JPS58116491A - アミノ酸のn―(ビンブラスチノイル―23)誘導体及びそれを含有する薬剤組成物 - Google Patents

アミノ酸のn―(ビンブラスチノイル―23)誘導体及びそれを含有する薬剤組成物

Info

Publication number
JPS58116491A
JPS58116491A JP57214573A JP21457382A JPS58116491A JP S58116491 A JPS58116491 A JP S58116491A JP 57214573 A JP57214573 A JP 57214573A JP 21457382 A JP21457382 A JP 21457382A JP S58116491 A JPS58116491 A JP S58116491A
Authority
JP
Japan
Prior art keywords
group
oil
carbon atoms
pharmaceutically acceptable
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP57214573A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0449557B2 (it
Inventor
アンドレ・ベノワ・レオン・トルエ
ジヤン・アルフレツド・エイ・ジエイ・アンナル
カンデユクリ・シヴアプラサダ・ブ−シヤナ・ラオ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Omnichem NV SA
Original Assignee
Omnichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem SA filed Critical Omnichem SA
Publication of JPS58116491A publication Critical patent/JPS58116491A/ja
Publication of JPH0449557B2 publication Critical patent/JPH0449557B2/ja
Granted legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04Dimeric indole alkaloids, e.g. vincaleucoblastine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP57214573A 1981-12-08 1982-12-07 アミノ酸のn―(ビンブラスチノイル―23)誘導体及びそれを含有する薬剤組成物 Granted JPS58116491A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LU83822 1981-12-08
LU83822A LU83822A1 (fr) 1981-12-08 1981-12-08 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
JPS58116491A true JPS58116491A (ja) 1983-07-11
JPH0449557B2 JPH0449557B2 (it) 1992-08-11

Family

ID=19729780

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57214573A Granted JPS58116491A (ja) 1981-12-08 1982-12-07 アミノ酸のn―(ビンブラスチノイル―23)誘導体及びそれを含有する薬剤組成物

Country Status (24)

Country Link
JP (1) JPS58116491A (it)
AT (1) AT390958B (it)
AU (1) AU564951B2 (it)
BE (1) BE895262A (it)
CA (1) CA1198422A (it)
CH (1) CH655727A5 (it)
DD (1) DD205906A5 (it)
DE (1) DE3245269A1 (it)
DK (1) DK161833C (it)
ES (1) ES517942A0 (it)
FR (1) FR2517680B1 (it)
GB (1) GB2111055B (it)
GR (1) GR77280B (it)
HU (1) HU187803B (it)
IE (1) IE55283B1 (it)
IL (1) IL67366A (it)
IT (1) IT1157126B (it)
LU (1) LU83822A1 (it)
NL (1) NL8204711A (it)
NZ (1) NZ202708A (it)
OA (1) OA07270A (it)
PT (1) PT75949B (it)
SE (1) SE452622B (it)
ZA (1) ZA828823B (it)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62175486A (ja) * 1986-01-13 1987-08-01 ラ レジョン ワロン ビンブラスチン誘導体
US4906086A (en) * 1987-06-19 1990-03-06 Honda Giken Kogyo Kabushiki Kaisha Rearview mirror device for motorcycles
JP2016511251A (ja) * 2013-04-19 2016-04-14 曁南大学 ビンブラスチン誘導体及びその製造方法、並びにその応用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR81790B (it) * 1983-04-29 1984-12-12 Omnichem Sa
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
US3848234A (en) * 1973-04-04 1974-11-12 Sperry Rand Corp Multi-processor system with multiple cache memories
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62175486A (ja) * 1986-01-13 1987-08-01 ラ レジョン ワロン ビンブラスチン誘導体
JPH075608B2 (ja) * 1986-01-13 1995-01-25 イ−ル−セルタ−ク ソシエテ アノニム ビンブラスチン誘導体
US4906086A (en) * 1987-06-19 1990-03-06 Honda Giken Kogyo Kabushiki Kaisha Rearview mirror device for motorcycles
JP2016511251A (ja) * 2013-04-19 2016-04-14 曁南大学 ビンブラスチン誘導体及びその製造方法、並びにその応用

Also Published As

Publication number Publication date
SE452622B (sv) 1987-12-07
IL67366A (en) 1987-01-30
IE55283B1 (en) 1990-08-01
FR2517680A1 (fr) 1983-06-10
NZ202708A (en) 1986-01-24
DD205906A5 (de) 1984-01-11
NL8204711A (nl) 1983-07-01
CH655727A5 (fr) 1986-05-15
ZA828823B (en) 1983-09-28
GR77280B (it) 1984-09-11
SE8206981L (sv) 1983-06-09
IT8268431A0 (it) 1982-12-07
JPH0449557B2 (it) 1992-08-11
DK541882A (da) 1983-06-09
AU564951B2 (en) 1987-09-03
ES8401768A1 (es) 1984-01-01
IT1157126B (it) 1987-02-11
PT75949A (fr) 1983-01-01
SE8206981D0 (sv) 1982-12-07
DK161833C (da) 1992-01-20
FR2517680B1 (fr) 1990-05-25
ES517942A0 (es) 1984-01-01
ATA444982A (de) 1990-01-15
PT75949B (fr) 1985-10-04
BE895262A (fr) 1983-06-07
IL67366A0 (en) 1983-03-31
CA1198422A (en) 1985-12-24
GB2111055A (en) 1983-06-29
GB2111055B (en) 1985-07-10
AT390958B (de) 1990-07-25
OA07270A (fr) 1984-04-30
IE822906L (en) 1983-06-08
LU83822A1 (fr) 1983-09-01
AU9084782A (en) 1983-06-16
HU187803B (en) 1986-02-28
DE3245269A1 (de) 1983-07-21
DK161833B (da) 1991-08-19

Similar Documents

Publication Publication Date Title
CA1196326A (en) Vinblastin-23-oyl amino acid derivatives
US4203898A (en) Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4639456A (en) Vinblastin-23-oyl amino acid derivatives
US4658058A (en) 11-O-methylspergualin
JPH02500738A (ja) 抗腫瘍組成物およびその使用法
JPS58116491A (ja) アミノ酸のn―(ビンブラスチノイル―23)誘導体及びそれを含有する薬剤組成物
KR100255074B1 (ko) 콜히친 유도체 및 그의 치료적 용도
US3665018A (en) Naphthacene derivatives
US3944554A (en) 4-Desacetoxy-3-hydroxyvinblastine
US3370057A (en) Leurosine
CA1067073A (en) Amide derivatives of vlb, leurosidine, leurocristine and related dimeric alkaloid
US4479957A (en) Use of vindesine in treating acute lymphatic leukemia and _other susceptible neoplasms
US4279915A (en) Method of treatment using new leurosine derivatives
KR840002164B1 (ko) 빈카로이코블라스틴 유도체의 제조방법
JPH01501004A (ja) ビンブラスチンの単離方法
CA1168231A (en) 20'-hydroxyvinblastine and related compounds
HU181874B (en) Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine
US4604381A (en) 4-demethoxy-13-dihydrodaunorubicin and use thereof
KR810001489B1 (ko) 빈카 알카로이드의 옥사졸리딘 디온 유도체의 제조방법
KR810000494B1 (ko) 빈카 알카로이드의 옥사졸리딘 디온 유도체의 제조방법
WO1996031518A1 (en) Novel tumor-inhibiting bisindole derivatives with calmodulin-liberator effect and pharmaceutical composition containing them
JPH0210836B2 (it)
JPH069418A (ja) パナキンケコール化合物、及び制癌剤
SE425852B (sv) Analogiforfarande for framstellning av derivat av vinkristin och leurosidin
GB2118932A (en) A daunorubicin derivative