JPH0144170B2 - - Google Patents

Info

Publication number
JPH0144170B2
JPH0144170B2 JP58198411A JP19841183A JPH0144170B2 JP H0144170 B2 JPH0144170 B2 JP H0144170B2 JP 58198411 A JP58198411 A JP 58198411A JP 19841183 A JP19841183 A JP 19841183A JP H0144170 B2 JPH0144170 B2 JP H0144170B2
Authority
JP
Japan
Prior art keywords
group
hydrogen
acid
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP58198411A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5995269A (ja
Inventor
Fuon Beebenburuku Uarutaa
Heeze Yoahimu
Engeru Yurugen
Teiire Kuruto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Publication of JPS5995269A publication Critical patent/JPS5995269A/ja
Publication of JPH0144170B2 publication Critical patent/JPH0144170B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP58198411A 1982-10-27 1983-10-25 抗てんかん性医薬品 Granted JPS5995269A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3239790 1982-10-27
DE3239790.9 1982-10-27

Publications (2)

Publication Number Publication Date
JPS5995269A JPS5995269A (ja) 1984-06-01
JPH0144170B2 true JPH0144170B2 (enExample) 1989-09-26

Family

ID=6176726

Family Applications (2)

Application Number Title Priority Date Filing Date
JP58198411A Granted JPS5995269A (ja) 1982-10-27 1983-10-25 抗てんかん性医薬品
JP58198412A Pending JPS5995270A (ja) 1982-10-27 1983-10-25 ２−アミノ−３−アシルアミノ−６−ベンジルアミノ−ピリジン誘導体、及びその製法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP58198412A Pending JPS5995270A (ja) 1982-10-27 1983-10-25 ２−アミノ−３−アシルアミノ−６−ベンジルアミノ−ピリジン誘導体、及びその製法

Country Status (8)

Country Link
US (1) US4554281A (enExample)
EP (1) EP0110091B1 (enExample)
JP (2) JPS5995269A (enExample)
AT (1) ATE25078T1 (enExample)
AU (1) AU561450B2 (enExample)
DE (1) DE3369315D1 (enExample)
ES (1) ES8406440A1 (enExample)
IT (2) IT1171880B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE46265T1 (de) * 1985-01-23 1989-09-15 Asta Pharma Ag Synergistische kombination von flupirtin und nicht-steroidalen antiphlogistika.
NO860825L (no) * 1985-03-23 1986-09-24 Degussa Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
DE4327516A1 (de) * 1993-08-17 1995-02-23 Asta Medica Ag Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
ZA953078B (en) * 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
DE19835918A1 (de) * 1998-08-07 2000-02-10 Dresden Arzneimittel Neue antikonvulsiv wirkende 4-Amino-1-aryl-pyridin-2-one und Verfahren zu deren Herstellung
US7799832B2 (en) * 2003-10-23 2010-09-21 Valeant Pharmaceuticals North America Combinations of retigabine and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
JP2008523139A (ja) * 2004-12-14 2008-07-03 アストラゼネカ・アクチエボラーグ 置換アミノピリジン類及びその使用
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
MX2009002002A (es) * 2006-08-23 2009-07-22 Valeant Pharmaceuticals Int Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potasio.
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
US8030518B2 (en) * 2006-11-28 2011-10-04 Valeant Pharmaceuticals International 1,4 diamino bicyclic retigabine analogues as potassium channel modulators
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
JP2009037141A (ja) 2007-08-03 2009-02-19 Ricoh Co Ltd 画像形成装置の管理装置及び管理システム
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
EP2231611A1 (en) * 2007-12-11 2010-09-29 NeuroSearch A/S Novel 2-pyrrolidinyl-3-amido-6-amino-pyridine derivatives useful as potassium channel activators
EP2231610A1 (en) * 2007-12-11 2010-09-29 NeuroSearch A/S Novel 2-dimethylamino-3-amido-6-amino-pyridine derivatives useful as potassium channel activators
WO2009074592A1 (en) * 2007-12-11 2009-06-18 Neurosearch A/S Novel 2-diethylamino-3-amido-6-amino-pyridine derivatives useful as potassium channel activators
JP2011506391A (ja) * 2007-12-11 2011-03-03 ノイロサーチ アクティーゼルスカブ カリウムチャネル活性化因子として有用な、新規の２−エチル−メチル−アミノ−３−アミド−６−アミノ−ピリジン誘導体
CN102351786A (zh) * 2011-11-01 2012-02-15 东南大学 一种氟吡汀丙二酸盐及其制备方法
WO2019014547A1 (en) * 2017-07-14 2019-01-17 Texas Tech University System FUNCTIONALIZED PYRIDINE CARBAMATES HAVING ENHANCED NEUROPROTECTOR ACTIVITY
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
MA56607A1 (fr) 2019-11-08 2022-10-31 Xenon Pharmaceuticals Inc Méthodes de traitement de troubles dépressifs
JP2024508660A (ja) 2021-02-09 2024-02-28 ゼノン・ファーマシューティカルズ・インコーポレイテッド 快感消失の治療に使用するための電位依存性カリウムチャネル開口薬

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE764362R (en) * 1966-05-12 1971-09-16 Degussa Subst amino pyridienes production
DE1670522C3 (de) * 1966-05-12 1978-08-31 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Neue Benzylaminopyridine
JPS5541411B2 (enExample) * 1973-04-28 1980-10-24

Also Published As

Publication number Publication date
JPS5995269A (ja) 1984-06-01
ES526765A0 (es) 1984-07-01
US4554281A (en) 1985-11-19
IT1171880B (it) 1987-06-10
EP0110091B1 (de) 1987-01-21
IT8349222A0 (it) 1983-10-26
EP0110091A1 (de) 1984-06-13
JPS5995270A (ja) 1984-06-01
IT8349223A1 (it) 1985-04-26
AU2058283A (en) 1984-05-03
ATE25078T1 (de) 1987-02-15
DE3369315D1 (en) 1987-02-26
IT1171879B (it) 1987-06-10
AU561450B2 (en) 1987-05-07
IT8349222A1 (it) 1985-04-26
IT8349223A0 (it) 1983-10-26
ES8406440A1 (es) 1984-07-01

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