JPH07505767A - ヒトインターロイキン−５に対するヒト化モノクローナル抗体の設計，クローン化および発現 - Google Patents

ヒトインターロイキン−５に対するヒト化モノクローナル抗体の設計，クローン化および発現

Info

Publication number
JPH07505767A
JPH07505767A JP5514104A JP51410493A JPH07505767A JP H07505767 A JPH07505767 A JP H07505767A JP 5514104 A JP5514104 A JP 5514104A JP 51410493 A JP51410493 A JP 51410493A JP H07505767 A JPH07505767 A JP H07505767A
Authority
JP
Japan
Prior art keywords
antibody
sequence
seq
human
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5514104A
Other languages
English (en)
Japanese (ja)
Inventor
チョウ，チュアン−チュー
マーゴールド，ニコラス・ジェイ
エイブラムス，ジョン・エス
ジェン，チュン−ハー
ペトロ，メアリー・イー
シルヴァー，ジョン・イー
ティンダル，スティーブン
ウインザー，ウィリアム・ティー
ザヴォドニー，ポール・ジェイ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JPH07505767A publication Critical patent/JPH07505767A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP5514104A 1992-02-06 1993-02-04 ヒトインターロイキン−５に対するヒト化モノクローナル抗体の設計，クローン化および発現 Pending JPH07505767A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83284292A 1992-02-06 1992-02-06
US832,842 1992-02-06
PCT/US1993/000759 WO1993016184A1 (en) 1992-02-06 1993-02-04 Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP11321698A Division JP2000210097A (ja) 1992-02-06 1999-11-11 ヒトインターロイキン−５に対する組換えモノクローナル抗体およびその可変領域を含む組換えポリペプチドおよびその発現

Publications (1)

Publication Number Publication Date
JPH07505767A true JPH07505767A (ja) 1995-06-29

Family

ID=25262763

Family Applications (2)

Application Number Title Priority Date Filing Date
JP5514104A Pending JPH07505767A (ja) 1992-02-06 1993-02-04 ヒトインターロイキン−５に対するヒト化モノクローナル抗体の設計，クローン化および発現
JP11321698A Pending JP2000210097A (ja) 1992-02-06 1999-11-11 ヒトインターロイキン−５に対する組換えモノクローナル抗体およびその可変領域を含む組換えポリペプチドおよびその発現

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP11321698A Pending JP2000210097A (ja) 1992-02-06 1999-11-11 ヒトインターロイキン−５に対する組換えモノクローナル抗体およびその可変領域を含む組換えポリペプチドおよびその発現

Country Status (21)

Country Link
US (1) US6451982B1 (enExample)
EP (1) EP0625201A1 (enExample)
JP (2) JPH07505767A (enExample)
KR (2) KR0150060B1 (enExample)
CN (1) CN1077991A (enExample)
AR (1) AR248044A1 (enExample)
AU (1) AU683836B2 (enExample)
CA (1) CA2129445A1 (enExample)
CZ (1) CZ291039B6 (enExample)
FI (1) FI943635A7 (enExample)
HU (1) HUT67943A (enExample)
IL (1) IL104620A (enExample)
NO (1) NO942912L (enExample)
NZ (1) NZ249633A (enExample)
PL (1) PL176393B1 (enExample)
RU (1) RU94045919A (enExample)
SG (1) SG49597A1 (enExample)
SK (1) SK280610B6 (enExample)
TN (1) TNSN93012A1 (enExample)
WO (1) WO1993016184A1 (enExample)
ZA (1) ZA93779B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002523379A (ja) * 1998-08-19 2002-07-30 味の素株式会社 抗血栓薬およびヒト化抗フォンビルブランド因子モノクローナル抗体
JP2008500274A (ja) * 2003-12-24 2008-01-10 レイ・ライン・ジェノミクス・ソシエタ・ペル・アツィオーニ 抗体のヒト化の方法およびそれによって得られるヒト化抗体
JP2014503209A (ja) * 2010-12-22 2014-02-13 テバ ファーマシューティカルズ オーストラリア プロプライアタリー リミティド 改善された半減期を有する修飾された抗体

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IL104620A (en) 1992-02-06 2000-02-29 Schering Plough Corp Humanized monoclonal antibodies against human interleukin-5
GB9412230D0 (en) 1994-06-17 1994-08-10 Celltech Ltd Interleukin-5 specific recombiant antibodies
USRE39548E1 (en) * 1994-06-17 2007-04-03 Celltech R&D Limited Interleukin-5 specific recombinant antibodies
US6056957A (en) * 1994-08-04 2000-05-02 Schering Corporation Humanized monoclonal antibodies against human interleukin-5
US7399837B2 (en) 1995-12-22 2008-07-15 Smithkline Beecham Corporation Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
US5683892A (en) * 1994-12-23 1997-11-04 Smithkline Beecham Corporation DNA encoding recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders
EP0800536B1 (en) * 1994-12-23 2006-11-29 Smithkline Beecham Corporation Recombinant il-5 antagonists useful in treatment of il-5 mediated disorders
US5683983A (en) * 1995-06-07 1997-11-04 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5654276A (en) * 1995-06-07 1997-08-05 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
US5677280A (en) * 1995-06-07 1997-10-14 Glaxo Group Limited Peptides and compounds that bind to the IL-5 receptor
US5668110A (en) * 1995-06-07 1997-09-16 Affymax Technologies N.V. Peptides and compounds that bind to the IL-5 receptor
CA2205007C (en) 1995-09-11 2010-12-14 Masamichi Koike Antibody against human interleukin-5 receptor .alpha. chain
US7109299B1 (en) 1999-12-16 2006-09-19 Affymax, Inc. Peptides and compounds that bind to the IL-5 receptor
KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
ES2327830T3 (es) 2002-03-29 2009-11-04 Schering Corporation Anticuerpos monoclonales humanos anti-interleuquina-5 y metodos y composiciones que los contienen.
US7927840B2 (en) * 2006-09-11 2011-04-19 Gen Probe Incorporated Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region
EP3241915B1 (en) * 2002-10-16 2021-06-23 Gen-Probe Incorporated Compositions and methods for detecting west nile virus
BRPI0317376B8 (pt) 2002-12-17 2021-05-25 Merck Patent Gmbh proteína de fusão de anticorpo-il2 designada como hu14.18-il2, usos da mesma, vetor e composição farmacêutica
JP4954709B2 (ja) 2004-10-28 2012-06-20 協和発酵キリン株式会社 子宮内膜症治療剤
EP3072522B1 (en) 2005-01-06 2019-04-24 Novo Nordisk A/S Anti-kir combination treatments and methods
WO2006099875A1 (en) 2005-03-23 2006-09-28 Genmab A/S Antibodies against cd38 for treatment of multiple myeloma
ITRM20050290A1 (it) 2005-06-07 2006-12-08 Lay Line Genomics Spa Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
EP2606906A1 (en) 2007-04-30 2013-06-26 GlaxoSmithKline LLC Methods for administering anti-IL-5 antibodies
CA2719786A1 (en) 2008-03-28 2009-10-01 Glaxosmithkline Llc Methods of treatment
AU2009306708A1 (en) * 2008-10-23 2010-04-29 F. Hoffmann-La Roche Ag Determination of immunoglobulin encoding nucleid acid
EP2791172B1 (en) 2011-12-16 2017-07-19 Synthon Biopharmaceuticals B.V. Compounds and methods for treating inflammatory diseases
US9677018B2 (en) 2013-01-09 2017-06-13 Thyssenkrupp Industrial Solutions Ag Process for the production of synthesis gas from hard coal
HUE050202T2 (hu) 2014-09-08 2020-11-30 Cephalon Inc Reslizumab alkalmazása közepestõl súlyosig terjedõ eozinofil asztma kezelésére
KR20240099511A (ko) 2015-08-24 2024-06-28 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 생물제약 조성물
EP3634467A4 (en) 2017-06-06 2021-07-28 GlaxoSmithKline LLC BIOPHARMACEUTICAL COMPOSITIONS AND METHODS FOR PEDIATRIC PATIENTS
JP2019026625A (ja) * 2017-08-03 2019-02-21 日本全薬工業株式会社 抗イヌｃｄ２０モノクローナル抗体
US11224653B2 (en) 2017-08-24 2022-01-18 Cephalon, Inc. Treatment strategy for non-responders to 100MG subcutaneous mepolizumab
MX2020003034A (es) * 2017-09-29 2020-07-22 Jiangsu Hengrui Medicine Co Anticuerpo il-5, fragmento de union a antigeno del mismo y su aplicacion medica.
CN109942706A (zh) * 2017-12-21 2019-06-28 三生国健药业（上海）股份有限公司 结合人il-5的单克隆抗体、其制备方法和用途
TW202535949A (zh) 2023-12-20 2025-09-16 美商必治妥美雅史谷比公司 靶向IL-18受體β(IL-18RB)之抗體及相關方法

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GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5091513A (en) 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
GB8720833D0 (en) 1987-09-04 1987-10-14 Celltech Ltd Recombinant dna product
US5096704A (en) 1988-11-03 1992-03-17 Schering Corporation Method of treating eosinophilia
ZA898322B (en) * 1988-11-03 1990-11-28 Schering Corp Method of preventing or reducing eosinophilia
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
CA2041271A1 (en) * 1990-04-30 1991-10-31 Bradford A. Jameson Peptide analogs to proteins of the immunoglobin superfamily
IL104620A (en) 1992-02-06 2000-02-29 Schering Plough Corp Humanized monoclonal antibodies against human interleukin-5

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002523379A (ja) * 1998-08-19 2002-07-30 味の素株式会社 抗血栓薬およびヒト化抗フォンビルブランド因子モノクローナル抗体
JP2008500274A (ja) * 2003-12-24 2008-01-10 レイ・ライン・ジェノミクス・ソシエタ・ペル・アツィオーニ 抗体のヒト化の方法およびそれによって得られるヒト化抗体
JP2014503209A (ja) * 2010-12-22 2014-02-13 テバ ファーマシューティカルズ オーストラリア プロプライアタリー リミティド 改善された半減期を有する修飾された抗体

Also Published As

Publication number Publication date
EP0625201A1 (en) 1994-11-23
SK91894A3 (en) 1995-02-08
IL104620A0 (en) 1993-06-10
KR950700413A (ko) 1995-01-16
FI943635A0 (fi) 1994-08-05
SG49597A1 (en) 1998-06-15
FI943635L (fi) 1994-08-05
NO942912D0 (enExample) 1994-08-05
CZ291039B6 (cs) 2002-12-11
IL104620A (en) 2000-02-29
CZ191094A3 (en) 1994-12-15
RU94045919A (ru) 1996-11-10
AU683836B2 (en) 1997-11-27
FI943635A7 (fi) 1994-08-05
CA2129445A1 (en) 1993-08-07
NZ249633A (en) 1995-12-21
AR248044A1 (es) 1995-05-31
JP2000210097A (ja) 2000-08-02
HUT67943A (en) 1995-05-29
HU9402293D0 (en) 1994-10-28
PL176393B1 (pl) 1999-05-31
WO1993016184A1 (en) 1993-08-19
KR0150060B1 (ko) 1998-08-17
NO942912L (no) 1994-10-06
CN1077991A (zh) 1993-11-03
AU3656093A (en) 1993-09-03
ZA93779B (en) 1993-08-05
US6451982B1 (en) 2002-09-17
TNSN93012A1 (fr) 1994-03-17
SK280610B6 (sk) 2000-05-16

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