JPS5692894A - Cephalosporin derivative and its manufacture - Google Patents

Cephalosporin derivative and its manufacture

Info

Publication number
JPS5692894A
JPS5692894A JP16148780A JP16148780A JPS5692894A JP S5692894 A JPS5692894 A JP S5692894A JP 16148780 A JP16148780 A JP 16148780A JP 16148780 A JP16148780 A JP 16148780A JP S5692894 A JPS5692894 A JP S5692894A
Authority
JP
Japan
Prior art keywords
salt
manufacture
see diagramm
hydrate
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP16148780A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6145995B2 (https=
Inventor
Montafuon Maruku
Rainaa Roorando
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS5692894A publication Critical patent/JPS5692894A/ja
Publication of JPS6145995B2 publication Critical patent/JPS6145995B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Table Devices Or Equipment (AREA)
  • Laminated Bodies (AREA)
  • Peptides Or Proteins (AREA)
JP16148780A 1979-11-21 1980-11-18 Cephalosporin derivative and its manufacture Granted JPS5692894A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1038479 1979-11-21

Publications (2)

Publication Number Publication Date
JPS5692894A true JPS5692894A (en) 1981-07-27
JPS6145995B2 JPS6145995B2 (https=) 1986-10-11

Family

ID=4362652

Family Applications (2)

Application Number Title Priority Date Filing Date
JP16148780A Granted JPS5692894A (en) 1979-11-21 1980-11-18 Cephalosporin derivative and its manufacture
JP60285859A Granted JPS61143392A (ja) 1979-11-21 1985-12-20 セフアロスポリン誘導体及びその製造方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP60285859A Granted JPS61143392A (ja) 1979-11-21 1985-12-20 セフアロスポリン誘導体及びその製造方法

Country Status (21)

Country Link
EP (1) EP0030294B1 (https=)
JP (2) JPS5692894A (https=)
KR (1) KR860000852B1 (https=)
AT (1) ATE8896T1 (https=)
AU (1) AU533088B2 (https=)
CA (1) CA1146165A (https=)
DE (1) DE3068905D1 (https=)
DK (1) DK166728B1 (https=)
ES (2) ES496994A0 (https=)
FI (2) FI67385C (https=)
GR (1) GR71879B (https=)
HU (1) HU184941B (https=)
IE (1) IE50516B1 (https=)
IL (1) IL61486A (https=)
NO (2) NO166229C (https=)
NZ (1) NZ195547A (https=)
PH (2) PH17359A (https=)
PT (1) PT72084B (https=)
SI (1) SI8012952A8 (https=)
YU (1) YU42364B (https=)
ZA (1) ZA807099B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01186854A (ja) * 1988-01-18 1989-07-26 Takeda Chem Ind Ltd ２−置換オキシイミノ−３−オキソ酪酸の製造法

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0830051B2 (ja) * 1986-05-21 1996-03-27 武田薬品工業株式会社 ４−ハロゲノ−２−置換オキシイミノ−３−オキソ酪酸のエステルまたはアミドの製造法
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
AT411598B (de) * 1999-04-29 2004-03-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen
AT408225B (de) * 1999-04-29 2001-09-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen
WO2003004477A1 (en) * 2001-06-14 2003-01-16 Orchid Chemicals & Pharmaceuticals Limited 1,3,4-oxadiazol-2-yl thioesters and their use for acylating 7-aminocephalosporins
IN192139B (https=) 2001-11-26 2004-02-21 Lupin Ltd
AU2002337437A1 (en) * 2002-04-19 2003-11-03 Orchid Chemicals And Pharmaceuticals Limited A process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
US6919449B2 (en) 2002-04-19 2005-07-19 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
WO2004083216A1 (en) * 2003-03-20 2004-09-30 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of cephalosporins
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
ES2348299T3 (es) 2003-04-16 2010-12-02 Sandoz Ag Procedimientos para la preparación de cefepime.
US7098329B2 (en) * 2003-06-19 2006-08-29 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of a cephalosporin antibiotic
WO2005019227A1 (en) 2003-08-22 2005-03-03 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cephalosporin antibiotic
US20050059820A1 (en) * 2003-09-17 2005-03-17 Debashish Datta Method for manufacture of ceftriaxone sodium
WO2005040175A2 (en) * 2003-10-22 2005-05-06 Ranbaxy Laboratories Limited Process for the preparation of cephem carboxylic acids
US20050119244A1 (en) 2003-12-02 2005-06-02 Acs Dobfar S.P.A. Process for preparing cephalosporins with salified intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01186854A (ja) * 1988-01-18 1989-07-26 Takeda Chem Ind Ltd ２−置換オキシイミノ−３−オキソ酪酸の製造法

Also Published As

Publication number Publication date
AU533088B2 (en) 1983-10-27
ES8200694A1 (es) 1981-11-16
IE50516B1 (en) 1986-04-30
NO803516L (no) 1981-05-22
NO166228C (no) 1991-06-19
NO166229B (no) 1991-03-11
IE802408L (en) 1981-05-21
FI67385C (fi) 1985-03-11
IL61486A0 (en) 1980-12-31
KR830004315A (ko) 1983-07-09
PH18468A (en) 1985-07-18
CA1146165A (en) 1983-05-10
PH17359A (en) 1984-08-01
EP0030294A3 (en) 1981-12-09
NO166228B (no) 1991-03-11
PT72084B (en) 1982-07-30
ES8204997A1 (es) 1982-06-01
DK166728B1 (da) 1993-07-05
DK496380A (da) 1981-05-22
ES496994A0 (es) 1981-11-16
ATE8896T1 (de) 1984-08-15
EP0030294A2 (de) 1981-06-17
GR71879B (https=) 1983-08-03
FI71563B (fi) 1986-10-10
FI67385B (fi) 1984-11-30
FI842614A7 (fi) 1984-06-28
IL61486A (en) 1984-04-30
NO812083L (no) 1981-12-22
HU184941B (en) 1984-11-28
NO166229C (no) 1991-06-19
AU6443880A (en) 1981-05-28
YU295280A (en) 1983-06-30
FI842614A0 (fi) 1984-06-28
JPH0248559B2 (https=) 1990-10-25
ES503583A0 (es) 1982-06-01
SI8012952A8 (en) 1997-06-30
YU42364B (en) 1988-08-31
ZA807099B (en) 1981-11-25
JPS6145995B2 (https=) 1986-10-11
NZ195547A (en) 1983-05-10
KR860000852B1 (ko) 1986-07-09
EP0030294B1 (de) 1984-08-08
JPS61143392A (ja) 1986-07-01
FI71563C (fi) 1987-01-19
DE3068905D1 (en) 1984-09-13
FI793768A7 (fi) 1981-05-22
PT72084A (en) 1980-12-01

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