JPS54151982A - Nnheterocyclyll44piperidineamines - Google Patents

Nnheterocyclyll44piperidineamines

Info

Publication number
JPS54151982A
JPS54151982A JP3844779A JP3844779A JPS54151982A JP S54151982 A JPS54151982 A JP S54151982A JP 3844779 A JP3844779 A JP 3844779A JP 3844779 A JP3844779 A JP 3844779A JP S54151982 A JPS54151982 A JP S54151982A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP3844779A
Other languages
English (en)
Japanese (ja)
Other versions
JPS641477B2 (enExample
Inventor
Jiyansen Furan
Sutokubureeku Reimon
Toreman Jiyosefu
Ruiku Maruseru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26670178&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS54151982(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/002,276 external-priority patent/US4219559A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of JPS54151982A publication Critical patent/JPS54151982A/ja
Publication of JPS641477B2 publication Critical patent/JPS641477B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
JP3844779A 1978-04-03 1979-04-02 Nnheterocyclyll44piperidineamines Granted JPS54151982A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89253478A 1978-04-03 1978-04-03
US06/002,276 US4219559A (en) 1979-01-10 1979-01-10 N-Heterocyclyl-4-piperidinamines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP63144898A Division JPH01117880A (ja) 1978-04-03 1988-06-14 Ｎ‐ヘテロサイクリル‐４‐ピペリジンアミン類

Publications (2)

Publication Number Publication Date
JPS54151982A true JPS54151982A (en) 1979-11-29
JPS641477B2 JPS641477B2 (enExample) 1989-01-11

Family

ID=26670178

Family Applications (2)

Application Number Title Priority Date Filing Date
JP3844779A Granted JPS54151982A (en) 1978-04-03 1979-04-02 Nnheterocyclyll44piperidineamines
JP63144898A Granted JPH01117880A (ja) 1978-04-03 1988-06-14 Ｎ‐ヘテロサイクリル‐４‐ピペリジンアミン類

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP63144898A Granted JPH01117880A (ja) 1978-04-03 1988-06-14 Ｎ‐ヘテロサイクリル‐４‐ピペリジンアミン類

Country Status (29)

Country Link
EP (1) EP0005318B1 (enExample)
JP (2) JPS54151982A (enExample)
AT (1) AT373887B (enExample)
AU (1) AU523352B2 (enExample)
BG (1) BG38164A3 (enExample)
CA (1) CA1140119A (enExample)
CS (1) CS256358B2 (enExample)
CY (1) CY1250A (enExample)
DE (1) DE2961740D1 (enExample)
DK (1) DK169325B1 (enExample)
EG (1) EG13913A (enExample)
ES (1) ES479206A1 (enExample)
FI (1) FI64801C (enExample)
GR (1) GR64907B (enExample)
HK (1) HK3184A (enExample)
HU (1) HU182965B (enExample)
IE (1) IE47818B1 (enExample)
IL (1) IL56992A (enExample)
MY (1) MY8500046A (enExample)
NO (2) NO154058C (enExample)
NZ (1) NZ189978A (enExample)
PH (1) PH15877A (enExample)
PL (1) PL123380B1 (enExample)
PT (1) PT69429A (enExample)
RO (1) RO79320A (enExample)
SG (1) SG29883G (enExample)
SU (1) SU1056902A3 (enExample)
YU (2) YU42484B (enExample)
ZA (1) ZA791557B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56150086A (en) * 1980-03-10 1981-11-20 Janssen Pharmaceutica Nv 1-(4-aryl-cyclohexyl)piperidine derivatives, their manufactrue and their pharmacological use
JPS5921680A (ja) * 1982-07-12 1984-02-03 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ 新規なｎ−（二環式複素環）−４−ピペリジナミン類、その製法およびそれを含む薬学的組成物
JPS60149583A (ja) * 1983-11-30 1985-08-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 二環式複素環含有ｎ‐（二環式複素環）‐４‐ピペリジンアミン類
JPS60174778A (ja) * 1984-01-09 1985-09-09 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ Ｎ−ヘテロシクリル−４−ピペリジンアミン
JPS6110577A (ja) * 1983-10-06 1986-01-18 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ ５員複素環式環を含有するｎ−（二環式ヘテロシクリル）−４−ピペリジンアミン類
JPS62215575A (ja) * 1986-02-03 1987-09-22 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ Ｎ−複素環式−４−ピペリジンアミン類を含有している抗−ヒスタミン組成物類

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
CA2161876A1 (en) * 1993-05-20 1994-12-08 Den-Ichi Momose 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
IL138228A0 (en) * 1998-03-06 2001-10-31 Janssen Pharmaceutica Nv Glycine transport inhibitors
US6924287B1 (en) * 1999-06-28 2005-08-02 Janssen Pharmacatica, N.V. Respiratory syncytial virus replication inhibitors
KR100731271B1 (ko) * 1999-06-28 2007-06-21 얀센 파마슈티카 엔.브이. 호흡기 신시티움 바이러스 복제 억제제
CZ20014573A3 (cs) * 1999-06-28 2002-05-15 Janssen Pharmaceutica N. V. Inhibitory replikace respiračně syncyciálního viru
KR100879647B1 (ko) 2000-03-06 2009-01-20 아카디아 파마슈티칼스 인코포레이티드 세로토닌 관련 질병의 치료에 사용되는 아자시클릭 화합물
EP1970374A1 (en) 2001-02-02 2008-09-17 Teva Pharmaceutical Industries Ltd. Process for the production of substituted 2-(pyridin-2-ylmethylsulfinyl)-1H-benzimidazoles
KR100974901B1 (ko) 2001-12-28 2010-08-10 아카디아 파마슈티칼스 인코포레이티드 모노아민 수용체 조정자로서의 스피로아자사이클릭 화합물
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
AU2003247615B2 (en) 2002-06-24 2007-08-09 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
ES2367135T3 (es) 2003-01-16 2011-10-28 Acadia Pharmaceuticals Inc. Agonistas inversos selectivos de los receptores 2a o 2c de serotonina utilzados como agentes terapéuticos para enfermedades neurodegenerativas.
TWI356055B (en) 2003-12-18 2012-01-11 Tibotec Pharm Ltd Aminobenzimidazoles and benzimidazoles as inhibito
CN103450159A (zh) * 2003-12-18 2013-12-18 泰博特克药品有限公司 作为呼吸道合胞病毒复制的抑制剂的哌啶-氨基-苯并咪唑类衍生物
RU2369606C2 (ru) 2003-12-18 2009-10-10 Тиботек Фармасьютикалз Лтд. Производные 5- или 6-замещенных бензимидазолов в качестве ингибиторов репликации респираторного синцитиального вируса
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
RU2417986C2 (ru) 2004-09-27 2011-05-10 Акадиа Фармасьютикалз Инк. Синтез n-(4-фторбензил)-n-(1-метилпиперидин-4-ил)-n'-(4-(2-метилпропилокси)фенилметил)карбамида, а также его тартрата и кристаллических форм
PL2134330T3 (pl) 2007-03-19 2013-10-31 Acadia Pharm Inc Kombinacje odwrotnych agonistów i antagonistów 5-HT2A z antypsychotykami
WO2017015272A1 (en) 2015-07-20 2017-01-26 Acadia Pharmaceuticals Inc. Methods for preparing n-(4-fluorobenzyl)-n-(1-methylpiperidin-4-yl)-n'-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and polymorphic form c
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
EP3558311A1 (en) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin alone or in combination for use in the treatment of alzheimer's disease psychosis
WO2018200977A1 (en) 2017-04-28 2018-11-01 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
WO2019046167A1 (en) 2017-08-30 2019-03-07 Acadia Pharmaceuticals Inc. PIMAVANSERIN FORMULATIONS

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2857391A (en) * 1955-04-15 1958-10-21 Merck & Co Inc Aminomethylbenzimidazoles
US2971005A (en) * 1958-10-17 1961-02-07 Merck & Co Inc Nu-substituted derivatives of 2-benzylaminobenzimidazoles
BE788065A (fr) * 1971-08-26 1973-02-26 Degussa Nouvelles aza-benzimidazoles et procede pour leur preparation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56150086A (en) * 1980-03-10 1981-11-20 Janssen Pharmaceutica Nv 1-(4-aryl-cyclohexyl)piperidine derivatives, their manufactrue and their pharmacological use
JPS5921680A (ja) * 1982-07-12 1984-02-03 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ 新規なｎ−（二環式複素環）−４−ピペリジナミン類、その製法およびそれを含む薬学的組成物
JPS6110577A (ja) * 1983-10-06 1986-01-18 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ ５員複素環式環を含有するｎ−（二環式ヘテロシクリル）−４−ピペリジンアミン類
JPS60149583A (ja) * 1983-11-30 1985-08-07 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 二環式複素環含有ｎ‐（二環式複素環）‐４‐ピペリジンアミン類
JPS60174778A (ja) * 1984-01-09 1985-09-09 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ Ｎ−ヘテロシクリル−４−ピペリジンアミン
JPS62215575A (ja) * 1986-02-03 1987-09-22 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ Ｎ−複素環式−４−ピペリジンアミン類を含有している抗−ヒスタミン組成物類

Also Published As

Publication number Publication date
GR64907B (en) 1980-06-07
NO842563L (no) 1979-10-04
JPH0240666B2 (enExample) 1990-09-12
SU1056902A3 (ru) 1983-11-23
CS256358B2 (en) 1988-04-15
EP0005318B1 (en) 1982-01-06
YU42484B (en) 1988-10-31
NZ189978A (en) 1984-05-31
ZA791557B (en) 1980-11-26
CY1250A (en) 1984-08-31
HU182965B (en) 1984-03-28
NO791097L (no) 1979-10-04
MY8500046A (en) 1985-12-31
IL56992A (en) 1983-03-31
CA1140119A (en) 1983-01-25
YU78479A (en) 1983-10-31
EG13913A (en) 1982-09-30
NO154058B (no) 1986-04-01
ATA242579A (de) 1983-07-15
AU4529679A (en) 1979-10-18
YU43158B (en) 1989-04-30
AU523352B2 (en) 1982-07-22
DK169325B1 (da) 1994-10-10
PL123380B1 (en) 1982-10-30
FI791084A7 (fi) 1979-10-04
CS222779A2 (en) 1987-03-12
AT373887B (de) 1984-02-27
JPS641477B2 (enExample) 1989-01-11
ES479206A1 (es) 1979-12-16
DE2961740D1 (en) 1982-02-25
EP0005318A1 (en) 1979-11-14
PL214648A1 (enExample) 1980-03-24
IL56992A0 (en) 1979-07-25
IE790676L (en) 1979-10-03
NO154090C (no) 1986-07-16
RO79320A (ro) 1982-08-17
PH15877A (en) 1983-04-13
FI64801B (fi) 1983-09-30
NO154058C (no) 1986-07-09
SG29883G (en) 1984-04-19
BG38164A3 (bg) 1985-10-15
PT69429A (pt) 1979-05-01
HK3184A (en) 1984-01-20
IE47818B1 (en) 1984-06-27
FI64801C (fi) 1984-01-10
JPH01117880A (ja) 1989-05-10
NO154090B (no) 1986-04-07
YU50283A (en) 1983-12-31
DK129879A (da) 1979-10-04

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