JPH0631300B6 - - Google Patents

Info

Publication number
JPH0631300B6
JPH0631300B6 JP1988168637A JP16863788A JPH0631300B6 JP H0631300 B6 JPH0631300 B6 JP H0631300B6 JP 1988168637 A JP1988168637 A JP 1988168637A JP 16863788 A JP16863788 A JP 16863788A JP H0631300 B6 JPH0631300 B6 JP H0631300B6
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP1988168637A
Other languages
Japanese (ja)
Other versions
JPS6438096A (en
JPH0631300B2 (ja
Filing date
Publication date
Priority claimed from PCT/US1987/001612 external-priority patent/WO1989000576A1/en
Application filed filed Critical
Publication of JPS6438096A publication Critical patent/JPS6438096A/ja
Publication of JPH0631300B2 publication Critical patent/JPH0631300B2/ja
Application granted granted Critical
Publication of JPH0631300B6 publication Critical patent/JPH0631300B6/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

JP63168637A 1987-07-09 1988-07-06 結晶性アジスロマイシン2水和物及びその製法 Expired - Lifetime JPH0631300B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1987/001612 WO1989000576A1 (en) 1987-07-09 1987-07-09 Azithromycin dihydrate
WO87/1612 1987-07-09

Publications (3)

Publication Number Publication Date
JPS6438096A JPS6438096A (en) 1989-02-08
JPH0631300B2 JPH0631300B2 (ja) 1994-04-27
JPH0631300B6 true JPH0631300B6 (enrdf_load_html_response) 2006-10-11

Family

ID=22202456

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63168637A Expired - Lifetime JPH0631300B2 (ja) 1987-07-09 1988-07-06 結晶性アジスロマイシン2水和物及びその製法

Country Status (45)

Country Link
US (1) US6268489B1 (enrdf_load_html_response)
EP (1) EP0298650B1 (enrdf_load_html_response)
JP (1) JPH0631300B2 (enrdf_load_html_response)
KR (1) KR900006218B1 (enrdf_load_html_response)
CN (1) CN1016785B (enrdf_load_html_response)
AP (1) AP44A (enrdf_load_html_response)
AR (1) AR243532A1 (enrdf_load_html_response)
AT (1) ATE72446T1 (enrdf_load_html_response)
AU (1) AU604553B2 (enrdf_load_html_response)
BA (1) BA98213B1 (enrdf_load_html_response)
BG (1) BG47348A3 (enrdf_load_html_response)
CA (1) CA1314876C (enrdf_load_html_response)
CS (1) CS272241B2 (enrdf_load_html_response)
CY (1) CY1776A (enrdf_load_html_response)
DD (1) DD271705A5 (enrdf_load_html_response)
DE (1) DE3868296D1 (enrdf_load_html_response)
DK (1) DK172573B1 (enrdf_load_html_response)
EG (1) EG18527A (enrdf_load_html_response)
ES (1) ES2038756T3 (enrdf_load_html_response)
FI (1) FI91263C (enrdf_load_html_response)
GR (1) GR3003737T3 (enrdf_load_html_response)
HK (1) HK127594A (enrdf_load_html_response)
HU (1) HU211862A9 (enrdf_load_html_response)
IE (1) IE60354B1 (enrdf_load_html_response)
IL (1) IL86979A (enrdf_load_html_response)
IN (1) IN168879B (enrdf_load_html_response)
IS (1) IS1540B (enrdf_load_html_response)
LV (1) LV10624B (enrdf_load_html_response)
MA (1) MA21323A1 (enrdf_load_html_response)
MX (1) MX12213A (enrdf_load_html_response)
MY (1) MY103744A (enrdf_load_html_response)
NO (1) NO171556C (enrdf_load_html_response)
NZ (1) NZ225338A (enrdf_load_html_response)
OA (1) OA08743A (enrdf_load_html_response)
PH (1) PH30953A (enrdf_load_html_response)
PL (1) PL157145B1 (enrdf_load_html_response)
PT (1) PT87933B (enrdf_load_html_response)
RO (1) RO107257B1 (enrdf_load_html_response)
RU (1) RU2066324C1 (enrdf_load_html_response)
SG (1) SG27794G (enrdf_load_html_response)
SI (1) SI8811325A8 (enrdf_load_html_response)
UA (1) UA27040C2 (enrdf_load_html_response)
WO (1) WO1989000576A1 (enrdf_load_html_response)
YU (1) YU45075B (enrdf_load_html_response)
ZA (1) ZA884925B (enrdf_load_html_response)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
EP0539223A1 (en) * 1991-10-25 1993-04-28 Ono Pharmaceutical Co., Ltd. Glycine derivative monosodium salt tetrahydrate having an inhibitory effect on elastase
US5215980A (en) * 1992-01-17 1993-06-01 Merck & Co., Inc. 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
CN1034734C (zh) * 1993-12-10 1997-04-30 北京市集才药物研究所 一种新的阿齐红霉素结晶及其制备方法
US5605889A (en) 1994-04-29 1997-02-25 Pfizer Inc. Method of administering azithromycin
EP0758244B2 (en) * 1994-05-06 2008-02-13 Pfizer Inc. Controlled-release dosage forms of azithromycin
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
ATE348836T1 (de) * 1997-10-16 2007-01-15 Glaxosmithkline Zagreb Neue 3,6-hemiketale der 9a-azalidklasse
US6861411B1 (en) 1997-12-02 2005-03-01 Pfizer, Inc. Method of treating eye infections with azithromycin
PT102130A (pt) * 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
IL143376A0 (en) * 1998-11-30 2002-04-21 Teva Pharma Ethanolate of azithromycin, process for the manufacture, and pharmaceutical compositions thereof
US7056893B2 (en) 1999-03-31 2006-06-06 Insite Vision, Inc. Topical treatment for prevention of ocular infections
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
SK16472001A3 (sk) * 1999-05-18 2003-02-04 Pfizer Products Inc. Kryštalické formy makrolidového antibiotika
JP4703924B2 (ja) 1999-06-29 2011-06-15 サンド・アクチエンゲゼルシヤフト マクロライド
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
ATE388159T1 (de) 2000-01-04 2008-03-15 Teva Pharma Verfahren zur herstellung von azithromycin- dihydrat
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
DE60026718T2 (de) 2000-07-25 2006-11-16 Laboratorio Silanes, S.A. De C.V. Einstufiges verfahren zur herstellung von 7,16-deoxy-2-aza-10-o-cladinosil-12-o-desosaminil-4,5-dihydroxi-6-ethyl-3,5,9,11,13,15-hexamethylbicycle(11.2.11)hexadeca-1(2)-en-8-ona undeine neue form von 9-desoxo-9a-methyl-9a-aza-9a-homoerythromycin a
ES2172417B1 (es) * 2000-07-31 2003-09-16 Sint Quimica Sa Nueva forma mejorada de azitromicina monohidrato de menor higroscopicidad, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
JP2004506664A (ja) 2000-08-23 2004-03-04 ウォックハート・リミテッド 無水アジトロマイシンの製造法
EP1339730A2 (en) * 2000-11-27 2003-09-03 Biochemie S.A. Macrolide solvates
CN100341886C (zh) * 2000-11-27 2007-10-10 桑多斯股份公司 大环内酯类化合物的溶剂化物
IN190080B (enrdf_load_html_response) * 2001-01-29 2003-06-07 Alembic Ltd
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
EP1671979B1 (en) 2001-05-22 2008-08-13 Pfizer Products Inc. New Cristal Form of Azithromycin
NZ529118A (en) 2001-05-22 2005-10-28 Pfizer Prod Inc Crystal forms of azithromycin
CZ2004232A3 (cs) * 2001-08-21 2005-10-12 Pfizer Products Inc. Jednorázová dávka azithromycinu
WO2003053399A2 (en) * 2001-12-21 2003-07-03 Pfizer Products Inc. Methods for wet granulating azithromycin
AU2002348884A1 (en) * 2001-12-21 2003-07-09 Pfizer Products Inc. Directly compressible formulations of azithromycin
RU2283092C2 (ru) * 2002-02-01 2006-09-10 Пфайзер Продактс Инк. Сухие гранулированные композиции азитромицина
US7376064B2 (en) 2002-02-25 2008-05-20 Samsung Electronics Co., Ltd. Method and apparatus for recording data on optical recording medium
ITMI20021209A1 (it) * 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza
US6855813B2 (en) * 2002-07-19 2005-02-15 Alembic Limited Process for the preparation of azithromycin monohydrate
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
US7645876B2 (en) * 2004-12-01 2010-01-12 TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság Processes for producing crystalline macrolides
GB2395482A (en) * 2003-07-03 2004-05-26 Jubilant Organosys Ltd Process for preparing non-hygroscopic azithromycin dihydrate
US20050013835A1 (en) * 2003-07-15 2005-01-20 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
WO2005053639A2 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Controlled release multiparticulates formed with dissolution enhancers
MXPA06005913A (es) * 2003-12-04 2006-06-27 Pfizer Prod Inc Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
CA2547773A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate azithromycin compositions containing preferably a poloxamer and a glyceride
WO2005053656A1 (en) * 2003-12-04 2005-06-16 Pfizer Products Inc. Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
EP1691786A1 (en) * 2003-12-04 2006-08-23 Pfizer Products Inc. Multiparticulate compositions with improved stability
PL1691787T3 (pl) * 2003-12-04 2008-11-28 Pfizer Prod Inc Sposób wytwarzania farmaceutycznych systemów wielocząstkowych
RU2260012C1 (ru) * 2004-01-29 2005-09-10 Открытое акционерное общество "Акционерное курганское общество медицинских препаратов и изделий "Синтез" Способ кристаллизации азитромицина дигидрата
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
WO2006011160A1 (en) 2004-06-28 2006-02-02 Alembic Limited Process for the preparation of azithromycin monohydrate isopropanol clathrate
CN1308361C (zh) * 2004-08-09 2007-04-04 大连振邦氟涂料股份有限公司 乙烯-三氟氯乙烯共聚物的制备方法
US7683162B2 (en) * 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
CA2591923A1 (en) * 2004-12-21 2006-06-29 Pfizer Products Inc. Enteric coated azithromycin multiparticulates
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CN100366686C (zh) * 2006-01-12 2008-02-06 济南瑞氟化工科技有限公司 一种氟硅超双疏不粘涂料
AU2007256844A1 (en) * 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted erythromycin analogs
US7704959B2 (en) 2006-10-03 2010-04-27 Dow Pharmaceutical Sciences Azithromycin for the treatment of nodular acne
US20090062220A1 (en) * 2007-08-29 2009-03-05 Protia, Llc Deuterium-enriched azithromycin
CN101177441B (zh) * 2007-12-05 2012-05-23 浙江耐司康药业有限公司 一种稳定的阿奇霉素一水合物结晶的制备方法
CN101624412B (zh) * 2008-07-10 2012-07-04 刘力 大环内酯类衍生物及其制备和用途
DK2346509T3 (da) 2008-10-07 2020-08-03 Horizon Orphan Llc Inhalation af levofloxacin til at reducere lungeinflammation
MX345158B (es) 2008-10-07 2017-01-18 Raptor Pharmaceuticals Inc Formulaciones de fluoroquinolona en aerosol para farmacocinetica mejorada.
CN101418026B (zh) * 2008-10-09 2011-05-18 南京工业大学 一种晶型和粒度可控的阿奇霉素结晶工艺
CN101787063B (zh) * 2009-01-23 2012-12-19 刘力 抗感染药物及其制备和用途
EA201101319A1 (ru) 2009-03-13 2012-04-30 Да Волтерра Композиции и способы элиминации грамотрицательных бактерий
BR112012004692B8 (pt) 2009-09-04 2021-05-25 Mpex Pharmaceuticals Inc solução que compreende levofloxacina para uso em um método para tratar a fibrose cística em um ser humano
CN102911219A (zh) * 2011-08-03 2013-02-06 山东方明药业集团股份有限公司 一种阿齐霉素在水相直接结晶的方法
CN103159811A (zh) * 2011-12-10 2013-06-19 山东方明药业集团股份有限公司 一种阿齐霉素中间体9a-脱氧-9a-氮杂-9a-高红霉素A的制备方法
WO2013088274A1 (en) 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN102417531B (zh) * 2011-12-20 2014-06-11 浙江国邦药业有限公司 一种阿奇霉素一水合物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020270A (en) * 1974-05-02 1977-04-26 Societa' Farmaceutici Italia S.P.A. L-lyxohex-1-enopyranose derivative
US4219641A (en) * 1979-06-14 1980-08-26 The Upjohn Company Process for preparing erythromycin succinate
SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
YU43402B (en) * 1985-03-04 1989-06-30 Pliva Pharm & Chem Works Process for preparation of 11-aza-10-deoxo-10-dihydroeritromycin "a" by using electro-chemical reduction
WO1989002271A1 (en) 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents

Similar Documents

Publication Publication Date Title
JPH0631300B6 (enrdf_load_html_response)
CH672870GA3 (enrdf_load_html_response)
GR3005663T3 (enrdf_load_html_response)
GR3005171T3 (enrdf_load_html_response)
DE3991484T (enrdf_load_html_response)
FR2638586B1 (enrdf_load_html_response)
DE3991756T (enrdf_load_html_response)
FR2641127B1 (enrdf_load_html_response)
IN169818B (enrdf_load_html_response)
EP0753781A3 (enrdf_load_html_response)
DE3991216T (enrdf_load_html_response)
DE3991549T (enrdf_load_html_response)
FR2641035B1 (enrdf_load_html_response)
FR2641105B1 (enrdf_load_html_response)
DE3877564D1 (enrdf_load_html_response)
DK578488D0 (enrdf_load_html_response)
IN170476B (enrdf_load_html_response)
IN171203B (enrdf_load_html_response)
GR2000204Y (enrdf_load_html_response)
GR2000046Y (enrdf_load_html_response)
IN172329B (enrdf_load_html_response)
IN172542B (enrdf_load_html_response)
AU7442987A (enrdf_load_html_response)
IN172629B (enrdf_load_html_response)
AU7743087A (enrdf_load_html_response)