ES8401768A1 - Procedimiento de obtener alcaloides bisindolicos. - Google Patents

Procedimiento de obtener alcaloides bisindolicos.

Info

Publication number
ES8401768A1
ES8401768A1 ES517942A ES517942A ES8401768A1 ES 8401768 A1 ES8401768 A1 ES 8401768A1 ES 517942 A ES517942 A ES 517942A ES 517942 A ES517942 A ES 517942A ES 8401768 A1 ES8401768 A1 ES 8401768A1
Authority
ES
Spain
Prior art keywords
group
hydrogen atom
derivatives
compounds
vinblastinoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES517942A
Other languages
English (en)
Other versions
ES517942A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Omnichem NV SA
Original Assignee
Omnichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Omnichem SA filed Critical Omnichem SA
Publication of ES517942A0 publication Critical patent/ES517942A0/es
Publication of ES8401768A1 publication Critical patent/ES8401768A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO DE OBTENER ALCALOIDES BISINDOLICOS.CONSISTE EN QUE LOS DERIVADOS DE VINBLASTINA DE FORMULA (I), EN LA QUE R REPRESENTA UN ESTER DE ACIDO AMINADO ACOPLADO AL FRAGMENTO VINBLASTINOIL-23 POR UN ENLACE AMIDA, POSEYENDO EL GRUPO ESTER DE CADENA RECTA DE C2-9, EN LA QUE R1 ES UN GRUPO HIDROXILO, EN LA QUE R2 ES UN GRUPO ACILO C2-9 Y EN LA QUE R5 REPRESENTA UN GRUPO FORNILO SE LES HACE REACCIONAR A) CON UNA HIDRACINA ANHIDRA, A TEMPERATURA ENTRE 30 Y 70JC Y DURANTE 12 DIAS PARA OBTENER UNA VINBLASTINA 3-CARBOXIHIDRAZIDA MODIFICADA, B) DICHA COMPUESTO OBTENIDOSE TRATA EN PRESENCIA DE UN AGENTE NITROSANTE, COMO NITRITO SODICO EN PRESENCIA DE CLH METANOLICO Y A TEMPERATURA ENTRE 0 Y 5JC SE OBTIENE LA 3-CARBOXAZIDA Y C) SE TRATA DICHO COMPUESTO, CON 1 O 5 EQUIVALENTES DE UN ESTER BAB-AMINOACIDO, CONTENIENDO EL GRUPO ESTER DE C2 A C9 Y A TEMPERATURA ENTRE C3 Y 10JC Y CON DURACION DE 72 HORAS. SE OBTIENE LA N-04-DESACETIL-4-DESOXIVINBLASTIN-23 -OIL-L-TRIPTOFANATO DE ETILO DE FOR MULA (II).
ES517942A 1981-12-08 1982-12-06 Procedimiento de obtener alcaloides bisindolicos. Expired ES8401768A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU83822A LU83822A1 (fr) 1981-12-08 1981-12-08 Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique

Publications (2)

Publication Number Publication Date
ES517942A0 ES517942A0 (es) 1984-01-01
ES8401768A1 true ES8401768A1 (es) 1984-01-01

Family

ID=19729780

Family Applications (1)

Application Number Title Priority Date Filing Date
ES517942A Expired ES8401768A1 (es) 1981-12-08 1982-12-06 Procedimiento de obtener alcaloides bisindolicos.

Country Status (24)

Country Link
JP (1) JPS58116491A (es)
AT (1) AT390958B (es)
AU (1) AU564951B2 (es)
BE (1) BE895262A (es)
CA (1) CA1198422A (es)
CH (1) CH655727A5 (es)
DD (1) DD205906A5 (es)
DE (1) DE3245269A1 (es)
DK (1) DK161833C (es)
ES (1) ES8401768A1 (es)
FR (1) FR2517680B1 (es)
GB (1) GB2111055B (es)
GR (1) GR77280B (es)
HU (1) HU187803B (es)
IE (1) IE55283B1 (es)
IL (1) IL67366A (es)
IT (1) IT1157126B (es)
LU (1) LU83822A1 (es)
NL (1) NL8204711A (es)
NZ (1) NZ202708A (es)
OA (1) OA07270A (es)
PT (1) PT75949B (es)
SE (1) SE452622B (es)
ZA (1) ZA828823B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR81790B (es) * 1983-04-29 1984-12-12 Omnichem Sa
US4675400A (en) * 1985-06-17 1987-06-23 Eli Lilly And Company Bifunctional derivatives of 4-desacetyl indole-dihydroindole alkaloids
US4667030A (en) * 1985-06-17 1987-05-19 Eli Lilly And Company Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids
CA1335686C (fr) * 1986-01-13 1995-05-23 Rao K. S. P. Bhushana Vinblastine et composition pharmaceutique les contenant
US4906086A (en) * 1987-06-19 1990-03-06 Honda Giken Kogyo Kabushiki Kaisha Rearview mirror device for motorcycles
FR2626882B1 (fr) * 1988-02-08 1991-11-08 Ire Celltarg Sa Conjugues de derives de vinca comportant une chaine detergente en position c-3
CN105121447B (zh) * 2013-04-19 2018-02-02 暨南大学 长春碱类衍生物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
US3848234A (en) * 1973-04-04 1974-11-12 Sperry Rand Corp Multi-processor system with multiple cache memories
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
OA06421A (fr) * 1980-06-10 1981-09-30 Omnium Chimique Sa Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides.

Also Published As

Publication number Publication date
FR2517680B1 (fr) 1990-05-25
NL8204711A (nl) 1983-07-01
ATA444982A (de) 1990-01-15
SE452622B (sv) 1987-12-07
SE8206981L (sv) 1983-06-09
IT1157126B (it) 1987-02-11
BE895262A (fr) 1983-06-07
AU564951B2 (en) 1987-09-03
IT8268431A0 (it) 1982-12-07
LU83822A1 (fr) 1983-09-01
JPH0449557B2 (es) 1992-08-11
CH655727A5 (fr) 1986-05-15
PT75949B (fr) 1985-10-04
IE822906L (en) 1983-06-08
DE3245269A1 (de) 1983-07-21
DK161833B (da) 1991-08-19
IE55283B1 (en) 1990-08-01
JPS58116491A (ja) 1983-07-11
DD205906A5 (de) 1984-01-11
ES517942A0 (es) 1984-01-01
OA07270A (fr) 1984-04-30
NZ202708A (en) 1986-01-24
GB2111055A (en) 1983-06-29
DK541882A (da) 1983-06-09
IL67366A0 (en) 1983-03-31
HU187803B (en) 1986-02-28
GB2111055B (en) 1985-07-10
FR2517680A1 (fr) 1983-06-10
CA1198422A (en) 1985-12-24
AU9084782A (en) 1983-06-16
PT75949A (fr) 1983-01-01
DK161833C (da) 1992-01-20
GR77280B (es) 1984-09-11
SE8206981D0 (sv) 1982-12-07
ZA828823B (en) 1983-09-28
IL67366A (en) 1987-01-30
AT390958B (de) 1990-07-25

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20000601