JPH10512590A5 - - Google Patents
Info
- Publication number
- JPH10512590A5 JPH10512590A5 JP1997517176A JP51717697A JPH10512590A5 JP H10512590 A5 JPH10512590 A5 JP H10512590A5 JP 1997517176 A JP1997517176 A JP 1997517176A JP 51717697 A JP51717697 A JP 51717697A JP H10512590 A5 JPH10512590 A5 JP H10512590A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9503141 | 1995-11-02 | ||
| HU9503141A HU222994B1 (hu) | 1995-11-02 | 1995-11-02 | Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására |
| HU9603919 | 1996-02-09 | ||
| HU9503141/3919 | 1996-02-09 | ||
| HU9503141/29820 | 1996-10-04 | ||
| HU9629820 | 1996-10-04 | ||
| PCT/HU1996/000064 WO1997016439A1 (en) | 1995-11-02 | 1996-11-01 | Hydroxylamine derivatives useful for enhancing the molecular chaperon production and the preparation thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008261964A Division JP2009108048A (ja) | 1995-11-02 | 2008-10-08 | 分子シャペロン産生を増強するのに有用なヒドロキシルアミン誘導体およびそれの調製 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH10512590A JPH10512590A (ja) | 1998-12-02 |
| JPH10512590A5 true JPH10512590A5 (enExample) | 2004-10-21 |
| JP4531865B2 JP4531865B2 (ja) | 2010-08-25 |
Family
ID=27270113
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51717697A Expired - Fee Related JP4531865B2 (ja) | 1995-11-02 | 1996-11-01 | 分子シャペロン産生を増強するのに有用なヒドロキシルアミン誘導体およびそれの調製 |
| JP2008261964A Withdrawn JP2009108048A (ja) | 1995-11-02 | 2008-10-08 | 分子シャペロン産生を増強するのに有用なヒドロキシルアミン誘導体およびそれの調製 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008261964A Withdrawn JP2009108048A (ja) | 1995-11-02 | 2008-10-08 | 分子シャペロン産生を増強するのに有用なヒドロキシルアミン誘導体およびそれの調製 |
Country Status (31)
| Country | Link |
|---|---|
| US (4) | US6653326B1 (enExample) |
| EP (1) | EP0801649B1 (enExample) |
| JP (2) | JP4531865B2 (enExample) |
| KR (1) | KR19980700976A (enExample) |
| CN (1) | CN1152871C (enExample) |
| AT (1) | ATE221880T1 (enExample) |
| AU (1) | AU720195B2 (enExample) |
| BG (1) | BG63944B1 (enExample) |
| BR (1) | BR9607565B1 (enExample) |
| CA (1) | CA2209167C (enExample) |
| CZ (1) | CZ295562B6 (enExample) |
| DE (1) | DE69622840T2 (enExample) |
| DK (1) | DK0801649T3 (enExample) |
| EE (1) | EE04239B1 (enExample) |
| ES (1) | ES2176502T3 (enExample) |
| HR (1) | HRP960508B1 (enExample) |
| HU (1) | HU222994B1 (enExample) |
| IL (1) | IL121126A (enExample) |
| MX (1) | MX9704988A (enExample) |
| NO (1) | NO321140B1 (enExample) |
| NZ (1) | NZ320523A (enExample) |
| PL (1) | PL195634B1 (enExample) |
| PT (1) | PT801649E (enExample) |
| RS (1) | RS49981B (enExample) |
| RU (1) | RU2206320C2 (enExample) |
| SI (1) | SI0801649T1 (enExample) |
| SK (1) | SK284823B6 (enExample) |
| TR (1) | TR199700574T1 (enExample) |
| UA (1) | UA61050C2 (enExample) |
| WO (1) | WO1997016439A1 (enExample) |
| ZA (1) | ZA969249B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT78139A (hu) * | 1995-12-22 | 2000-11-28 | BIOREX Kutató és Fejlesztő Rt. | Készítmény, különösen a bőr öregedési folyamatainak mérséklésére |
| UA64716C2 (en) * | 1996-08-09 | 2004-03-15 | Pharmaceuticals for therapy or prevention of illnesses connected with dysfunction of vascular endothelial cells | |
| WO2000007580A2 (en) * | 1998-08-03 | 2000-02-17 | N-Gene Kutató Kft. | Pharmaceutical compositions against autoimmune diseases |
| HU226617B1 (en) * | 1998-12-14 | 2009-04-28 | Cytrx Corp | Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient |
| HUP9900475D0 (en) * | 1999-02-26 | 1999-04-28 | Biorex Kutato Fejlesztoe Kft | O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component |
| FR2792832B1 (fr) * | 1999-04-28 | 2002-05-10 | Codif Internat Sa | Procede de protection de la peau pour la prevenir de son vieillissement cellulaire |
| HUP0001583A2 (hu) * | 2000-04-18 | 2002-11-28 | BIOREX Kutató és Fejlesztő Rt. | Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké |
| WO2003000861A2 (en) * | 2001-06-22 | 2003-01-03 | The Regents Of The University Of California | Eukaryotic genes involved in adult lifespan regulation |
| HUP0105205A2 (hu) * | 2001-11-29 | 2003-08-28 | BIOREX Kutató és Fejlesztő Rt. | Metformint és egy hidroxilaminszármazékot tartalmazó, gyógyászati készítmény |
| RU2320330C2 (ru) * | 2002-01-11 | 2008-03-27 | СиУайТиАрЭкс КОРПОРЕЙШН | Производные карбоксамидина и их использование при лечении заболеваний сосудов |
| BRPI0408802B8 (pt) * | 2003-03-27 | 2021-07-27 | Childrens Hospital Med Ct | método para a detecção de uma lesão de célula tubular renal isquêmica e método para identificar a extensão desta lesão |
| HUP0303584A3 (en) * | 2003-10-30 | 2009-12-28 | Cytrx Corp | Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases |
| AU2005232159B2 (en) * | 2004-04-12 | 2008-10-16 | Torrent Pharmaceuticals Ltd. | 2-propene-1-ones as HSP 70 inducers |
| US7786093B2 (en) * | 2004-07-07 | 2010-08-31 | Health Wellness Foods Corporation | Antistress agent |
| FR2880022B1 (fr) * | 2004-12-24 | 2007-08-24 | Mayoly Spindler Soc Par Action | Nouveaux derives de la n-hydroxy-n'-phenyluree et de la n-hydroxy-n'-phenylthiouree et leur utilisation comme inhibiteurs de la synthese de la melanine |
| WO2008039514A1 (en) * | 2006-09-26 | 2008-04-03 | Cytrx Corporation | Pharmaceutical compositions and methods for treating diseases associated with neurodegeneration |
| JP2010511622A (ja) * | 2006-12-01 | 2010-04-15 | シトルックス コーポレイション | 発作の回復 |
| TW200901958A (en) * | 2007-05-04 | 2009-01-16 | Cytrx Corp | Diabetic wound healing |
| RU2010102899A (ru) * | 2007-06-29 | 2011-08-10 | Торрент Фармасьютикалз Лтд. (In) | Новые замещенные пиперидоны в качестве индукторов hsp |
| PL2659904T3 (pl) | 2008-06-26 | 2016-01-29 | Orphazyme Aps | Zastosowanie Hsp70 jako regulatora aktywności enzymatycznej |
| KR101645937B1 (ko) * | 2008-11-11 | 2016-08-08 | (주)아모레퍼시픽 | 육음외사에 의한 피부 변화를 정량하는 방법 및 이를 이용한 피부 개선 물질의 스크리닝 방법 |
| BRPI0919867A2 (pt) * | 2008-11-18 | 2015-12-15 | Santen Pharmaceutical Co Ltd | agente terapeutico ou profilatico para uma doenca degenerativa coriorretiniana, e metodo profilatico ou terapeutico para uma doenca degenerativa coriorrentiniana |
| US20110123473A1 (en) * | 2009-11-26 | 2011-05-26 | Basf Se | Use of highly-branched polycarbonates in cosmetic and dermatological formulations |
| DK2646044T3 (da) | 2010-11-30 | 2019-11-25 | Orphazyme As | Metoder til at øge den intracellulære aktivitet af Hsp70 |
| KR101275264B1 (ko) | 2011-08-24 | 2013-06-17 | 포항공과대학교 산학협력단 | 샤프로닌 단백질의 조절 물질 탐색 방법 |
| HUP1100534A2 (en) | 2011-09-26 | 2013-04-29 | Balazs Dr Hazay | Pharmaceutical composition for the treatment of muscle atrophy |
| HUP1100535A2 (en) | 2011-09-26 | 2013-04-29 | Bracelia Invest Ltd | Pharmaceutical composition for enhancement of stem cell treatment |
| RU2495928C2 (ru) * | 2012-01-30 | 2013-10-20 | Сергей Юрьевич Лешков | Средство для стимуляции синтеза белков теплового шока hsp 70 в клетках человека и животных; косметическое средство для стимуляции репаративных процессов; косметическое средство для снижения побочных эффектов агрессивных косметологических процедур; биологически активная добавка; пищевой продукт; способ снижения побочных эффектов агрессивных косметологических процедур |
| KR20250069686A (ko) | 2014-09-15 | 2025-05-19 | 제브라 덴마크 에이/에스 | 아리모클로몰 제제 |
| US10898476B2 (en) | 2016-04-13 | 2021-01-26 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
| LT3448382T (lt) | 2016-04-29 | 2021-04-12 | Orphazyme A/S | Arimoklomolis, skirtas su gliukocerebrozidaze susijusiems sutrikimams gydyti |
| WO2018215597A1 (en) | 2017-05-24 | 2018-11-29 | Orphazyme A/S | Heat shock protein inducers and frontotemporal disorders |
| CN108314630B (zh) * | 2018-02-08 | 2020-11-06 | 广西民族大学 | 一种肟醚类衍生物及其制备方法与应用 |
| EP3803406A1 (en) | 2018-05-28 | 2021-04-14 | Orphazyme A/S | Hsp70 protein levels in pbmc samples as biomarker for disease |
| HUP1800298A1 (hu) | 2018-08-30 | 2020-05-28 | N Gene Res Laboratories Inc | Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére |
| CN110048418B (zh) * | 2019-05-08 | 2023-03-24 | 辽宁工程技术大学 | 一种基于细胞-组织算法的微电网经济调度方法及装置 |
| IL299250A (en) | 2020-06-24 | 2023-02-01 | Kempharm Denmark As | Arimoclomol for the treatment of Gaucher disease |
| CN112094878A (zh) * | 2020-08-18 | 2020-12-18 | 周银根 | 一种二步酶提取香菇多糖的方法、香菇多糖提取物及其应用 |
| US20230416224A1 (en) | 2020-11-19 | 2023-12-28 | Zevra Denmark A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
| MX2023007551A (es) | 2020-12-24 | 2023-09-04 | Zevra Denmark As | Arimoclomol para el tratamiento de la enfermedad de niemann pick, tipo c, en pacientes con mutaciones de sentido erroneo de tipo reticulo endoplasmatico (er). |
| KR20240075869A (ko) * | 2021-09-28 | 2024-05-29 | 제브라 덴마크 에이/에스 | 디옥사진 및 gba 관련 질환의 치료에서의 이의 용도 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU177578B (en) * | 1976-08-27 | 1981-11-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing new 0-/3-amino-2-hydroxy-propyl/-amidoxime derivatives |
| DE2651083A1 (de) | 1976-11-09 | 1978-05-18 | Hoechst Ag | Neue o-alkylierte hydroxylamine, verfahren zu ihrer herstellung und ihre verwendung |
| HU207988B (en) | 1988-10-20 | 1993-07-28 | Biorex Kutato Fejlesztoe Kft | Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components |
| HUT54347A (en) | 1989-01-10 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Improved process for producing amidoximes |
| US5334600A (en) * | 1991-07-30 | 1994-08-02 | Ciba-Geigy Corporation | Isoquinolyl substituted hydroxylamine derivatives |
| HU216830B (hu) | 1992-07-21 | 1999-09-28 | BIOREX Kutató és Fejlesztő Rt., | N-[2-Hidroxi-3-amino-propoxi]-amidok és -imidátok, valamint dioxazinok, eljárás ezek előállítására, és a vegyületeket tartalmazó gyógyszerkészítmények |
| DK0758315T3 (da) * | 1994-05-06 | 1999-05-25 | Biorex Kutato Es Fejleszti Rt | Hidtil ukendte hydroximsyrederivater, farmaceutiske sammensætninger indeholdende dem og fremgangsmåde til fremstilling af d |
| HU9502843D0 (en) * | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
-
1995
- 1995-11-02 HU HU9503141A patent/HU222994B1/hu not_active IP Right Cessation
-
1996
- 1996-01-11 UA UA97084081A patent/UA61050C2/uk unknown
- 1996-10-31 HR HR960508A patent/HRP960508B1/xx not_active IP Right Cessation
- 1996-11-01 EP EP96935195A patent/EP0801649B1/en not_active Expired - Lifetime
- 1996-11-01 BR BRPI9607565-1A patent/BR9607565B1/pt not_active IP Right Cessation
- 1996-11-01 NZ NZ320523A patent/NZ320523A/en not_active IP Right Cessation
- 1996-11-01 CN CNB961923059A patent/CN1152871C/zh not_active Expired - Fee Related
- 1996-11-01 AT AT96935195T patent/ATE221880T1/de active
- 1996-11-01 DK DK96935195T patent/DK0801649T3/da active
- 1996-11-01 SK SK881-97A patent/SK284823B6/sk not_active IP Right Cessation
- 1996-11-01 JP JP51717697A patent/JP4531865B2/ja not_active Expired - Fee Related
- 1996-11-01 RS YUP-587/96A patent/RS49981B/sr unknown
- 1996-11-01 TR TR97/00574T patent/TR199700574T1/xx unknown
- 1996-11-01 IL IL12112696A patent/IL121126A/en not_active IP Right Cessation
- 1996-11-01 PL PL96322015A patent/PL195634B1/pl not_active IP Right Cessation
- 1996-11-01 WO PCT/HU1996/000064 patent/WO1997016439A1/en not_active Ceased
- 1996-11-01 DE DE69622840T patent/DE69622840T2/de not_active Expired - Lifetime
- 1996-11-01 ES ES96935195T patent/ES2176502T3/es not_active Expired - Lifetime
- 1996-11-01 CZ CZ19972072A patent/CZ295562B6/cs not_active IP Right Cessation
- 1996-11-01 PT PT96935195T patent/PT801649E/pt unknown
- 1996-11-01 AU AU73263/96A patent/AU720195B2/en not_active Ceased
- 1996-11-01 CA CA002209167A patent/CA2209167C/en not_active Expired - Fee Related
- 1996-11-01 EE EE9700146A patent/EE04239B1/xx not_active IP Right Cessation
- 1996-11-01 US US08/860,582 patent/US6653326B1/en not_active Expired - Lifetime
- 1996-11-01 RU RU97113758/14A patent/RU2206320C2/ru not_active IP Right Cessation
- 1996-11-01 MX MX9704988A patent/MX9704988A/es unknown
- 1996-11-01 SI SI9630518T patent/SI0801649T1/xx unknown
- 1996-11-04 ZA ZA9609249A patent/ZA969249B/xx unknown
-
1997
- 1997-07-01 BG BG101713A patent/BG63944B1/bg unknown
- 1997-07-01 NO NO19973059A patent/NO321140B1/no not_active IP Right Cessation
- 1997-07-02 KR KR97070004575A patent/KR19980700976A/ko active Pending
-
2003
- 2003-07-10 US US10/618,157 patent/US7148239B2/en not_active Expired - Fee Related
- 2003-07-10 US US10/618,162 patent/US7745465B2/en not_active Expired - Fee Related
-
2008
- 2008-10-08 JP JP2008261964A patent/JP2009108048A/ja not_active Withdrawn
-
2010
- 2010-06-25 US US12/823,823 patent/US20100267711A1/en not_active Abandoned