enExample)
SK (1) SK278605B6 (enExample)
SU (1) SU1482531A3 (enExample)
UA (1) UA6340A1 (enExample)
YU (1) YU45024B (enExample)
ZA (1) ZA867063B (enExample)
ZM (1) ZM8586A1 (enExample)
ZW (1) ZW19386A1 (enExample)

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FR2809730B1 (fr) * 2000-05-31 2002-07-19 Sanofi Synthelabo Derives de 1,4-diazabicyclo[3.2.2] nonanebenzoxazole, -benzothiazole et -benzimidazole, leur preparation et leur application therapeutique
CA2438815A1 (en) * 2001-03-02 2002-09-12 Neurosearch A/S Novel 2,5-diazabicyclo[2.2.1]heptane derivatives
WO2004024729A1 (en) * 2002-09-10 2004-03-25 Pfizer Products Inc. Diazabicyclic compounds useful in the treatment of cns and other disorders
CA2499128C (en) * 2002-09-25 2012-07-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
US7396833B2 (en) 2003-12-22 2008-07-08 Memory Pharmaceuticals Corporation Indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, and preparation and uses thereof
CN103724343A (zh) 2004-03-25 2014-04-16 记忆药物公司 吲唑、苯并噻唑、苯并异噻唑、苯并异噁唑及其制备和用途
CA2567977A1 (en) * 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
KR20070015607A (ko) * 2004-05-07 2007-02-05 메모리 파마슈티칼스 코포레이션 1ｈ-인다졸, 벤조티아졸, 1,2-벤조이속사졸,1,2-벤조이소티아졸, 및 크로몬 및 그의 제조법 및 용도
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
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Also Published As

Publication number Publication date
MW5886A1 (en) 1987-12-09
FI87565B (fi) 1992-10-15
NO863718D0 (no) 1986-09-17
MX3751A (es) 1993-09-01
ATE72245T1 (de) 1992-02-15
NZ217614A (en) 1989-11-28
CY1774A (en) 1995-10-20
DE19675019I2 (de) 2004-01-29
OA08410A (fr) 1988-06-30
HK132795A (en) 1995-09-01
IE58966B1 (en) 1993-12-01
EG18184A (en) 1992-12-30
SG28094G (en) 1994-10-28
EP0215650A3 (en) 1987-12-02
HUT43070A (en) 1987-09-28
FI863756L (fi) 1987-03-19
PT83388A (en) 1986-10-01
SK667886A3 (en) 1997-11-05
MX173358B (es) 1994-02-23
CA1340734C (en) 1999-09-14
NO170335C (no) 1992-10-07
DK445886A (da) 1987-05-27
ES2001428A6 (es) 1988-05-16
HU200462B (en) 1990-06-28
PL261410A1 (en) 1987-11-16
LU90356I2 (fr) 1999-04-26
PT83388B (pt) 1989-05-12
SK278605B6 (en) 1997-11-05
MA20770A1 (fr) 1987-04-01
IN166416B (enExample) 1990-05-05
UA6340A1 (uk) 1994-12-29
MY102518A (en) 1992-07-31
CN86106385A (zh) 1987-06-03
AU576302B2 (en) 1988-08-18
IE862479L (en) 1987-03-18
YU45024B (en) 1991-06-30
FI87565C (fi) 1993-01-25
DK445886D0 (da) 1986-09-17
AU6276886A (en) 1987-03-19
SU1482531A3 (ru) 1989-05-23
ZW19386A1 (en) 1986-12-10
EP0215650B1 (en) 1992-01-29
GR862363B (en) 1987-01-19
YU161786A (en) 1987-10-31
DD259190A5 (de) 1988-08-17
BG49275A3 (en) 1991-09-16
DK171276B1 (da) 1996-08-19
ZM8586A1 (en) 1987-03-27
BG61091B2 (bg) 1996-10-31
CZ667886A3 (en) 1993-02-17
IL80033A0 (en) 1986-12-31
US4775668A (en) 1988-10-04
KR870000961B1 (ko) 1987-05-14
EP0215650A2 (en) 1987-03-25
PH25338A (en) 1991-04-30
DE3683711D1 (de) 1992-03-12
PH24048A (en) 1990-03-05
NO863718L (no) 1987-03-19
FI863756A0 (fi) 1986-09-17
JPH0798819B2 (ja) 1995-10-25
US5091383A (en) 1992-02-25
JPS62103083A (ja) 1987-05-13
US4861779A (en) 1989-08-29
PL149987B1 (en) 1990-04-30
KR870003106A (ko) 1987-04-15
CZ277825B6 (en) 1993-06-16
NO170335B (no) 1992-06-29
ZA867063B (en) 1988-04-27
IL80033A (en) 1992-05-25

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