JPH11507036A5 - - Google Patents

Info

Publication number
JPH11507036A5
JPH11507036A5 JP1997500868A JP50086897A JPH11507036A5 JP H11507036 A5 JPH11507036 A5 JP H11507036A5 JP 1997500868 A JP1997500868 A JP 1997500868A JP 50086897 A JP50086897 A JP 50086897A JP H11507036 A5 JPH11507036 A5 JP H11507036A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1997500868A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11507036A (ja
Filing date
Publication date
Priority claimed from US08/472,996 external-priority patent/US5643935A/en
Application filed filed Critical
Publication of JPH11507036A publication Critical patent/JPH11507036A/ja
Publication of JPH11507036A5 publication Critical patent/JPH11507036A5/ja
Ceased legal-status Critical Current

Links

JP9500868A 1995-06-07 1996-06-03 ジカチオン性ビス−ベンズイミダゾール類を用いた感染病治療方法 Ceased JPH11507036A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/472,996 US5643935A (en) 1995-06-07 1995-06-07 Method of combatting infectious diseases using dicationic bis-benzimidazoles
US08/472,996 1995-06-07
PCT/US1996/008084 WO1996040145A1 (en) 1995-06-07 1996-06-03 Methods of combatting infectious diseases using dicationic bis-benzimidazoles

Publications (2)

Publication Number Publication Date
JPH11507036A JPH11507036A (ja) 1999-06-22
JPH11507036A5 true JPH11507036A5 (enExample) 2004-07-22

Family

ID=23877744

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9500868A Ceased JPH11507036A (ja) 1995-06-07 1996-06-03 ジカチオン性ビス−ベンズイミダゾール類を用いた感染病治療方法

Country Status (9)

Country Link
US (11) US5643935A (enExample)
EP (1) EP0831832B1 (enExample)
JP (1) JPH11507036A (enExample)
AT (1) ATE256464T1 (enExample)
AU (1) AU705261B2 (enExample)
CA (1) CA2223912A1 (enExample)
DE (1) DE69631134T2 (enExample)
ES (1) ES2213775T3 (enExample)
WO (1) WO1996040145A1 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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US5770617A (en) * 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
US5935982A (en) * 1997-02-28 1999-08-10 The University Of North Carolina At Chapel Hill Methods of treating retroviral infection and compounds useful therefor
US6635668B1 (en) 1998-07-22 2003-10-21 The University Of North Carolina At Chapel Hill Imidazoline receptor binding compounds
EP1685836A3 (en) * 1998-09-17 2007-05-09 University Of North Carolina At Chapel Hill Antifungal activity of dicationic molecules
US6326395B1 (en) 1998-09-17 2001-12-04 Duke University Antifungal activity of dicationic molecules
CN1297281C (zh) * 1999-03-29 2007-01-31 希拉生物化学股份有限公司 治疗白血病的方法
US7115665B1 (en) 2000-11-16 2006-10-03 Onocozyme Pharma, Inc. Inhibitors of endo-exonuclease activity for treating cancer
ATE431734T1 (de) * 1999-11-16 2009-06-15 Oncozyme Pharma Inc Pentamidine zur behandlung von krebs
US7156809B2 (en) 1999-12-17 2007-01-02 Q-Tec Systems Llc Method and apparatus for health and disease management combining patient data monitoring with wireless internet connectivity
US6677377B2 (en) * 2000-06-21 2004-01-13 Georgetown University School Of Medicine Structure based discovery of inhibitors of matriptase for the treatment of cancer and other conditions
US6706754B2 (en) * 2000-11-06 2004-03-16 The United States Of America As Represented By The Secretary Of The Army Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
MXPA04001153A (es) * 2001-08-31 2005-02-17 Neurochem Int Ltd Derivados de amidina para tratar la amiloidosis.
WO2004047724A2 (en) 2002-05-16 2004-06-10 Genelabs Technologies, Inc Aryl and heteroaryl compounds as antibacterial and antifungal agents
MXPA04012628A (es) 2002-06-13 2005-03-23 Patricia Olivershaffer DERIVADOS Y COMPUESTOS RELACIONADOS DEL áCIDO 2-UREIDO-6-HETEROARIL-3H-BENZOIMIDAZOL-4-CARBOXILICO COMO INHIBIDORES DE GIRASA Y/O TOPOISOMERASA IV PARA EL TRATAMIENTO DE INFECCIONES BACTERIALES.
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) * 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US7569591B2 (en) * 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7618974B2 (en) * 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7582641B2 (en) * 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) * 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
WO2005020913A2 (en) * 2003-08-25 2005-03-10 Combinatorx, Incorporated Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
EP1734884B1 (en) 2004-03-16 2021-06-16 Guidance Endodontics, LLC Endodontic files
AU2005233632A1 (en) 2004-04-13 2005-10-27 Icagen, Inc. Polycyclic pyridines as potassium ion channel modulators
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
US7817792B2 (en) * 2006-05-04 2010-10-19 Microsoft Corporation Hyperlink-based softphone call and management
DE102007013854A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Tetrahydrochinoline
DE102007013856A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydropyrrolochinoline
DE102007013855A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydrochinoline
EP2194981B1 (en) * 2007-10-05 2011-11-23 Université de Mons-Hainaut Bisbenzimidazoles as antimalarial agents
ES2787599T3 (es) 2009-05-13 2020-10-16 Univ Virginia Patent Foundation Inhibidores de leucemia inv(16)
US8481551B2 (en) 2011-01-14 2013-07-09 Vertex Pharmaceuticals Incorporated Gyrase and topoisomerase IV inhibitors
CN103384666A (zh) 2011-01-14 2013-11-06 沃泰克斯药物股份有限公司 固体形式的促旋酶抑制剂（r）-1-乙基-3-[5-[2-（1-羟基-1-甲基-乙基）嘧啶-5-基]-7-（四氢呋喃-2-基）-1氢-苯并咪唑-2-基]脲
CN103403000B (zh) 2011-01-14 2017-05-31 斯派罗吹耐姆公司 固体形式的促旋酶抑制剂（r）‑1‑乙基‑3‑[6‑氟‑5‑[2‑（1‑羟基‑1‑甲基‑乙基）嘧啶‑5‑基]‑7‑（四氢呋喃‑2‑基）‑1氢‑苯并咪唑‑2‑基]脲
NZ612920A (en) 2011-01-14 2015-10-30 Vertex Pharma Process of making gyrase and topoisomerase iv inhibitors
KR101941420B1 (ko) 2011-06-20 2019-01-23 스페로 트리넴, 인코포레이티드 자이라제 및 토포이소머라제 억제제의 인산에스테르
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases
TWI595002B (zh) 2012-07-18 2017-08-11 思沛羅三南公司 （Ｒ）－２－（５－（２－（３－乙基脲基）－６－氟－７－（四氫呋喃－２－基）－１Ｈ－苯并［ｄ］咪唑－５－基）嘧啶－２－基）丙烷－２－基磷酸二氫鹽之固體形式及其鹽
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
WO2016186967A1 (en) * 2015-05-15 2016-11-24 Gilead Sciences, Inc. Benzimidazole and imadazopyridine carboximidamide compounds having activity as inhibitors of indoleamine 2,3-dioxygenase
CN109475542A (zh) 2016-07-27 2019-03-15 弗吉尼亚大学专利基金会 用于治疗癌症的组合疗法
EP3493848B1 (en) * 2016-08-02 2021-09-29 Friedrich-Alexander-Universität Erlangen-Nürnberg Heterocyclic diamidines

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1542284A (en) * 1976-01-09 1979-03-14 Barcrest Ltd Recording electrical information
ES467739A1 (es) * 1977-03-16 1979-07-01 Hoechst Ag Procedimiento para la preparacion de compuestos de bisbenci-midazolil sustituidos
DE2839989A1 (de) * 1978-09-14 1980-04-03 Hoechst Ag Substituierte bisbenzimidazolylverbindungen, ihre herstellung und ihre verwendung
US4933347A (en) * 1988-10-25 1990-06-12 University Of North Carolina At Chapel Hill Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia
US4963589A (en) * 1988-10-25 1990-10-16 The University Of North Carolina At Chapel Hill Methods for treating Giardia lamblia
US5134152A (en) * 1989-12-07 1992-07-28 Sankyo Company, Limited Oxetane derivatives and their use as anti-fungal or fungicidal agents
FR2674246B1 (fr) * 1991-03-21 1993-07-09 Roussel Uclaf Nouveaux derives de l'acide alpha-methylene 5-thiazolacetique, leur procede de preparation et les intermediaires de ce procede, leur application a titre de fongicides et les compositions les renfermant.
EP0508527A1 (en) * 1991-04-11 1992-10-14 UNIROYAL CHEMICAL COMPANY, Inc. New fungicidally active pyrazole compounds
US5362910A (en) * 1991-10-08 1994-11-08 Nicca Chemical Co., Ltd. Germicidal and fungicidal agent and a germicidal and fungicidal method
JPH05140114A (ja) * 1991-11-22 1993-06-08 Otsuka Chem Co Ltd アゾール−１−カルボン酸エステル誘導体及び殺菌剤
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
US5667975A (en) * 1994-05-06 1997-09-16 The University Of North Carolina Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans

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