JPS6145608B2 - - Google Patents

Info

Publication number
JPS6145608B2
JPS6145608B2 JP53049610A JP4961078A JPS6145608B2 JP S6145608 B2 JPS6145608 B2 JP S6145608B2 JP 53049610 A JP53049610 A JP 53049610A JP 4961078 A JP4961078 A JP 4961078A JP S6145608 B2 JPS6145608 B2 JP S6145608B2
Authority
JP
Japan
Prior art keywords
collagen
drug
carrier
chemically modified
active drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP53049610A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5446817A (en
Inventor
Teruo Myata
Eru Rubin Arubaato
Daburyu Dan Miruku
Eichi Sutenzeru Kaato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of JPS5446817A publication Critical patent/JPS5446817A/ja
Publication of JPS6145608B2 publication Critical patent/JPS6145608B2/ja
Granted legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
JP4961078A 1977-09-21 1978-04-26 Drugs conveying body * production thereof and drugs conveying body for ophthalmology Granted JPS5446817A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/835,302 US4164559A (en) 1977-09-21 1977-09-21 Collagen drug delivery device

Publications (2)

Publication Number Publication Date
JPS5446817A JPS5446817A (en) 1979-04-13
JPS6145608B2 true JPS6145608B2 (cg-RX-API-DMAC10.html) 1986-10-08

Family

ID=25269163

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4961078A Granted JPS5446817A (en) 1977-09-21 1978-04-26 Drugs conveying body * production thereof and drugs conveying body for ophthalmology

Country Status (6)

Country Link
US (1) US4164559A (cg-RX-API-DMAC10.html)
JP (1) JPS5446817A (cg-RX-API-DMAC10.html)
AU (1) AU520078B2 (cg-RX-API-DMAC10.html)
GB (1) GB1594805A (cg-RX-API-DMAC10.html)
NZ (1) NZ188435A (cg-RX-API-DMAC10.html)
PH (1) PH13977A (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03121203U (cg-RX-API-DMAC10.html) * 1990-03-27 1991-12-12

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2843963A1 (de) * 1978-10-09 1980-04-24 Merck Patent Gmbh Im koerper resorbierbare geformte masse auf basis von kollagen und ihre verwendung in der medizin
US4374121A (en) * 1979-09-12 1983-02-15 Seton Company Macromolecular biologically active collagen articles
JPS5767521A (en) * 1980-09-25 1982-04-24 Yamanouchi Pharmaceut Co Ltd Agent for improving circulation blood vessel
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
US4432964A (en) * 1981-08-24 1984-02-21 Alza Corporation Topical composition containing steroid in two forms released independently from polymeric carrier
FR2524312B1 (fr) * 1982-04-01 1985-10-04 Tech Cuir Centre Nouvelles formes de micro-encapsulation de substances medicamenteuses par des couches homogenes de collagene natif
US4505855A (en) * 1982-09-30 1985-03-19 Massachusetts General Hospital Transparent non-fibrilized collagen material by ultracentrifugation
US4478818A (en) * 1982-12-27 1984-10-23 Alza Corporation Ocular preparation housing steroid in two different therapeutic forms
GB8306353D0 (en) * 1983-03-08 1983-04-13 Stuart J F B Monitoring of drug levels
JPS6025920A (ja) * 1983-07-22 1985-02-08 Japan Atom Energy Res Inst 薬物含有徐放性複合体及びその調製方法
JPS6028936A (ja) * 1983-07-27 1985-02-14 Koken:Kk アテロコラ−ゲン水溶液およびその製造方法
JPS6084213A (ja) * 1983-10-14 1985-05-13 Sumitomo Chem Co Ltd 徐放性消炎鎮痛製剤
JPS6089418A (ja) * 1983-10-20 1985-05-20 Sumitomo Chem Co Ltd 徐放性制癌剤
US4563184A (en) * 1983-10-17 1986-01-07 Bernard Korol Synthetic resin wound dressing and method of treatment using same
FR2559780B1 (fr) * 1984-02-21 1990-05-04 Tech Cuir Centre Systemes biocompatibles implantables a base de collagene permettant la conservation et/ou la culture cellulaires et/ou la liberation controlee de principes actifs
US4748152A (en) * 1985-01-22 1988-05-31 Opticol Corp. Succinylated atelocollagen solution for use in viscosurgery and as a vitreous substitute
US4851513A (en) * 1985-09-06 1989-07-25 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for opthalmic use and method of preparation
US4713446A (en) * 1985-09-06 1987-12-15 Minnesota Mining And Manufacturing Company Viscoelastic collagen solution for ophthalmic use and method of preparation
US4883864A (en) * 1985-09-06 1989-11-28 Minnesota Mining And Manufacturing Company Modified collagen compound and method of preparation
ES2054613T3 (es) * 1985-12-27 1994-08-16 Sumitomo Pharma Un metodo para preparar una formulacion de liberacion mantenida.
FR2601371B1 (fr) * 1986-07-11 1989-05-12 Merieux Inst Procede de traitement du collagene en vue, notamment, d'en faciliter la reticulation et collagene obtenu par application dudit procede
US5128134A (en) * 1986-09-17 1992-07-07 Fyodorov Svyatoslav N Ophthalmological collagen coverings
US5989579A (en) * 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
US5322691A (en) * 1986-10-02 1994-06-21 Sohrab Darougar Ocular insert with anchoring protrusions
US5147647A (en) * 1986-10-02 1992-09-15 Sohrab Darougar Ocular insert for the fornix
US5094855A (en) * 1986-10-13 1992-03-10 Moskovsky Nauchno-Teknichesky Compleks "Mikrochirurgija Glaza" Opthalmological collagen coverings
DE68907066T2 (de) * 1988-01-29 1993-12-16 Koken Kk Verbesserte Formulierungen mit kontrollierter Abgabe.
US4969912A (en) * 1988-02-18 1990-11-13 Kelman Charles D Human collagen processing and autoimplant use
AU632273B2 (en) * 1988-03-09 1992-12-24 Terumo Kabushiki Kaisha Medical material permitting cells to enter thereinto and artificial skin
US4882150A (en) * 1988-06-03 1989-11-21 Kaufman Herbert E Drug delivery system
US4923700A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Artificial tear suspension
US4865846A (en) * 1988-06-03 1989-09-12 Kaufman Herbert E Drug delivery system
US4923699A (en) * 1988-06-03 1990-05-08 Kaufman Herbert E Eye treatment suspension
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5936035A (en) * 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5800541A (en) * 1988-11-21 1998-09-01 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5475052A (en) * 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US4946450A (en) * 1989-04-18 1990-08-07 Biosource Genetics Corporation Glucan/collagen therapeutic eye shields
US4978352A (en) * 1989-06-07 1990-12-18 Fedorov Svjatoslav N Process for producing collagen-based cross-linked biopolymer, an implant from said biopolymer, method for producing said implant, and method for hermetization of corneal or scleral wounds involved in eye injuries, using said implant
US5138030A (en) * 1989-10-10 1992-08-11 Pachence James M Process for extracting type I collagen form an avian source, and applications therefor
US5103840A (en) * 1990-05-07 1992-04-14 Kavoussi Harold P Viscoelastic collagen gel for ophthalmic surgery
US5322648A (en) * 1991-08-26 1994-06-21 Vitaphore Corporation Process for forming shaped collagen devices
US5259998A (en) * 1991-10-04 1993-11-09 Chiron Ophthalmics, Inc. Method for casting dissolvable ophthalmic shields in a mold
CA2140053C (en) * 1994-02-09 2000-04-04 Joel S. Rosenblatt Collagen-based injectable drug delivery system and its use
US5466233A (en) * 1994-04-25 1995-11-14 Escalon Ophthalmics, Inc. Tack for intraocular drug delivery and method for inserting and removing same
DE4414755C2 (de) * 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
US5928667A (en) * 1994-06-24 1999-07-27 University Of Maryland Drug delivery device and method for employing the same
EP0713707A1 (en) 1994-11-23 1996-05-29 Collagen Corporation In situ crosslinkable, injectable collagen composition for tissue augmention
US5518732A (en) * 1995-02-14 1996-05-21 Chiron Vision, Inc. Bio-erodible ophthalmic shield
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
JPH11501512A (ja) * 1995-03-03 1999-02-09 メタボレックス,インコーポレイティド ゲル化ポリマーによる新規の被包方法
DE19508029C2 (de) * 1995-03-07 1997-10-09 Richard Prof Dr Sueverkruep Darreichungsform zur äußerlichen Applikation von ophthalmischen Arzneistoffen und Verfahren zur Herstellung derselben
US6962979B1 (en) * 1995-03-14 2005-11-08 Cohesion Technologies, Inc. Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
US5788959A (en) * 1995-04-24 1998-08-04 University Of Maryland, Baltimore County Drug delivery device and method for employing the same
US5677284A (en) * 1995-06-06 1997-10-14 Regen Biologics, Inc. Charged collagen particle-based delivery matrix
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US7883693B2 (en) 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
CA2239775C (en) 1995-12-18 2008-07-15 Collagen Corporation Crosslinked polymer compositions and methods for their use
DE69739275D1 (de) * 1996-01-05 2009-04-09 Autoimmune Inc Methode zur herstellung von type-ii kollagen
US6299895B1 (en) 1997-03-24 2001-10-09 Neurotech S.A. Device and method for treating ophthalmic diseases
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US6083522A (en) * 1997-01-09 2000-07-04 Neucoll, Inc. Devices for tissue repair and methods for preparation and use thereof
JPH1156897A (ja) * 1997-08-18 1999-03-02 Koken Co Ltd コラーゲン眼科手術補助剤
US6197934B1 (en) 1998-05-22 2001-03-06 Collagenesis, Inc. Compound delivery using rapidly dissolving collagen film
WO2001013119A1 (en) * 1999-08-17 2001-02-22 Luminex Corporation Encapsulation of fluorescent particles
PT2093245E (pt) 1999-08-27 2012-05-29 Angiodevice Internat Gmbh Dispositivo biocompatível de polímeros
WO2002062335A2 (en) 2001-01-16 2002-08-15 Vascular Therapies, Llc Implantable device containing resorbable matrix material and anti-proliferative drugs for preventing or treating failure of hemodialysis vascular access and other vascular grafts
CA2450771C (en) 2001-06-12 2010-09-07 Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US20030181371A1 (en) * 2001-12-28 2003-09-25 Angiotech Pharmaceuticals, Inc. Compositions and methods of using collajolie
US20070225631A1 (en) * 2002-10-04 2007-09-27 Bowlin Gary L Sealants for Skin and Other Tissues
US20050013845A1 (en) * 2002-11-12 2005-01-20 Warren Stephen L. Adhesive bioerodible ocular drug delivery system
WO2004060405A2 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
CA2511521C (en) 2002-12-30 2012-02-07 Angiotech International Ag Drug delivery from rapid gelling polymer composition
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
JP2007526009A (ja) 2003-06-19 2007-09-13 バスキュラー セラピーズ エルエルシー 血管閉鎖装具に対する組織反応を調節するための医療装具及び方法
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
WO2005020907A2 (en) 2003-08-26 2005-03-10 Vista Scientific Ocular drug delivery device
CN104174071A (zh) 2004-04-28 2014-12-03 安希奥设备国际有限责任公司 用于形成交联生物材料的组合物和系统及关联的制备方法与用途
CA2581093C (en) 2004-09-17 2014-11-18 Angiotech Biomaterials Corporation Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
US8313763B2 (en) * 2004-10-04 2012-11-20 Tolmar Therapeutics, Inc. Sustained delivery formulations of rapamycin compounds
US20060210604A1 (en) * 2004-10-04 2006-09-21 Eric Dadey Ocular delivery of polymeric delivery formulations
EP2932971A1 (en) 2005-03-04 2015-10-21 Otonomy, Inc. Ketamine formulations
WO2006113845A1 (en) * 2005-04-19 2006-10-26 Therabit, Inc. Implantable tissue-reactive biomaterial compositions and systems, and methods of use thereof
US20060247776A1 (en) * 2005-05-02 2006-11-02 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for augmenting intervertebral discs
US20070005140A1 (en) * 2005-06-29 2007-01-04 Kim Daniel H Fabrication and use of biocompatible materials for treating and repairing herniated spinal discs
US20070233252A1 (en) * 2006-02-23 2007-10-04 Kim Daniel H Devices, systems and methods for treating intervertebral discs
WO2007115259A2 (en) 2006-03-31 2007-10-11 Qlt Plug Delivery, Inc. Nasolacrimal drainage system implants for drug therapy
US8703122B2 (en) * 2006-05-31 2014-04-22 Baxter International Inc. Method for directed cell in-growth and controlled tissue regeneration in spinal surgery
US7803148B2 (en) * 2006-06-09 2010-09-28 Neurosystec Corporation Flow-induced delivery from a drug mass
TWI436793B (zh) 2006-08-02 2014-05-11 Baxter Int 快速作用之乾密封膠及其使用和製造方法
WO2008035376A2 (en) * 2006-09-19 2008-03-27 Council Of Scientific & Industrial Research A novel bio-erodible insert for ophthalmic applications and a process for the preparation thereof
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US8790698B2 (en) 2007-10-30 2014-07-29 Baxter International Inc. Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
AU2009208729A1 (en) * 2008-01-31 2009-08-06 Sofradim Production Preparation of terminally-sterilized collagen that is soluble at neutral pH
CN102014973A (zh) 2008-02-29 2011-04-13 弗罗桑医疗设备公司 用于促进止血和/或伤口愈合的装置
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
SG2014007389A (en) 2009-01-29 2014-04-28 Forsight Vision4 Inc Posterior segment drug delivery
US20100226962A1 (en) * 2009-03-03 2010-09-09 Rodstrom Theron R Peri-corneal drug delivery device
US9039783B2 (en) 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
EP2442835B1 (en) * 2009-06-16 2014-12-10 Baxter International Inc Hemostatic sponge
HRP20151425T1 (hr) 2009-08-10 2016-01-29 Samumed, Llc Inhibitori indazola wnt signalnog puta i njihove terapeutske uporabe
HUE038789T2 (hu) * 2009-10-07 2018-11-28 Kerecis Ehf Vázanyag sebkezelésre és/vagy sebgyógyításban történõ alkalmazásra
CA2776748A1 (en) * 2009-10-08 2011-04-14 Neurotech Usa, Inc. Use of pedf in an encapsulated cell-based delivery system
CN102753203A (zh) 2009-12-16 2012-10-24 巴克斯特国际公司 止血海绵
HUE035612T2 (en) 2009-12-21 2018-05-28 Samumed Llc 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
US8469934B2 (en) * 2010-01-27 2013-06-25 Alcon Research, Ltd. Pulsatile peri-corneal drug delivery device
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
CN102917691A (zh) 2010-06-01 2013-02-06 巴克斯特国际公司 用于生产干燥、稳定的止血组合物的方法
US8940335B2 (en) 2010-06-01 2015-01-27 Baxter International Inc. Process for making dry and stable hemostatic compositions
EP2575775B1 (en) 2010-06-01 2018-04-04 Baxter International Inc. Process for making dry and stable hemostatic compositions
KR20130108269A (ko) * 2010-08-02 2013-10-02 유클리드 시스템스 코포레이션 약물의 지속 전달을 위한 콜라겐계 이식물
WO2012019139A1 (en) 2010-08-05 2012-02-09 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
CN105435338B (zh) 2010-08-05 2019-03-26 弗赛特影像4股份有限公司 用于药物输送的注入器装置和方法
HRP20211909T1 (hr) 2010-08-05 2022-03-18 Forsight Vision4, Inc. Uređaj za liječenja oka
EP3915367A1 (en) 2010-08-18 2021-12-01 BioSplice Therapeutics, Inc. Diketones and hydroxyketones as catenin signaling pathway activators
CA2818612C (en) 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
CN108744262A (zh) 2010-11-23 2018-11-06 普莱萨格生命科学公司 用于实体递送的治疗方法和组合物
US10398592B2 (en) 2011-06-28 2019-09-03 Forsight Vision4, Inc. Diagnostic methods and apparatus
US9102105B2 (en) 2011-09-13 2015-08-11 Vista Scientific Llc Method for forming an ocular drug delivery device
RU2627693C2 (ru) 2011-09-14 2017-08-10 СЭМЬЮМЕД, ЭлЭлСи ИНДАЗОЛ-3-КАРБОКСАМИДЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ СИГНАЛЬНОГО ПУТИ WNT/b-КАТЕНИНА
DK2755600T3 (da) 2011-09-16 2021-05-03 Forsight Vision4 Inc Fluidudvekslingsindretning
JP6195569B2 (ja) 2011-10-11 2017-09-13 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated 止血組成物
CA2851338C (en) 2011-10-11 2019-11-05 Baxter International Inc. Hemostatic compositions
PT2771027E (pt) 2011-10-27 2015-11-26 Baxter Healthcare Sa Composições hemostáticas
JP2014534864A (ja) 2011-10-28 2014-12-25 プレサージュ バイオサイエンシズ,インコーポレイテッド 薬物デリバリー方法
JP6241624B2 (ja) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ/エス 止血ペーストを収容する加圧容器
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
SG10201710585UA (en) 2012-05-04 2018-02-27 Samumed Llc 1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
JP6394916B2 (ja) 2012-06-12 2018-09-26 フェロサン メディカル デバイシーズ エイ/エス 乾燥止血組成物
MX370487B (es) 2013-01-08 2019-12-16 Samumed Llc Inhibidores de 3-(benzo-imidazol-2-il)-indazol de la senda de señalización de wnt y usos terapéuticos de los mismos.
JP6401189B2 (ja) 2013-02-22 2018-10-03 サミュメッド リミテッド ライアビリティ カンパニー Wnt/β−カテニンシグナル伝達経路活性化剤としてのγ−ジケトン
CA2905496A1 (en) 2013-03-14 2014-09-25 Forsight Vision4, Inc. Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CN105828844B (zh) 2013-12-11 2019-09-27 弗罗桑医疗设备公司 包含挤出增强剂的干组合物
MA39763A (fr) 2014-03-20 2017-01-25 Samumed Llc Indazole-3-carboxamides 5-substitués, et préparation et utilisation de ceux-ci
SG11201700943TA (en) 2014-08-08 2017-03-30 Forsight Vision4 Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
HRP20192161T1 (hr) 2014-08-20 2020-02-21 Samumed, Llc Gama-diketoni za liječenje i prevenciju starenja kože i bora
WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040188A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
US11046818B2 (en) 2014-10-13 2021-06-29 Ferrosan Medical Devices A/S Dry composition for use in haemostasis and wound healing
CN114587774B (zh) 2014-11-10 2024-07-19 弗赛特影像4股份有限公司 治疗眼睛的系统
CN107206165B (zh) 2014-12-24 2020-10-23 弗罗桑医疗设备公司 用于保持并混合第一和第二物质的注射器
US10010502B2 (en) 2015-05-19 2018-07-03 Amorphex Therapeutics Llc Device that delivers a sustained low-dose of a myopia-suppressing drug, while preserving pupillary function and accommodation
AU2016290433B2 (en) 2015-07-03 2018-05-24 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
US10383861B2 (en) 2015-08-03 2019-08-20 Sammumed, LLC 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1H-pyrazolo[3,4-C]pyridines and therapeutic uses thereof
US10226453B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-indol-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10231956B2 (en) 2015-08-03 2019-03-19 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017024021A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017023996A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridines and therapeutic uses thereof
US10195185B2 (en) 2015-08-03 2019-02-05 Samumed, Llc 3-(1H-imidazo[4,5-C]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017024004A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017023984A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[3,2-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
US10392383B2 (en) 2015-08-03 2019-08-27 Samumed, Llc 3-(1H-benzo[d]imidazol-2-yl)-1H-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
WO2017023986A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-indazoles and therapeutic uses thereof
WO2017023988A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[4,3-b]pyridines and therapeutic uses thereof
US10226448B2 (en) 2015-08-03 2019-03-12 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-yl)-1H-pyrazolo[3,4-B]pyridines and therapeutic uses thereof
US10519169B2 (en) 2015-08-03 2019-12-31 Samumed, Llc 3-(1H-pyrrolo[2,3-C]pyridin-2-yl)-1 H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
WO2017023980A1 (en) 2015-08-03 2017-02-09 Samumed, Llc. 3-(1h-pyrrolo[2,3-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
WO2017024026A1 (en) 2015-08-03 2017-02-09 Samumed, Llc 3-(1h-indol-2-yl)-1h-pyrazolo[3,4-c]pyridines and therapeutic uses thereof
US10329309B2 (en) 2015-08-03 2019-06-25 Samumed, Llc 3-(3H-imidazo[4,5-B]pyridin-2-yl)-1H-pyrazolo[4,3-B]pyridines and therapeutic uses thereof
US10463651B2 (en) 2015-08-03 2019-11-05 Samumed, Llc 3-(1H-pyrrolo[3,2-C]pyridin-2-YL)-1H-indazoles and therapeutic uses thereof
MX389958B (es) 2015-11-06 2025-03-20 Samumed Llc 2- (1h-indazol-3-il) -3h-imidazo[4,5-c] piridinas y usos antiinflamatorios de las mismas.
WO2017087902A1 (en) 2015-11-20 2017-05-26 Forsight Vision4, Inc. Porous structures for extended release drug delivery devices
WO2017176886A1 (en) 2016-04-05 2017-10-12 Forsight Vision4, Inc. Implantable ocular drug delivery devices
AR108326A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108325A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
RS63813B1 (sr) 2016-06-01 2023-01-31 Biosplice Therapeutics Inc Postupak pripreme n-(5-(3-(7-(3-fluorofenil)-3h-imidazo[4,5-c]piridin-2-il)-1h-indazol-5-il)piridin-3-il)-3-metilbutanamida
BR112019008061A2 (pt) 2016-10-21 2019-09-17 Samumed Llc métodos de uso de indazol-3-carboxamidas e seu uso como inibidores da via de sinalização de wnt/b-catenina
MA46696A (fr) 2016-11-07 2019-09-11 Samumed Llc Formulations injectables à dose unique prêtes à l'emploi
WO2019079626A1 (en) 2017-10-19 2019-04-25 Samumed, Llc 6- (HETEROARYL 5-CHAIN) ISOQUINOLIN-3-YL CARBOXAMIDES, THEIR PREPARATION AND THEIR USE
WO2019084497A1 (en) 2017-10-27 2019-05-02 Samumed, Llc 6- (HETEROARYL AND ARYL WITH 6 CHAINS) ISOQUINOLIN-3-YL CARBOXAMIDES, THEIR PREPARATION AND THEIR USE
US10413537B2 (en) 2017-10-27 2019-09-17 Samumed, Llc 6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
US10703748B2 (en) 2017-10-31 2020-07-07 Samumed, Llc Diazanaphthalen-3-yl carboxamides and preparation and use thereof
WO2019103906A1 (en) 2017-11-21 2019-05-31 Forsight Vision4, Inc. Fluid exchange apparatus for expandable port delivery system and methods of use
AU2019224075A1 (en) 2018-02-23 2020-09-10 Samumed, Llc 5-heteroaryl substituted indazole-3-carboxamides and preparation and use thereof
EP3790600B1 (en) 2018-05-09 2023-12-27 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
US10759799B2 (en) 2018-06-15 2020-09-01 Samumed, Llc Indazole containing macrocycles and therapeutic uses thereof
US10654833B2 (en) 2018-06-28 2020-05-19 Hepatikos Therapeutics, Llc ASK1 isoindolin-1-one inhibitors and methods of use thereof
WO2020150545A1 (en) 2019-01-17 2020-07-23 Samumed, Llc Pyrazole derivatives as modulators of the wnt/b-catenin signaling pathway
US12257184B2 (en) 2019-10-24 2025-03-25 Denis LaBombard Ocular device and drug delivery system, with case
WO2021168341A1 (en) 2020-02-21 2021-08-26 Samumed, Llc Solid forms of 1-(5-(3-(7-(3-fluorophenyl)-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridin-5-yl)pyridin-3-yl)-n,n-dimethylmethanamine
WO2023030435A1 (en) 2021-09-01 2023-03-09 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells
WO2023064349A1 (en) 2021-10-12 2023-04-20 Biosplice Therapeutics, Inc. 1h-pyrrolo[2,3-b]pyridines as dyrk1a inhibitors
US12134625B2 (en) 2021-10-12 2024-11-05 Biosplice Therapeutics, Inc. Pyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof
WO2023125689A1 (en) 2021-12-28 2023-07-06 Shanghai Qisheng Biological Preparation Co., Ltd. Hyaluronic acid-collagen copolymer compositions and medical applications thereof
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
CA3260560A1 (en) 2022-06-23 2023-12-28 Biosplice Therapeutics, Inc. 4-ALCOXYPYRROLO[2,1-F][1,2,4]TRIAZINES AND THEIR PREPARATION AND USES
WO2024097391A1 (en) 2022-11-03 2024-05-10 Biosplice Therapeutics, Inc. 4-aminopyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof
EP4676931A1 (en) 2023-04-07 2026-01-14 BioSplice Therapeutics, Inc. Pyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof
WO2025137469A1 (en) 2023-12-22 2025-06-26 Biosplice Therapeutics, Inc. 4-alkoxypyrrolo[2,1-f][1,2,4]triazines and preparation and uses thereof
WO2025231425A1 (en) 2024-05-03 2025-11-06 Biosplice Therapeutics, Inc. 4-aminopyrrolo[2,l-f][l,2,4]triazines and preparation and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5325006B2 (cg-RX-API-DMAC10.html) * 1973-08-17 1978-07-24

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03121203U (cg-RX-API-DMAC10.html) * 1990-03-27 1991-12-12

Also Published As

Publication number Publication date
AU520078B2 (en) 1982-01-14
JPS5446817A (en) 1979-04-13
GB1594805A (en) 1981-08-05
AU4000078A (en) 1980-03-27
NZ188435A (en) 1981-03-16
PH13977A (en) 1980-11-20
US4164559A (en) 1979-08-14

Similar Documents

Publication Publication Date Title
JPS6145608B2 (cg-RX-API-DMAC10.html)
US4946450A (en) Glucan/collagen therapeutic eye shields
US5759532A (en) Controlled release of miotic and myriatic drugs in the anterior chamber
US4447562A (en) Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
US5792103A (en) Viscosurgical method and apparatus
US4486416A (en) Protection of human and animal cells subject to exposure to trauma
US5631243A (en) Collagen-based viscoelastic solution for visco-surgery
EP0167363B1 (en) Crosslinked glycosaminoglycans and their use
US5036056A (en) Methods for treating damaged corneal, uterine, or cartilage tissue
Nakagawa et al. Evaluation of collagen gel and hyaluronic acid as vitreous substitutes
Vasantha et al. Collagen ophthalmic inserts for pilocarpine drug delivery system
US4913904A (en) Ophthalmological collagen coverings
US5259998A (en) Method for casting dissolvable ophthalmic shields in a mold
US3911098A (en) Medicament carrier
JPS62500720A (ja) 眼科用組成物
RU2121825C1 (ru) Глазные капли "интертоник"
Aquavella et al. Therapeutic applications of a collagen bandage lens: A preliminary report
JPH0723317B2 (ja) 角膜上皮層障害症治療剤
CN1066328C (zh) 阿尔加托品烷在药物制备中的应用
JPS597684B2 (ja) コラ−ゲンを用いた眼用徐放性制御医薬剤
JPS5857319A (ja) 高粘性ヒアルロン酸製剤
JP2001206850A (ja) 眼組織再生誘導剤
RU2076672C1 (ru) Глазная пленка
KR820000292B1 (ko) 교원질 약물 운반체의 제조방법
RU2098079C1 (ru) Глазной гель