JPH10506375A - カンプトセシン化合物の水溶性エステル - Google Patents

カンプトセシン化合物の水溶性エステル

Info

Publication number
JPH10506375A
JPH10506375A JP8505140A JP50514096A JPH10506375A JP H10506375 A JPH10506375 A JP H10506375A JP 8505140 A JP8505140 A JP 8505140A JP 50514096 A JP50514096 A JP 50514096A JP H10506375 A JPH10506375 A JP H10506375A
Authority
JP
Japan
Prior art keywords
alkyl
camptothecin
alkoxy
hydrogen
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8505140A
Other languages
English (en)
Japanese (ja)
Inventor
イー ウォール，モンロー
シー ワニ，マンスク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RTI International Inc
Original Assignee
RTI International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RTI International Inc filed Critical RTI International Inc
Publication of JPH10506375A publication Critical patent/JPH10506375A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP8505140A 1994-07-20 1995-07-20 カンプトセシン化合物の水溶性エステル Pending JPH10506375A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/277,642 US5646159A (en) 1994-07-20 1994-07-20 Water-soluble esters of camptothecin compounds
US08/277,642 1994-07-20
PCT/US1995/008786 WO1996002546A1 (en) 1994-07-20 1995-07-20 Water-soluble esters of camptothecin compounds

Publications (1)

Publication Number Publication Date
JPH10506375A true JPH10506375A (ja) 1998-06-23

Family

ID=23061768

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8505140A Pending JPH10506375A (ja) 1994-07-20 1995-07-20 カンプトセシン化合物の水溶性エステル

Country Status (5)

Country Link
US (3) US5646159A (enExample)
EP (1) EP0815113A1 (enExample)
JP (1) JPH10506375A (enExample)
AU (1) AU705792B2 (enExample)
WO (1) WO1996002546A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003519234A (ja) * 1999-12-29 2003-06-17 リサーチ・トライアングル・インスティチュート トポイソメラーゼＩ阻害を有するカンプトテシンβ−アラニンエステル
JP2004529114A (ja) * 2001-03-01 2004-09-24 カリフォルニア パシフィック メディカル センター 窒素を基礎とするカンプトテシン誘導体
JP2005529935A (ja) * 2002-05-31 2005-10-06 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ カンプトテシンの２０位のエステル
JP2006523646A (ja) * 2003-03-18 2006-10-19 アンセルム（アンスティテュ ナシオナル デ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） 化合物および病気に関連する遺伝子の特異的かつ同時阻害のための化合物の使用、および関連薬物
JP2008504235A (ja) * 2004-05-13 2008-02-14 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 細胞分裂阻害剤として７位にて環状ペプチドと接合したカンプトテシン
JP2016531877A (ja) * 2013-09-27 2016-10-13 チャイナ メディカル ユニバーシティ ホスピタル カンプトセシンの新規な２０（ｓ）−スルホニルアミジン誘導体および当該誘導体の強力な抗癌剤としての使用方法

Families Citing this family (44)

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JPH08333370A (ja) * 1995-06-08 1996-12-17 Kyorin Pharmaceut Co Ltd 水に可溶な新規フルオロエチルカンプトテシン誘導体、及びその製造方法
WO1997019085A1 (en) * 1995-11-22 1997-05-29 Research Triangle Institute Camptothecin compounds with combined topoisomerase i inhibition and dna alkylation properties
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6441025B2 (en) * 1996-03-12 2002-08-27 Pg-Txl Company, L.P. Water soluble paclitaxel derivatives
CA2267328A1 (en) 1996-09-30 1998-04-09 Bayer Aktiengesellschaft Glycoconjugates from modified camptothecin derivates (20-o-linkage)
DE19640207A1 (de) * 1996-09-30 1998-04-02 Bayer Ag Glycokonjugate von modifizierten Camptothecin-Derivaten (A- oder B-Ring-Verknüpfung)
ID23424A (id) 1997-05-14 2000-04-20 Bayer Ag Glikokonjugat dari 20(s)-kamptotesin
US6011042A (en) * 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
CA2309652C (en) * 1997-11-10 2013-01-29 Memorial Sloan-Kettering Cancer Center Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol
US6111107A (en) * 1997-11-20 2000-08-29 Enzon, Inc. High yield method for stereoselective acylation of tertiary alcohols
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6268375B1 (en) * 1999-12-29 2001-07-31 Research Triangle Institute 10, 11-difluoromethylenedioxycamptothecin compounds with topoisomerase I inhibition
WO2001052828A2 (en) * 2000-01-18 2001-07-26 University Of Massachusetts Glutamine prevention of delayed-onset irinotecan-induced diarrhea
US20030195161A1 (en) * 2000-03-17 2003-10-16 Bissery Marie Christine Composition comprising camptothecin or a camptothecin derivative and a topoisomerase II inhibitor for the treatment of cancer
US20020077290A1 (en) * 2000-03-17 2002-06-20 Rama Bhatt Polyglutamic acid-camptothecin conjugates and methods of preparation
US6756037B2 (en) 2000-03-31 2004-06-29 Enzon, Inc. Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
US6777387B2 (en) 2000-03-31 2004-08-17 Enzon Pharmaceuticals, Inc. Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
US7220824B1 (en) 2000-08-28 2007-05-22 Bayer Aktiengesellschaft Integrin-mediated drug targeting
US6350756B1 (en) 2001-01-18 2002-02-26 California Pacific Medical Center Camptothecin derivatives
ATE378342T1 (de) * 2001-02-20 2007-11-15 Enzon Inc Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
EP1238678A1 (en) 2001-03-08 2002-09-11 Bayer Aktiengesellschaft Enzyme-activated cytostatic conjugates with integrin ligands
US6703399B2 (en) 2002-05-06 2004-03-09 The Stehlin Foundation For Cancer Research Halo-alkyl esters of camptothecins and methods of treating cancer using these compounds
US6699875B2 (en) * 2002-05-06 2004-03-02 The Stehlin Foundation For Cancer Research Cascade esters of camptothecins and methods of treating cancer using these compounds
AU2003243380A1 (en) * 2002-06-03 2003-12-19 California Pacific Medical Center Nitrogen-based homo-camptothecin derivatives
WO2003101406A1 (en) * 2002-06-03 2003-12-11 California Pacific Medical Center Homo-camptothecin derivatives
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7071204B2 (en) * 2003-06-30 2006-07-04 Research Triangle Institute Camptothecin analogs having an E-ring ketone
WO2005062985A2 (en) * 2003-12-23 2005-07-14 American Bioscience, Inc. Di-ester prodrugs of camptothecin, process for their preparation and their therapeutical applications
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
US7875602B2 (en) * 2005-10-21 2011-01-25 Sutter West Bay Hospitals Camptothecin derivatives as chemoradiosensitizing agents
CN1982313B (zh) * 2005-12-13 2010-12-01 深圳市天和医药科技开发有限公司 10位取代基上含多个有机羧酸基团的喜树碱化合物及其制法与组合物
US8168648B2 (en) 2009-03-06 2012-05-01 Taiwan Liposome Co., Ltd. Camptothecin derivatives and uses thereof
CN103864811A (zh) * 2012-12-13 2014-06-18 天津科技大学 一种新颖的10-羟基喜树碱20位衍生物制备方法及其在抗肿瘤药物中的应用
CN108822120A (zh) * 2018-07-11 2018-11-16 浙江工业大学 Fl118氨基酸盐酸盐及其制备方法与应用
EA202191244A1 (ru) 2018-11-05 2021-10-11 Байер Фарма Акциенгезельшафт Новые цитостатические конъюгаты с лигандами интегрина
US20240423973A1 (en) 2021-10-04 2024-12-26 Vincerx Pharma Gmbh Compounds, pharmaceutical compositions, and methods for the treatment, prevention, or management of hyperproliferative disorders
JP2024536628A (ja) 2021-10-04 2024-10-04 ヴィンセルクス ファーマ ゲーエムベーハー 過剰増殖性障害の処置、予防、または管理のための化合物、医薬組成物、および方法

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5198300A (en) * 1975-02-20 1976-08-30 Kanputoteshin oyobi sonoruijitaino seizoho
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS595188A (ja) * 1982-06-30 1984-01-12 Yakult Honsha Co Ltd １０−ヒドロキシカンプトテシンの製造法
JPS5951287A (ja) * 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS5951289A (ja) * 1982-09-17 1984-03-24 Yakult Honsha Co Ltd 新規な９−置換−カンプトテシン誘導体
JPS6019790A (ja) * 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS6150984A (ja) * 1984-07-05 1986-03-13 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS6185389A (ja) * 1984-10-03 1986-04-30 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS6185319A (ja) * 1984-10-03 1986-04-30 Yakult Honsha Co Ltd 抗腫瘍剤
DE3682874D1 (de) * 1985-10-21 1992-01-23 Daiichi Seiyaku Co Pyranoindolizinderivate und verfahren zu ihrer herstellung.
US5122526A (en) * 1987-03-31 1992-06-16 Research Triangle Institute Camptothecin and analogs thereof and pharmaceutical compositions and method using them
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5244903A (en) * 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5227380A (en) * 1987-03-31 1993-07-13 Research Triangle Institute Pharmaceutical compositions and methods employing camptothecins
US4894456A (en) * 1987-03-31 1990-01-16 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5364858A (en) * 1987-03-31 1994-11-15 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
US5106742A (en) * 1987-03-31 1992-04-21 Wall Monroe E Camptothecin analogs as potent inhibitors of topoisomerase I
US4981968A (en) * 1987-03-31 1991-01-01 Research Triangle Institute Synthesis of camptothecin and analogs thereof
US5049668A (en) * 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
US5122606A (en) * 1987-04-14 1992-06-16 Research Triangle Institute 10,11-methylenedioxy camptothecins
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5225404A (en) * 1989-11-06 1993-07-06 New York University Methods of treating colon tumors with tumor-inhibiting camptothecin compounds
ATE136898T1 (de) * 1991-10-29 1996-05-15 Glaxo Wellcome Inc Wasserlösliche camptothecinderivate
US5559235A (en) * 1991-10-29 1996-09-24 Glaxo Wellcome Inc. Water soluble camptothecin derivatives
US5342947A (en) * 1992-10-09 1994-08-30 Glaxo Inc. Preparation of water soluble camptothecin derivatives
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
GB9320781D0 (en) * 1993-10-08 1993-12-01 Erba Carlo Spa Polymer-bound camptothecin derivatives
US5614529A (en) * 1994-09-22 1997-03-25 Research Triangle Institute Inhibition of plasmodia parasites by camptothecin compounds

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003519234A (ja) * 1999-12-29 2003-06-17 リサーチ・トライアングル・インスティチュート トポイソメラーゼＩ阻害を有するカンプトテシンβ−アラニンエステル
JP2004529114A (ja) * 2001-03-01 2004-09-24 カリフォルニア パシフィック メディカル センター 窒素を基礎とするカンプトテシン誘導体
JP2005529935A (ja) * 2002-05-31 2005-10-06 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ カンプトテシンの２０位のエステル
JP2006523646A (ja) * 2003-03-18 2006-10-19 アンセルム（アンスティテュ ナシオナル デ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル） 化合物および病気に関連する遺伝子の特異的かつ同時阻害のための化合物の使用、および関連薬物
JP2008504235A (ja) * 2004-05-13 2008-02-14 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 細胞分裂阻害剤として７位にて環状ペプチドと接合したカンプトテシン
JP2016531877A (ja) * 2013-09-27 2016-10-13 チャイナ メディカル ユニバーシティ ホスピタル カンプトセシンの新規な２０（ｓ）−スルホニルアミジン誘導体および当該誘導体の強力な抗癌剤としての使用方法

Also Published As

Publication number Publication date
AU705792B2 (en) 1999-06-03
US5916896A (en) 1999-06-29
WO1996002546A1 (en) 1996-02-01
AU3195395A (en) 1996-02-16
EP0815113A4 (enExample) 1998-01-07
EP0815113A1 (en) 1998-01-07
US5646159A (en) 1997-07-08
US6040313A (en) 2000-03-21

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