JPH0564151B2 - - Google Patents

Info

Publication number
JPH0564151B2
JPH0564151B2 JP59030988A JP3098884A JPH0564151B2 JP H0564151 B2 JPH0564151 B2 JP H0564151B2 JP 59030988 A JP59030988 A JP 59030988A JP 3098884 A JP3098884 A JP 3098884A JP H0564151 B2 JPH0564151 B2 JP H0564151B2
Authority
JP
Japan
Prior art keywords
compound
oxo
azabicyclo
ene
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59030988A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60174787A (ja
Inventor
Kenichi Mochida
Takehiro Ogasa
Junichi Shimada
Tadashi Hirata
Kyoshi Sato
Makoto Okaji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd
Priority to JP59030988A priority Critical patent/JPS60174787A/ja
Priority to US06/702,623 priority patent/US4640919A/en
Priority to DE8585101834T priority patent/DE3578422D1/de
Priority to EP85101834A priority patent/EP0154253B1/en
Publication of JPS60174787A publication Critical patent/JPS60174787A/ja
Publication of JPH0564151B2 publication Critical patent/JPH0564151B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP59030988A 1984-02-21 1984-02-21 ３位置換カルバセフエム化合物 Granted JPS60174787A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP59030988A JPS60174787A (ja) 1984-02-21 1984-02-21 ３位置換カルバセフエム化合物
US06/702,623 US4640919A (en) 1984-02-21 1985-02-19 3-substituted carbacepem compounds having antibacterial effect
DE8585101834T DE3578422D1 (de) 1984-02-21 1985-02-20 3-substituierte carbacephem-verbindung und sie enthaltende pharmazeutische zusammensetzung.
EP85101834A EP0154253B1 (en) 1984-02-21 1985-02-20 3-substituted carbacephem compound and a pharmaceutical composition containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59030988A JPS60174787A (ja) 1984-02-21 1984-02-21 ３位置換カルバセフエム化合物

Publications (2)

Publication Number Publication Date
JPS60174787A JPS60174787A (ja) 1985-09-09
JPH0564151B2 true JPH0564151B2 (en, 2012) 1993-09-14

Family

ID=12318998

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59030988A Granted JPS60174787A (ja) 1984-02-21 1984-02-21 ３位置換カルバセフエム化合物

Country Status (4)

Country Link
US (1) US4640919A (en, 2012)
EP (1) EP0154253B1 (en, 2012)
JP (1) JPS60174787A (en, 2012)
DE (1) DE3578422D1 (en, 2012)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4673737A (en) * 1985-08-02 1987-06-16 Harvard University 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof
JPH0791291B2 (ja) * 1985-12-30 1995-10-04 イ−ライ・リリ−・アンド・カンパニ− １−カルバセフアロスポリン抗生物質
ATE79119T1 (de) * 1986-10-03 1992-08-15 Lilly Co Eli 7-((meta-substituiert)-phenylglycin>-1-carba-1dethia-cephalosporine.
US4885291A (en) * 1988-01-14 1989-12-05 Eli Lilly And Company 1-carba(dethia)-3-cephem derivatives
DE3803169A1 (de) 1988-02-03 1989-08-17 Bayer Ag Ss-lactam-antibiotika, verfahren zu ihrer herstellung und ihre verwendung als und in arzneimitteln
US5106842A (en) * 1990-10-22 1992-04-21 Bristol-Myers Squibb Co. Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof
US5206360A (en) * 1990-10-22 1993-04-27 Bristol-Myers Squibb Company Intermediates for cyclobutenedione substituted (1-carba)cephalosporin compounds
US5169843A (en) * 1990-10-22 1992-12-08 Bristol-Myers Squibb Company Antibiotic C-3 cyclobutenedione substituted (1-carba) cephalosporin compounds, cmpositions, and methods of use thereof
US5099015A (en) * 1991-01-10 1992-03-24 Eli Lilly And Company Trifluoromethyl 1-carba(1-dethia)cephems
US5077287A (en) * 1991-01-18 1991-12-31 Eli Lilly And Company 3-thiazolylthio carbacephem antibacterial agents
JP3238209B2 (ja) * 1992-09-30 2001-12-10 塩野義製薬株式会社 チオメチルチオカルバセファロスポリン誘導体
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
AU5985596A (en) * 1995-05-31 1996-12-18 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
US20080146535A1 (en) * 2003-04-30 2008-06-19 Tomasz Glinka Compositions comprising carbacephem beta-lactam antibiotics and beta-lactamase inhibitors
CA2526875A1 (en) * 2003-04-30 2004-11-18 Trine Pharmaceuticals, Inc. Carbacephem beta-lactam antibiotics
CN101835777A (zh) * 2007-10-25 2010-09-15 尔察祯有限公司 碳头孢烯β-内酰胺抗生素
WO2010030810A1 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. Carbacephem beta-lactam antibiotics

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
ZA766941B (en) * 1975-11-21 1978-06-28 Merck & Co Inc 3-(substituted thio)cephalosporins,derivatives and nuclear analogues thereof
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
SE7902598L (sv) * 1978-03-25 1979-10-04 Kyowa Hakko Kogyo Kk Cephalosporinanaloger
JPS55138396A (en) * 1979-04-14 1980-10-29 Kyowa Hakko Kogyo Co Ltd Production of cephalosporin analogs
JPS5616491A (en) * 1979-07-19 1981-02-17 Kyowa Hakko Kogyo Co Ltd Cephalosporin analog
NO155548C (no) * 1979-02-10 1987-04-15 Kyowa Hakko Kogyo Kk Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger.
EP0082501A1 (en) * 1981-12-18 1983-06-29 Kyowa Hakko Kogyo Co., Ltd Beta-lactam compound and a pharmaceutical composition containing the same
EP0112481A1 (en) * 1982-11-12 1984-07-04 Kyowa Hakko Kogyo Co., Ltd Beta-lactam compound

Also Published As

Publication number Publication date
JPS60174787A (ja) 1985-09-09
EP0154253B1 (en) 1990-06-27
US4640919A (en) 1987-02-03
DE3578422D1 (de) 1990-08-02
EP0154253A1 (en) 1985-09-11

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