|
US4749576A
(en)
*
|
1984-05-10 |
1988-06-07 |
Ciba-Geigy Corporation |
Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
|
|
JPS61218517A
(ja)
*
|
1985-03-25 |
1986-09-29 |
Bio Materiaru Yunibaasu:Kk |
経皮吸収製剤
|
|
FR2585246A1
(fr)
*
|
1985-07-26 |
1987-01-30 |
Cortial |
Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
|
|
US4794002A
(en)
*
|
1985-11-01 |
1988-12-27 |
Monsanto Company |
Modified polymeric surfaces and process for preparing same
|
|
US4983400A
(en)
*
|
1986-06-16 |
1991-01-08 |
Merck & Co., Inc. |
Controlled release combination of carbidopa/levodopa
|
|
US4780236A
(en)
*
|
1986-06-20 |
1988-10-25 |
Kiwi Brands, Inc. |
Lavoratory cleansing block containing polyethylene gycol disteatrate, guar gum and sodium chloride
|
|
US4743248A
(en)
*
|
1986-08-11 |
1988-05-10 |
Alza Corporation |
Dosage form for delivering acid sensitive beneficial agent
|
|
GB8620845D0
(en)
*
|
1986-08-28 |
1986-10-08 |
Reckitt & Colmann Prod Ltd |
Treatment of textile surfaces
|
|
US5219575A
(en)
*
|
1987-06-26 |
1993-06-15 |
Duphar International Research B.V. |
Compositions with controlled zero-order delivery rate and method of preparing these compositions
|
|
EP0297650A1
(en)
*
|
1987-06-26 |
1989-01-04 |
Duphar International Research B.V |
Compositions with controlled zero-order delivery rate and method of preparing these compositions
|
|
US4910015A
(en)
*
|
1987-10-19 |
1990-03-20 |
Massachusetts Institute Of Technology |
Surface-active polysiloxanes and drug releasing materials thereof
|
|
GB8801863D0
(en)
*
|
1988-01-28 |
1988-02-24 |
Fulmer Yarsley Ltd |
Pharmaceutical formulations with controlled drug release
|
|
US6440457B1
(en)
*
|
1993-05-27 |
2002-08-27 |
Alza Corporation |
Method of administering antidepressant dosage form
|
|
DE69603577T2
(de)
|
1995-02-10 |
1999-11-25 |
Medtronic, Inc. |
Verfahren und vorrichtung zur verabreichung von analgetika
|
|
US5945125A
(en)
*
|
1995-02-28 |
1999-08-31 |
Temple University |
Controlled release tablet
|
|
US20030203036A1
(en)
|
2000-03-17 |
2003-10-30 |
Gordon Marc S. |
Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
|
|
GB9703673D0
(en)
*
|
1997-02-21 |
1997-04-09 |
Bradford Particle Design Ltd |
Method and apparatus for the formation of particles
|
|
US6039968A
(en)
*
|
1997-06-24 |
2000-03-21 |
Hoechst Marion Roussel |
Intravaginal drug delivery device
|
|
DE19843904A1
(de)
*
|
1998-09-24 |
2000-03-30 |
Basf Ag |
Feste Dosierungsform mit polymerem Bindemittel
|
|
DE19843903A1
(de)
*
|
1998-09-24 |
2000-03-30 |
Basf Ag |
Feste Dosierungsform mit copolymerem Bindemittel
|
|
US6706283B1
(en)
|
1999-02-10 |
2004-03-16 |
Pfizer Inc |
Controlled release by extrusion of solid amorphous dispersions of drugs
|
|
US7943162B2
(en)
*
|
1999-10-21 |
2011-05-17 |
Alcon, Inc. |
Drug delivery device
|
|
YU35302A
(sh)
|
1999-12-23 |
2005-03-15 |
Pfizer Products Inc. |
Dozirani oblik leka sa inicijalnim hidrogelom
|
|
US20030086972A1
(en)
*
|
2000-08-09 |
2003-05-08 |
Appel Leah E. |
Hydrogel-driven drug dosage form
|
|
GB0027357D0
(en)
*
|
2000-11-09 |
2000-12-27 |
Bradford Particle Design Plc |
Particle formation methods and their products
|
|
MXPA03011610A
(es)
*
|
2001-07-23 |
2004-07-01 |
Alcon Inc |
Dispositivo para la administracion de farmacos oftalmicos.
|
|
ES2278936T3
(es)
|
2001-07-23 |
2007-08-16 |
Alcon, Inc. |
Dispositivo de administracion de farmacos oftalmicos.
|
|
GB0216562D0
(en)
|
2002-04-25 |
2002-08-28 |
Bradford Particle Design Ltd |
Particulate materials
|
|
US9339459B2
(en)
|
2003-04-24 |
2016-05-17 |
Nektar Therapeutics |
Particulate materials
|
|
GB0310636D0
(en)
*
|
2003-05-08 |
2003-06-11 |
Nektar Therapeutics Uk Ltd |
Particulate materials
|
|
KR20060015587A
(ko)
|
2003-05-08 |
2006-02-17 |
넥타 쎄라퓨틱스 유케이 리미티드 |
미립물
|
|
AU2004258857A1
(en)
*
|
2003-07-10 |
2005-02-03 |
Alcon, Inc. |
Ophthalmic drug delivery device
|
|
US20060246109A1
(en)
*
|
2005-04-29 |
2006-11-02 |
Hossainy Syed F |
Concentration gradient profiles for control of agent release rates from polymer matrices
|
|
EP2664337B1
(en)
|
2005-09-27 |
2019-08-14 |
TissueTech, Inc. |
Amniotic membrane preparations and purified compositions and methods of use
|
|
US8187639B2
(en)
*
|
2005-09-27 |
2012-05-29 |
Tissue Tech, Inc. |
Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
|
|
US7858609B2
(en)
|
2005-11-28 |
2010-12-28 |
Marinus Pharmaceuticals |
Solid ganaxolone formulations and methods for the making and use thereof
|
|
US8246973B2
(en)
|
2006-06-21 |
2012-08-21 |
Advanced Cardiovascular Systems, Inc. |
Freeze-thaw method for modifying stent coating
|
|
WO2008079440A2
(en)
|
2006-07-10 |
2008-07-03 |
Medipacs, Inc. |
Super elastic epoxy hydrogel
|
|
WO2008021368A2
(en)
|
2006-08-11 |
2008-02-21 |
The Johns Hopkins University |
Compositions and methods for neuroprotection
|
|
ES2617150T3
(es)
|
2006-09-22 |
2017-06-15 |
Pharmacyclics Llc |
Inhibidores de tirosina cinasa de Bruton
|
|
MX2010002712A
(es)
|
2007-09-10 |
2010-06-09 |
Calcimedica Inc |
Compuestos que modulan calcio intracelular.
|
|
JP2011505520A
(ja)
|
2007-12-03 |
2011-02-24 |
メディパックス インコーポレイテッド |
流体計量供給装置
|
|
EP2321303B1
(en)
|
2008-08-27 |
2019-11-27 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
DK2421901T3
(en)
|
2009-04-24 |
2016-01-11 |
Tissue Tech Inc |
Compositions comprising HC-HA complex, and methods of use thereof
|
|
WO2011032011A1
(en)
|
2009-09-10 |
2011-03-17 |
Medipacs, Inc. |
Low profile actuator and improved method of caregiver controlled administration of therapeutics
|
|
US7741330B1
(en)
|
2009-10-12 |
2010-06-22 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of Bruton's tyrosine kinase
|
|
US9500186B2
(en)
|
2010-02-01 |
2016-11-22 |
Medipacs, Inc. |
High surface area polymer actuator with gas mitigating components
|
|
US20130030237A1
(en)
|
2010-04-15 |
2013-01-31 |
Charles Theuer |
Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
|
|
WO2011139765A2
(en)
|
2010-04-27 |
2011-11-10 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
AU2011248877B9
(en)
|
2010-04-27 |
2015-11-05 |
Calcimedica Inc. |
Compounds that modulate intracellular calcium
|
|
CA3007788C
(en)
|
2010-06-03 |
2020-03-10 |
Pharmacyclics Llc |
The use of inhibitors of bruton's tyrosine kinase (btk)
|
|
CN106905311A
(zh)
|
2010-08-27 |
2017-06-30 |
钙医学公司 |
调节细胞内钙的化合物
|
|
WO2012061556A1
(en)
|
2010-11-03 |
2012-05-10 |
Flugen, Inc. |
Wearable drug delivery device having spring drive and sliding actuation mechanism
|
|
CA2767773C
(en)
|
2011-02-11 |
2015-11-24 |
Grain Processing Corporation |
Composition comprising a salt and a crystallization interrupter
|
|
WO2012149486A1
(en)
|
2011-04-28 |
2012-11-01 |
Tissuetech, Inc. |
Methods of modulating bone remodeling
|
|
US9682044B2
(en)
|
2011-06-10 |
2017-06-20 |
Tissuetech, Inc. |
Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
|
|
NZ621221A
(en)
|
2011-09-13 |
2016-07-29 |
Pharmacyclics Llc |
Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
JP2015508407A
(ja)
|
2012-01-06 |
2015-03-19 |
アビデ セラピューティクス,インク. |
カルバメート化合物およびその製造および使用
|
|
JP2015510956A
(ja)
|
2012-03-14 |
2015-04-13 |
メディパックス インコーポレイテッド |
過剰反応性分子を含むスマートポリマー材料
|
|
BR112014030424A8
(pt)
|
2012-06-04 |
2017-07-11 |
Pharmacyclics Inc |
Formas cristalinas de um inibidor de quinase de tirosina de bruton
|
|
KR102236805B1
(ko)
|
2012-07-11 |
2021-04-05 |
티슈테크, 인코포레이티드 |
Hc-ha/ptx3 복합체를 함유하는 조성물 및 이의 사용 방법
|
|
DK2900674T3
(en)
|
2012-09-28 |
2017-07-03 |
Univ Washington Through Its Center For Commercialization |
RELATIONSHIPS AND PROCEDURES FOR PREVENTION, TREATMENT AND / OR PROTECTION AGAINST SENSITIVE CELL DEATH
|
|
US9512116B2
(en)
|
2012-10-12 |
2016-12-06 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
US9611263B2
(en)
|
2013-10-08 |
2017-04-04 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
KR20160093675A
(ko)
|
2013-12-05 |
2016-08-08 |
파마싸이클릭스 엘엘씨 |
브루톤 티로신 키나제의 억제제
|
|
WO2015164213A1
(en)
|
2014-04-23 |
2015-10-29 |
The Research Foundation For The State University Of New York |
A rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjuction therewith
|
|
TW201603818A
(zh)
|
2014-06-03 |
2016-02-01 |
組織科技股份有限公司 |
組成物及方法
|
|
US9775978B2
(en)
|
2014-07-25 |
2017-10-03 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having a retaining member
|
|
US9764122B2
(en)
|
2014-07-25 |
2017-09-19 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having an occluding member
|
|
US9839644B2
(en)
|
2014-09-09 |
2017-12-12 |
ARKAY Therapeutics, LLC |
Formulations and methods for treatment of metabolic syndrome
|
|
US9359316B1
(en)
|
2014-11-25 |
2016-06-07 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic TRPV1 agonists
|
|
DK3253766T3
(da)
|
2015-02-06 |
2019-12-09 |
Univ Washington |
Forbindelser og fremgangsmåder til forebyggelse eller behandling af sansehårscelledød
|
|
US10227333B2
(en)
|
2015-02-11 |
2019-03-12 |
Curtana Pharmaceuticals, Inc. |
Inhibition of OLIG2 activity
|
|
WO2016138025A2
(en)
|
2015-02-23 |
2016-09-01 |
Tissuetech, Inc. |
Apparatuses and methods for treating ophthalmic diseases and disorders
|
|
CA2977521C
(en)
|
2015-02-27 |
2024-03-19 |
Curtana Pharmaceuticals, Inc. |
1-(aryl)-3-(heteroaryl) urea compounds and their use as olig2 inhibitors
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
MA41828A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
|
|
MA41827A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
|
|
BR112017024253A2
(pt)
|
2015-05-11 |
2018-07-24 |
Abide Therapeutics Inc |
métodos de tratamento de inflamação ou dor neuropática.
|
|
TWI720984B
(zh)
|
2015-05-20 |
2021-03-11 |
美商帝聖工業公司 |
用於防止上皮細胞增生及上皮-間質轉移之組合物及方法
|
|
BR112018003836A2
(pt)
|
2015-08-31 |
2018-12-04 |
Pharmacyclics Llc |
combinações de inibidor de btk para tratar mieloma múltiplo
|
|
US10076650B2
(en)
|
2015-11-23 |
2018-09-18 |
Warsaw Orthopedic, Inc. |
Enhanced stylet for drug depot injector
|
|
ES2952064T3
(es)
|
2015-12-16 |
2023-10-26 |
Walter & Eliza Hall Inst Medical Res |
Inhibición de la proteína SH2 inducida por citocinas en células NK
|
|
KR20180101521A
(ko)
|
2016-01-19 |
2018-09-12 |
얀센 파마슈티카 엔.브이. |
Btk 저해제를 포함하는 제형/조성물
|
|
CN114681462A
(zh)
|
2016-01-19 |
2022-07-01 |
詹森药业有限公司 |
包含btk抑制剂的配制品/组合物
|
|
TW201733600A
(zh)
|
2016-01-29 |
2017-10-01 |
帝聖工業公司 |
胎兒扶持組織物及使用方法
|
|
WO2017147146A1
(en)
|
2016-02-23 |
2017-08-31 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic trpv1 agonists
|
|
JP7049683B2
(ja)
|
2016-04-04 |
2022-04-07 |
シノピア バイオサイエンシーズ,インク. |
トラピジルを使用する錐体外路症候群の処置
|
|
CA3025268A1
(en)
|
2016-05-25 |
2017-11-30 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic trpv1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
|
|
WO2017205769A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
WO2017205762A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
WO2017205766A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
US10549081B2
(en)
|
2016-06-23 |
2020-02-04 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having a retaining member
|
|
US11090702B2
(en)
*
|
2016-06-28 |
2021-08-17 |
Trustees Of Tufts College |
Compositions and methods for delivery of active agents
|
|
SG11201900405XA
(en)
|
2016-07-18 |
2019-02-27 |
Arthrosi Therapeutics Inc |
Compounds, compositions and methods for treating or preventing a sympton associated with gout or hyperuricemia
|
|
KR102605329B1
(ko)
|
2016-08-26 |
2023-11-22 |
커타나 파마슈티칼스, 인크. |
Olig2 활성의 억제
|
|
US10434261B2
(en)
|
2016-11-08 |
2019-10-08 |
Warsaw Orthopedic, Inc. |
Drug pellet delivery system and method
|
|
US11142517B2
(en)
|
2016-11-16 |
2021-10-12 |
H. Lundbeck A/S |
Crystalline forms of a MAGL inhibitor
|
|
AU2017361254B2
(en)
|
2016-11-16 |
2021-09-23 |
H. Lundbeck A/S. |
Pharmaceutical formulations
|
|
KR20200086257A
(ko)
|
2017-09-01 |
2020-07-16 |
유니버시티 오브 워싱톤 |
감각 모 세포 사멸 예방 또는 치료용 화합물의 결정질 형태
|
|
US11685722B2
(en)
|
2018-02-28 |
2023-06-27 |
Curtana Pharmaceuticals, Inc. |
Inhibition of Olig2 activity
|
|
KR20210073513A
(ko)
|
2018-07-27 |
2021-06-18 |
컨센트릭 애널지식스, 인크. |
페놀성 trpv1 작용제의 peg화된 프로드럭
|
|
WO2020118114A1
(en)
|
2018-12-06 |
2020-06-11 |
Arthrosi Therapeutics, Inc. |
Methods for treating or preventing gout or hyperuricemia
|
|
US12145917B2
(en)
|
2018-12-06 |
2024-11-19 |
Arthrosi Therapeutics, Inc. |
Crystalline forms of a compound for treating or preventing gout or hyperuricemia
|
|
MX2021007925A
(es)
|
2018-12-31 |
2021-10-26 |
Biomea Fusion Llc |
Inhibidores irreversibles de la interaccion menina-mll.
|
|
CA3133093A1
(en)
|
2019-03-15 |
2020-09-24 |
Unicycive Therapeutics, Inc. |
Nicorandil derivatives
|
|
EP4125853A4
(en)
|
2020-03-26 |
2024-07-03 |
Sinopia Biosciences, Inc. |
Isotopically-labelled trapidil derivatives
|
|
JP2023523219A
(ja)
|
2020-04-21 |
2023-06-02 |
ハー・ルンドベック・アクチエゼルスカベット |
モノアシルグリセロールリパーゼ阻害剤の合成
|
|
US12435085B2
(en)
|
2020-05-11 |
2025-10-07 |
Casi Pharmaceuticals, Inc. |
Crystalline forms and formulations of a VCP/p97 inhibitor
|
|
US20240124467A1
(en)
|
2020-12-16 |
2024-04-18 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin-mll interaction
|
|
CA3204457A1
(en)
|
2021-01-06 |
2022-07-14 |
Ben SESSA |
Mdma in the treatment of alcohol use disorder
|
|
CA3218884A1
(en)
|
2021-05-11 |
2022-11-17 |
David Nutt |
Therapeutic aminoindane compounds and compositions
|
|
WO2022256720A2
(en)
|
2021-06-03 |
2022-12-08 |
Arcadia Medicine, Inc. |
Enantiomeric entactogen compositions and methods of their use
|
|
US12251385B2
(en)
|
2021-08-11 |
2025-03-18 |
Biomea Fusion, Inc. |
Covalent inhibitors of menin-MLL interaction for diabetes mellitus
|
|
TW202313004A
(zh)
|
2021-08-20 |
2023-04-01 |
美商拜歐米富士恩股份有限公司 |
Menin-mll相互作用之不可逆抑制劑的結晶形式
|
|
EP4392028A4
(en)
|
2021-08-23 |
2025-09-24 |
Alexander Shulgin Res Institute Inc |
DEUTERATED EMPATHOGENS
|
|
WO2023028092A2
(en)
|
2021-08-23 |
2023-03-02 |
Alexander Shulgin Research Institute |
Fluorinated empathogens
|
|
WO2023027966A1
(en)
|
2021-08-24 |
2023-03-02 |
Biomea Fusion, Inc. |
Pyrazine compounds as irreversible inhibitors of flt3
|
|
WO2023034184A1
(en)
|
2021-08-31 |
2023-03-09 |
Cerespir Incorporated |
Co-crystals
|
|
CA3230779A1
(en)
|
2021-09-03 |
2023-03-09 |
Paul Daley |
Asymmetric allyl tryptamines
|
|
WO2023039240A1
(en)
|
2021-09-13 |
2023-03-16 |
Biomea Fusion, Inc. |
IRREVERSIBLE INHIBITORS OF KRas
|
|
CA3232827A1
(en)
|
2021-09-25 |
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|
|
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|
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|
|
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|
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|
|
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|
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|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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|
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|
|
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(en)
|
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|
|
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|
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|