JPH08504409A - アミノメチルインダン、‐ベンゾフラン及び‐ベンゾチオフエン - Google Patents
アミノメチルインダン、‐ベンゾフラン及び‐ベンゾチオフエンInfo
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- JPH08504409A JPH08504409A JP6513690A JP51369094A JPH08504409A JP H08504409 A JPH08504409 A JP H08504409A JP 6513690 A JP6513690 A JP 6513690A JP 51369094 A JP51369094 A JP 51369094A JP H08504409 A JPH08504409 A JP H08504409A
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
- C07C211/60—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton containing a ring other than a six-membered aromatic ring forming part of at least one of the condensed ring systems
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- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/80—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
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- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
- C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
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- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
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- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
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- C07C2601/00—Systems containing only non-condensed rings
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- C07C2601/14—The ring being saturated
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Cardiology (AREA)
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- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fats And Perfumes (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.一般式I 〔式中X及びYのうちの1つはCH2であり、もう1つはCH2,O及びSより 成る群から選ばれる; R1は低級アルキル、低級アルケニル、低級アルキニル、シクロアル(キ/ ケニ)ル、シルロアル(キ/ケニ)ル-低級アル(ケニ/キニ)ル、アリール-低 級アルキル、アシル、低級-アルキルスルホニル、トリフルオロメチルスルホニ ル、アリールスルホニル、R10ZCO-(式中ZはO又はSであり、R10はアル キル、アルケニル、アルキニル、シクロアル(キ/ケニ)ル、シクロアル(キ/ ケニ)ルアルキル、又はアリールである。)又はR11R12NCO-(式中R11及 びR12は独立して水素、アルキル、アルケニル、アルキニル、シクロアル(キ/ ケニ)ル、シクロアル(キ/ケニル)ルアル(キ/ケニ/キニ)ル、又はアリー ルである。)より成る群から選ばれる; R2は水素、低級アルキル、低級アルケニル、低級アルキニル、シクロアル (キ/ケニ)ル、シクロアル(キ/ケニ)ル-低級アル(キ/ケニ/キニ)ル、 アリール-低級アルキルより成る群から選ばれる; R3-R5は水素、ハロゲン、低級アルキル、低級アルコキシ、アシル、低級 アルキルチオ、ヒドロキシ、低級アルキルスルホニル、シアノ、トリフルオロメ チル、シクロアルキル、シクロアルキルアルキル又はニトロより成る群から選ば れる;R6及びR7は夫々水素又は低級アルキルあるいはこれらが一緒になって連 結し、3〜7員成炭素環状環を形成する; R8及びR9は独立して水素、アルキル、アルケニル、アルキニル、シクロア ル(キ/ケニ)ル、シクロアル(キ/ケニ)ル-アル(キ/ケニ/キニ)ル、ア リールアルキル又は基 (式中R3は水素、低級アルキル、低級アルケニル、低級アルキニル、シ クロアル(キ/ケニ)ル-低級アル(キ/ケニ/キニ)ル、アリール-低級アルキ ル又はアリールであり、WはO又はS,rは2〜6である)である; R8及びR9は一緒になって連結し、窒素原子1個を有する3〜7員成環を形 成する; 但し、存在するアルキル-、シクロアルキル-又はシクロアルキルアルキル基 のいずれもヒドロキシ基1又は二個で場合により置換され、このヒドロキシ基は 場合により更に脂肪族又は芳香族カルボン酸でエステル化される;そして存在す るアリールのいずれもハロゲン、低級アルキル、低級アルコキシ、低級アルキル チオ、ヒドロキシ、低級アルキルスルホニル、シアノ、トリフルオロメチル、シ クロアルキル、シクロアルキルアルキル又はニトロによって場合により置換され ている。〕 の化合物及びその薬学的に容認された酸付加塩。 2.XはCH2、O又はS、YはCH2である、請求の範囲1記載の化合物。 3.R1はアルキル-低級アルキル基、アシル基、低級アルキルスルホニル基又は 基R11R12N-CO-(式中R11は水素又は低級アルキルであり、R12は水素、ア ルキル、アリール又はシクロアルキルである。)であり、R2は水素又は低級ア ルキルである、請求の範囲1記載の化合物。 4.R1はベンジル又は置換されたベンジル、ホルミル、アルキルカルボニル、 アリールカルボニル又は基R11R12N-CO-(式中R11は水素又は低級アル キル、R12は水素、低級アルキル、フエニル、置換されたフエニル又はC5-6シ クロアルキルである。)である、請求の範囲3記載の化合物。 5.R3,R4,R5の夫々は水素又はハロゲンであり、R6及びR7はともに水素 である、請求の範囲1ないし4のいずれかに記載した化合物。 6.R8は水素又は低級アルキルであり、R9は低級アルキル、アリール-低級ア ルキル、シクロアルキル-低級アルキル又は請求の範囲1に示した式1aの基( 式中WはO、R13は水素、低級アルキル、シクロアルキル又はアリールである。 )あるいはR8及びR9は連結して窒素原子1個を有するC3-C7員環を形成する 、請求の範囲1記載の化合物。 7.R9はフエニル-低級アルキル、置換されたフエニル-低級アルキル、インド リル-低級アルキル、シクロヘキシル-低級アルキル又は式1aの基(式中WはO 、R13は水素又は低級アルキル、シクロアルキル、フエニル又は置換されたフエ ニル基である。)であり、あるいはR8及びR9は連結して、ピロリジン又はピペ リジンを形成する、請求の範囲6記載の化合物。 8.請求の範囲1記載の新規化合物又はその薬学的に容認された酸付加塩少なく とも1個を治療上有効な量で及び薬学的に容認されたキャリヤー又は希釈剤1種 又はそれ以上と組合せて含有する、医薬。 9.請求の範囲1記載の化合物又はその酸付加塩を、精神病、不安障害、うつ病 、インパルスコントロール障害、アルコール乱用、攻撃性、虚血疾患、通常の抗 精神病剤によって誘発される副作用又は心臓血管障害の治療用医薬の製造に使用 する方法。 10.治療上有効な量で請求の範囲1記載の新規化合物又はその薬学的に容認さ れた酸付加塩をこれを必要とする人に投与する、精神病、不安障害、うつ病、イ ンパルスコントロール障害、アルコール乱用、攻撃性、虚血疾患、通常の抗精神 病剤によって誘発される副作用又は心臓血管障害の治療方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK921482A DK148292D0 (da) | 1992-12-09 | 1992-12-09 | Forbindelser |
DK1482/92 | 1992-12-09 | ||
PCT/DK1993/000413 WO1994013620A1 (en) | 1992-12-09 | 1993-12-08 | Aminomethylindans, -benzofuranes and -benzothiophenes |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08504409A true JPH08504409A (ja) | 1996-05-14 |
JP3731827B2 JP3731827B2 (ja) | 2006-01-05 |
Family
ID=8105305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51369094A Expired - Fee Related JP3731827B2 (ja) | 1992-12-09 | 1993-12-08 | アミノメチルインダン、‐ベンゾフラン及び‐ベンゾチオフエン |
Country Status (21)
Country | Link |
---|---|
US (2) | US5807889A (ja) |
EP (1) | EP0673360B1 (ja) |
JP (1) | JP3731827B2 (ja) |
KR (1) | KR100357976B1 (ja) |
AT (1) | ATE170168T1 (ja) |
AU (1) | AU675262B2 (ja) |
CA (1) | CA2151377C (ja) |
CZ (1) | CZ289820B6 (ja) |
DE (1) | DE69320652T2 (ja) |
DK (2) | DK148292D0 (ja) |
ES (1) | ES2119991T3 (ja) |
FI (1) | FI114464B (ja) |
HU (1) | HU225111B1 (ja) |
IL (1) | IL107805A0 (ja) |
NO (1) | NO304686B1 (ja) |
NZ (1) | NZ258116A (ja) |
RU (1) | RU2141474C1 (ja) |
SG (1) | SG48233A1 (ja) |
SK (1) | SK281014B6 (ja) |
WO (1) | WO1994013620A1 (ja) |
ZA (1) | ZA939204B (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011503122A (ja) * | 2007-11-16 | 2011-01-27 | 江▲蘇▼恒瑞医▲薬▼股▲分▼有限公司 | 4,5−ジメトキシ−1−(メチルアミノメチル)−ベンゾシクロブタンの分離 |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9614347D0 (en) * | 1996-07-09 | 1996-09-04 | Smithkline Beecham Spa | Novel compounds |
FR2752839B1 (fr) * | 1996-08-29 | 1998-10-09 | Synthelabo | Derives de benzofurane, leur preparation et leur application en therapeutique |
DE19642451A1 (de) * | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
US7053092B2 (en) | 2001-01-29 | 2006-05-30 | Otsuka Pharmaceutical Co., Ltd. | 5-HT1a receptor subtype agonist |
AR032641A1 (es) * | 2001-01-29 | 2003-11-19 | Otsuka Pharma Co Ltd | Agonista de subtipo de receptor 5-ht 1a. |
US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
US8703772B2 (en) | 2001-09-25 | 2014-04-22 | Otsuka Pharmaceutical Co., Ltd. | Low hygroscopic aripiprazole drug substance and processes for the preparation thereof |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
WO2006133339A2 (en) * | 2005-06-07 | 2006-12-14 | Neurocrine Biosciences, Inc. | Monoamine re-uptake inhibitors and methods relating thereto |
EP2063905B1 (en) | 2006-09-18 | 2014-07-30 | Raptor Pharmaceutical Inc | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
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DE2322470A1 (de) * | 1973-05-04 | 1974-11-21 | Boehringer Sohn Ingelheim | Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung |
FR2391211A2 (fr) * | 1977-05-18 | 1978-12-15 | Roussel Uclaf | Nouveaux derives de 2,3-dihydroa(4-(3-indolyl) 1-piperidinyl) methyl 1,4-benzodioxin-2-methanol, un procede de preparation, et leur application comme medicaments |
DE2827874A1 (de) * | 1978-06-24 | 1980-02-07 | Merck Patent Gmbh | Indolalkylamine und verfahren zu ihrer herstellung |
GB2093837B (en) * | 1981-03-02 | 1985-04-24 | Abbott Lab | Aminoalkyl subsituted 1,2,3,4-tetrahydronaphtalenes |
US4500543A (en) * | 1982-06-01 | 1985-02-19 | Abbott Laboratories | Substituted 1-aminomethyl-phthalans |
FR2533924A1 (fr) * | 1982-10-05 | 1984-04-06 | Roussel Uclaf | Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant |
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GB8610909D0 (en) * | 1986-05-03 | 1986-06-11 | Beecham Group Plc | Compounds |
GB8704572D0 (en) * | 1987-02-26 | 1987-04-01 | Lundbeck & Co As H | Organic compounds |
GB8707122D0 (en) * | 1987-03-25 | 1987-04-29 | Pfizer Ltd | Antiarrhythmic agents |
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GB8820651D0 (en) * | 1988-09-01 | 1988-10-05 | Glaxo Group Ltd | Medicaments |
US5225596A (en) * | 1989-01-09 | 1993-07-06 | The Upjohn Company | Halo substituted aminotetralins |
DE3919624A1 (de) * | 1989-06-15 | 1990-12-20 | Boehringer Ingelheim Kg | Neue 2,5-diaminotetraline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
DE3924365A1 (de) * | 1989-07-22 | 1991-01-24 | Boehringer Ingelheim Kg | 2-amino-7-carbamoyl-1,2,3,4- tetrahydronaphthaline, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DK152090D0 (da) * | 1990-06-22 | 1990-06-22 | Lundbaek A S H | Piperidylsubstituerede indolderivater |
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Cited By (1)
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JP2011503122A (ja) * | 2007-11-16 | 2011-01-27 | 江▲蘇▼恒瑞医▲薬▼股▲分▼有限公司 | 4,5−ジメトキシ−1−(メチルアミノメチル)−ベンゾシクロブタンの分離 |
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