ATE256464T1 - Verfahren zur bekämpfung infektiöser krankheiten unter verwendung dikationischer bis-benzimidazole - Google Patents

Verfahren zur bekämpfung infektiöser krankheiten unter verwendung dikationischer bis-benzimidazole

Info

Publication number
ATE256464T1
ATE256464T1 AT96916817T AT96916817T ATE256464T1 AT E256464 T1 ATE256464 T1 AT E256464T1 AT 96916817 T AT96916817 T AT 96916817T AT 96916817 T AT96916817 T AT 96916817T AT E256464 T1 ATE256464 T1 AT E256464T1
Authority
AT
Austria
Prior art keywords
benzimidazoles
infectious diseases
controlling infectious
dicationic bis
dicationic
Prior art date
Application number
AT96916817T
Other languages
German (de)
English (en)
Inventor
Christine C Dykstra
John R Perfect
David W Boykin
David W Wilson
Richard R Tidwell
Original Assignee
Univ North Carolina
Univ Duke
Univ Georgia State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina, Univ Duke, Univ Georgia State filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE256464T1 publication Critical patent/ATE256464T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT96916817T 1995-06-07 1996-06-03 Verfahren zur bekämpfung infektiöser krankheiten unter verwendung dikationischer bis-benzimidazole ATE256464T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/472,996 US5643935A (en) 1995-06-07 1995-06-07 Method of combatting infectious diseases using dicationic bis-benzimidazoles
PCT/US1996/008084 WO1996040145A1 (en) 1995-06-07 1996-06-03 Methods of combatting infectious diseases using dicationic bis-benzimidazoles

Publications (1)

Publication Number Publication Date
ATE256464T1 true ATE256464T1 (de) 2004-01-15

Family

ID=23877744

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96916817T ATE256464T1 (de) 1995-06-07 1996-06-03 Verfahren zur bekämpfung infektiöser krankheiten unter verwendung dikationischer bis-benzimidazole

Country Status (9)

Country Link
US (11) US5643935A (enExample)
EP (1) EP0831832B1 (enExample)
JP (1) JPH11507036A (enExample)
AT (1) ATE256464T1 (enExample)
AU (1) AU705261B2 (enExample)
CA (1) CA2223912A1 (enExample)
DE (1) DE69631134T2 (enExample)
ES (1) ES2213775T3 (enExample)
WO (1) WO1996040145A1 (enExample)

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EP2194981B1 (en) * 2007-10-05 2011-11-23 Université de Mons-Hainaut Bisbenzimidazoles as antimalarial agents
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US8481551B2 (en) 2011-01-14 2013-07-09 Vertex Pharmaceuticals Incorporated Gyrase and topoisomerase IV inhibitors
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CN103403000B (zh) 2011-01-14 2017-05-31 斯派罗吹耐姆公司 固体形式的促旋酶抑制剂（r）‑1‑乙基‑3‑[6‑氟‑5‑[2‑（1‑羟基‑1‑甲基‑乙基）嘧啶‑5‑基]‑7‑（四氢呋喃‑2‑基）‑1氢‑苯并咪唑‑2‑基]脲
NZ612920A (en) 2011-01-14 2015-10-30 Vertex Pharma Process of making gyrase and topoisomerase iv inhibitors
KR101941420B1 (ko) 2011-06-20 2019-01-23 스페로 트리넴, 인코포레이티드 자이라제 및 토포이소머라제 억제제의 인산에스테르
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Also Published As

Publication number Publication date
US5817686A (en) 1998-10-06
US6046226A (en) 2000-04-04
AU705261B2 (en) 1999-05-20
US5972969A (en) 1999-10-26
US6017941A (en) 2000-01-25
US5639755A (en) 1997-06-17
US6156779A (en) 2000-12-05
US5792782A (en) 1998-08-11
EP0831832A4 (en) 1999-07-07
US5817687A (en) 1998-10-06
DE69631134D1 (de) 2004-01-29
US5939440A (en) 1999-08-17
US6294565B1 (en) 2001-09-25
WO1996040145A1 (en) 1996-12-19
CA2223912A1 (en) 1996-12-19
EP0831832A1 (en) 1998-04-01
DE69631134T2 (de) 2004-09-02
AU5956696A (en) 1996-12-30
ES2213775T3 (es) 2004-09-01
JPH11507036A (ja) 1999-06-22
US5643935A (en) 1997-07-01
EP0831832B1 (en) 2003-12-17

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