JPH0580980B2 - - Google Patents
Info
- Publication number
- JPH0580980B2 JPH0580980B2 JP60285819A JP28581985A JPH0580980B2 JP H0580980 B2 JPH0580980 B2 JP H0580980B2 JP 60285819 A JP60285819 A JP 60285819A JP 28581985 A JP28581985 A JP 28581985A JP H0580980 B2 JPH0580980 B2 JP H0580980B2
- Authority
- JP
- Japan
- Prior art keywords
- light
- antigen
- antibody
- reaction
- scattered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 claims description 52
- 239000002245 particle Substances 0.000 claims description 32
- 230000010287 polarization Effects 0.000 claims description 29
- 239000000427 antigen Substances 0.000 claims description 26
- 102000036639 antigens Human genes 0.000 claims description 26
- 108091007433 antigens Proteins 0.000 claims description 26
- 239000010419 fine particle Substances 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 230000008105 immune reaction Effects 0.000 claims description 9
- 239000011859 microparticle Substances 0.000 claims description 9
- 238000001514 detection method Methods 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 description 15
- 238000005259 measurement Methods 0.000 description 15
- 239000000243 solution Substances 0.000 description 14
- 238000003018 immunoassay Methods 0.000 description 8
- 230000005684 electric field Effects 0.000 description 7
- 230000035945 sensitivity Effects 0.000 description 6
- 230000001360 synchronised effect Effects 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940027941 immunoglobulin g Drugs 0.000 description 4
- 238000002372 labelling Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000001427 coherent effect Effects 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 238000003127 radioimmunoassay Methods 0.000 description 3
- 230000005653 Brownian motion process Effects 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 238000005537 brownian motion Methods 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 2
- 229940099472 immunoglobulin a Drugs 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 239000004816 latex Substances 0.000 description 2
- 229920000126 latex Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 1
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 230000005697 Pockels effect Effects 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000001032 anti-candidal effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 238000000760 immunoelectrophoresis Methods 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000011146 organic particle Substances 0.000 description 1
- 239000011242 organic-inorganic particle Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 208000006379 syphilis Diseases 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/21—Polarisation-affecting properties
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4792—Polarisation of scatter light
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60285819A JPS62145165A (ja) | 1985-12-20 | 1985-12-20 | 光の位相変調を利用した免疫反応の測定方法および装置 |
| US06/941,107 US4799796A (en) | 1985-12-20 | 1986-12-12 | Method and apparatus for measuring immunological reaction with the aid of phase-modulation of light |
| DE19863643108 DE3643108A1 (de) | 1985-12-20 | 1986-12-17 | Verfahren und vorrichtung zum messen immunologischer reaktionen mittels phasenmodulierten lichtes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60285819A JPS62145165A (ja) | 1985-12-20 | 1985-12-20 | 光の位相変調を利用した免疫反応の測定方法および装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62145165A JPS62145165A (ja) | 1987-06-29 |
| JPH0580980B2 true JPH0580980B2 (US20030220297A1-20031127-C00009.png) | 1993-11-11 |
Family
ID=17696495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60285819A Granted JPS62145165A (ja) | 1985-12-20 | 1985-12-20 | 光の位相変調を利用した免疫反応の測定方法および装置 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US4799796A (US20030220297A1-20031127-C00009.png) |
| JP (1) | JPS62145165A (US20030220297A1-20031127-C00009.png) |
| DE (1) | DE3643108A1 (US20030220297A1-20031127-C00009.png) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4912059A (en) * | 1988-10-21 | 1990-03-27 | The Johns Hopkins University | Phase sensitive differential polarimetry technique and apparatus |
| US5133602A (en) * | 1991-04-08 | 1992-07-28 | International Business Machines Corporation | Particle path determination system |
| JPH0749303A (ja) * | 1993-04-01 | 1995-02-21 | High Yield Technol Inc | 粒子センサ及び粒子検出方法 |
| CZ286103B6 (cs) * | 1993-11-26 | 2000-01-12 | Rokos A Spol., S.R.O. | Způsob měření spektropolarimetrických vlastností opticky aktivních látek a dichrograf k provedení tohoto způsobu |
| DE4343663C1 (de) * | 1993-12-21 | 1995-04-20 | Fraunhofer Ges Forschung | Vorrichtung zur polarisationsempfindlichen Spektroskopie |
| US5903352A (en) * | 1995-01-27 | 1999-05-11 | Canon Kabushiki Kaisha | Apparatus and method for measuring optical anisotropy |
| US5940178A (en) * | 1996-07-03 | 1999-08-17 | Beckman Instruments, Inc. | Nephelometer and turbidimeter combination |
| US6188477B1 (en) * | 1998-05-04 | 2001-02-13 | Cornell Research Foundation, Inc. | Optical polarization sensing apparatus and method |
| US6445485B1 (en) * | 2000-01-21 | 2002-09-03 | At&T Corp. | Micro-machine polarization-state controller |
| JP4559650B2 (ja) * | 2001-03-22 | 2010-10-13 | シチズンホールディングス株式会社 | 旋光度測定装置及び旋光度測定方法 |
| CN1479864A (zh) * | 2001-08-28 | 2004-03-03 | ���µ�����ҵ��ʽ���� | 特定成分信息测量装置 |
| CN101960294B (zh) * | 2008-03-19 | 2013-01-23 | 小幡彻 | 凝胶粒子测定装置 |
| WO2011149525A1 (en) | 2010-05-25 | 2011-12-01 | Arryx, Inc. | Holographic fluctuation microscopy apparatus and method for determining mobility of particle and/or cell dispersions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1068409A (en) * | 1975-12-12 | 1979-12-18 | Pierre-Andre Grandchamp | Determination of parameters of an autocorrelation function |
| US4480916A (en) * | 1982-07-06 | 1984-11-06 | The United States Of America As Represented By The Secretary Of The Navy | Phase-modulated polarizing interferometer |
| JPS6128866A (ja) * | 1984-07-18 | 1986-02-08 | Toshimitsu Musha | 光強度ゆらぎを用いる免疫反応の測定方法および装置 |
| JPS62118255A (ja) * | 1985-11-19 | 1987-05-29 | Toshimitsu Musha | 磁界を用いた免疫反応の検出法 |
-
1985
- 1985-12-20 JP JP60285819A patent/JPS62145165A/ja active Granted
-
1986
- 1986-12-12 US US06/941,107 patent/US4799796A/en not_active Expired - Fee Related
- 1986-12-17 DE DE19863643108 patent/DE3643108A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3643108A1 (de) | 1987-07-16 |
| DE3643108C2 (US20030220297A1-20031127-C00009.png) | 1988-11-17 |
| US4799796A (en) | 1989-01-24 |
| JPS62145165A (ja) | 1987-06-29 |
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