JPH08510455A - １７，２０―リアーゼ阻害活性を有するカルバゾール誘導体 - Google Patents

１７，２０―リアーゼ阻害活性を有するカルバゾール誘導体

Info

Publication number
JPH08510455A
JPH08510455A JP7500181A JP50018195A JPH08510455A JP H08510455 A JPH08510455 A JP H08510455A JP 7500181 A JP7500181 A JP 7500181A JP 50018195 A JP50018195 A JP 50018195A JP H08510455 A JPH08510455 A JP H08510455A
Authority
JP
Japan
Prior art keywords
formula
compound
group
carbazole
ylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7500181A
Other languages
English (en)
Japanese (ja)
Inventor
クライブ チェリー，ピーター
デリック クッカー，ジョン
デビッド サール，アンドリュウ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JPH08510455A publication Critical patent/JPH08510455A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
JP7500181A 1993-05-21 1994-05-19 １７，２０―リアーゼ阻害活性を有するカルバゾール誘導体 Pending JPH08510455A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939310635A GB9310635D0 (en) 1993-05-21 1993-05-21 Chemical compounds
GB9310635.9 1993-05-21
PCT/EP1994/001613 WO1994027989A1 (fr) 1993-05-21 1994-05-19 Derives de carbazole a activite d'inhibition de 17,20-lyase

Publications (1)

Publication Number Publication Date
JPH08510455A true JPH08510455A (ja) 1996-11-05

Family

ID=10736007

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7500181A Pending JPH08510455A (ja) 1993-05-21 1994-05-19 １７，２０―リアーゼ阻害活性を有するカルバゾール誘導体

Country Status (19)

Country Link
EP (1) EP0699196A1 (fr)
JP (1) JPH08510455A (fr)
CN (1) CN1126473A (fr)
AU (1) AU6928794A (fr)
BG (1) BG100154A (fr)
CA (1) CA2162921A1 (fr)
CZ (1) CZ305195A3 (fr)
FI (1) FI955587A0 (fr)
GB (1) GB9310635D0 (fr)
HU (1) HUT73790A (fr)
IL (1) IL109703A0 (fr)
NO (1) NO954681D0 (fr)
OA (1) OA10195A (fr)
PE (1) PE31195A1 (fr)
PL (1) PL311702A1 (fr)
SK (1) SK142495A3 (fr)
TW (1) TW279866B (fr)
WO (1) WO1994027989A1 (fr)
ZA (1) ZA943494B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016515098A (ja) * 2013-02-27 2016-05-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ブロモドメイン阻害剤として有用なカルバゾール化合物

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2170874A1 (fr) * 1993-09-30 1995-04-06 Minoru Okada Derive d'azole et composition pharmaceutique le contenant
WO1996014090A1 (fr) * 1994-11-07 1996-05-17 Janssen Pharmaceutica N.V. Compositions comprenant des carbazoles et des cyclodextrines
WO1996026927A1 (fr) * 1995-03-01 1996-09-06 Yamanouchi Pharmaceutical Co., Ltd. Derives d'imidazole et composition medicinale a base desdits derives
WO1998037070A1 (fr) * 1997-02-21 1998-08-27 Takeda Chemical Industries, Ltd. Composes a anneaux condenses, leur procede de production et leur utilisation
MY134929A (en) 2000-11-17 2008-01-31 Takeda Pharmaceutical Novel imidazole derivatives, production method thereof and use thereof
EP1344777B1 (fr) 2000-11-20 2011-03-16 Takeda Pharmaceutical Company Limited Derives de l'imidazole, leur procede de preparation et leur application
EP1348706B1 (fr) 2000-12-08 2009-08-19 Takeda Pharmaceutical Company Limited Derives thiazole substitues porteurs de groupes 3-pyridyl, procede d'elaboration et leur utilisation
BRPI0611705A2 (pt) * 2005-06-24 2016-11-16 Lilly Co Eli composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso de composto
GB0525323D0 (en) 2005-12-13 2006-01-18 Sterix Ltd Compound
US8093279B2 (en) 2005-12-13 2012-01-10 Gillian Reed, legal representative Compound
CN100586932C (zh) * 2007-01-26 2010-02-03 中国医学科学院医药生物技术研究所 抗肿瘤化合物及其制备方法
DK2445903T3 (da) 2009-06-26 2014-06-23 Novartis Ag 1,3-Disubstituerede imidazolidin-2-on-derivater som CYP17-inhibitorer
EP2531029B1 (fr) * 2010-02-04 2016-10-19 Radius Health, Inc. Modulateurs sélectifs du récepteur des androgènes
ME02474B (fr) 2010-05-12 2017-02-20 Radius Health Inc Schémas thérapeutiques
KR101594660B1 (ko) 2010-08-04 2016-02-16 펠피큐어 파마슈티걸즈 아이엔씨 전립선 암종의 치료를 위한 병용 요법
WO2012035078A1 (fr) 2010-09-16 2012-03-22 Novartis Ag Inhibiteurs de la 17α-hydroxylase/c17,20-lyase
BR112013007685B1 (pt) 2010-09-28 2021-11-09 Radius Pharmaceuticals, Inc Compostos moduladores de receptor andrógeno seletivos, composição farmacêutica compreendendo os referidos compostos, método de identificação de um composto capaz de modular um receptor andrógeno, usos de um composto ou da composição e processo para a preparação de um composto
CN103649073B (zh) 2011-04-28 2016-04-13 诺瓦提斯公司 17α-羟化酶/C17,20-裂合酶抑制剂
US20160022606A1 (en) 2013-03-14 2016-01-28 Pellficure Pharmaceuticals Inc. Novel therapy for prostate carcinoma
EP4035664A3 (fr) 2014-03-28 2022-11-30 Duke University Traitement du cancer faisant intervenir des modulateurs sélectifs des récepteurs des strogènes
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
WO2016040896A1 (fr) 2014-09-12 2016-03-17 Pellficure Pharmaceuticals, Inc. Compositions et méthodes de traitement d'un carcinome de la prostate
RU2769527C2 (ru) 2016-06-22 2022-04-01 Эллипсес Фарма Лтд Способы лечения ar+ рака молочной железы
CA3044812A1 (fr) 2016-10-24 2018-05-03 Pellficure Pharmaceuticals Inc. Compositions pharmaceutiques de 5-hydroxy-2-methylnaphtalene-1, 4-dione
KR102322802B1 (ko) 2017-01-05 2021-11-04 래디어스 파마슈티컬스, 인코포레이티드 Rad1901-2hcl의 다형 형태

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS229934B2 (en) * 1981-07-07 1984-07-16 Pfizer Production method subst.indolylacryte acid derivative
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016515098A (ja) * 2013-02-27 2016-05-26 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ブロモドメイン阻害剤として有用なカルバゾール化合物

Also Published As

Publication number Publication date
PL311702A1 (en) 1996-03-04
NO954681L (no) 1995-11-20
EP0699196A1 (fr) 1996-03-06
TW279866B (fr) 1996-07-01
AU6928794A (en) 1994-12-20
IL109703A0 (en) 1994-08-26
OA10195A (en) 1996-12-18
GB9310635D0 (en) 1993-07-07
FI955587A (fi) 1995-11-20
HUT73790A (en) 1996-09-30
NO954681D0 (no) 1995-11-20
CN1126473A (zh) 1996-07-10
ZA943494B (en) 1995-01-23
CA2162921A1 (fr) 1994-12-08
PE31195A1 (es) 1995-10-18
WO1994027989A1 (fr) 1994-12-08
HU9503321D0 (en) 1996-01-29
BG100154A (en) 1996-07-31
CZ305195A3 (en) 1996-06-12
SK142495A3 (en) 1996-06-05
FI955587A0 (fi) 1995-11-20

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