DK2646044T3 - Metoder til at øge den intracellulære aktivitet af Hsp70 - Google Patents
Metoder til at øge den intracellulære aktivitet af Hsp70 Download PDFInfo
- Publication number
- DK2646044T3 DK2646044T3 DK11844130T DK11844130T DK2646044T3 DK 2646044 T3 DK2646044 T3 DK 2646044T3 DK 11844130 T DK11844130 T DK 11844130T DK 11844130 T DK11844130 T DK 11844130T DK 2646044 T3 DK2646044 T3 DK 2646044T3
- Authority
- DK
- Denmark
- Prior art keywords
- hsp70
- methods
- increase
- intracellular activity
- intracellular
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F12/00—Accessing, addressing or allocating within memory systems or architectures
- G06F12/02—Addressing or allocation; Relocation
- G06F12/08—Addressing or allocation; Relocation in hierarchically structured memory systems, e.g. virtual memory systems
- G06F12/0802—Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches
- G06F12/0806—Multiuser, multiprocessor or multiprocessing cache systems
- G06F12/0815—Cache consistency protocols
- G06F12/0831—Cache consistency protocols using a bus scheme, e.g. with bus monitoring or watching means
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F12/00—Accessing, addressing or allocating within memory systems or architectures
- G06F12/02—Addressing or allocation; Relocation
- G06F12/08—Addressing or allocation; Relocation in hierarchically structured memory systems, e.g. virtual memory systems
- G06F12/0802—Addressing of a memory level in which the access to the desired data or data block requires associative addressing means, e.g. caches
- G06F12/0877—Cache access modes
- G06F12/0882—Page mode
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- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
- G06F13/14—Handling requests for interconnection or transfer
- G06F13/16—Handling requests for interconnection or transfer for access to memory bus
- G06F13/1668—Details of memory controller
- G06F13/1673—Details of memory controller using buffers
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F13/00—Interconnection of, or transfer of information or other signals between, memories, input/output devices or central processing units
- G06F13/38—Information transfer, e.g. on bus
- G06F13/40—Bus structure
- G06F13/4063—Device-to-bus coupling
- G06F13/4068—Electrical coupling
- G06F13/4072—Drivers or receivers
- G06F13/4077—Precharging or discharging
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C11/00—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
- G11C11/21—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements
- G11C11/34—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices
- G11C11/40—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors
- G11C11/401—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells
- G11C11/4063—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing
- G11C11/407—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing for memory cells of the field-effect type
- G11C11/4074—Power supply or voltage generation circuits, e.g. bias voltage generators, substrate voltage generators, back-up power, power control circuits
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C11/00—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor
- G11C11/21—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements
- G11C11/34—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices
- G11C11/40—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors
- G11C11/401—Digital stores characterised by the use of particular electric or magnetic storage elements; Storage elements therefor using electric elements using semiconductor devices using transistors forming cells needing refreshing or charge regeneration, i.e. dynamic cells
- G11C11/4063—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing
- G11C11/407—Auxiliary circuits, e.g. for addressing, decoding, driving, writing, sensing or timing for memory cells of the field-effect type
- G11C11/409—Read-write [R-W] circuits
- G11C11/4093—Input/output [I/O] data interface arrangements, e.g. data buffers
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
- G11C7/06—Sense amplifiers; Associated circuits, e.g. timing or triggering circuits
- G11C7/065—Differential amplifiers of latching type
-
- G—PHYSICS
- G11—INFORMATION STORAGE
- G11C—STATIC STORES
- G11C7/00—Arrangements for writing information into, or reading information out from, a digital store
- G11C7/10—Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers
- G11C7/1072—Input/output [I/O] data interface arrangements, e.g. I/O data control circuits, I/O data buffers for memories with random access ports synchronised on clock signal pulse trains, e.g. synchronous memories, self timed memories
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Computer Hardware Design (AREA)
- Zoology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201070520 | 2010-11-30 | ||
PCT/DK2011/050444 WO2012072082A1 (en) | 2010-11-30 | 2011-11-22 | Methods for increasing intracellular activity of hsp70 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2646044T3 true DK2646044T3 (da) | 2019-11-25 |
Family
ID=46171210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11844130T DK2646044T3 (da) | 2010-11-30 | 2011-11-22 | Metoder til at øge den intracellulære aktivitet af Hsp70 |
Country Status (15)
Country | Link |
---|---|
US (4) | US9662375B2 (da) |
EP (2) | EP2646044B1 (da) |
JP (1) | JP2013544263A (da) |
CN (1) | CN103338784A (da) |
AU (1) | AU2011335545A1 (da) |
BR (1) | BR112013013143A2 (da) |
CA (1) | CA2817773A1 (da) |
DK (1) | DK2646044T3 (da) |
ES (1) | ES2753169T3 (da) |
HU (1) | HUE046235T2 (da) |
IL (1) | IL225941A0 (da) |
PL (1) | PL2646044T3 (da) |
PT (1) | PT2646044T (da) |
RU (1) | RU2013125923A (da) |
WO (1) | WO2012072082A1 (da) |
Families Citing this family (38)
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PT2659904E (pt) | 2008-06-26 | 2016-01-22 | Orphazyme Aps | Uso da hsp70 como um regulador da atividade enzimática |
BR112013013143A2 (pt) | 2010-11-30 | 2016-08-23 | Orphazyme Aps | composto, e, método de tratamento de uma doença de armazenagem lisossômica |
US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
JP6023328B2 (ja) * | 2012-07-31 | 2016-11-09 | ザ カトリック ユニバーシティ オブ コリア インダストリー−アカデミック コーオペレイション ファウンデーション | レバミピドを有効成分として含む高脂血症及びこれと関連した疾患の予防または治療用組成物 |
US20160038521A1 (en) * | 2013-03-15 | 2016-02-11 | University Of Iowa Research Foundation | Therapeutic methods |
US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
US9725710B2 (en) | 2014-01-08 | 2017-08-08 | Flodesign Sonics, Inc. | Acoustophoresis device with dual acoustophoretic chamber |
WO2015119989A1 (en) * | 2014-02-04 | 2015-08-13 | New York University | Progranulin (pgrn) and its derivatives for diagnosis and treatment of lysosomal storage diseases |
US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
CA2961097C (en) | 2014-09-15 | 2023-09-26 | Orphazyme Aps | Extended-release pharmaceutical formulation comprising arimoclomol |
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US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
US11420136B2 (en) | 2016-10-19 | 2022-08-23 | Flodesign Sonics, Inc. | Affinity cell extraction by acoustics |
US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
US11390656B2 (en) | 2015-08-04 | 2022-07-19 | New York University | Progranulin (PGRN) fragments and derivatives for treatment or alleviation of lysosomal storage diseases |
EP3442530A1 (en) * | 2016-04-13 | 2019-02-20 | Orphazyme A/S | Heat shock proteins and cholesterol homeostasis |
LT3448382T (lt) | 2016-04-29 | 2021-04-12 | Orphazyme A/S | Arimoklomolis, skirtas su gliukocerebrozidaze susijusiems sutrikimams gydyti |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
CN107022553A (zh) * | 2017-06-08 | 2017-08-08 | 扬州大学 | 芍药hsp70基因及其植物表达载体和应用 |
CA3085784A1 (en) | 2017-12-14 | 2019-06-20 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
WO2019210301A1 (en) * | 2018-04-27 | 2019-10-31 | The Medical College Of Wisconsin, Inc. | Use of lentivector-transduced t-rapa cells for amelioration of lysosomal storage disorders |
TWI808169B (zh) * | 2018-04-30 | 2023-07-11 | 美商阿米庫斯醫療股份有限公司 | 基因治療構築體及使用方法 |
CN112166326A (zh) * | 2018-05-28 | 2021-01-01 | 奥菲泽米有限公司 | Pbmc样本中的hsp70蛋白水平作为疾病的生物标记物 |
US20220087962A1 (en) * | 2019-01-30 | 2022-03-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods for treating age-related diseases or conditions |
CN110974833A (zh) * | 2019-12-02 | 2020-04-10 | 吉林省博大伟业制药有限公司 | 一种单独应用聚普瑞锌治疗萎缩性胃炎药物的医药用途 |
EP4125946A4 (en) * | 2020-03-27 | 2024-04-24 | Univ Texas | MONOCLONAL ANTIBODIES TARGETING HSP70 AND THEIR THERAPEUTIC USES |
WO2022106614A1 (en) | 2020-11-19 | 2022-05-27 | Orphazyme A/S | Processes for preparing arimoclomol citrate and intermediates thereof |
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- 2011-11-22 BR BR112013013143A patent/BR112013013143A2/pt not_active IP Right Cessation
- 2011-11-22 HU HUE11844130A patent/HUE046235T2/hu unknown
- 2011-11-22 JP JP2013541210A patent/JP2013544263A/ja active Pending
- 2011-11-22 AU AU2011335545A patent/AU2011335545A1/en not_active Abandoned
- 2011-11-22 WO PCT/DK2011/050444 patent/WO2012072082A1/en active Application Filing
- 2011-11-22 US US13/885,553 patent/US9662375B2/en active Active
- 2011-11-22 CN CN2011800575624A patent/CN103338784A/zh active Pending
- 2011-11-22 ES ES11844130T patent/ES2753169T3/es active Active
- 2011-11-22 CA CA2817773A patent/CA2817773A1/en not_active Abandoned
- 2011-11-22 DK DK11844130T patent/DK2646044T3/da active
- 2011-11-22 PL PL11844130T patent/PL2646044T3/pl unknown
- 2011-11-22 PT PT118441302T patent/PT2646044T/pt unknown
- 2011-11-22 EP EP11844130.2A patent/EP2646044B1/en active Active
- 2011-11-22 EP EP19193723.4A patent/EP3626255A1/en not_active Withdrawn
- 2011-11-22 RU RU2013125923/10A patent/RU2013125923A/ru not_active Application Discontinuation
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RU2013125923A (ru) | 2015-01-10 |
US20170266263A1 (en) | 2017-09-21 |
BR112013013143A2 (pt) | 2016-08-23 |
HUE046235T2 (hu) | 2020-02-28 |
EP2646044B1 (en) | 2019-08-28 |
PL2646044T3 (pl) | 2020-03-31 |
PT2646044T (pt) | 2019-11-12 |
US20130230506A1 (en) | 2013-09-05 |
ES2753169T3 (es) | 2020-04-07 |
CN103338784A (zh) | 2013-10-02 |
CA2817773A1 (en) | 2012-06-07 |
JP2013544263A (ja) | 2013-12-12 |
EP2646044A1 (en) | 2013-10-09 |
IL225941A0 (en) | 2013-07-31 |
AU2011335545A1 (en) | 2013-06-13 |
EP3626255A1 (en) | 2020-03-25 |
US20220374361A1 (en) | 2022-11-24 |
US10532085B2 (en) | 2020-01-14 |
US9662375B2 (en) | 2017-05-30 |
WO2012072082A1 (en) | 2012-06-07 |
US20200188492A1 (en) | 2020-06-18 |
EP2646044A4 (en) | 2014-08-06 |
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