JPH10109970A5 - - Google Patents
Info
- Publication number
- JPH10109970A5 JPH10109970A5 JP1997224613A JP22461397A JPH10109970A5 JP H10109970 A5 JPH10109970 A5 JP H10109970A5 JP 1997224613 A JP1997224613 A JP 1997224613A JP 22461397 A JP22461397 A JP 22461397A JP H10109970 A5 JPH10109970 A5 JP H10109970A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- bis
- group
- acid guanidide
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19633966:9 | 1996-08-22 | ||
| DE19633966A DE19633966A1 (de) | 1996-08-22 | 1996-08-22 | Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPH10109970A JPH10109970A (ja) | 1998-04-28 |
| JPH10109970A5 true JPH10109970A5 (https=) | 2005-06-02 |
| JP4081159B2 JP4081159B2 (ja) | 2008-04-23 |
Family
ID=7803413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP22461397A Expired - Fee Related JP4081159B2 (ja) | 1996-08-22 | 1997-08-21 | フェニル−置換されたアルケニルカルボン酸グアニジド、それらの製法、医薬または診断剤としてのそれらの使用およびそれらを含有する医薬 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6005010A (https=) |
| EP (1) | EP0825178B1 (https=) |
| JP (1) | JP4081159B2 (https=) |
| KR (1) | KR19980018898A (https=) |
| CN (1) | CN1065861C (https=) |
| AR (1) | AR008305A1 (https=) |
| AT (1) | ATE202338T1 (https=) |
| AU (1) | AU713664B2 (https=) |
| BR (1) | BR9704483A (https=) |
| CA (1) | CA2213714C (https=) |
| CZ (1) | CZ265997A3 (https=) |
| DE (2) | DE19633966A1 (https=) |
| DK (1) | DK0825178T3 (https=) |
| ES (1) | ES2158413T3 (https=) |
| GR (1) | GR3036123T3 (https=) |
| HR (1) | HRP970450B1 (https=) |
| HU (1) | HUP9701416A3 (https=) |
| ID (1) | ID18066A (https=) |
| IL (1) | IL121590A (https=) |
| MX (1) | MX9706380A (https=) |
| NO (1) | NO309468B1 (https=) |
| NZ (1) | NZ328639A (https=) |
| PL (1) | PL321748A1 (https=) |
| PT (1) | PT825178E (https=) |
| RU (1) | RU2193026C2 (https=) |
| SI (1) | SI0825178T1 (https=) |
| SK (1) | SK282632B6 (https=) |
| TR (1) | TR199700827A2 (https=) |
| ZA (1) | ZA977494B (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19633966A1 (de) * | 1996-08-22 | 1998-02-26 | Hoechst Ag | Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19849722A1 (de) * | 1998-10-28 | 2000-05-04 | Aventis Pharma Gmbh | Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| WO2000067756A1 (en) * | 1999-05-07 | 2000-11-16 | The Trustees Of The Universtiy Of Pennsylvania | Methods for controlling intraocular pressure |
| DE19960204A1 (de) * | 1999-12-14 | 2001-06-28 | Aventis Pharma Gmbh | Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10015248A1 (de) * | 2000-03-28 | 2001-10-04 | Merck Patent Gmbh | Bisamidino-Verbindungen als NHE-3 Inhibitoren |
| DE10046993A1 (de) * | 2000-09-22 | 2002-04-11 | Aventis Pharma Gmbh | Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament |
| DE10063294A1 (de) | 2000-12-19 | 2002-07-04 | Aventis Pharma Gmbh | Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10161767A1 (de) * | 2001-12-15 | 2003-06-26 | Merck Patent Gmbh | 2-Guanidino-4-heterocyclyl-chinazoline |
| DE10163239A1 (de) * | 2001-12-21 | 2003-07-10 | Aventis Pharma Gmbh | Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament |
| US20030187045A1 (en) * | 2001-12-21 | 2003-10-02 | Uwe Heinelt | Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic |
| US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
| US20050054705A1 (en) * | 2003-02-04 | 2005-03-10 | Aventis Pharma Deutschland Gmbh | N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them |
| DE10304374A1 (de) * | 2003-02-04 | 2004-08-05 | Aventis Pharma Deutschland Gmbh | Neue substituierte 2-Aminoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10341240A1 (de) | 2003-09-08 | 2005-04-07 | Aventis Pharma Deutschland Gmbh | Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE102005001411A1 (de) | 2005-01-12 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| ATE479679T1 (de) * | 2007-06-28 | 2010-09-15 | Sanofi Aventis Us Llc | Verfahren zur herstellung von n-(2-chlor-4-methyl-3-thienyl)-1h-benzimidazol- 2-amin hydrochlorid und zwischenprodukte dafür |
| KR101169862B1 (ko) * | 2007-10-26 | 2012-07-31 | 제이에스알 가부시끼가이샤 | 액정 배향제, 액정 배향막의 형성 방법 및 액정 표시 소자 |
| BRPI0918502A2 (pt) | 2008-09-02 | 2015-12-01 | Sanofi Aventis | aminoindanos substituídos e análogos dos mesmos, e o uso farmacêutico dos mesmos |
| SI2384318T1 (en) | 2008-12-31 | 2018-03-30 | Ardelyx, Inc. | MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT |
| WO2018129556A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| US20120088737A2 (en) * | 2009-10-02 | 2012-04-12 | Ajinomoto Co., Inc | Novel acyl guanidine derivatives |
| MX366293B (es) | 2012-08-21 | 2019-07-04 | Ardelyx Inc | Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal. |
| US10376481B2 (en) | 2012-08-21 | 2019-08-13 | Ardelyx, Inc. | Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders |
| LT2983667T (lt) | 2013-04-12 | 2019-07-10 | Ardelyx, Inc. | Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai |
| EA201991676A1 (ru) | 2017-01-09 | 2020-01-30 | Арделикс, Инк. | Ингибиторы nhe-опосредованного антипорта |
| CA3049678A1 (en) | 2017-01-09 | 2018-07-12 | Ardelyx, Inc. | Compounds useful for treating gastrointestinal tract disorders |
| CN118440135A (zh) | 2017-08-04 | 2024-08-06 | 阿德利克斯股份有限公司 | 用于治疗高钾血症的甘草次酸衍生物 |
| KR20260004570A (ko) | 2019-02-07 | 2026-01-08 | 알데릭스, 인코포레이티드 | 고칼륨혈증 치료에 사용하기 위한 글리시레틴산 유도체 |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4544670A (en) * | 1982-08-24 | 1985-10-01 | William H. Rorer, Inc. | Method of treating coccidiosis with acyl guanidines |
| DE4328352A1 (de) * | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4421536A1 (de) * | 1994-06-20 | 1995-12-21 | Hoechst Ag | Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19633966A1 (de) * | 1996-08-22 | 1998-02-26 | Hoechst Ag | Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
-
1996
- 1996-08-22 DE DE19633966A patent/DE19633966A1/de not_active Withdrawn
-
1997
- 1997-08-18 DE DE59703851T patent/DE59703851D1/de not_active Expired - Lifetime
- 1997-08-18 SI SI9730153T patent/SI0825178T1/xx unknown
- 1997-08-18 PT PT97114244T patent/PT825178E/pt unknown
- 1997-08-18 AT AT97114244T patent/ATE202338T1/de not_active IP Right Cessation
- 1997-08-18 DK DK97114244T patent/DK0825178T3/da active
- 1997-08-18 ES ES97114244T patent/ES2158413T3/es not_active Expired - Lifetime
- 1997-08-18 EP EP97114244A patent/EP0825178B1/de not_active Expired - Lifetime
- 1997-08-19 HU HU9701416A patent/HUP9701416A3/hu unknown
- 1997-08-20 CN CN97117484A patent/CN1065861C/zh not_active Expired - Fee Related
- 1997-08-20 NZ NZ328639A patent/NZ328639A/xx unknown
- 1997-08-20 TR TR97/00827A patent/TR199700827A2/xx unknown
- 1997-08-20 AR ARP970103787A patent/AR008305A1/es unknown
- 1997-08-20 SK SK1138-97A patent/SK282632B6/sk unknown
- 1997-08-20 US US08/915,329 patent/US6005010A/en not_active Expired - Lifetime
- 1997-08-20 CZ CZ972659A patent/CZ265997A3/cs unknown
- 1997-08-21 ZA ZA9707494A patent/ZA977494B/xx unknown
- 1997-08-21 HR HR970450A patent/HRP970450B1/xx not_active IP Right Cessation
- 1997-08-21 NO NO973850A patent/NO309468B1/no not_active IP Right Cessation
- 1997-08-21 ID IDP972923A patent/ID18066A/id unknown
- 1997-08-21 RU RU97114306/04A patent/RU2193026C2/ru not_active IP Right Cessation
- 1997-08-21 AU AU35192/97A patent/AU713664B2/en not_active Ceased
- 1997-08-21 JP JP22461397A patent/JP4081159B2/ja not_active Expired - Fee Related
- 1997-08-21 IL IL12159097A patent/IL121590A/en not_active IP Right Cessation
- 1997-08-21 MX MX9706380A patent/MX9706380A/es not_active IP Right Cessation
- 1997-08-22 KR KR1019970040115A patent/KR19980018898A/ko not_active Ceased
- 1997-08-22 BR BR9704483A patent/BR9704483A/pt active Search and Examination
- 1997-08-22 CA CA002213714A patent/CA2213714C/en not_active Expired - Fee Related
- 1997-08-22 PL PL97321748A patent/PL321748A1/xx unknown
-
2001
- 2001-06-27 GR GR20010400976T patent/GR3036123T3/el not_active IP Right Cessation
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