JPH0515712B2 - - Google Patents
Info
- Publication number
- JPH0515712B2 JPH0515712B2 JP62065519A JP6551987A JPH0515712B2 JP H0515712 B2 JPH0515712 B2 JP H0515712B2 JP 62065519 A JP62065519 A JP 62065519A JP 6551987 A JP6551987 A JP 6551987A JP H0515712 B2 JPH0515712 B2 JP H0515712B2
- Authority
- JP
- Japan
- Prior art keywords
- glycolide
- alumina
- purified
- flask
- methylene chloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims abstract description 89
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims abstract description 36
- 238000000034 method Methods 0.000 claims abstract description 28
- 239000002904 solvent Substances 0.000 claims abstract description 13
- 239000002002 slurry Substances 0.000 claims abstract description 10
- 238000000746 purification Methods 0.000 claims abstract description 8
- 238000001704 evaporation Methods 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims abstract description 6
- 239000003960 organic solvent Substances 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims abstract description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical group ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 48
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 21
- 229910052757 nitrogen Inorganic materials 0.000 claims description 11
- 239000012298 atmosphere Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical group C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
- 230000002596 correlated effect Effects 0.000 claims description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 abstract description 30
- 238000006116 polymerization reaction Methods 0.000 abstract description 21
- 239000004633 polyglycolic acid Substances 0.000 abstract description 17
- 238000004519 manufacturing process Methods 0.000 abstract description 10
- 239000003356 suture material Substances 0.000 description 10
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 9
- 235000011089 carbon dioxide Nutrition 0.000 description 9
- 238000012546 transfer Methods 0.000 description 8
- 239000003054 catalyst Substances 0.000 description 7
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 7
- 239000011521 glass Substances 0.000 description 7
- 238000010438 heat treatment Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- -1 polytetrafluoroethylene Polymers 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000002274 desiccant Substances 0.000 description 5
- 239000012299 nitrogen atmosphere Substances 0.000 description 5
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 5
- 239000004810 polytetrafluoroethylene Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960004275 glycolic acid Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 description 1
- ODNBVEIAQAZNNM-UHFFFAOYSA-N 1-(6-chloroimidazo[1,2-b]pyridazin-3-yl)ethanone Chemical group C1=CC(Cl)=NN2C(C(=O)C)=CN=C21 ODNBVEIAQAZNNM-UHFFFAOYSA-N 0.000 description 1
- CSDQQAQKBAQLLE-UHFFFAOYSA-N 4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Chemical compound C1=CC(Cl)=CC=C1C1C(C=CS2)=C2CCN1 CSDQQAQKBAQLLE-UHFFFAOYSA-N 0.000 description 1
- GUNJVIDCYZYFGV-UHFFFAOYSA-K Antimony trifluoride Inorganic materials F[Sb](F)F GUNJVIDCYZYFGV-UHFFFAOYSA-K 0.000 description 1
- 101100493711 Caenorhabditis elegans bath-41 gene Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- 229940095564 anhydrous calcium sulfate Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 239000002729 catgut Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000007859 condensation product Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Chemical compound O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F6/00—Post-polymerisation treatments
- C08F6/14—Treatment of polymer emulsions
- C08F6/16—Purification
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Polyesters Or Polycarbonates (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Physical Water Treatments (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Control Of El Displays (AREA)
- Paper (AREA)
- Carbon And Carbon Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
- Steroid Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Artificial Filaments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US841489 | 1986-03-19 | ||
| US06/841,489 US4650851A (en) | 1986-03-19 | 1986-03-19 | Purification of glycolide |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4248248A Division JPH0678426B2 (ja) | 1986-03-19 | 1992-09-17 | 縫合等級のポリグリコール酸の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62270574A JPS62270574A (ja) | 1987-11-24 |
| JPH0515712B2 true JPH0515712B2 (OSRAM) | 1993-03-02 |
Family
ID=25285006
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62065519A Granted JPS62270574A (ja) | 1986-03-19 | 1987-03-19 | グリコリドの精製 |
| JP4248248A Expired - Lifetime JPH0678426B2 (ja) | 1986-03-19 | 1992-09-17 | 縫合等級のポリグリコール酸の製造法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4248248A Expired - Lifetime JPH0678426B2 (ja) | 1986-03-19 | 1992-09-17 | 縫合等級のポリグリコール酸の製造法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4650851A (OSRAM) |
| EP (1) | EP0238273B1 (OSRAM) |
| JP (2) | JPS62270574A (OSRAM) |
| KR (1) | KR910005054B1 (OSRAM) |
| AT (1) | ATE52257T1 (OSRAM) |
| AU (1) | AU582680B2 (OSRAM) |
| CA (1) | CA1258466A (OSRAM) |
| DE (1) | DE3762417D1 (OSRAM) |
| DK (1) | DK138187A (OSRAM) |
| ES (1) | ES2014472B3 (OSRAM) |
| FI (1) | FI85374C (OSRAM) |
| GR (1) | GR3000606T3 (OSRAM) |
| IL (1) | IL81904A (OSRAM) |
| MX (1) | MX165808B (OSRAM) |
| NO (1) | NO871121L (OSRAM) |
| PT (1) | PT84494B (OSRAM) |
| ZA (1) | ZA872019B (OSRAM) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2030409T3 (es) * | 1986-10-24 | 1992-11-01 | Boehringer Ingelheim Kg | Procedimiento para preparar y purificar compuestos termolabiles . |
| ATE79386T1 (de) * | 1986-12-19 | 1992-08-15 | Akzo Nv | Herstellung von polymilchsaeure und copolymeren daraus. |
| US4900535A (en) * | 1986-12-22 | 1990-02-13 | Comalco Aluminum Limited | Recovery of fluoride values from waste materials |
| US5223630A (en) * | 1989-10-10 | 1993-06-29 | E. I. Du Pont De Nemours And Company | Glycolide purification process |
| US5171270A (en) * | 1990-03-29 | 1992-12-15 | Herrick Robert S | Canalicular implant having a collapsible flared section and method |
| US5163959A (en) * | 1990-03-29 | 1992-11-17 | Herrick Robert S | Method for treating an eye with a canalicular implant having a collapsible flared section |
| EP0576534A1 (en) * | 1991-03-11 | 1994-01-05 | Henkel Corporation | Process for controlled depolymerization of feed material to produce a product with lower molecular weight |
| JP2603769B2 (ja) * | 1991-05-22 | 1997-04-23 | 株式会社 ワコール | 人体の体表面に圧接して着用されるテーピング機能を有する下腿部用サポーター |
| US5675021A (en) * | 1992-03-19 | 1997-10-07 | Chronopol, Inc. | Method to produce and purify cyclic esters |
| US5686630A (en) * | 1993-09-29 | 1997-11-11 | Chronopol, Inc. | Purifying cyclic esters by aqueous solvent extraction |
| US5420304A (en) * | 1992-03-19 | 1995-05-30 | Biopak Technology, Ltd. | Method to produce cyclic esters |
| DE59305524D1 (de) * | 1992-09-16 | 1997-04-03 | Basf Ag | Verfahren zur Herstellung von Glykolid und Lactid |
| US5412067A (en) * | 1993-05-10 | 1995-05-02 | Mitsui Toatsu Chemicals, Inc. | Preparation process of polyester |
| US6150497A (en) * | 1998-01-14 | 2000-11-21 | Sherwood Services Ag | Method for the production of polyglycolic acid |
| US7404825B2 (en) * | 2001-06-11 | 2008-07-29 | Herrick Ii Robert S | Implant capable of forming a differential image in an eye |
| CN100999516B (zh) * | 2006-01-12 | 2010-11-10 | 中南大学 | 乙交酯的提纯方法 |
| FI128487B (en) | 2013-05-06 | 2020-06-15 | Teknologian Tutkimuskeskus Vtt Oy | Glycolic acid polymers and process for their preparation |
| EP3215550B1 (en) | 2014-11-06 | 2024-10-16 | Teknologian Tutkimuskeskus VTT OY | Method of producing glycolic acid polymers |
| CN106928180B (zh) * | 2015-12-31 | 2020-01-03 | 上海浦景化工技术股份有限公司 | 一种从粗乙交酯中连续精制乙交酯的装置及方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3463158A (en) * | 1963-10-31 | 1969-08-26 | American Cyanamid Co | Polyglycolic acid prosthetic devices |
| US3297033A (en) * | 1963-10-31 | 1967-01-10 | American Cyanamid Co | Surgical sutures |
| US3442871A (en) * | 1966-05-04 | 1969-05-06 | American Cyanamid Co | Process for polymerizing a glycolide |
| US3457280A (en) * | 1967-06-12 | 1969-07-22 | American Cyanamid Co | Alpha-glycolide and methods for the isolation thereof |
| US3435008A (en) * | 1967-08-22 | 1969-03-25 | American Cyanamid Co | Method for preparation of isomerically pure beta-glycolide and polymerization method for glycolide compositions employing partial hydrolyzate of said beta-glycolide |
| US3597449A (en) * | 1967-11-16 | 1971-08-03 | American Cyanamid Co | Stable glycolide and lactide composition |
| US3763190A (en) * | 1972-04-19 | 1973-10-02 | Stanford Research Inst | Preparation of pure glycolide |
| US4387264A (en) * | 1981-05-04 | 1983-06-07 | Atlantic Richfield Company | Diolefin monomer purification process for anionic polymerization |
-
1986
- 1986-03-19 US US06/841,489 patent/US4650851A/en not_active Expired - Fee Related
-
1987
- 1987-03-13 AT AT87302194T patent/ATE52257T1/de not_active IP Right Cessation
- 1987-03-13 ES ES87302194T patent/ES2014472B3/es not_active Expired - Lifetime
- 1987-03-13 EP EP87302194A patent/EP0238273B1/en not_active Expired - Lifetime
- 1987-03-13 DE DE8787302194T patent/DE3762417D1/de not_active Expired - Fee Related
- 1987-03-16 IL IL81904A patent/IL81904A/xx unknown
- 1987-03-17 PT PT84494A patent/PT84494B/pt not_active IP Right Cessation
- 1987-03-17 CA CA000532229A patent/CA1258466A/en not_active Expired
- 1987-03-18 MX MX005615A patent/MX165808B/es unknown
- 1987-03-18 DK DK138187A patent/DK138187A/da not_active Application Discontinuation
- 1987-03-18 FI FI871182A patent/FI85374C/fi not_active IP Right Cessation
- 1987-03-18 NO NO871121A patent/NO871121L/no unknown
- 1987-03-18 AU AU70149/87A patent/AU582680B2/en not_active Ceased
- 1987-03-19 ZA ZA872019A patent/ZA872019B/xx unknown
- 1987-03-19 JP JP62065519A patent/JPS62270574A/ja active Granted
- 1987-03-19 KR KR1019870002472A patent/KR910005054B1/ko not_active Expired
-
1990
- 1990-04-26 GR GR90400228T patent/GR3000606T3/el unknown
-
1992
- 1992-09-17 JP JP4248248A patent/JPH0678426B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| KR910005054B1 (ko) | 1991-07-22 |
| ES2014472B3 (es) | 1990-07-16 |
| FI85374C (fi) | 1992-04-10 |
| JPH0678426B2 (ja) | 1994-10-05 |
| US4650851A (en) | 1987-03-17 |
| FI871182L (fi) | 1987-09-20 |
| EP0238273A2 (en) | 1987-09-23 |
| ZA872019B (en) | 1988-10-26 |
| DK138187D0 (da) | 1987-03-18 |
| PT84494B (pt) | 1989-11-10 |
| JPS62270574A (ja) | 1987-11-24 |
| NO871121L (no) | 1987-09-21 |
| KR870008918A (ko) | 1987-10-22 |
| ATE52257T1 (de) | 1990-05-15 |
| DE3762417D1 (de) | 1990-05-31 |
| FI85374B (fi) | 1991-12-31 |
| CA1258466A (en) | 1989-08-15 |
| FI871182A0 (fi) | 1987-03-18 |
| PT84494A (en) | 1987-04-01 |
| IL81904A0 (en) | 1987-10-20 |
| GR3000606T3 (en) | 1991-09-27 |
| NO871121D0 (no) | 1987-03-18 |
| DK138187A (da) | 1987-09-20 |
| AU582680B2 (en) | 1989-04-06 |
| MX165808B (es) | 1992-12-07 |
| EP0238273B1 (en) | 1990-04-25 |
| EP0238273A3 (en) | 1988-10-26 |
| JPH06136103A (ja) | 1994-05-17 |
| AU7014987A (en) | 1987-09-24 |
| IL81904A (en) | 1991-07-18 |
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