HUP9701416A3 - Phenyl-substituted guanidides of alkenyl-carboxylic acids, process for producing them, and pharmaceutical compositions containing them - Google Patents

Phenyl-substituted guanidides of alkenyl-carboxylic acids, process for producing them, and pharmaceutical compositions containing them

Info

Publication number
HUP9701416A3
HUP9701416A3 HU9701416A HUP9701416A HUP9701416A3 HU P9701416 A3 HUP9701416 A3 HU P9701416A3 HU 9701416 A HU9701416 A HU 9701416A HU P9701416 A HUP9701416 A HU P9701416A HU P9701416 A3 HUP9701416 A3 HU P9701416A3
Authority
HU
Hungary
Prior art keywords
guanidides
alkenyl
phenyl
substituted
producing
Prior art date
Application number
HU9701416A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HU9701416D0 publication Critical patent/HU9701416D0/hu
Publication of HUP9701416A2 publication Critical patent/HUP9701416A2/hu
Publication of HUP9701416A3 publication Critical patent/HUP9701416A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
    • C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Surgery (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HU9701416A 1996-08-22 1997-08-19 Phenyl-substituted guanidides of alkenyl-carboxylic acids, process for producing them, and pharmaceutical compositions containing them HUP9701416A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19633966A DE19633966A1 (de) 1996-08-22 1996-08-22 Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (3)

Publication Number Publication Date
HU9701416D0 HU9701416D0 (en) 1997-10-28
HUP9701416A2 HUP9701416A2 (hu) 1998-03-30
HUP9701416A3 true HUP9701416A3 (en) 1998-07-28

Family

ID=7803413

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9701416A HUP9701416A3 (en) 1996-08-22 1997-08-19 Phenyl-substituted guanidides of alkenyl-carboxylic acids, process for producing them, and pharmaceutical compositions containing them

Country Status (29)

Country Link
US (1) US6005010A (https=)
EP (1) EP0825178B1 (https=)
JP (1) JP4081159B2 (https=)
KR (1) KR19980018898A (https=)
CN (1) CN1065861C (https=)
AR (1) AR008305A1 (https=)
AT (1) ATE202338T1 (https=)
AU (1) AU713664B2 (https=)
BR (1) BR9704483A (https=)
CA (1) CA2213714C (https=)
CZ (1) CZ265997A3 (https=)
DE (2) DE19633966A1 (https=)
DK (1) DK0825178T3 (https=)
ES (1) ES2158413T3 (https=)
GR (1) GR3036123T3 (https=)
HR (1) HRP970450B1 (https=)
HU (1) HUP9701416A3 (https=)
ID (1) ID18066A (https=)
IL (1) IL121590A (https=)
MX (1) MX9706380A (https=)
NO (1) NO309468B1 (https=)
NZ (1) NZ328639A (https=)
PL (1) PL321748A1 (https=)
PT (1) PT825178E (https=)
RU (1) RU2193026C2 (https=)
SI (1) SI0825178T1 (https=)
SK (1) SK282632B6 (https=)
TR (1) TR199700827A2 (https=)
ZA (1) ZA977494B (https=)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19633966A1 (de) * 1996-08-22 1998-02-26 Hoechst Ag Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19849722A1 (de) * 1998-10-28 2000-05-04 Aventis Pharma Gmbh Substituierte Phenyl-alkenoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO2000067756A1 (en) * 1999-05-07 2000-11-16 The Trustees Of The Universtiy Of Pennsylvania Methods for controlling intraocular pressure
DE19960204A1 (de) * 1999-12-14 2001-06-28 Aventis Pharma Gmbh Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10015248A1 (de) * 2000-03-28 2001-10-04 Merck Patent Gmbh Bisamidino-Verbindungen als NHE-3 Inhibitoren
DE10046993A1 (de) * 2000-09-22 2002-04-11 Aventis Pharma Gmbh Substituierte Zimtsäureguanidide, Verfahren zur ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltendes Medikament
DE10063294A1 (de) 2000-12-19 2002-07-04 Aventis Pharma Gmbh Substituierte Heterocyclo-Norbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10161767A1 (de) * 2001-12-15 2003-06-26 Merck Patent Gmbh 2-Guanidino-4-heterocyclyl-chinazoline
DE10163239A1 (de) * 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament
US20030187045A1 (en) * 2001-12-21 2003-10-02 Uwe Heinelt Substituted imidazolidines, process for their preparation, and their use as a medicament or diagnostic
US7049333B2 (en) 2002-06-04 2006-05-23 Sanofi-Aventis Deutschland Gmbh Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis
US20050054705A1 (en) * 2003-02-04 2005-03-10 Aventis Pharma Deutschland Gmbh N-substituted (benzoimidazol-2-yl) phenylamines, process for their preparation, their use as medicament or diagnostic aid, and medicament comprising them
DE10304374A1 (de) * 2003-02-04 2004-08-05 Aventis Pharma Deutschland Gmbh Neue substituierte 2-Aminoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10341240A1 (de) 2003-09-08 2005-04-07 Aventis Pharma Deutschland Gmbh Substituierte Thienoimidazole, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE102005001411A1 (de) 2005-01-12 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
ATE479679T1 (de) * 2007-06-28 2010-09-15 Sanofi Aventis Us Llc Verfahren zur herstellung von n-(2-chlor-4-methyl-3-thienyl)-1h-benzimidazol- 2-amin hydrochlorid und zwischenprodukte dafür
KR101169862B1 (ko) * 2007-10-26 2012-07-31 제이에스알 가부시끼가이샤 액정 배향제, 액정 배향막의 형성 방법 및 액정 표시 소자
BRPI0918502A2 (pt) 2008-09-02 2015-12-01 Sanofi Aventis aminoindanos substituídos e análogos dos mesmos, e o uso farmacêutico dos mesmos
SI2384318T1 (en) 2008-12-31 2018-03-30 Ardelyx, Inc. MEASURES AND PROCEDURES FOR THE INHIBITION OF ANTIPORT INHIBITED BY NHE IN THE TREATMENT OF DISEASES RELATED TO STRENGTH OF FLAMMABILITY OR TRADEMARITY WITH SOLO, AND THE EMISSION OF GASTROINTESTINAL TREATMENT
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives
MX366293B (es) 2012-08-21 2019-07-04 Ardelyx Inc Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal.
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
LT2983667T (lt) 2013-04-12 2019-07-10 Ardelyx, Inc. Nhe3 rišantys junginiai ir fosfato pernešimo slopinimo būdai
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
CA3049678A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds useful for treating gastrointestinal tract disorders
CN118440135A (zh) 2017-08-04 2024-08-06 阿德利克斯股份有限公司 用于治疗高钾血症的甘草次酸衍生物
KR20260004570A (ko) 2019-02-07 2026-01-08 알데릭스, 인코포레이티드 고칼륨혈증 치료에 사용하기 위한 글리시레틴산 유도체
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4544670A (en) * 1982-08-24 1985-10-01 William H. Rorer, Inc. Method of treating coccidiosis with acyl guanidines
DE4328352A1 (de) * 1993-08-24 1995-03-02 Hoechst Ag Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4421536A1 (de) * 1994-06-20 1995-12-21 Hoechst Ag Perfluoralkylgruppen tragende phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19633966A1 (de) * 1996-08-22 1998-02-26 Hoechst Ag Phenylsubstituierte Alkenylcarbonsäure-guanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
CN1065861C (zh) 2001-05-16
DK0825178T3 (da) 2001-09-03
AU3519297A (en) 1998-02-26
TR199700827A2 (xx) 1998-03-21
IL121590A (en) 2002-05-23
ATE202338T1 (de) 2001-07-15
BR9704483A (pt) 1998-12-29
JP4081159B2 (ja) 2008-04-23
HRP970450B1 (en) 2003-02-28
PL321748A1 (en) 1998-03-02
SK113897A3 (en) 1998-03-04
HUP9701416A2 (hu) 1998-03-30
CA2213714C (en) 2007-08-14
DE19633966A1 (de) 1998-02-26
GR3036123T3 (en) 2001-09-28
CN1174833A (zh) 1998-03-04
ID18066A (id) 1998-02-26
HU9701416D0 (en) 1997-10-28
RU2193026C2 (ru) 2002-11-20
ES2158413T3 (es) 2001-09-01
CA2213714A1 (en) 1998-02-22
SI0825178T1 (en) 2001-10-31
DE59703851D1 (de) 2001-07-26
AU713664B2 (en) 1999-12-09
NO973850L (no) 1998-02-23
EP0825178B1 (de) 2001-06-20
PT825178E (pt) 2001-10-30
HRP970450A2 (en) 1998-08-31
KR19980018898A (ko) 1998-06-05
JPH10109970A (ja) 1998-04-28
IL121590A0 (en) 1998-02-08
NZ328639A (en) 1999-01-28
EP0825178A1 (de) 1998-02-25
US6005010A (en) 1999-12-21
MX9706380A (es) 1998-02-28
NO973850D0 (no) 1997-08-21
AR008305A1 (es) 1999-12-29
CZ265997A3 (cs) 1998-03-18
SK282632B6 (sk) 2002-10-08
NO309468B1 (no) 2001-02-05
ZA977494B (en) 1998-02-23

Similar Documents

Publication Publication Date Title
HUP9701416A3 (en) Phenyl-substituted guanidides of alkenyl-carboxylic acids, process for producing them, and pharmaceutical compositions containing them
HU9603484D0 (en) Pharmaceutical compositions and process for producing symptom-transduction
HUP0000808A3 (en) Pharmaceutical composition of fenofibrate and method for preparing same
HUP9601529A3 (en) Pyrimidinedion-, pyrimidinetrion-, triazinedion-, tetrahydro-quinazolinedion- derivatives, pharmaceutical compositions containing them, process for producing them and their use
HU9400413D0 (en) Imidazoly-alcenoic acids, pharmaceutical compositions containing them, and process for producing them
HUP9900055A3 (en) 4-aryl-1-phenylalkyl-1,2,3,6-tetrahydropyridin -derivatives, process for producing them and pharmaceutical compositions containing them
HUP9902850A3 (en) Quinazoline derivatives, process for producing them and pharmaceutical compositions containing them
HUP9603433A3 (en) 4-6-diaryl-pyrimidine-derivatives, process for producing them and pharmaceutical compositions containing them
HUP9701264A3 (en) Aminoacid derivatives, process for producing them and pharmaceutical compositions containing them
HUP9901739A3 (en) Aminoisoquinolines and aminothienopyridine derivatives, process for producing thereof and pharmaceutical compositions containing them
ZA984266B (en) Pharmaceutical composition and process of preparation
HUP9901473A3 (en) 2,3-benzodiazepine derivatives, process for producing them and pharmaceutical compositions containing them
HUP0001522A3 (en) Benzoimidazole derivatives, process for producing them and pharmaceutical compositions containing them
HUP9700598A3 (en) Process for producing pharmaceutical composition useful for profilacting and treating pancreatitis
GR3034020T3 (en) Maltitol composition and its process of preparation
HUP0003823A2 (en) Cyanoguanidines process for producing them and pharmaceutical compositions containing them
HUP9602748A2 (en) Novel n-pyrimidinyl-sulfonamides, process for producing them and pharmaceutical compositions containing them
HUP9601331A3 (en) Piperazine- and homopiperazine-derivatives, process for producing them and pharmaceutical compositions containing them
HU9503932D0 (en) Substituted benzol-sulfonyl-ureas and-thioureas, pharmaceutical compositions containing them and process for producing them
HU9503931D0 (en) Substituted benzol-sulfonyl-ureas and -thioureas, pharmaceutical compositions containing them and process for producing them
HUP0004177A3 (en) 4,5-diaryloxazole derivatives, pharmaceutical compositions containing them and process for producing them
HUT49351A (en) Process for producing new condensed diazepinones and pharmaceutical compositions comprising same
HU9400950D0 (en) 4-alkyl-3-chlor-benzenesulfinic acids, 4-alkyl-3-chlor-benzenesulfonylcarboxylic acids, 4-alkyl-3-chlor-alkyl-sulfonylbenzenes and process for preparation of them
HUP9801061A3 (en) Esters of carbapenems, process for producing them and pharmaceutical compositions containing the same
HUP9600218A3 (en) Substituted thiophenyl-sulfonyl-urea- and -thiourea derivatives process for producing them and pharmaceutical compositions containing them