JPH05504683A - 組み換えチロトロピン受容体 - Google Patents

組み換えチロトロピン受容体

Info

Publication number
JPH05504683A
JPH05504683A JP3504332A JP50433290A JPH05504683A JP H05504683 A JPH05504683 A JP H05504683A JP 3504332 A JP3504332 A JP 3504332A JP 50433290 A JP50433290 A JP 50433290A JP H05504683 A JPH05504683 A JP H05504683A
Authority
JP
Japan
Prior art keywords
tsh
receptor
thyrotropin
cells
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3504332A
Other languages
English (en)
Japanese (ja)
Other versions
JPH04503455A (ja
Inventor
ラポポート，バジル
Original Assignee
ニコルス　インスティテュート　ダイアグノスティックス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニコルス　インスティテュート　ダイアグノスティックス filed Critical ニコルス　インスティテュート　ダイアグノスティックス
Publication of JPH04503455A publication Critical patent/JPH04503455A/ja
Publication of JPH05504683A publication Critical patent/JPH05504683A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
JP3504332A 1989-12-20 1990-12-19 組み換えチロトロピン受容体 Pending JPH05504683A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US313,421 1989-02-21
US45197389A 1989-12-20 1989-12-20
US451,973 1989-12-20
US57501890A 1990-08-30 1990-08-30
US575,018 1990-08-30
PCT/US1990/007387 WO1991009137A1 (fr) 1989-12-20 1990-12-19 Recepteur de thyrotropine recombinant

Publications (2)

Publication Number Publication Date
JPH04503455A JPH04503455A (ja) 1992-06-25
JPH05504683A true JPH05504683A (ja) 1993-07-22

Family

ID=27036589

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3504332A Pending JPH05504683A (ja) 1989-12-20 1990-12-19 組み換えチロトロピン受容体

Country Status (5)

Country Link
EP (1) EP0506890A4 (fr)
JP (1) JPH05504683A (fr)
AU (1) AU7257391A (fr)
IE (1) IE904641A1 (fr)
WO (1) WO1991009137A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002544493A (ja) * 1999-05-10 2002-12-24 トロピックス・インコーポレーテッド 環状ヌクレオチドモノホスフェートのための競合的化学ルミネセンス検定
JP2004500580A (ja) * 2000-03-30 2004-01-08 ダイアグノスティック　ハイブリッズ，インコーポレーテッド 自己免疫疾患の診断
US9739775B2 (en) 2000-03-30 2017-08-22 Diagnostic Hybrids, Inc. Methods of using chimeric receptors to identify autoimmune disease

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69015175T2 (de) * 1989-05-05 1995-06-29 Genentech Inc Glykoprotein-hormonrezeptor-moleküle.
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
CA2066263C (fr) * 1989-09-08 1999-11-02 New England Medical Center Hospitals, Inc. Recepteur de thyrotropine
DE68927461T2 (de) * 1989-12-14 1997-03-20 B.R.A.H.M.S Diagnostica Gmbh, 12099 Berlin Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide
EP0719858A3 (fr) * 1994-12-27 1997-12-29 Tosoh Corporation Lignée cellulaire de myélome exprimant le récepteur humain recombinant pour l'hormone stimulatrice de la thyroide
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19728991A1 (de) * 1996-11-06 1999-02-11 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
DE50010992D1 (de) * 1999-10-12 2005-09-22 Ulrich Loos Verfahren zur bestimmung von autoantikörpern gegen den tsh-rezeptor
ES2736165T3 (es) 2001-08-23 2019-12-26 Rsr Ltd Regiones epítopo de un receptor de tirotropina (TSH), sus usos y anticuerpos para las mismas
AU2003285540A1 (en) * 2002-11-29 2004-06-23 Rsr Limited Antibody for the thyrotropin receptor and uses thereof
CN102050875B (zh) * 2010-12-10 2013-05-29 天津市协和医药科技有限公司 一种促甲状腺素受体的提取及纯化方法
FR3126005A1 (fr) * 2021-08-04 2023-02-10 Upec Activateur pharmacologique et/ou génétique pour son utilisation pour préserver et régénérer la structure et la fonction musculaire en bloquant la sénescence
CN115925966A (zh) * 2021-09-22 2023-04-07 厦门英博迈生物科技有限公司 一种重组促甲状腺激素受体蛋白、制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472508A (en) * 1982-12-30 1984-09-18 The Beth Israel Hospital Association Test for detecting and measuring the graves' disease-specific immunoglobulins
US4818684A (en) * 1985-09-10 1989-04-04 The Trustees Of Columbia University In The City Of New York Auto-anti-idiotypic monoclonal antibodies to steroid receptors and uses thereof
DE69015175T2 (de) * 1989-05-05 1995-06-29 Genentech Inc Glykoprotein-hormonrezeptor-moleküle.
CA2066263C (fr) * 1989-09-08 1999-11-02 New England Medical Center Hospitals, Inc. Recepteur de thyrotropine
DE68927461T2 (de) * 1989-12-14 1997-03-20 B.R.A.H.M.S Diagnostica Gmbh, 12099 Berlin Polypeptide mit Thyrotropinrezeptor-Aktivität, kodierende Nukleinsäuresequenzen für solche Rezeptoren und Verwendung dieser Polypeptide
WO1992008726A1 (fr) * 1990-11-15 1992-05-29 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Gene de rat recepteur de thyrotropine et utilisation dudit gene

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002544493A (ja) * 1999-05-10 2002-12-24 トロピックス・インコーポレーテッド 環状ヌクレオチドモノホスフェートのための競合的化学ルミネセンス検定
JP2004500580A (ja) * 2000-03-30 2004-01-08 ダイアグノスティック　ハイブリッズ，インコーポレーテッド 自己免疫疾患の診断
US9739775B2 (en) 2000-03-30 2017-08-22 Diagnostic Hybrids, Inc. Methods of using chimeric receptors to identify autoimmune disease
US10041943B2 (en) 2000-03-30 2018-08-07 Diagnostic Hybrids, Inc. Methods of using chimeric receptors to identify autoimmune disease

Also Published As

Publication number Publication date
IE904641A1 (en) 1991-07-17
AU7257391A (en) 1991-07-18
EP0506890A4 (en) 1993-06-30
EP0506890A1 (fr) 1992-10-07
WO1991009137A1 (fr) 1991-06-27

Similar Documents

Publication Publication Date Title
JPH05504683A (ja) 組み換えチロトロピン受容体
JPH06506697A (ja) ヒトｐｆ４ａ受容体とその使用
JPH11500621A (ja) 蛋白質チロシンキナーゼキメラによる細胞性免疫の再指示
JP2001501444A (ja) Ｏｂ受容体ならびに体重障害の診断および治療の方法
JPH05505112A (ja) Ａｉｄｓ、ａｒｃおよびｈｉｖ感染の予防および治療に有用な抗ｃｄ４抗体ホモログ
JPH06506598A (ja) 副甲状腺ホルモンのレセプターとそれをコードしているｄｎａ
JPH10501701A (ja) Ｈｔｋリガンド
JP2000507081A (ja) 肥満症を治療するための核酸
JPH04506752A (ja) チロトロピンレセプター活性を有するポリペプチド、このレセプターとポリペプチドとをコードする核酸、そしてこのようなペプチドの利用
DE60125169T2 (de) Regulation eines menschlichen dopamine-ähnlichen g-protein gekoppelten rezeptor.
US20050221436A1 (en) Human neuropeptide Y-like G protein-coupled receptor
US20020077468A1 (en) Corticotropin-releasing factor2 receptors
US20020128443A1 (en) Polynucleotides encoding thrombin receptor homologs
JP2002500633A (ja) Ｅｄｇ−１様受容体
JPH1128093A (ja) 新規ヒト・７−トランスメンブラン受容体をコードしているｃＤＮＡクローンＨＤＰＢＩ３０
JPH09501307A (ja) オピオイドレセプター：組成物および方法
JPH08502164A (ja) オピオイドレセプター遺伝子
AU718311B2 (en) A C5a-like seven transmembrane receptor
JPH05501952A (ja) Ｔｓｈ受容体
DE60127102T2 (de) Regulation des menschliches lipoxin a4 rezeptor-ähnliches protein
JPH04500603A (ja) クローン化腎炎抗原
JP2002514078A (ja) Ｆｔｈｍａ−０７０関連蛋白質ファミリーおよびｔ８５関連蛋白質ファミリーの新規分子ならびにそれらの使用
US6747139B1 (en) Nucleic acid encoding human thyrotropin receptor
KR100971270B1 (ko) 이피에프 수용체 에세이, 화합물 및 치료학적 조성물
JP2004506426A (ja) ヒトｐ２ｙ１様ｇタンパク共役受容体の調節