JPS5995270A - ２−アミノ−３−アシルアミノ−６−ベンジルアミノ−ピリジン誘導体、及びその製法 - Google Patents

２−アミノ−３−アシルアミノ−６−ベンジルアミノ−ピリジン誘導体、及びその製法

Info

Publication number
JPS5995270A
JPS5995270A JP58198412A JP19841283A JPS5995270A JP S5995270 A JPS5995270 A JP S5995270A JP 58198412 A JP58198412 A JP 58198412A JP 19841283 A JP19841283 A JP 19841283A JP S5995270 A JPS5995270 A JP S5995270A
Authority
JP
Japan
Prior art keywords
group
phenyl
amino
alkoxy
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP58198412A
Other languages
English (en)
Japanese (ja)
Inventor
ヴアルタ−・フオン・ベ−ベンブルク
ヨアヒム　・ヘ−ゼ
ユルゲン・エンゲル
クルト・テイ−レ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Deutsche Gold und Silber Scheideanstalt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH, Deutsche Gold und Silber Scheideanstalt filed Critical Degussa GmbH
Publication of JPS5995270A publication Critical patent/JPS5995270A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP58198412A 1982-10-27 1983-10-25 ２−アミノ−３−アシルアミノ−６−ベンジルアミノ−ピリジン誘導体、及びその製法 Pending JPS5995270A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE32397909 1982-10-27
DE3239790 1982-10-27

Publications (1)

Publication Number Publication Date
JPS5995270A true JPS5995270A (ja) 1984-06-01

Family

ID=6176726

Family Applications (2)

Application Number Title Priority Date Filing Date
JP58198412A Pending JPS5995270A (ja) 1982-10-27 1983-10-25 ２−アミノ−３−アシルアミノ−６−ベンジルアミノ−ピリジン誘導体、及びその製法
JP58198411A Granted JPS5995269A (ja) 1982-10-27 1983-10-25 抗てんかん性医薬品

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP58198411A Granted JPS5995269A (ja) 1982-10-27 1983-10-25 抗てんかん性医薬品

Country Status (8)

Country Link
US (1) US4554281A (enExample)
EP (1) EP0110091B1 (enExample)
JP (2) JPS5995270A (enExample)
AT (1) ATE25078T1 (enExample)
AU (1) AU561450B2 (enExample)
DE (1) DE3369315D1 (enExample)
ES (1) ES526765A0 (enExample)
IT (2) IT1171880B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3665538D1 (en) * 1985-01-23 1989-10-19 Asta Pharma Ag Synergistic combination of flupirtin and non-steroidal anti-phlogistics
NO860825L (no) * 1985-03-23 1986-09-24 Degussa Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
DE4327516A1 (de) * 1993-08-17 1995-02-23 Asta Medica Ag Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
ZA953078B (en) * 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
DE19835918A1 (de) * 1998-08-07 2000-02-10 Dresden Arzneimittel Neue antikonvulsiv wirkende 4-Amino-1-aryl-pyridin-2-one und Verfahren zu deren Herstellung
US7799832B2 (en) * 2003-10-23 2010-09-21 Valeant Pharmaceuticals North America Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
EP1831170A4 (en) * 2004-12-14 2009-10-14 Astrazeneca Ab SUBSTITUTED AMINOPYRIDINES AND THEIR USE
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
NZ575652A (en) * 2006-08-23 2011-08-26 Valeant Pharmaceuticals Int Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
KR20090083479A (ko) * 2006-11-28 2009-08-03 밸리언트 파마슈티컬즈 인터내셔널 칼륨 채널 조절제로서의 1,4 디아미노 이환 레티가빈 유사체
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
JP2009037141A (ja) 2007-08-03 2009-02-19 Ricoh Co Ltd 画像形成装置の管理装置及び管理システム
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
EP2231608A1 (en) * 2007-12-11 2010-09-29 NeuroSearch A/S Novel 2-diethylamino-3-amido-6-amino-pyridine derivatives useful as potassium channel activators
WO2009074594A1 (en) * 2007-12-11 2009-06-18 Neurosearch A/S Novel 2-ethyl-methyl-amino-3-amido-6-amino-pyridine derivatives useful as potassium channel activators
EP2231610A1 (en) * 2007-12-11 2010-09-29 NeuroSearch A/S Novel 2-dimethylamino-3-amido-6-amino-pyridine derivatives useful as potassium channel activators
JP2011506390A (ja) * 2007-12-11 2011-03-03 ノイロサーチ アクティーゼルスカブ カリウムチャネル活性化因子として有用な、新規の２−ピロリジニル−３−アミド−６−アミノ−ピリジン誘導体
CN102351786A (zh) * 2011-11-01 2012-02-15 东南大学 一种氟吡汀丙二酸盐及其制备方法
WO2019014547A1 (en) * 2017-07-14 2019-01-17 Texas Tech University System FUNCTIONALIZED PYRIDINE CARBAMATES HAVING ENHANCED NEUROPROTECTOR ACTIVITY
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
CA3155812A1 (en) 2019-11-08 2021-05-14 Cynthia Louise HARDEN Methods of treating depressive disorders
TW202245744A (zh) 2021-02-09 2022-12-01 加拿大商再諾製藥公司 治療失樂症之方法及用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50840A (enExample) * 1973-04-28 1975-01-07

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670523A1 (de) * 1966-05-12 1970-12-03 Degussa Verfahren zur Herstellung neuer substituierter Aminopyridine
BE764362R (en) * 1966-05-12 1971-09-16 Degussa Subst amino pyridienes production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50840A (enExample) * 1973-04-28 1975-01-07

Also Published As

Publication number Publication date
IT1171880B (it) 1987-06-10
IT8349222A1 (it) 1985-04-26
EP0110091B1 (de) 1987-01-21
ES8406440A1 (es) 1984-07-01
JPH0144170B2 (enExample) 1989-09-26
ES526765A0 (es) 1984-07-01
JPS5995269A (ja) 1984-06-01
US4554281A (en) 1985-11-19
AU2058283A (en) 1984-05-03
IT1171879B (it) 1987-06-10
ATE25078T1 (de) 1987-02-15
IT8349223A0 (it) 1983-10-26
EP0110091A1 (de) 1984-06-13
IT8349223A1 (it) 1985-04-26
DE3369315D1 (en) 1987-02-26
AU561450B2 (en) 1987-05-07
IT8349222A0 (it) 1983-10-26

Similar Documents

Publication Publication Date Title
DE2065635C3 (de) 10-Dioxo-11 -methyldibenzothiazepinderivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zubereitungen
JPS5995269A (ja) 抗てんかん性医薬品
CH638513A5 (de) Verfahren zur herstellung neuer 4-amino-4-arylcyclohexanonketale.
JPS6084251A (ja) 鎮痛用新規化合物および組成物
JPS5874608A (ja) アヘン製剤に関して末梢「きつ」抗作用を有する製薬組成物
DE2438399C3 (de) a-substituierte Benzhydrolderivate und ihre Salze, solche enthaltende Arzneimittel und Verfahren zur Herstellung derselben
DD284026A5 (de) Verfahren zur herstellung von estern
PL140765B1 (en) Process for preparing 3-phenoxy-1-azetidinecarboxamides
DE2240887A1 (de) Neue biguanid-derivate, verfahren zu ihrer herstellung und ihre anwendungsmoeglichkeiten
DE2231067C2 (de) Phenoxathiinderivate, Verfahren zu deren Herstellung sowie pharmazeutische Präparate mit einem Gehalt an Phenoxathiinderivaten zur Bekämpfung von Virusinfektionen
DE2729414A1 (de) Thiazolidincarbonsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
CN106831662B (zh) 一种胺基多元醇代烟曲霉素及其合成方法与应用
DE2748291A1 (de) Triglyceride, verfahren zu ihrer herstellung und ihre verwendung zur behandlung von entzuendungen
DE2721987A1 (de) P-acetamidophenolderivat
JPH0471067B2 (enExample)
DE2755122C2 (de) Neue Acylderivate des Hellebrigenins, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
DE2525250C2 (de) N,N'-Phenylendioxamsäureester, Verfahren zu deren Herstellung sowie pharmazeutische Präparate, die diese Verbindungen enthalten
US4218447A (en) Acyl derivatives of hellebrigenin
US3903147A (en) Upsilon-glutamyl amide of dopamine
DE2513693A1 (de) Theophyllinderivate, verfahren zu deren herstellung und arzneimittel
DE2167258C2 (de) s-Triazolyl-benzophenon-Derivate
US4443474A (en) Pharmaceutical N-phenyl carbamoyl glycinate compositions
DE2005590A1 (de) Antiparasitäre Mittel
DE3005359A1 (de) O-alkoxycarbonylphenyl-ester der flufenaminsaeure, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE2227846A1 (de) Phenoxyessigsaeure-derivate und verfahren zu ihrer herstellung