JPH11507036A - ジカチオン性ビス−ベンズイミダゾール類を用いた感染病治療方法 - Google Patents
ジカチオン性ビス−ベンズイミダゾール類を用いた感染病治療方法Info
- Publication number
- JPH11507036A JPH11507036A JP9500868A JP50086897A JPH11507036A JP H11507036 A JPH11507036 A JP H11507036A JP 9500868 A JP9500868 A JP 9500868A JP 50086897 A JP50086897 A JP 50086897A JP H11507036 A JPH11507036 A JP H11507036A
- Authority
- JP
- Japan
- Prior art keywords
- bis
- benzimidazolyl
- structural formula
- following structural
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/472,996 US5643935A (en) | 1995-06-07 | 1995-06-07 | Method of combatting infectious diseases using dicationic bis-benzimidazoles |
| US08/472,996 | 1995-06-07 | ||
| PCT/US1996/008084 WO1996040145A1 (en) | 1995-06-07 | 1996-06-03 | Methods of combatting infectious diseases using dicationic bis-benzimidazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH11507036A true JPH11507036A (ja) | 1999-06-22 |
| JPH11507036A5 JPH11507036A5 (enExample) | 2004-07-22 |
Family
ID=23877744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9500868A Ceased JPH11507036A (ja) | 1995-06-07 | 1996-06-03 | ジカチオン性ビス−ベンズイミダゾール類を用いた感染病治療方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (11) | US5643935A (enExample) |
| EP (1) | EP0831832B1 (enExample) |
| JP (1) | JPH11507036A (enExample) |
| AT (1) | ATE256464T1 (enExample) |
| AU (1) | AU705261B2 (enExample) |
| CA (1) | CA2223912A1 (enExample) |
| DE (1) | DE69631134T2 (enExample) |
| ES (1) | ES2213775T3 (enExample) |
| WO (1) | WO1996040145A1 (enExample) |
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| US5770617A (en) * | 1996-03-20 | 1998-06-23 | Rutgers, The State University Of New Jersey | Terbenzimidazoles useful as antifungal agents |
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| US6635668B1 (en) | 1998-07-22 | 2003-10-21 | The University Of North Carolina At Chapel Hill | Imidazoline receptor binding compounds |
| EP1685836A3 (en) * | 1998-09-17 | 2007-05-09 | University Of North Carolina At Chapel Hill | Antifungal activity of dicationic molecules |
| US6326395B1 (en) | 1998-09-17 | 2001-12-04 | Duke University | Antifungal activity of dicationic molecules |
| CN1297281C (zh) * | 1999-03-29 | 2007-01-31 | 希拉生物化学股份有限公司 | 治疗白血病的方法 |
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| MXPA04001153A (es) * | 2001-08-31 | 2005-02-17 | Neurochem Int Ltd | Derivados de amidina para tratar la amiloidosis. |
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| US20050100508A1 (en) * | 2003-11-12 | 2005-05-12 | Nichols M. J. | Methods for identifying drug combinations for the treatment of proliferative diseases |
| US20050158320A1 (en) * | 2003-11-12 | 2005-07-21 | Nichols M. J. | Combinations for the treatment of proliferative diseases |
| US7262223B2 (en) * | 2004-01-23 | 2007-08-28 | Neurochem (International) Limited | Amidine derivatives for treating amyloidosis |
| EP1734884B1 (en) | 2004-03-16 | 2021-06-16 | Guidance Endodontics, LLC | Endodontic files |
| AU2005233632A1 (en) | 2004-04-13 | 2005-10-27 | Icagen, Inc. | Polycyclic pyridines as potassium ion channel modulators |
| DE102004031656A1 (de) * | 2004-06-30 | 2006-01-19 | Merck Patent Gmbh | Tetrahydrochinoline |
| US7817792B2 (en) * | 2006-05-04 | 2010-10-19 | Microsoft Corporation | Hyperlink-based softphone call and management |
| DE102007013854A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Tetrahydrochinoline |
| DE102007013856A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydropyrrolochinoline |
| DE102007013855A1 (de) | 2007-03-20 | 2008-09-25 | Merck Patent Gmbh | Substituierte Tetrahydrochinoline |
| EP2194981B1 (en) * | 2007-10-05 | 2011-11-23 | Université de Mons-Hainaut | Bisbenzimidazoles as antimalarial agents |
| ES2787599T3 (es) | 2009-05-13 | 2020-10-16 | Univ Virginia Patent Foundation | Inhibidores de leucemia inv(16) |
| US8481551B2 (en) | 2011-01-14 | 2013-07-09 | Vertex Pharmaceuticals Incorporated | Gyrase and topoisomerase IV inhibitors |
| CN103384666A (zh) | 2011-01-14 | 2013-11-06 | 沃泰克斯药物股份有限公司 | 固体形式的促旋酶抑制剂（r）-1-乙基-3-[5-[2-（1-羟基-1-甲基-乙基）嘧啶-5-基]-7-（四氢呋喃-2-基）-1氢-苯并咪唑-2-基]脲 |
| CN103403000B (zh) | 2011-01-14 | 2017-05-31 | 斯派罗吹耐姆公司 | 固体形式的促旋酶抑制剂（r）‑1‑乙基‑3‑[6‑氟‑5‑[2‑（1‑羟基‑1‑甲基‑乙基）嘧啶‑5‑基]‑7‑（四氢呋喃‑2‑基）‑1氢‑苯并咪唑‑2‑基]脲 |
| NZ612920A (en) | 2011-01-14 | 2015-10-30 | Vertex Pharma | Process of making gyrase and topoisomerase iv inhibitors |
| KR101941420B1 (ko) | 2011-06-20 | 2019-01-23 | 스페로 트리넴, 인코포레이티드 | 자이라제 및 토포이소머라제 억제제의 인산에스테르 |
| WO2014014845A1 (en) | 2012-07-18 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases |
| TWI595002B (zh) | 2012-07-18 | 2017-08-11 | 思沛羅三南公司 | （Ｒ）－２－（５－（２－（３－乙基脲基）－６－氟－７－（四氫呋喃－２－基）－１Ｈ－苯并［ｄ］咪唑－５－基）嘧啶－２－基）丙烷－２－基磷酸二氫鹽之固體形式及其鹽 |
| GB201506658D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| GB201506660D0 (en) | 2015-04-20 | 2015-06-03 | Cellcentric Ltd | Pharmaceutical compounds |
| WO2016186967A1 (en) * | 2015-05-15 | 2016-11-24 | Gilead Sciences, Inc. | Benzimidazole and imadazopyridine carboximidamide compounds having activity as inhibitors of indoleamine 2,3-dioxygenase |
| CN109475542A (zh) | 2016-07-27 | 2019-03-15 | 弗吉尼亚大学专利基金会 | 用于治疗癌症的组合疗法 |
| EP3493848B1 (en) * | 2016-08-02 | 2021-09-29 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Heterocyclic diamidines |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1542284A (en) * | 1976-01-09 | 1979-03-14 | Barcrest Ltd | Recording electrical information |
| ES467739A1 (es) * | 1977-03-16 | 1979-07-01 | Hoechst Ag | Procedimiento para la preparacion de compuestos de bisbenci-midazolil sustituidos |
| DE2839989A1 (de) * | 1978-09-14 | 1980-04-03 | Hoechst Ag | Substituierte bisbenzimidazolylverbindungen, ihre herstellung und ihre verwendung |
| US4933347A (en) * | 1988-10-25 | 1990-06-12 | University Of North Carolina At Chapel Hill | Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia |
| US4963589A (en) * | 1988-10-25 | 1990-10-16 | The University Of North Carolina At Chapel Hill | Methods for treating Giardia lamblia |
| US5134152A (en) * | 1989-12-07 | 1992-07-28 | Sankyo Company, Limited | Oxetane derivatives and their use as anti-fungal or fungicidal agents |
| FR2674246B1 (fr) * | 1991-03-21 | 1993-07-09 | Roussel Uclaf | Nouveaux derives de l'acide alpha-methylene 5-thiazolacetique, leur procede de preparation et les intermediaires de ce procede, leur application a titre de fongicides et les compositions les renfermant. |
| EP0508527A1 (en) * | 1991-04-11 | 1992-10-14 | UNIROYAL CHEMICAL COMPANY, Inc. | New fungicidally active pyrazole compounds |
| US5362910A (en) * | 1991-10-08 | 1994-11-08 | Nicca Chemical Co., Ltd. | Germicidal and fungicidal agent and a germicidal and fungicidal method |
| JPH05140114A (ja) * | 1991-11-22 | 1993-06-08 | Otsuka Chem Co Ltd | アゾール−１−カルボン酸エステル誘導体及び殺菌剤 |
| US5428051A (en) * | 1992-10-13 | 1995-06-27 | University Of North Carolina | Methods of combating pneumocystis carinii pneumonia and compounds useful therefor |
| US5667975A (en) * | 1994-05-06 | 1997-09-16 | The University Of North Carolina | Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans |
-
1995
- 1995-06-07 US US08/472,996 patent/US5643935A/en not_active Expired - Fee Related
-
1996
- 1996-05-01 US US08/641,510 patent/US5639755A/en not_active Expired - Fee Related
- 1996-06-03 CA CA002223912A patent/CA2223912A1/en not_active Abandoned
- 1996-06-03 AT AT96916817T patent/ATE256464T1/de not_active IP Right Cessation
- 1996-06-03 ES ES96916817T patent/ES2213775T3/es not_active Expired - Lifetime
- 1996-06-03 EP EP96916817A patent/EP0831832B1/en not_active Expired - Lifetime
- 1996-06-03 WO PCT/US1996/008084 patent/WO1996040145A1/en not_active Ceased
- 1996-06-03 JP JP9500868A patent/JPH11507036A/ja not_active Ceased
- 1996-06-03 AU AU59566/96A patent/AU705261B2/en not_active Ceased
- 1996-06-03 DE DE69631134T patent/DE69631134T2/de not_active Expired - Fee Related
-
1997
- 1997-05-29 US US08/865,424 patent/US5792782A/en not_active Expired - Lifetime
- 1997-05-29 US US08/865,427 patent/US5817686A/en not_active Expired - Fee Related
- 1997-05-29 US US08/865,425 patent/US5817687A/en not_active Expired - Fee Related
-
1998
- 1998-08-07 US US09/130,496 patent/US5939440A/en not_active Expired - Fee Related
- 1998-09-01 US US09/145,367 patent/US5972969A/en not_active Expired - Lifetime
- 1998-09-01 US US09/145,368 patent/US6017941A/en not_active Expired - Lifetime
-
1999
- 1999-07-13 US US09/352,391 patent/US6046226A/en not_active Expired - Lifetime
-
2000
- 2000-01-04 US US09/477,386 patent/US6156779A/en not_active Expired - Lifetime
- 2000-04-06 US US09/544,643 patent/US6294565B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE256464T1 (de) | 2004-01-15 |
| US5817686A (en) | 1998-10-06 |
| US6046226A (en) | 2000-04-04 |
| AU705261B2 (en) | 1999-05-20 |
| US5972969A (en) | 1999-10-26 |
| US6017941A (en) | 2000-01-25 |
| US5639755A (en) | 1997-06-17 |
| US6156779A (en) | 2000-12-05 |
| US5792782A (en) | 1998-08-11 |
| EP0831832A4 (en) | 1999-07-07 |
| US5817687A (en) | 1998-10-06 |
| DE69631134D1 (de) | 2004-01-29 |
| US5939440A (en) | 1999-08-17 |
| US6294565B1 (en) | 2001-09-25 |
| WO1996040145A1 (en) | 1996-12-19 |
| CA2223912A1 (en) | 1996-12-19 |
| EP0831832A1 (en) | 1998-04-01 |
| DE69631134T2 (de) | 2004-09-02 |
| AU5956696A (en) | 1996-12-30 |
| ES2213775T3 (es) | 2004-09-01 |
| US5643935A (en) | 1997-07-01 |
| EP0831832B1 (en) | 2003-12-17 |
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