JPH0631300B6 - - Google Patents

Info

Publication number
JPH0631300B6
JPH0631300B6 JP1988168637A JP16863788A JPH0631300B6 JP H0631300 B6 JPH0631300 B6 JP H0631300B6 JP 1988168637 A JP1988168637 A JP 1988168637A JP 16863788 A JP16863788 A JP 16863788A JP H0631300 B6 JPH0631300 B6 JP H0631300B6
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1988168637A
Other languages
Japanese (ja)
Other versions
JPH0631300B2 (ja
JPS6438096A (en
Filing date
Publication date
Priority claimed from PCT/US1987/001612 external-priority patent/WO1989000576A1/en
Application filed filed Critical
Publication of JPS6438096A publication Critical patent/JPS6438096A/ja
Publication of JPH0631300B2 publication Critical patent/JPH0631300B2/ja
Application granted granted Critical
Publication of JPH0631300B6 publication Critical patent/JPH0631300B6/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP63168637A 1987-07-09 1988-07-06 結晶性アジスロマイシン2水和物及びその製法 Expired - Lifetime JPH0631300B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
WO87/1612 1987-07-09
PCT/US1987/001612 WO1989000576A1 (en) 1987-07-09 1987-07-09 Azithromycin dihydrate

Publications (3)

Publication Number Publication Date
JPS6438096A JPS6438096A (en) 1989-02-08
JPH0631300B2 JPH0631300B2 (ja) 1994-04-27
JPH0631300B6 true JPH0631300B6 (en:Method) 2006-10-11

Family

ID=22202456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63168637A Expired - Lifetime JPH0631300B2 (ja) 1987-07-09 1988-07-06 結晶性アジスロマイシン2水和物及びその製法

Country Status (45)

Country Link
US (1) US6268489B1 (en:Method)
EP (1) EP0298650B1 (en:Method)
JP (1) JPH0631300B2 (en:Method)
KR (1) KR900006218B1 (en:Method)
CN (1) CN1016785B (en:Method)
AP (1) AP44A (en:Method)
AR (1) AR243532A1 (en:Method)
AT (1) ATE72446T1 (en:Method)
AU (1) AU604553B2 (en:Method)
BA (1) BA98213B1 (en:Method)
BG (1) BG47348A3 (en:Method)
CA (1) CA1314876C (en:Method)
CS (1) CS272241B2 (en:Method)
CY (1) CY1776A (en:Method)
DD (1) DD271705A5 (en:Method)
DE (1) DE3868296D1 (en:Method)
DK (1) DK172573B1 (en:Method)
EG (1) EG18527A (en:Method)
ES (1) ES2038756T3 (en:Method)
FI (1) FI91263C (en:Method)
GR (1) GR3003737T3 (en:Method)
HK (1) HK127594A (en:Method)
HU (1) HU211862A9 (en:Method)
IE (1) IE60354B1 (en:Method)
IL (1) IL86979A (en:Method)
IN (1) IN168879B (en:Method)
IS (1) IS1540B (en:Method)
LV (1) LV10624B (en:Method)
MA (1) MA21323A1 (en:Method)
MX (1) MX12213A (en:Method)
MY (1) MY103744A (en:Method)
NO (1) NO171556C (en:Method)
NZ (1) NZ225338A (en:Method)
OA (1) OA08743A (en:Method)
PH (1) PH30953A (en:Method)
PL (1) PL157145B1 (en:Method)
PT (1) PT87933B (en:Method)
RO (1) RO107257B1 (en:Method)
RU (1) RU2066324C1 (en:Method)
SG (1) SG27794G (en:Method)
SI (1) SI8811325A8 (en:Method)
UA (1) UA27040C2 (en:Method)
WO (1) WO1989000576A1 (en:Method)
YU (1) YU45075B (en:Method)
ZA (1) ZA884925B (en:Method)

Families Citing this family (78)

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US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0539223A1 (en) * 1991-10-25 1993-04-28 Ono Pharmaceutical Co., Ltd. Glycine derivative monosodium salt tetrahydrate having an inhibitory effect on elastase
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) * 1993-12-10 1997-04-30 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
US6068859A (en) 1994-05-06 2000-05-30 Pfizer Inc. Controlled-release dosage forms of Azithromycin
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
SI1437359T1 (sl) * 1997-10-16 2007-06-30 Glaxosmithkline Zagreb Novi 3,6-hemiketali iz razreda 9a-azalidov
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) * 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2229804T3 (es) * 1998-11-30 2005-04-16 Teva Pharmaceutical Industries Ltd. Etannolato de azitromicina, procedimiento para su fabricacion y composiciones farmaceuticas que lo contienen.
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
ES2302689T3 (es) * 1999-05-18 2008-08-01 Pfizer Products Inc. Nuevas formas cristalinas de un antibiotico macrolido.
US6703372B1 (en) * 1999-06-29 2004-03-09 Biochemie S.A. Macrolides
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
IL150564A0 (en) * 2000-01-04 2003-02-12 Teva Pharma Preparation method of azithromycin dihydrate
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
US6528492B1 (en) 2000-07-25 2003-03-04 Instituto De Investigacion En Quimica Aplicada S.C. Single-step process for preparing 7, 16-deoxy-2-aza-10-0-cladinosil-12-0-desosaminil-4, 5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethylbicycle (11.2.1) hexadeca-1(2)-en-ona and obtaining a new form of 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ES2172417B1 (es) * 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
ATE306491T1 (de) 2000-08-23 2005-10-15 Wockhardt Ltd Verfahren zur herstellung von wasserfreiem azithromycin
CN100341886C (zh) * 2000-11-27 2007-10-10 桑多斯股份公司 大环内酯类化合物的溶剂化物
AU2002221895A1 (en) * 2000-11-27 2002-06-03 Biochemie S.A. Macrolide solvates
IN190080B (en:Method) * 2001-01-29 2003-06-07 Alembic Ltd
KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
NZ539801A (en) * 2001-05-22 2006-10-27 Pfizer Prod Inc Crystal forms of azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
SI1390377T1 (sl) 2001-05-22 2006-06-30 Pfizer Prod Inc Nova kristalna oblika azitromicina
CA2458135A1 (en) * 2001-08-21 2003-03-06 Pfizer Products Inc. Single dose azithromycin for treating respiratory infections
BR0215175A (pt) * 2001-12-21 2004-12-28 Pfizer Prod Inc Métodos para a granulação úmida de azitromicina
NZ532707A (en) * 2001-12-21 2006-07-28 Pfizer Prod Inc Directly compressible formulations of azithromycin
AU2003201146B2 (en) * 2002-02-01 2008-04-17 Pfizer Products Inc. Dry granulated formulations of azithromycin
US7376064B2 (en) 2002-02-25 2008-05-20 Samsung Electronics Co., Ltd. Method and apparatus for recording data on optical recording medium
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
US6855813B2 (en) * 2002-07-19 2005-02-15 Alembic Limited Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
GB2395482A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Process for preparing non-hygroscopic azithromycin dihydrate
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
CN1889931A (zh) * 2003-12-04 2007-01-03 辉瑞产品公司 利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾-冻凝方法
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
WO2005053656A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
BRPI0416534A (pt) * 2003-12-04 2007-01-09 Pfizer Prod Inc composições multiparticuladas com estabilidade melhorada
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
JP2007513145A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 医薬用多微粒子の製造方法
JP2007513146A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 液体系プロセスによるアジスロマイシンマルチパーティキュレート剤形
RU2260012C1 (ru) * 2004-01-29 2005-09-10 Открытое акционерное общество "Акционерное курганское общество медицинских препаратов и изделий "Синтез" Способ кристаллизации азитромицина дигидрата
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
WO2006011160A1 (en) 2004-06-28 2006-02-02 Alembic Limited Process for the preparation of azithromycin monohydrate isopropanol clathrate
CN1308361C (zh) * 2004-08-09 2007-04-04 大连振邦氟涂料股份有限公司 乙烯-三氟氯乙烯共聚物的制备方法
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
EP1817315A1 (en) * 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Processes for producing crystalline macrolides
WO2006067576A1 (en) * 2004-12-21 2006-06-29 Pfizer Products Inc. Enteric coated azithromycin multiparticulates
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CN100366686C (zh) * 2006-01-12 2008-02-06 济南瑞氟化工科技有限公司 一种氟硅超双疏不粘涂料
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US7704959B2 (en) 2006-10-03 2010-04-27 Dow Pharmaceutical Sciences Azithromycin for the treatment of nodular acne
US20090062220A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched azithromycin
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
CN101624412B (zh) * 2008-07-10 2012-07-04 刘力 大环内酯类衍生物及其制备和用途
LT2344129T (lt) 2008-10-07 2018-05-10 Horizon Orphan Llc Aerozolinės fluorchinolono kompozicijos, skirtos farmakokinetikų pagerinimui
HRP20201150T8 (hr) 2008-10-07 2021-06-25 Horizon Orphan Llc Inhalacija levofloksacina za smanjenje upale pluća
CN101418026B (zh) * 2008-10-09 2011-05-18 南京工业大学 一种晶型和粒度可控的阿奇霉素结晶工艺
CN101787063B (zh) * 2009-01-23 2012-12-19 刘力 抗感染药物及其制备和用途
AU2010223233A1 (en) 2009-03-13 2011-10-06 Assistance Publique - Hopitaux De Paris Compositions and methods for elimination of Gram-negative bacteria
CA2938650C (en) 2009-09-04 2018-01-09 Raptor Pharmaceuticals Inc. Use of aerosolized levofloxacin for treating cystic fibrosis
CN102911219A (zh) * 2011-08-03 2013-02-06 山东方明药业集团股份有限公司 一种阿齐霉素在水相直接结晶的方法
CN103159811A (zh) * 2011-12-10 2013-06-19 山东方明药业集团股份有限公司 一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法
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PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
YU43402B (en) * 1985-03-04 1989-06-30 Pliva Pharm & Chem Works Process for preparation of 11-aza-10-deoxo-10-dihydroeritromycin "a" by using electro-chemical reduction
WO1989002271A1 (en) 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

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