JPS58180477A - ヒスタミンｈ↓２−受容体拮抗活性をもつ置換３，４−ジアミノ−１，２，５−チアジアゾ−ル - Google Patents

ヒスタミンｈ↓２−受容体拮抗活性をもつ置換３，４−ジアミノ−１，２，５−チアジアゾ−ル

Info

Publication number
JPS58180477A
JPS58180477A JP58051740A JP5174083A JPS58180477A JP S58180477 A JPS58180477 A JP S58180477A JP 58051740 A JP58051740 A JP 58051740A JP 5174083 A JP5174083 A JP 5174083A JP S58180477 A JPS58180477 A JP S58180477A
Authority
JP
Japan
Prior art keywords
formula
hydrogen
lower alkyl
hydrate
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP58051740A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0568472B2 (de
Inventor
ロニ−・レイ・クレンシヨウ
アルド・アントニオ・アルジエリ−
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of JPS58180477A publication Critical patent/JPS58180477A/ja
Publication of JPH0568472B2 publication Critical patent/JPH0568472B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP58051740A 1982-03-29 1983-03-29 ヒスタミンｈ↓２−受容体拮抗活性をもつ置換３，４−ジアミノ−１，２，５−チアジアゾ−ル Granted JPS58180477A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36320782A 1982-03-29 1982-03-29
US363207 1982-03-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP5124585A Division JPH06135925A (ja) 1982-03-29 1993-04-16 ヒスタミンｈ▲２▼−受容体拮抗活性をもつ置換３，４−ジアミノ−１，２，５−チアジアゾール用中間体

Publications (2)

Publication Number Publication Date
JPS58180477A true JPS58180477A (ja) 1983-10-21
JPH0568472B2 JPH0568472B2 (de) 1993-09-29

Family

ID=23429274

Family Applications (2)

Application Number Title Priority Date Filing Date
JP58051740A Granted JPS58180477A (ja) 1982-03-29 1983-03-29 ヒスタミンｈ↓２−受容体拮抗活性をもつ置換３，４−ジアミノ−１，２，５−チアジアゾ−ル
JP5124585A Pending JPH06135925A (ja) 1982-03-29 1993-04-16 ヒスタミンｈ▲２▼−受容体拮抗活性をもつ置換３，４−ジアミノ−１，２，５−チアジアゾール用中間体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP5124585A Pending JPH06135925A (ja) 1982-03-29 1993-04-16 ヒスタミンｈ▲２▼−受容体拮抗活性をもつ置換３，４−ジアミノ−１，２，５−チアジアゾール用中間体

Country Status (30)

Country Link
JP (2) JPS58180477A (de)
KR (1) KR880002209B1 (de)
AT (1) AT386599B (de)
AU (2) AU557577B2 (de)
BE (1) BE896291A (de)
CH (2) CH660880A5 (de)
CS (2) CS250229B2 (de)
DD (2) DD219768A5 (de)
DE (1) DE3311281A1 (de)
DK (2) DK166677B1 (de)
ES (3) ES8404683A1 (de)
FR (2) FR2542741B1 (de)
GB (2) GB2117769B (de)
GR (1) GR78524B (de)
HU (2) HU196386B (de)
IE (1) IE55596B1 (de)
IL (1) IL68259A0 (de)
IT (1) IT1164633B (de)
LU (1) LU84716A1 (de)
MY (1) MY8700942A (de)
NL (1) NL8301063A (de)
NO (1) NO163055C (de)
NZ (1) NZ203726A (de)
OA (1) OA07356A (de)
PT (1) PT76459B (de)
SE (2) SE461040B (de)
SU (2) SU1419518A3 (de)
YU (1) YU44849B (de)
ZA (1) ZA832154B (de)
ZW (1) ZW7683A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
US4593039A (en) * 1984-04-02 1986-06-03 Merck & Co., Inc. 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols
US4644006A (en) * 1984-06-22 1987-02-17 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
JPH0622828B2 (ja) * 1986-06-30 1994-03-30 フアナツク株式会社 直圧式型締機構
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3018289A (en) * 1960-02-10 1962-01-23 Wyandotte Chemicals Corp Process for preparing oxamidines
GB1595291A (en) * 1976-09-21 1981-08-12 Smith Kline French Lab Pyrimidone and thiopyrimidone derivatives
DK160611C (da) * 1979-09-04 1991-09-16 Bristol Myers Squibb Co Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
DE3175201D1 (en) * 1980-04-30 1986-10-02 Merck & Co Inc Aminothiadiazoles as gastric secretion inhibitors
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives

Also Published As

Publication number Publication date
DD210909A5 (de) 1984-06-27
ES8505978A1 (es) 1985-06-16
DK81192A (da) 1992-06-18
ES8505977A1 (es) 1985-06-16
NO163055C (no) 1990-03-28
NZ203726A (en) 1986-05-09
GR78524B (de) 1984-09-27
GB2117769B (en) 1985-08-29
IE830686L (en) 1983-09-29
YU74483A (en) 1986-02-28
ES520982A0 (es) 1984-05-16
LU84716A1 (fr) 1983-12-05
KR840004095A (ko) 1984-10-06
SE8301725D0 (sv) 1983-03-28
ZA832154B (en) 1983-12-28
GB8308518D0 (en) 1983-05-05
SE8301725L (sv) 1983-11-25
SE8704689L (sv) 1987-11-25
PT76459A (en) 1983-04-01
OA07356A (fr) 1984-08-31
HU196386B (en) 1988-11-28
SE464302B (sv) 1991-04-08
DK141383D0 (da) 1983-03-28
SE461040B (sv) 1989-12-18
AT386599B (de) 1988-09-12
BE896291A (fr) 1983-09-28
IT8348005A0 (it) 1983-03-28
CH655111A5 (de) 1986-03-27
SU1355123A3 (ru) 1987-11-23
JPH0568472B2 (de) 1993-09-29
CH660880A5 (de) 1987-05-29
HU188742B (en) 1986-05-28
SU1419518A3 (ru) 1988-08-23
IT1164633B (it) 1987-04-15
DE3311281A1 (de) 1983-11-24
ATA111083A (de) 1988-02-15
ZW7683A1 (en) 1984-01-04
KR880002209B1 (ko) 1988-10-18
DK81192D0 (da) 1992-06-18
AU6327286A (en) 1987-01-08
FR2597867A1 (fr) 1987-10-30
PT76459B (en) 1986-03-11
GB2117769A (en) 1983-10-19
FR2597867B1 (fr) 1989-12-08
ES527685A0 (es) 1985-06-16
AU557577B2 (en) 1986-12-24
AU1290783A (en) 1983-10-06
YU44849B (en) 1991-04-30
NO831100L (no) 1983-09-30
MY8700942A (en) 1987-12-31
GB2149406A (en) 1985-06-12
FR2542741A1 (fr) 1984-09-21
IE55596B1 (en) 1990-11-21
FR2542741B1 (fr) 1989-12-08
AU586037B2 (en) 1989-06-29
GB8432809D0 (en) 1985-02-06
ES527686A0 (es) 1985-06-16
ES8404683A1 (es) 1984-05-16
NO163055B (no) 1989-12-18
CS250229B2 (en) 1987-04-16
SE8704689D0 (sv) 1987-11-25
CS250240B2 (en) 1987-04-16
DK166677B1 (da) 1993-06-28
DD219768A5 (de) 1985-03-13
DK141383A (da) 1983-09-30
JPH06135925A (ja) 1994-05-17
IL68259A0 (en) 1983-06-15
GB2149406B (en) 1986-01-02
NL8301063A (nl) 1983-10-17

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