JPS50155690A - - Google Patents

Info

Publication number
JPS50155690A
JPS50155690A JP49064823A JP6482374A JPS50155690A JP S50155690 A JPS50155690 A JP S50155690A JP 49064823 A JP49064823 A JP 49064823A JP 6482374 A JP6482374 A JP 6482374A JP S50155690 A JPS50155690 A JP S50155690A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP49064823A
Other languages
Japanese (ja)
Other versions
JPS5612114B2 (enExample
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to JP6482374A priority Critical patent/JPS5612114B2/ja
Priority to US05/576,651 priority patent/US3983140A/en
Priority to GB2303575A priority patent/GB1453425A/en
Priority to DE2524355A priority patent/DE2524355C2/de
Priority to CH732475A priority patent/CH614975A5/xx
Priority to CA228,761A priority patent/CA1046439A/en
Priority to FR7517687A priority patent/FR2313035B1/fr
Priority to SE7506498A priority patent/SE425253B/xx
Priority to AT430475A priority patent/AT343582B/de
Priority to DK255375AA priority patent/DK136485B/da
Priority to BE157165A priority patent/BE830033A/xx
Priority to NLAANVRAGE7506848,A priority patent/NL176872C/xx
Priority to US05/637,673 priority patent/US4049495A/en
Publication of JPS50155690A publication Critical patent/JPS50155690A/ja
Publication of JPS5612114B2 publication Critical patent/JPS5612114B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP6482374A 1974-06-07 1974-06-07 Expired JPS5612114B2 (enExample)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP6482374A JPS5612114B2 (enExample) 1974-06-07 1974-06-07
US05/576,651 US3983140A (en) 1974-06-07 1975-05-12 Physiologically active substances
GB2303575A GB1453425A (en) 1974-06-07 1975-05-23 2-oxo-tetrahydropyran derivatives and fermentative process for producing the same
DE2524355A DE2524355C2 (de) 1974-06-07 1975-06-02 Tetrahydropyranderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
CH732475A CH614975A5 (enExample) 1974-06-07 1975-06-06
CA228,761A CA1046439A (en) 1974-06-07 1975-06-06 Physiologically active substances from penicillium citrinum
FR7517687A FR2313035B1 (fr) 1974-06-07 1975-06-06 Substances a action physiologique et leur procede de preparation par fermentation
SE7506498A SE425253B (sv) 1974-06-07 1975-06-06 Forfarande for framstellning av fysiologiskt aktiva foreningar betecknande ml-236 genom odling av stammar tillhorande den kenda arten penicillium citrinum samt utvinning
AT430475A AT343582B (de) 1974-06-07 1975-06-06 Verfahren zur herstellung von neuen physiologisch aktiven verbindungen
DK255375AA DK136485B (da) 1974-06-07 1975-06-06 Fremgangsmåde til fremstilling af fysiologisk aktive forbindelser, kaldet ML-236 A, ML-236 B og ML-236 C.
BE157165A BE830033A (fr) 1974-06-07 1975-06-09 Substances a action physiologique et leur procede de preparation par fermentation
NLAANVRAGE7506848,A NL176872C (nl) 1974-06-07 1975-06-09 Werkwijze ter bereiding van een farmaceutisch preparaat voor de behandeling van arteriosclerose en hyperlipemie, aldus verkregen gevormd geneesmiddel, alsmede werkwijze ter bereiding van een voor een dergelijk preparaat geschikte fysiologisch werkzame stof.
US05/637,673 US4049495A (en) 1974-06-07 1975-12-04 Physiologically active substances and fermentative process for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6482374A JPS5612114B2 (enExample) 1974-06-07 1974-06-07

Publications (2)

Publication Number Publication Date
JPS50155690A true JPS50155690A (enExample) 1975-12-16
JPS5612114B2 JPS5612114B2 (enExample) 1981-03-18

Family

ID=13269345

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6482374A Expired JPS5612114B2 (enExample) 1974-06-07 1974-06-07

Country Status (12)

Country Link
US (1) US3983140A (enExample)
JP (1) JPS5612114B2 (enExample)
AT (1) AT343582B (enExample)
BE (1) BE830033A (enExample)
CA (1) CA1046439A (enExample)
CH (1) CH614975A5 (enExample)
DE (1) DE2524355C2 (enExample)
DK (1) DK136485B (enExample)
FR (1) FR2313035B1 (enExample)
GB (1) GB1453425A (enExample)
NL (1) NL176872C (enExample)
SE (1) SE425253B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57123140A (en) * 1981-01-23 1982-07-31 Sankyo Co Ltd Ml-236b carboxylic acid amine salt and remedy for hyperlipemia containing said salt as active component

Families Citing this family (294)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4137322A (en) * 1976-11-02 1979-01-30 Sankyo Company Limited ML-236B carboxylic acid derivatives and their use as antihyperlipemic agents
JPS53147073A (en) * 1977-05-24 1978-12-21 Sankyo Co Ltd Mevalonolactone derivatives
NZ191762A (en) * 1978-10-19 1982-09-14 Merck & Co Inc Hypocholesteremic composition containing cholesterol synthesis inhibitor and anion exchange resin
ZA795567B (en) * 1978-10-19 1981-06-24 Merck & Co Inc Treatment of hypercholesteremia
JPS5559180A (en) * 1978-10-30 1980-05-02 Sankyo Co Ltd 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent
JPS5925599B2 (ja) 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4294926A (en) * 1979-06-15 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4375475A (en) * 1979-08-17 1983-03-01 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4459422A (en) * 1979-08-17 1984-07-10 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4567289A (en) * 1979-08-17 1986-01-28 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4710513A (en) * 1979-08-17 1987-12-01 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
US4294846A (en) * 1979-09-21 1981-10-13 Merck & Co., Inc. Hypocholesteremic fermentation products and products of preparation
AU548996B2 (en) 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
US4444784A (en) * 1980-08-05 1984-04-24 Merck & Co., Inc. Antihypercholesterolemic compounds
US4282155A (en) * 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
US4293496A (en) * 1980-02-04 1981-10-06 Merck & Co., Inc. 6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
US4322563A (en) * 1980-04-14 1982-03-30 Merck & Co., Inc. Substituted biphenyl-2-carboxaldehydes
JPS56150037A (en) * 1980-04-22 1981-11-20 Sankyo Co Ltd Hydronaphthalene compound
US4420491A (en) * 1980-05-28 1983-12-13 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
US4450171A (en) * 1980-08-05 1984-05-22 Merck & Co., Inc. Antihypercholesterolemic compounds
US4343814A (en) * 1980-11-17 1982-08-10 Merck & Co., Inc. Hypocholesterolemic fermentation products
US4432996A (en) * 1980-11-17 1984-02-21 Merck & Co., Inc. Hypocholesterolemic fermentation products and process of preparation
JPS5815968A (ja) * 1981-07-21 1983-01-29 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製法
US4387242A (en) * 1981-08-21 1983-06-07 Merck & Co., Inc. Hypocholesterolemic fermentation products and process of preparation
US4376863A (en) * 1981-08-21 1983-03-15 Merck & Co., Inc. Hypocholesterolemic fermentation products
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
US5354772A (en) * 1982-11-22 1994-10-11 Sandoz Pharm. Corp. Indole analogs of mevalonolactone and derivatives thereof
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US4503072A (en) * 1982-12-22 1985-03-05 Merck & Co., Inc. Antihypercholesterolemic compounds
US4582915A (en) * 1983-10-11 1986-04-15 Merck & Co., Inc. Process for C-methylation of 2-methylbutyrates
DE3480923D1 (de) * 1983-10-11 1990-02-08 Merck & Co Inc Verfahren zur c-methylierung von 2-methylbutyraten.
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DK136485C (enExample) 1978-03-13
JPS5612114B2 (enExample) 1981-03-18
US3983140A (en) 1976-09-28
GB1453425A (en) 1976-10-20
NL176872C (nl) 1985-06-17
NL7506848A (nl) 1975-12-09
CA1046439A (en) 1979-01-16
DK136485B (da) 1977-10-17
CH614975A5 (enExample) 1979-12-28
SE425253B (sv) 1982-09-13
SE7506498L (sv) 1975-12-08
ATA430475A (de) 1977-10-15
FR2313035A1 (fr) 1976-12-31
DE2524355C2 (de) 1983-07-21
FR2313035B1 (fr) 1978-11-10
DK255375A (enExample) 1975-12-08
BE830033A (fr) 1975-12-09
DE2524355A1 (de) 1975-12-18
AT343582B (de) 1978-06-12

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