JPH09501839A - プロスタグランジンレセプターep▲下2▼をコードするdna - Google Patents
プロスタグランジンレセプターep▲下2▼をコードするdnaInfo
- Publication number
- JPH09501839A JPH09501839A JP7507844A JP50784495A JPH09501839A JP H09501839 A JPH09501839 A JP H09501839A JP 7507844 A JP7507844 A JP 7507844A JP 50784495 A JP50784495 A JP 50784495A JP H09501839 A JPH09501839 A JP H09501839A
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- cells
- dna
- protein
- cdna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.プロスタグランジンに特異的に結合することを特徴とする単離及び精製され たプロスタグランジンEP2レセプター。 2.アミノ酸配列 (配列番号2) によって特徴づけられた請求項1に記載の単離及び精製されたプロスタグランジ ンレセプタータンパク質。 3.請求項2に記載のアミノ酸配列によって特徴づけられたプロスタグランジン レセプタータンパク質をコードしている単離及び精製されたDNA分子。 4.プロスタグランジンレセプタータンパク質をコードしている単離及び精製さ れたDNA分子であって、前記DN A分子がヌクレオチド配列 (配列番号1) によって特徴づけられたDNA分子。 5.組換え宿主細胞中でプロスタグランジンレセプタータンパク質を発現させる ための請求項4のDNA分子を含む発現ベクター。 6.組換えプロスタグランジンレセプタータンパク質を発現させるための請求項 5に記載の発現ベクターを含む宿主細胞。 7.組換え宿主細胞中でプロスタグランジンレセプタータンパク質を発現させる 方法であって、 (a)請求項5に記載の発現ベクターを適当な宿主細胞に移入し、 (b)プロスタグランジンレセプタータンパク質が発現ベクターから発現し得る条 件下に段階(a)の宿主細胞を培養する方法。 8.プロスタグランジンレセプター活性のモジュレーターを選定する方法であっ て、 (a)プロスタグランジンレセプター活性のモジュレーターを、請求項2に記載の アミノ酸配列の全部または一部によって特徴づけられるプロスタグランジンレセ プターと組み合 わせ、 (b)プロスタグランジンレセプターに対するモジュレーターの効果を測定する方 法。 9.請求項1に記載のアミノ酸配列によって特徴づけられるプロスタグランジン レセプタータンパク質に特異的に結合する抗体。
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/115,365 | 1993-08-31 | ||
US08/115,365 US5605814A (en) | 1993-08-31 | 1993-08-31 | DNA encoding human prostaglandin receptor EP2 |
US115,365 | 1993-08-31 | ||
PCT/CA1994/000470 WO1995006664A1 (en) | 1993-08-31 | 1994-08-29 | Dna encoding prostaglandin receptor ep2 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09501839A true JPH09501839A (ja) | 1997-02-25 |
JP3118460B2 JP3118460B2 (ja) | 2000-12-18 |
Family
ID=22360918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP07507844A Expired - Lifetime JP3118460B2 (ja) | 1993-08-31 | 1994-08-29 | プロスタグランジンレセプターep▲下2▼をコードするdna |
Country Status (5)
Country | Link |
---|---|
US (2) | US5605814A (ja) |
EP (1) | EP0716662A1 (ja) |
JP (1) | JP3118460B2 (ja) |
CA (1) | CA2170509C (ja) |
WO (1) | WO1995006664A1 (ja) |
Families Citing this family (33)
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US6051398A (en) * | 1991-11-20 | 2000-04-18 | Trustees Of Dartmouth College | Nucleic acids encoding CR3 polypeptide, vector and transformed cell thereof, and expression thereof |
US6395878B1 (en) * | 1994-05-05 | 2002-05-28 | Allergan Sales, Inc. | Nucleic acid encoding a human EP prostaglandin receptor |
EP0812353A2 (en) | 1995-01-26 | 1997-12-17 | Merck Frosst Canada Inc. | Prostaglandin receptor dp |
UA59384C2 (uk) * | 1996-12-20 | 2003-09-15 | Пфайзер, Інк. | Похідні сульфонамідів та амідів як агоністи простагландину, фармацевтична композиція та способи лікування на їх основі |
EP0951282B1 (en) | 1996-12-20 | 2008-04-02 | Pfizer Inc. | Prevention and treatment of skeletal disorder with ep2 receptor subtype selective prostaglandin e2 agonists |
US6133420A (en) * | 1997-01-27 | 2000-10-17 | Smithkline Beecham Corporation | GPR14 polypeptides |
MXPA01008955A (es) | 1999-03-05 | 2002-04-24 | Procter & Gamble | Analogos de prostaglandinas selectivas de fp no saturadas de c16. |
US6894175B1 (en) | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
US20040235749A1 (en) * | 1999-09-15 | 2004-11-25 | Sylvain Chemtob | G-protein coupled receptor antagonists |
NZ520762A (en) * | 1999-12-06 | 2005-02-25 | Chu Sainte Justine | Peptide and peptidomimetic antagonists of a G protein coupled receptor in treatments for regulating fluid filtration in the kidney |
PT1132086E (pt) | 2000-01-31 | 2006-09-29 | Pfizer Prod Inc | Utilizacao de agonistas selectivos para o receptor da prostaglandina (pge2) 4 (ep4) para o tratamento de falha renal aguda e cronica |
US20020172693A1 (en) * | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
US20020146439A1 (en) * | 2000-03-31 | 2002-10-10 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020037914A1 (en) * | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
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JP3508865B2 (ja) * | 1992-02-24 | 2004-03-22 | 周 成宮 | プロスタグランジンe受容蛋白質、それをコードするdnaおよびその製造法 |
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- 1994-08-29 WO PCT/CA1994/000470 patent/WO1995006664A1/en not_active Application Discontinuation
- 1994-08-29 EP EP94925311A patent/EP0716662A1/en not_active Withdrawn
- 1994-08-29 JP JP07507844A patent/JP3118460B2/ja not_active Expired - Lifetime
- 1994-08-29 CA CA002170509A patent/CA2170509C/en not_active Expired - Lifetime
- 1994-08-29 US US08/586,897 patent/US5759789A/en not_active Expired - Lifetime
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JP3118460B2 (ja) | 2000-12-18 |
US5605814A (en) | 1997-02-25 |
EP0716662A1 (en) | 1996-06-19 |
CA2170509A1 (en) | 1995-03-09 |
WO1995006664A1 (en) | 1995-03-09 |
US5759789A (en) | 1998-06-02 |
CA2170509C (en) | 2003-02-11 |
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