JPS6127390B2 - - Google Patents

Info

Publication number
JPS6127390B2
JPS6127390B2 JP59211572A JP21157284A JPS6127390B2 JP S6127390 B2 JPS6127390 B2 JP S6127390B2 JP 59211572 A JP59211572 A JP 59211572A JP 21157284 A JP21157284 A JP 21157284A JP S6127390 B2 JPS6127390 B2 JP S6127390B2
Authority
JP
Japan
Prior art keywords
methoxy
compound
methyl
benzomorphan
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP59211572A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60142964A (ja
Inventor
Arufuretsudo Monzuka Toomasu
Danieru Machisukera Jon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of JPS60142964A publication Critical patent/JPS60142964A/ja
Publication of JPS6127390B2 publication Critical patent/JPS6127390B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP59211572A 1974-04-18 1984-10-11 ベンゾモルフアン類の製法 Granted JPS60142964A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46200774A 1974-04-18 1974-04-18
US462007 1995-06-05

Publications (2)

Publication Number Publication Date
JPS60142964A JPS60142964A (ja) 1985-07-29
JPS6127390B2 true JPS6127390B2 (OSRAM) 1986-06-25

Family

ID=23834846

Family Applications (3)

Application Number Title Priority Date Filing Date
JP50046634A Expired JPS6218552B2 (OSRAM) 1974-04-18 1975-04-18
JP59211572A Granted JPS60142964A (ja) 1974-04-18 1984-10-11 ベンゾモルフアン類の製法
JP59211573A Granted JPS60120868A (ja) 1974-04-18 1984-10-11 ベンゾモルフアン類の製法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP50046634A Expired JPS6218552B2 (OSRAM) 1974-04-18 1975-04-18

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP59211573A Granted JPS60120868A (ja) 1974-04-18 1984-10-11 ベンゾモルフアン類の製法

Country Status (23)

Country Link
JP (3) JPS6218552B2 (OSRAM)
BE (1) BE828054A (OSRAM)
CA (1) CA1040630A (OSRAM)
CH (1) CH623812A5 (OSRAM)
CS (1) CS199586B2 (OSRAM)
DD (1) DD119787A5 (OSRAM)
DE (1) DE2517220A1 (OSRAM)
DK (2) DK155999C (OSRAM)
FI (1) FI60564C (OSRAM)
FR (1) FR2267774B1 (OSRAM)
GB (1) GB1493420A (OSRAM)
HU (1) HU173039B (OSRAM)
IE (1) IE41003B1 (OSRAM)
IL (1) IL47114A (OSRAM)
LU (1) LU72315A1 (OSRAM)
NL (1) NL159971C (OSRAM)
NO (1) NO143155C (OSRAM)
OA (1) OA04983A (OSRAM)
PH (1) PH12067A (OSRAM)
SE (1) SE427181B (OSRAM)
SU (1) SU721002A3 (OSRAM)
YU (1) YU93275A (OSRAM)
ZA (1) ZA752471B (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01179624A (ja) * 1988-01-12 1989-07-17 Matsushita Refrig Co Ltd 生鮮物貯蔵装置
GB2442535B (en) 2006-10-05 2011-07-13 Ngf Europ Ltd Method and articles

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation

Also Published As

Publication number Publication date
JPS60120868A (ja) 1985-06-28
BE828054A (fr) 1975-10-17
SE427181B (sv) 1983-03-14
JPS50142568A (OSRAM) 1975-11-17
SE7504469L (sv) 1975-10-20
DE2517220C2 (OSRAM) 1990-04-19
CH623812A5 (en) 1981-06-30
AU8025875A (en) 1976-10-21
DK155999C (da) 1989-11-06
SU721002A3 (ru) 1980-03-05
IE41003B1 (en) 1979-09-26
FR2267774B1 (OSRAM) 1978-08-04
PH12067A (en) 1978-10-30
JPH0119387B2 (OSRAM) 1989-04-11
CS199586B2 (en) 1980-07-31
DD119787A5 (OSRAM) 1976-05-12
DK155999B (da) 1989-06-12
DE2517220A1 (de) 1975-11-06
NO143155B (no) 1980-09-15
FI751106A7 (OSRAM) 1975-10-19
OA04983A (fr) 1980-11-30
YU93275A (en) 1982-02-28
DK194088A (da) 1988-04-08
FR2267774A1 (OSRAM) 1975-11-14
IL47114A0 (en) 1975-06-25
HU173039B (hu) 1979-02-28
ZA752471B (en) 1976-03-31
NO751371L (OSRAM) 1975-10-21
NL7504648A (nl) 1975-10-21
LU72315A1 (OSRAM) 1976-03-17
CA1040630A (en) 1978-10-17
DK166375A (da) 1975-10-19
IE41003L (en) 1975-10-18
GB1493420A (en) 1977-11-30
FI60564B (fi) 1981-10-30
FI60564C (fi) 1982-02-10
JPS60142964A (ja) 1985-07-29
NL159971C (nl) 1979-09-17
DK194088D0 (da) 1988-04-08
NO143155C (no) 1980-12-29
JPS6218552B2 (OSRAM) 1987-04-23
IL47114A (en) 1979-01-31

Similar Documents

Publication Publication Date Title
JP5695296B2 (ja) 低レベルのアルファ，ベータ−不飽和ケトン化合物を伴うモルフィナン−６−オン生成物の製造方法
JPS6363544B2 (OSRAM)
JPS582956B2 (ja) ７及び７−８置換された４，５αエポキシモルフイナン−６−オン化合物
JPS61271275A (ja) モルヒナン誘導体
US4272540A (en) 14-Methoxymorphinan-6-one compounds and therapeutic methods of treating pain and drug dependence with them
JPS6125714B2 (OSRAM)
TWI478928B (zh) 用於製備ｎ－烯丙基化合物之過渡金屬催化的製程及其用途
US4230712A (en) 7-Methyl-8β-lower alkyl or 7-methyl-8-lower alkyl B/C cis or trans morphinan-6-one compounds and therapeutic method of treating pain employing them
JPS5835197B2 (ja) チンツウザイ
TW505645B (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions
JPS6127390B2 (OSRAM)
EP0028717A1 (en) 6,7-Benzomorphan derivatives, processes for their production, pharmaceutical compositions containing said derivatives and their use as pharmaceuticals
JPH085889B2 (ja) 経口活性非耽溺性鎮痛剤
JPH0260653B2 (OSRAM)
JPS649316B2 (OSRAM)
JPH06312989A (ja) （１ｒｓ，２ｒｓ，４ｓｒ）−２−（６−クロロ−３−ピリジル）−７−アザビシクロ［２．２．１］ヘプタンの製造方法
EP0068384B1 (en) 17-cyclopropylmethyl-3-hydroxy-14-methoxy 7 alpha-methylmorphinan-6-one
GB1559980A (en) 11-hydroxy - 6 - hydroxymethyl - 1,2,3,4,5,6-hexahydro - 2,6 - methano - 3 - benzazocines
KR800000849B1 (ko) 벤조모르판 유도체의 제조방법
US3926995A (en) Theophylline derivatives
EP0019254B1 (en) 7-methyl and 7-methyl-8-lower alkyl b/c cis or trans morphinan-6-one compounds, process for their preparation and pharmaceutical preparations containing them
JPS6212221B2 (OSRAM)
Deschamps Investigations into naloxone-based degradation products in Suboxone® sublingual film
Ghavimi-Alagha Synthesis and receptor affinity of 7 [beta]-substituted analogs of codeine: total synthesis of 8, 14-dihydromorphinandienone alkaloids
EP0070427A2 (en) Octahydro-4a,7-ethano- and -etheno-benzofuro(3,2-e)isoquinoline derivatives