CA2066263C - Recepteur de thyrotropine - Google Patents

Recepteur de thyrotropine

Info

Publication number
CA2066263C
CA2066263C CA002066263A CA2066263A CA2066263C CA 2066263 C CA2066263 C CA 2066263C CA 002066263 A CA002066263 A CA 002066263A CA 2066263 A CA2066263 A CA 2066263A CA 2066263 C CA2066263 C CA 2066263C
Authority
CA
Canada
Prior art keywords
receptor
nucleic acid
tsh
cell
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002066263A
Other languages
English (en)
Other versions
CA2066263A1 (fr
Inventor
Roger Cone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New England Medical Center Hospitals Inc
Original Assignee
New England Medical Center Hospitals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Medical Center Hospitals Inc filed Critical New England Medical Center Hospitals Inc
Publication of CA2066263A1 publication Critical patent/CA2066263A1/fr
Application granted granted Critical
Publication of CA2066263C publication Critical patent/CA2066263C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Protéine présentant l'activité biologique d'un récepteur de thyrotropine mammifère, et acide nucléique purifié codant ladite protéine.
CA002066263A 1989-09-08 1990-09-07 Recepteur de thyrotropine Expired - Fee Related CA2066263C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US40489989A 1989-09-08 1989-09-08
US404,899 1989-09-08
US56566990A 1990-08-10 1990-08-10
US565,669 1990-08-10
PCT/US1990/005066 WO1991003483A1 (fr) 1989-09-08 1990-09-07 Recepteur de thyrotropine

Publications (2)

Publication Number Publication Date
CA2066263A1 CA2066263A1 (fr) 1991-03-09
CA2066263C true CA2066263C (fr) 1999-11-02

Family

ID=27018824

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002066263A Expired - Fee Related CA2066263C (fr) 1989-09-08 1990-09-07 Recepteur de thyrotropine

Country Status (4)

Country Link
EP (1) EP0493434A4 (fr)
JP (1) JP3181582B2 (fr)
CA (1) CA2066263C (fr)
WO (1) WO1991003483A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033990T2 (de) * 1989-05-05 2003-02-13 Genentech Inc Glykoprotein-Hormonrezeptor-Moleküle
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
US5744348A (en) * 1989-09-08 1998-04-28 New England Medical Center Hospitals, Inc. TSH receptor
ATE145240T1 (de) * 1989-12-14 1996-11-15 Brahms Diagnostica Gmbh Polypeptide mit thyrotropinrezeptor-aktivität, kodierende nukleinsäuresequenzen für solche rezeptoren und verwendung dieser polypeptide
JPH05504683A (ja) * 1989-12-20 1993-07-22 ニコルス　インスティテュート　ダイアグノスティックス 組み換えチロトロピン受容体
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
CA2304986A1 (fr) * 1997-09-24 1999-04-01 Merck & Co., Inc. Recepteur hormonal glycoproteique aomf05 couple par proteines g
GB9823397D0 (en) 1998-10-27 1998-12-23 Rsr Ltd Assays for thyroid autoantibodies
US8501415B2 (en) 2002-11-26 2013-08-06 B.R.A.H.M.S. Gmbh Identification of TSH receptor autoantibodies using affinity-purified antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69033990T2 (de) * 1989-05-05 2003-02-13 Genentech Inc Glykoprotein-Hormonrezeptor-Moleküle
ATE145240T1 (de) * 1989-12-14 1996-11-15 Brahms Diagnostica Gmbh Polypeptide mit thyrotropinrezeptor-aktivität, kodierende nukleinsäuresequenzen für solche rezeptoren und verwendung dieser polypeptide
JPH05504683A (ja) * 1989-12-20 1993-07-22 ニコルス　インスティテュート　ダイアグノスティックス 組み換えチロトロピン受容体
FR2657014A1 (fr) * 1990-01-15 1991-07-19 Inst Nat Sante Rech Med Recepteur humain de la tsh. sequence codant pour ce recepteur.

Also Published As

Publication number Publication date
EP0493434A4 (en) 1993-05-05
JP3181582B2 (ja) 2001-07-03
WO1991003483A1 (fr) 1991-03-21
CA2066263A1 (fr) 1991-03-09
JPH05501952A (ja) 1993-04-15
EP0493434A1 (fr) 1992-07-08

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