JPH11246531A5 - - Google Patents
Info
- Publication number
- JPH11246531A5 JPH11246531A5 JP1998328502A JP32850298A JPH11246531A5 JP H11246531 A5 JPH11246531 A5 JP H11246531A5 JP 1998328502 A JP1998328502 A JP 1998328502A JP 32850298 A JP32850298 A JP 32850298A JP H11246531 A5 JPH11246531 A5 JP H11246531A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- group
- aryl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19751251:8 | 1997-11-19 | ||
| DE19751251A DE19751251A1 (de) | 1997-11-19 | 1997-11-19 | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH11246531A JPH11246531A (ja) | 1999-09-14 |
| JPH11246531A5 true JPH11246531A5 (https=) | 2006-02-02 |
| JP4567821B2 JP4567821B2 (ja) | 2010-10-20 |
Family
ID=7849203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP32850298A Expired - Fee Related JP4567821B2 (ja) | 1997-11-19 | 1998-11-18 | 置換されたイミダゾリジン誘導体、その製法および使用ならびにそれを含有する医薬製剤 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US6331552B1 (https=) |
| EP (1) | EP0918059B1 (https=) |
| JP (1) | JP4567821B2 (https=) |
| KR (1) | KR100738820B1 (https=) |
| CN (1) | CN1330638C (https=) |
| AR (1) | AR016011A1 (https=) |
| AT (1) | ATE243708T1 (https=) |
| AU (1) | AU755893B2 (https=) |
| BR (1) | BR9804695B1 (https=) |
| CA (1) | CA2254420C (https=) |
| CZ (1) | CZ297564B6 (https=) |
| DE (2) | DE19751251A1 (https=) |
| DK (1) | DK0918059T3 (https=) |
| ES (1) | ES2202718T3 (https=) |
| HR (1) | HRP980602B1 (https=) |
| HU (1) | HU229481B1 (https=) |
| ID (1) | ID21305A (https=) |
| IL (1) | IL127132A (https=) |
| MY (1) | MY118313A (https=) |
| NO (1) | NO325303B1 (https=) |
| NZ (1) | NZ332855A (https=) |
| PL (1) | PL194692B1 (https=) |
| PT (1) | PT918059E (https=) |
| RU (1) | RU2239641C2 (https=) |
| SI (1) | SI0918059T1 (https=) |
| SK (1) | SK284851B6 (https=) |
| TR (1) | TR199802344A2 (https=) |
| TW (1) | TWI230155B (https=) |
| ZA (1) | ZA9810543B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| US6723711B2 (en) | 1999-05-07 | 2004-04-20 | Texas Biotechnology Corporation | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| DE19922462A1 (de) * | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| YU41202A (sh) | 1999-12-28 | 2005-03-15 | Pfizer Products Inc. | Ne-peptidni inhibitori vezivanja za ćeliju zavisnog od vla-4 korisni pri tretiranju inflamatornih, autoimunih i respiratornih bolesti |
| GB0010105D0 (en) * | 2000-04-26 | 2000-06-14 | Ml Lab Plc | Cell ablation |
| DE10111877A1 (de) * | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| DE10111876A1 (de) | 2001-03-10 | 2002-09-19 | Aventis Pharma Gmbh | Bis(trifluormethyl)hydantoine als Zwischenprodukte für pharmazeutische Wirkstoffe |
| US20030154499A1 (en) * | 2001-06-08 | 2003-08-14 | Monika Wasel-Nielen | Mouse unable to express functional alpha-4 integrin protein, and methods for assaying compounds or agents for alpha-4 integrin protein antagonist activity and a genetic marker for evaluating efficacy of modulators of signaling activity of a VLA-4 receptor |
| WO2003000662A2 (en) * | 2001-06-22 | 2003-01-03 | Aventis Pharmaceuticals Inc. | Chiral preparation of a diastereomeric compound |
| DE10134366A1 (de) * | 2001-07-14 | 2003-01-23 | Aventis Pharma Gmbh | Verfahren zur Herstellung der enantiomeren Formen von 2-substituierten 2-(2,5-Dioxoimidazolidin-l-yl)-essigsäure- Derivaten |
| DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
| DK1474425T3 (da) * | 2002-01-07 | 2006-09-25 | Eisai Co Ltd | Deazapuriner og anvendelser deraf |
| EP1539744A4 (en) * | 2002-07-11 | 2007-06-06 | Vicuron Pharm Inc | N-HYDROXYAMIDE DERIVATIVES WITH ANTIBACTERIAL EFFECT |
| US7041693B2 (en) * | 2002-10-04 | 2006-05-09 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| JP4591347B2 (ja) * | 2003-03-17 | 2010-12-01 | 宇部興産株式会社 | 3−アミノ−3−アリールプロピオン酸n−アルキルエステル及びその製造方法並びに光学活性3−アミノ−3−アリールプロピオン酸及びその対掌エステルの製造方法 |
| EA009646B1 (ru) | 2003-05-30 | 2008-02-28 | Рэнбакси Лабораториз Лтд. | Замещённые производные пиррола и их применение в качестве ингибиторов hmg-coa |
| DE102004009822A1 (de) | 2004-02-28 | 2005-09-15 | Zf Lenksysteme Gmbh | Verfahren zum Betrieb eines Lenksystems mit Signalplausibilisierung |
| JP2009514851A (ja) | 2005-11-08 | 2009-04-09 | ランバクシー ラボラトリーズ リミテッド | (3r,5r)−7−[2−(4−フルオロフェニル)−5−イソプロピル−3−フェニル−4−[(4−ヒドロキシメチルフェニルアミノ)カルボニル]−ピロール−1−イル]−3,5−ジヒドロキシ−ヘプタン酸ヘミカルシウム塩の製法 |
| WO2008103378A2 (en) | 2007-02-20 | 2008-08-28 | Merrimack Pharmaceuticals, Inc. | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
| MX2010011145A (es) | 2008-04-11 | 2011-04-11 | Merrimack Pharmaceuticals Inc | Enlazadores de la albumina de suero humana y conjugados de la misma. |
| US8633123B2 (en) * | 2008-08-22 | 2014-01-21 | Novomer, Inc. | Catalysts and methods for polymer synthesis |
| DE102009012314A1 (de) | 2009-03-09 | 2010-09-16 | Bayer Schering Pharma Aktiengesellschaft | Oxo-heterocyclisch substituierte Alkylcarbonsäuren und ihre Verwendung |
| EP3326645B1 (en) | 2010-10-25 | 2020-03-18 | Biogen MA Inc. | Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels |
| EP3112353A1 (en) * | 2015-06-30 | 2017-01-04 | Studiengesellschaft Kohle MbH | Substituted imidazolium sulfuranes and their use |
| EP3773573B1 (en) * | 2018-04-12 | 2026-03-18 | Morphic Therapeutic, Inc. | Antagonists of human integrin (alpha4)(beta7) |
| WO2020113088A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Diarylhydantoin compounds and methods of use thereof |
| KR20220046605A (ko) * | 2019-08-05 | 2022-04-14 | 뽈리쁠뤼스-트랑스펙씨옹 (쏘시에떼 아노님) | 양이온성 중합체에 그래프트된 헤테로사이클릭 화합물을 포함하는, 세포 내로 핵산 분자를 형질감염시키기 위한 조성물, 및 이의 적용 |
| TWI775182B (zh) | 2019-10-16 | 2022-08-21 | 美商莫菲克醫療股份有限公司 | 抑制人類整合素αβ |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE235866C (https=) | ||||
| DE3044236A1 (de) | 1980-11-25 | 1982-06-16 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| DE2937779A1 (de) | 1979-09-19 | 1981-04-09 | Hoechst Ag, 6000 Frankfurt | Aminosaeurederivate und verfahren zu ihrer herstellung |
| FR2487829A2 (fr) | 1979-12-07 | 1982-02-05 | Science Union & Cie | Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| FR2503155A2 (fr) | 1980-10-02 | 1982-10-08 | Science Union & Cie | Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme |
| US4350704A (en) | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
| DE3177130D1 (de) | 1980-08-30 | 1990-01-11 | Hoechst Ag | Aminosaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung. |
| US4344949A (en) | 1980-10-03 | 1982-08-17 | Warner-Lambert Company | Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids |
| LU88621I2 (fr) | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
| US4374847A (en) | 1980-10-27 | 1983-02-22 | Ciba-Geigy Corporation | 1-Carboxyalkanoylindoline-2-carboxylic acids |
| DE3226768A1 (de) | 1981-11-05 | 1983-05-26 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
| IE55867B1 (en) | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| DE3210496A1 (de) | 1982-03-23 | 1983-10-06 | Hoechst Ag | Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3211397A1 (de) | 1982-03-27 | 1983-11-10 | Hoechst Ag, 6230 Frankfurt | Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| DE3211676A1 (de) | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3227055A1 (de) | 1982-07-20 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | Neue derivate der 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-aza-bicyclo(2.2.2)octan-3-carbonsaeure als zwischenstufe und verfahren zu deren herstellung |
| DE3242151A1 (de) | 1982-11-13 | 1984-05-17 | Hoechst Ag, 6230 Frankfurt | Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3246503A1 (de) | 1982-12-16 | 1984-06-20 | Hoechst Ag, 6230 Frankfurt | Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung |
| DE3643012A1 (de) | 1986-12-17 | 1988-06-30 | Hoechst Ag | 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung |
| DE3818850A1 (de) | 1988-06-03 | 1989-12-07 | Hoechst Ag | Oligopeptide mit zyklischen prolin-analogen aminosaeuren |
| DE4009506A1 (de) * | 1990-03-24 | 1991-09-26 | Hoechst Ag | Hydantoinderivate |
| DE4126277A1 (de) * | 1991-08-08 | 1993-02-11 | Cassella Ag | Hydantoinderivate |
| RU2032672C1 (ru) * | 1991-08-20 | 1995-04-10 | Институт физико-органической химии и углехимии им.Л.М.Литвиненко АН Украины | 1,3-бис-(2,3-диакрилоилоксипропил) -5,5-диметил-2,4-имидазолидиндион в качестве модификатора фотополимеризующихся акрилатных композиций |
| DK0626861T4 (da) * | 1992-01-13 | 2004-08-16 | Biogen Inc | Behandling af astma. |
| JPH07506566A (ja) * | 1992-02-12 | 1995-07-20 | バイオゲン インコーポレイテッド | 炎症性胃腸病の処置 |
| DE4207254A1 (de) * | 1992-03-07 | 1993-09-09 | Cassella Ag | 4-oxo-2-thioxoimidazolidin-derivate |
| DE4213634A1 (de) * | 1992-04-24 | 1993-10-28 | Cassella Ag | 2,4-Dioxo-imidazolidin-Derivate |
| DE4224414A1 (de) | 1992-07-24 | 1994-01-27 | Cassella Ag | Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung |
| DE4228717A1 (de) * | 1992-08-28 | 1994-03-03 | Cassella Ag | Imidazolidin-Derivate |
| CA2153228A1 (en) | 1993-01-08 | 1994-07-21 | Shiu-Lan Ng Chiang | Peptide inhibitors of cell adhesion |
| DE69419721T2 (de) | 1993-01-12 | 2000-04-27 | Biogen, Inc. | Rekombinante anti-vla4 antikörpermoleküle |
| ATE161730T1 (de) | 1993-02-09 | 1998-01-15 | Biogen Inc | Antikörper zur behandlung von insulinabhängigen diabetes |
| DE4308034A1 (de) * | 1993-03-13 | 1994-09-15 | Cassella Ag | Neue Heterocyclen, ihre Herstellung und ihre Verwendung |
| DE4427979A1 (de) * | 1993-11-15 | 1996-02-15 | Cassella Ag | Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung |
| WO1995015973A1 (en) | 1993-12-06 | 1995-06-15 | Cytel Corporation | Cs-1 peptidomimetics, compositions and methods of using the same |
| HU220799B1 (hu) | 1994-01-25 | 2002-05-28 | Elan Pharmaceuticals, Inc. | Humanizált antitestek VLA-4 leukocita adhéziós molekula ellen |
| AU2958195A (en) * | 1994-06-29 | 1996-01-25 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin |
| US5811391A (en) | 1994-08-25 | 1998-09-22 | Cytel Corporation | Cyclic CS-1 peptidomimetics, compositions and methods of using same |
| GB9524630D0 (en) | 1994-12-24 | 1996-01-31 | Zeneca Ltd | Chemical compounds |
| US6306840B1 (en) | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
| DE19515177A1 (de) | 1995-04-28 | 1996-10-31 | Cassella Ag | Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe |
| US6248713B1 (en) | 1995-07-11 | 2001-06-19 | Biogen, Inc. | Cell adhesion inhibitors |
| ES2171768T3 (es) * | 1996-03-20 | 2002-09-16 | Hoechst Ag | Inhibidores de la resorcion osea y antagonistas de receptores de vitronectina. |
| NZ333904A (en) | 1996-07-25 | 2000-06-23 | Biogen Inc | VLA-4 and IIb/IIIa cell adhesion inhibitors |
| DE19647382A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647381A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19647380A1 (de) * | 1996-11-15 | 1998-05-20 | Hoechst Ag | 5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten |
| DE19648053C1 (de) | 1996-11-20 | 1998-03-12 | Siemens Ag | Elektromagnetisches Schaltgerät |
| WO1998042656A1 (en) | 1997-03-21 | 1998-10-01 | Cytel Corporation | Novel compounds |
-
1997
- 1997-11-19 DE DE19751251A patent/DE19751251A1/de not_active Withdrawn
-
1998
- 1998-11-13 EP EP98121670A patent/EP0918059B1/de not_active Expired - Lifetime
- 1998-11-13 DE DE59808804T patent/DE59808804D1/de not_active Expired - Lifetime
- 1998-11-13 DK DK98121670T patent/DK0918059T3/da active
- 1998-11-13 PT PT98121670T patent/PT918059E/pt unknown
- 1998-11-13 SI SI9830509T patent/SI0918059T1/xx unknown
- 1998-11-13 ES ES98121670T patent/ES2202718T3/es not_active Expired - Lifetime
- 1998-11-13 AT AT98121670T patent/ATE243708T1/de active
- 1998-11-16 ID IDP981494A patent/ID21305A/id unknown
- 1998-11-17 CZ CZ0372698A patent/CZ297564B6/cs not_active IP Right Cessation
- 1998-11-17 AR ARP980105821A patent/AR016011A1/es active IP Right Grant
- 1998-11-17 NZ NZ332855A patent/NZ332855A/en not_active IP Right Cessation
- 1998-11-17 CA CA002254420A patent/CA2254420C/en not_active Expired - Fee Related
- 1998-11-17 HU HU9802653A patent/HU229481B1/hu not_active IP Right Cessation
- 1998-11-17 SK SK1580-98A patent/SK284851B6/sk not_active IP Right Cessation
- 1998-11-17 TR TR1998/02344A patent/TR199802344A2/xx unknown
- 1998-11-18 ZA ZA9810543A patent/ZA9810543B/xx unknown
- 1998-11-18 BR BRPI9804695-0A patent/BR9804695B1/pt not_active IP Right Cessation
- 1998-11-18 HR HR980602A patent/HRP980602B1/xx not_active IP Right Cessation
- 1998-11-18 JP JP32850298A patent/JP4567821B2/ja not_active Expired - Fee Related
- 1998-11-18 AU AU92421/98A patent/AU755893B2/en not_active Ceased
- 1998-11-18 IL IL12713298A patent/IL127132A/xx not_active IP Right Cessation
- 1998-11-18 NO NO19985368A patent/NO325303B1/no not_active IP Right Cessation
- 1998-11-18 MY MYPI98005253A patent/MY118313A/en unknown
- 1998-11-18 RU RU98120859/04A patent/RU2239641C2/ru not_active IP Right Cessation
- 1998-11-18 KR KR1019980049376A patent/KR100738820B1/ko not_active Expired - Fee Related
- 1998-11-19 PL PL329790A patent/PL194692B1/pl unknown
- 1998-11-19 CN CNB981225195A patent/CN1330638C/zh not_active Expired - Fee Related
- 1998-12-04 TW TW087118969A patent/TWI230155B/zh not_active IP Right Cessation
-
2000
- 2000-03-01 US US09/516,587 patent/US6331552B1/en not_active Expired - Lifetime
-
2001
- 2001-09-14 US US09/952,028 patent/US6521654B2/en not_active Expired - Lifetime
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