JPH044295B2 - - Google Patents

Info

Publication number
JPH044295B2
JPH044295B2 JP57023504A JP2350482A JPH044295B2 JP H044295 B2 JPH044295 B2 JP H044295B2 JP 57023504 A JP57023504 A JP 57023504A JP 2350482 A JP2350482 A JP 2350482A JP H044295 B2 JPH044295 B2 JP H044295B2
Authority
JP
Japan
Prior art keywords
drug
rate
enhancer
skin
absorption enhancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57023504A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57154122A (en
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPS57154122A publication Critical patent/JPS57154122A/ja
Publication of JPH044295B2 publication Critical patent/JPH044295B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP57023504A 1981-02-17 1982-02-16 Administration vehicle for coadministration of drug and percutaneous absorption promoting agent Granted JPS57154122A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/235,068 US4379454A (en) 1981-02-17 1981-02-17 Dosage for coadministering drug and percutaneous absorption enhancer

Publications (2)

Publication Number Publication Date
JPS57154122A JPS57154122A (en) 1982-09-22
JPH044295B2 true JPH044295B2 (en:Method) 1992-01-27

Family

ID=22883968

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57023504A Granted JPS57154122A (en) 1981-02-17 1982-02-16 Administration vehicle for coadministration of drug and percutaneous absorption promoting agent

Country Status (16)

Country Link
US (1) US4379454A (en:Method)
JP (1) JPS57154122A (en:Method)
AU (2) AU547007B2 (en:Method)
CA (1) CA1166961A (en:Method)
CH (1) CH657055A5 (en:Method)
CY (1) CY1400A (en:Method)
DE (1) DE3205258A1 (en:Method)
FR (1) FR2499859B1 (en:Method)
GB (1) GB2093694B (en:Method)
HK (1) HK90687A (en:Method)
IE (1) IE52930B1 (en:Method)
IT (1) IT1218310B (en:Method)
MX (2) MX161285A (en:Method)
MY (1) MY8700746A (en:Method)
SE (1) SE452407B (en:Method)
SG (1) SG68387G (en:Method)

Families Citing this family (343)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2105990B (en) * 1981-08-27 1985-06-19 Nitto Electric Ind Co Adhesive skin patches
US4460370A (en) * 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication application cell
DE3204582A1 (de) * 1982-02-10 1983-08-25 Hassia Verpackung Gmbh, 6479 Ranstadt Verfahren zur kontinuierlichen herstellung von pflasterpackungen fuer die transdermale verabreichung von medikamenten
DE3347277A1 (de) * 1983-12-28 1985-07-11 Bayer Ag, 5090 Leverkusen Wirkstoffabgabesysteme
US4573996A (en) * 1984-01-03 1986-03-04 Jonergin, Inc. Device for the administration of an active agent to the skin or mucosa
ATE42901T1 (de) * 1984-03-05 1989-05-15 Nitto Denko Corp Haftendes arzneimittelpraeparat fuer perkutane absorption.
US4725439A (en) * 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4704282A (en) * 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
DE3424837C1 (de) * 1984-07-03 1986-01-16 Hassia-Verpackung Karl Klein Gmbh, 1000 Berlin Depot-Pflaster
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4649075A (en) * 1984-08-09 1987-03-10 Leonora Jost Transdermal and transmucosal vortexed foam devices and the method of making
ES8608895A1 (es) * 1984-08-17 1986-07-16 Allpack Ind Lohnverpackung Parche adhesivo farmaceutico y procedimiento para su fabri- cacion
US4927687A (en) * 1984-10-01 1990-05-22 Biotek, Inc. Sustained release transdermal drug delivery composition
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
WO1986002272A1 (en) * 1984-10-11 1986-04-24 Key Pharmaceuticals, Inc. Physiological means of enhancing transdermal delivery of drugs
US4883669A (en) * 1985-02-25 1989-11-28 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration
US4904475A (en) * 1985-05-03 1990-02-27 Alza Corporation Transdermal delivery of drugs from an aqueous reservoir
US4645502A (en) * 1985-05-03 1987-02-24 Alza Corporation Transdermal delivery of highly ionized fat insoluble drugs
GB8512358D0 (en) * 1985-05-16 1985-06-19 Euro Celtique Sa Transdermal delivery system
US4690683A (en) * 1985-07-02 1987-09-01 Rutgers, The State University Of New Jersey Transdermal varapamil delivery device
US4698062A (en) * 1985-10-30 1987-10-06 Alza Corporation Medical device for pulsatile transdermal delivery of biologically active agents
JPS63502986A (ja) * 1985-12-12 1988-11-02 フレックスコン・カンパニ−・インコ−ポレ−テッド 経皮方法および接着剤
US4710191A (en) * 1985-12-16 1987-12-01 Jonergin, Inc. Therapeutic device for the administration of medicaments
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
DE3770836D1 (de) * 1986-02-14 1991-07-25 Ciba Geigy Ag Dermale und transdermale therapeutische systeme mit musterfoermig aufgetragener klebschicht, sowie verfahren zur dessen herstellung.
US5560922A (en) * 1986-05-30 1996-10-01 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
ATE71287T1 (de) * 1986-06-13 1992-01-15 Alza Corp Aktivierung eines transdermalen drogenabgabesystems durch feuchtigkeit.
US4755180A (en) * 1986-06-16 1988-07-05 Alza Corporation Dosage form comprising solubility regulating member
USRE37934E1 (en) 1986-08-28 2002-12-10 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system
US6126963A (en) 1986-08-28 2000-10-03 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US6110488A (en) * 1986-08-28 2000-08-29 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US5820876A (en) 1986-08-28 1998-10-13 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
DE3629304A1 (de) * 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
US6117448A (en) * 1986-08-28 2000-09-12 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
US4938759A (en) * 1986-09-02 1990-07-03 Alza Corporation Transdermal delivery device having a rate controlling adhesive
US4908027A (en) * 1986-09-12 1990-03-13 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5344656A (en) * 1986-09-12 1994-09-06 Alza Corporation Subsaturated transdermal therapeutic system having improved release characteristics
US5422118A (en) * 1986-11-07 1995-06-06 Pure Pac, Inc. Transdermal administration of amines with minimal irritation and high transdermal flux rate
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
AU607172B2 (en) * 1986-12-22 1991-02-28 Cygnus, Inc. Diffusion matrix for transdermal drug administration
US5006342A (en) * 1986-12-22 1991-04-09 Cygnus Corporation Resilient transdermal drug delivery device
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
AU601528B2 (en) * 1986-12-22 1990-09-13 Ortho-Mcneil Pharmaceutical, Inc. Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers
US5322695A (en) * 1987-01-09 1994-06-21 Hercon Laboratories Corporation Moisture-vapor-permeable dressing
US4940586A (en) * 1987-02-26 1990-07-10 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4865848A (en) * 1987-02-26 1989-09-12 Alza Corporation Skin permeation enhancer compositions using sucrose esters
US4746515A (en) * 1987-02-26 1988-05-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolaurate
US4816258A (en) * 1987-02-26 1989-03-28 Alza Corporation Transdermal contraceptive formulations
US4788062A (en) * 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
US5071656A (en) * 1987-03-05 1991-12-10 Alza Corporation Delayed onset transdermal delivery device
US5000956A (en) * 1987-03-09 1991-03-19 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5118509A (en) * 1987-03-09 1992-06-02 Alza Corporation Inducing skin tolerance to a sensitizing drug
US5049387A (en) * 1987-03-09 1991-09-17 Alza Corporation Inducing skin tolerance to a sensitizing drug
US5077054A (en) * 1987-03-09 1991-12-31 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
US5171576A (en) * 1987-03-09 1992-12-15 Alza Corporation Prevention of contact allergy by coadministration of a corticosteroid with a sensitizing drug
CH674618A5 (en:Method) * 1987-04-02 1990-06-29 Ciba Geigy Ag
US5045553A (en) * 1987-06-24 1991-09-03 Fujisawa Pharmaceutical Company, Ltd. Pharmaceutical composition for percutaneous drug absorption and percutaneous drug absorption promoter
US4804541A (en) * 1987-08-11 1989-02-14 Moleculon, Inc. Transdermal administration using benzyl alcohol
US4764379A (en) * 1987-08-24 1988-08-16 Alza Corporation Transdermal drug delivery device with dual permeation enhancers
US4820720A (en) * 1987-08-24 1989-04-11 Alza Corporation Transdermal drug composition with dual permeation enhancers
US4917895A (en) * 1987-11-02 1990-04-17 Alza Corporation Transdermal drug delivery device
US4837027A (en) * 1987-11-09 1989-06-06 Alza Corporation Transdermal drug delivery device
US4781924A (en) * 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US4863738A (en) * 1987-11-23 1989-09-05 Alza Corporation Skin permeation enhancer compositions using glycerol monooleate
FR2623718B1 (fr) * 1987-11-27 1994-04-15 Fabre Medicament Pierre Dispositif therapeutique transdermique et son procede de preparation
US5068226A (en) * 1987-12-07 1991-11-26 Cyclex, Inc. Pharmaceutical preparations containing cyclodextrins and their use in iontophoretic therapies
US4979946A (en) * 1987-12-14 1990-12-25 The Kendall Company Environmental absorbent dressing
US5064654A (en) * 1989-01-11 1991-11-12 Ciba-Geigy Corporation Mixed solvent mutually enhanced transdermal therapeutic system
US5925372A (en) * 1987-12-16 1999-07-20 Novartis Corporation Mixed solvent mutually enhanced transdermal therapeutic system
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
US5223261A (en) * 1988-02-26 1993-06-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
US4885154A (en) * 1988-03-01 1989-12-05 Alza Corporation Method for reducing sensitization or irritation in transdermal drug delivery and means therefor
US5719197A (en) * 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5300291A (en) * 1988-03-04 1994-04-05 Noven Pharmaceuticals, Inc. Method and device for the release of drugs to the skin
US5641504A (en) * 1988-06-09 1997-06-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
PT90820B (pt) * 1988-06-14 1995-05-31 Alza Corp Dispositivo de libertacao transdermica sub-saturado
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5181914A (en) * 1988-08-22 1993-01-26 Zook Gerald P Medicating device for nails and adjacent tissue
EP0364211B1 (en) * 1988-10-11 1994-12-21 Shire Holdings Ltd. A percutaneous pharmaceutical preparation
US5026556A (en) * 1988-11-10 1991-06-25 Norwich Eaton Pharmaceuticals, Inc. Compositions for the transdermal delivery of pharmaceutical actives
CA2004203A1 (en) * 1988-12-01 1990-06-01 Sharad K. Govil Compositions for transdermal delivery of estradiol
US5332577A (en) * 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
US5241925A (en) * 1988-12-27 1993-09-07 Dermamed Apparatus and techniques for administering veterinary medicaments
US5223262A (en) * 1989-02-23 1993-06-29 University Of Utah Transdermal delivery system utilizing one way membranes
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5788983A (en) * 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5139023A (en) * 1989-06-02 1992-08-18 Theratech Inc. Apparatus and method for noninvasive blood glucose monitoring
WO1990015568A2 (en) * 1989-06-02 1990-12-27 Stanley Theodore H Apparatus and methods for noninvasive blood glucose monitoring
US5232703A (en) * 1989-07-21 1993-08-03 Izhak Blank Estradiol compositions and methods for topical application
US4956171A (en) * 1989-07-21 1990-09-11 Paco Pharmaceutical Services, Inc. Transdermal drug delivery using a dual permeation enhancer and method of performing the same
DE69007886T2 (de) * 1989-07-21 1994-11-17 Izhak Blank Östradiol enthaltende Mittel und Verfahren zur topischen Anwendung.
US5252334A (en) * 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
US5324521A (en) * 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
ES2097145T3 (es) 1990-03-28 1997-04-01 Noven Pharma Metodo y dispositivo para la liberacion de farmacos en la piel.
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
ES2099747T3 (es) * 1990-06-01 1997-06-01 Population Council Inc Aplicacion topica terapeuticamente eficaz de la st1435.
US5071704A (en) * 1990-06-13 1991-12-10 Fischel Ghodsian Fariba Device for controlled release of vapors and scents
US5455043A (en) * 1990-06-13 1995-10-03 Fischel-Ghodsian; Fariba Device for controlled release of vaporous medications through nasal route
US5160741A (en) * 1990-07-06 1992-11-03 Alza Corporation Reduction or prevention of skin irritation by drugs
US5130139A (en) * 1990-07-06 1992-07-14 Alza Corporation Reduction or prevention of skin irritation by drugs
US5149539A (en) * 1990-08-03 1992-09-22 Alza Corporation Reduction or prevention of sensitization to drugs
US5120545A (en) * 1990-08-03 1992-06-09 Alza Corporation Reduction or prevention of sensitization to drugs
FI931916A7 (fi) * 1990-10-29 1993-04-28 Alza Corp Ihonläpäisevät ehkäisyseokset, -menetelmät ja -laitteet
US5198223A (en) * 1990-10-29 1993-03-30 Alza Corporation Transdermal formulations, methods and devices
US5320850A (en) * 1990-10-29 1994-06-14 Alza Corporation Transdermal delivery of the gestogen ST-1435 and devices therefor
US5314694A (en) * 1990-10-29 1994-05-24 Alza Corporation Transdermal formulations, methods and devices
US5512292A (en) * 1990-10-29 1996-04-30 Alza Corporation Transdermal contraceptive formulations methods and devices
DE4115849A1 (de) * 1991-05-15 1992-11-19 Lohmann Therapie Syst Lts Penetrationsfoerdernde substanz
US5402777A (en) * 1991-06-28 1995-04-04 Alza Corporation Methods and devices for facilitated non-invasive oxygen monitoring
CN1042699C (zh) * 1991-07-10 1999-03-31 生达化学制药股份有限公司 雌性激素经皮吸收贴片
US5203768A (en) * 1991-07-24 1993-04-20 Alza Corporation Transdermal delivery device
US5464387A (en) * 1991-07-24 1995-11-07 Alza Corporation Transdermal delivery device
US5189986A (en) * 1991-09-23 1993-03-02 Alza Corporation Veterinary transdermal active agent delivery device
US5705185A (en) * 1991-09-25 1998-01-06 Beta Pharmaceuticals Co. Transdermal delivery of estradiol and process for manufacturing said device
US5518734A (en) * 1991-09-25 1996-05-21 Beta Pharmaceuticals Co. Transdermal delivery system for estradiol and process for manufacturing said device
US5352456A (en) * 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
WO1993007870A1 (en) * 1991-10-18 1993-04-29 Alza Corporation Device for the transdermal administration of melatonin
US5229130A (en) * 1991-12-20 1993-07-20 Cygnus Therapeutics Systems Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems
KR950701516A (ko) * 1992-05-13 1995-04-28 에드워드 엘. 만델 옥시부티닌의 경피 투여(Transdermal Administration of Oxybutynin)
US5900250A (en) * 1992-05-13 1999-05-04 Alza Corporation Monoglyceride/lactate ester permeation enhancer for oxybutnin
DE4336557C2 (de) 1993-05-06 1997-07-17 Lohmann Therapie Syst Lts Estradiolhaltiges transdermales therapeutisches System, Verfahren zu seiner Herstellung und seine Verwendung
US5330452A (en) * 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5451407A (en) * 1993-06-21 1995-09-19 Alza Corporation Reduction or prevention of skin irritation or sensitization during transdermal administration of a irritating or sensitizing drug
WO1995001167A2 (en) * 1993-06-25 1995-01-12 Alza Corporation Incorporating poly-n-vinyl amide in a transdermal system
US5415866A (en) * 1993-07-12 1995-05-16 Zook; Gerald P. Topical drug delivery system
US5691377A (en) * 1993-07-30 1997-11-25 University Of Maryland Eastern Shore And University Of Maryland College Park Use of N-methyl-aspartic acid for enhancing growth and altering body composition
DE4332094C2 (de) * 1993-09-22 1995-09-07 Lohmann Therapie Syst Lts Lösemittelfrei herstellbares Wirkstoffpflaster und Verfahren zu seiner Herstellung
KR960011044B1 (ko) * 1993-09-27 1996-08-16 재단법인 한국화학연구소 알칸올 투과가 우수한 고분자막
US5747065A (en) * 1993-09-29 1998-05-05 Lee; Eun Soo Monoglyceride/lactate ester permeation enhancer for oxybutynin
US5641507A (en) * 1993-12-06 1997-06-24 Devillez; Richard L. Delivery system for dermatological and cosmetic ingredients
US5962011A (en) * 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
US5466465A (en) * 1993-12-30 1995-11-14 Harrogate Holdings, Limited Transdermal drug delivery system
DE4400770C1 (de) * 1994-01-13 1995-02-02 Lohmann Therapie Syst Lts Wirkstoffhaltiges Pflaster zur Abgabe von Estradiol mit mindestens einem Penetrationsverstärker, Verfahren zu seiner Herstellung und seine Verwendung
US5635203A (en) * 1994-09-29 1997-06-03 Alza Corporation Transdermal device having decreased delamination
US5505958A (en) * 1994-10-31 1996-04-09 Algos Pharmaceutical Corporation Transdermal drug delivery device and method for its manufacture
CN1170360A (zh) * 1994-12-21 1998-01-14 瑟垃技术有限公司 具有粘性贴面和剥离密封圆片的经皮输送系统
DE19500662C2 (de) * 1995-01-12 2001-04-26 Lohmann Therapie Syst Lts Estradiolhaltiges Pflaster und seine Verwendung
US5882676A (en) * 1995-05-26 1999-03-16 Alza Corporation Skin permeation enhancer compositions using acyl lactylates
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
US6572879B1 (en) * 1995-06-07 2003-06-03 Alza Corporation Formulations for transdermal delivery of pergolide
US5840327A (en) * 1995-08-21 1998-11-24 Alza Corporation Transdermal drug delivery device having enhanced adhesion
US5902603A (en) * 1995-09-14 1999-05-11 Cygnus, Inc. Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
EP0863751B1 (en) 1995-12-01 2001-10-24 Alza Corporation Improved method for preventing crystal formation in a dispersion of a liquid in a matrix
US6238700B1 (en) 1995-12-01 2001-05-29 Alza Corporation Method for preventing crystal formation in a dispersion of a liquid in a matrix
US5733571A (en) * 1995-12-08 1998-03-31 Euro-Celtique, S.A. Transdermal patch for comparative evaluations
US5730721A (en) * 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
US6007837A (en) * 1996-07-03 1999-12-28 Alza Corporation Drug delivery devices and process of manufacture
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
ATE229817T1 (de) * 1996-10-24 2003-01-15 Alza Corp Penetrationsfördernde substanzen für die transdermale verabreichung von wirkstoffen, vorrichtungen und verfahren zur herstellung
US6019988A (en) * 1996-11-18 2000-02-01 Bristol-Myers Squibb Company Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage
DE19701949A1 (de) * 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermales therapeutisches System
DE19700913C2 (de) * 1997-01-14 2001-01-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Hormonen
US6203817B1 (en) 1997-02-19 2001-03-20 Alza Corporation Reduction of skin reactions caused by transdermal drug delivery
US5968547A (en) * 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
GB9711032D0 (en) * 1997-05-30 1997-07-23 Johnson Matthey Plc Compound as a stimulant for the central nervous system
US6174545B1 (en) 1997-07-01 2001-01-16 Alza Corporation Drug delivery devices and process of manufacture
US6420622B1 (en) * 1997-08-01 2002-07-16 3M Innovative Properties Company Medical article having fluid control film
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
ATE302041T1 (de) * 1997-12-11 2005-09-15 Alza Corp Vorrichtung zur erhöhung des transdermalen wirkstoffeflusses
JP4061022B2 (ja) * 1997-12-11 2008-03-12 アルザ・コーポレーション 経皮輸送剤の流量促進装置
EP1911488A3 (en) 1997-12-11 2008-12-03 Alza Corporation Device for enhancing transdermal agent flux
CA2313700C (en) 1997-12-11 2009-11-24 Alza Corporation Device for enhancing transdermal agent flux
CA2315890C (en) 1997-12-22 2009-08-11 Alza Corporation Rate controlling membranes for controlled drug delivery devices
US6267984B1 (en) 1997-12-22 2001-07-31 Alza Corporation Skin permeation enhancer compositions comprising a monoglyceride and ethyl palmitate
US6269820B1 (en) 1998-02-26 2001-08-07 Xomed Surgical Products, Inc. Method of controlling post-operative leakage associated with tumescent liposuction
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
DE19834007C1 (de) 1998-07-29 2000-02-24 Lohmann Therapie Syst Lts Estradiolhaltiges Pflaster zur transdermalen Applikation von Hormonen und seine Verwendung
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
DK1140039T3 (da) * 1998-12-18 2010-03-22 Alza Corp Transparente indretninger til perkutan nikotinadministration
US20070196490A1 (en) * 1999-01-22 2007-08-23 Powderject Research Limited Method of enhancing needleless transdermal powered drug delivery
ES2295021T3 (es) * 1999-03-25 2008-04-16 Metabolix, Inc. Utilizacion y aplicaciones medicas de polimeros de poli(hidroxialcanoatos).
KR100622332B1 (ko) * 1999-04-01 2006-09-13 알자 코포레이션 폴리우레탄 약물 리저버를 함유하는 경피 약물 수송 장치
US6544541B1 (en) 1999-06-02 2003-04-08 Cardiovascular Solutions, Inc. Devices and compounds for treating arterial restenosis
AU780953B2 (en) 1999-08-30 2005-04-28 Tepha, Inc. Flushable disposable polymeric products
ES2253278T3 (es) 1999-12-10 2006-06-01 Alza Corporation Dispositivo y procedimiento para mejorar la perforacion cutanea con microprotuberancias.
JP4653893B2 (ja) * 2000-01-27 2011-03-16 純一 須藤 二層型経皮吸収製剤
US7179483B2 (en) * 2000-04-26 2007-02-20 Watson Pharmaceuticals, Inc. Compositions and methods for transdermal oxybutynin therapy
FR2814074B1 (fr) * 2000-09-15 2003-03-07 Theramex Nouvelles compositions estro-progestatives topiques a effet systemique
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
US8329734B2 (en) * 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
ES2312585T3 (es) * 2001-06-05 2009-03-01 Ronald Aung-Din Terapia contra la migraña por via topica.
US20090162342A1 (en) * 2001-06-07 2009-06-25 Sanomune Inc. Therapeutic uses of glandular kallikrein
US20040033253A1 (en) * 2002-02-19 2004-02-19 Ihor Shevchuk Acyl opioid antagonists
AU2003251482A1 (en) 2002-06-10 2003-12-22 Euro-Celtique, S.A. Disposal systems of transdermal delivery devices to prevent misuse of the active agents contained therein
US7099713B2 (en) 2002-06-28 2006-08-29 Battelle Memorial Institute Skin conduction and transport systems
JP4726486B2 (ja) * 2002-08-02 2011-07-20 アブ サイエンス ２−（３−アミノアリール）アミノ−４−アリール−チアゾールおよびそれらのｃ−ｋｉｔ阻害薬としての使用法
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
EP1530469B1 (en) * 2002-08-20 2009-02-25 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and free-base form of an antagonist
US20040086579A1 (en) * 2002-11-05 2004-05-06 Higgins James W. Dietary supplement comprising parthenolide
US7192614B2 (en) 2002-11-05 2007-03-20 Gelstat Corporation Compositions and methods of treatment to alleviate or prevent migrainous headaches and their associated symptoms
US6866856B2 (en) * 2002-12-31 2005-03-15 Avon Products, Inc. Compositions and delivery methods for the treatment of wrinkles, fine lines and hyperhidrosis
US7060303B2 (en) * 2002-12-31 2006-06-13 Avon Products, Inc. Use of purslane to treat facial wrinkles
US20040191301A1 (en) * 2003-03-27 2004-09-30 Van Duren Albert Philip Transdermal device having a phase change material
EP1608347B1 (en) * 2003-03-28 2014-08-13 Sigmoid Pharma Limited Solid oral dosage form containing seamless microcapsules
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
AU2004238229B2 (en) * 2003-05-08 2007-07-12 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US20040247705A1 (en) * 2003-06-06 2004-12-09 Roberts Stephen C. Transdermal compositions and methods of treatment to alleviate or prevent migrainous headaches and their associated symptoms
US20040247706A1 (en) * 2003-06-06 2004-12-09 Roberts Stephen C. Transdermal dietary supplement comprising parthenolide
US20060200100A1 (en) * 2003-06-18 2006-09-07 Rosati Coni F Method and apparatus for supplying gas to an area
WO2004112723A2 (en) 2003-06-20 2004-12-29 Ronald Aung-Din Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions
CA2531833C (en) * 2003-07-08 2009-10-20 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
CA2534238A1 (en) 2003-07-28 2005-02-10 Alza Corporation Transdermal warfarin-containing delivery system
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
AU2004268560B2 (en) * 2003-08-22 2008-08-21 Tepha, Inc. Polyhydroxyalkanoate nerve regeneration devices
NZ546645A (en) * 2003-10-23 2010-02-26 Ab Science 2-Aminoaryloxazole compounds as tyrosine kinase inhibitors
EP1682211B1 (en) 2003-10-27 2009-11-18 Universität Basel Transdermal drug delivery system
US20070191815A1 (en) 2004-09-13 2007-08-16 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
US7504385B2 (en) * 2003-12-17 2009-03-17 Avon Products, Inc. si-RNA-mediated gene silencing technology to inhibit tyrosinase and reduce pigmentation
US7105263B2 (en) * 2003-12-30 2006-09-12 Samsung Electronics Company Dry toner comprising encapsulated pigment, methods and uses
US20050232983A1 (en) * 2004-04-14 2005-10-20 Indevus Pharmaceuticals, Inc. Transdermal patch
US20060008432A1 (en) * 2004-07-07 2006-01-12 Sebastiano Scarampi Gilsonite derived pharmaceutical delivery compositions and methods: nail applications
ES2395464T3 (es) * 2004-08-03 2013-02-12 Tepha, Inc. Suturas de polihidroxialcanoato no rizadas
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP2322146B1 (en) * 2004-09-27 2012-12-12 Sigmoid Pharma Limited Microcapsule formulations comprising two pharmaceutically active ingredients
US20060127463A1 (en) * 2004-12-15 2006-06-15 Nugara Peter N Composite structure including a low vinyl acetate layer
WO2006066117A1 (en) * 2004-12-17 2006-06-22 Alza Corporation Temperature modulation of transdermal drug delivery
US7618662B2 (en) 2004-12-22 2009-11-17 Avon Products, Inc Use of natural plant extracts in cosmetic compositions
US7514092B2 (en) 2004-12-22 2009-04-07 Avon Products, Inc. Compositions and methods of their use for improving the condition and appearance of skin
US7351745B2 (en) 2004-12-22 2008-04-01 Avon Products, Inc Compositions and methods of their use for improving the condition and appearance of skin
US7410658B2 (en) * 2004-12-22 2008-08-12 Avon Products, Inc. Use of Alisma orientale in cosmetics and compositions thereof
DE102004062614B4 (de) * 2004-12-24 2011-12-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit aktivierbarer Übersättigung und kontrollierter Permeationförderung sowie Verfahren zu dessen Herstellung
ES2362221T3 (es) * 2005-01-28 2011-06-29 Tepha, Inc. Embolización con partículas poli-4-hidroxibutirato.
US20060188558A1 (en) * 2005-02-18 2006-08-24 Mylan Technologies, Inc. Transdermal systems having control delivery system
JP5204643B2 (ja) 2005-04-04 2013-06-05 アブ サイエンス 置換オキサゾール誘導体、およびチロシンキナーゼ阻害薬としてのそれらの使用
WO2006124585A2 (en) * 2005-05-13 2006-11-23 Alza Corporation Multilayer drug system for the delivery of galantamine
WO2006127905A2 (en) 2005-05-24 2006-11-30 Chrono Therapeutics, Inc. Portable drug delivery device
US8383149B2 (en) 2005-09-23 2013-02-26 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
US9056061B2 (en) * 2005-09-23 2015-06-16 Alza Corporation Transdermal nicotine salt delivery system
WO2007035942A2 (en) * 2005-09-23 2007-03-29 Alza Corporation Transdermal risperidone delivery system
US20070104771A1 (en) * 2005-09-23 2007-05-10 Jay Audett Transdermal galantamine delivery system
WO2007121188A2 (en) * 2006-04-10 2007-10-25 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
US8518926B2 (en) * 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
DK2026803T3 (da) * 2006-05-16 2012-04-16 Knopp Neurosciences Inc Sammensætninger af R(+) og S(-) pramipexol og fremgangsmåder til anvendelse heraf
US20070278289A1 (en) * 2006-05-31 2007-12-06 Toshiba Tec Kabushiki Kaisha Payment adjusting apparatus and program therefor
US7833284B2 (en) * 2006-06-28 2010-11-16 The Cleveland Clinic Foundation Anti-adhesion membrane
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
JP5443164B2 (ja) 2006-09-26 2014-03-19 インフェクティアス ディジーズ リサーチ インスティチュート 合成アジュバントを含むワクチン組成物
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
US8524695B2 (en) * 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
US7642062B2 (en) 2006-12-29 2010-01-05 Avon Products Inc. Compositions and methods of their use for improving the condition and appearance of skin
WO2008103818A1 (en) * 2007-02-21 2008-08-28 University Of Louisville Research Foundation Therapeutic cotinine compositions
WO2008113056A2 (en) * 2007-03-14 2008-09-18 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
WO2008116004A2 (en) 2007-03-19 2008-09-25 Vita Sciences, Llc Transdermal patch and method for delivery of vitamin b12
CN101677964A (zh) 2007-04-04 2010-03-24 希格默伊德药业有限公司 他克莫司药物组合物
EP2586428B1 (en) 2007-04-26 2023-11-08 Sublimity Therapeutics Limited Manufacture of multiple minicapsules
CA2685591A1 (en) * 2007-05-01 2008-11-06 Sigmoid Pharma Limited Pharmaceutical nimodipine compositions
EP2173330B1 (de) * 2007-07-04 2012-04-04 Acino AG Reservoirsystem mit verschlossener membran
US20090304776A1 (en) * 2008-06-06 2009-12-10 Totada Shantha Transmucosal delivery of therapeutic agents and methods of use thereof
US7883487B2 (en) * 2008-06-16 2011-02-08 Shantha Totada R Transdermal local anesthetic patch with injection port
CA2729346A1 (en) 2008-06-30 2010-01-14 Afgin Pharma, Llc Topical regional neuro-affective therapy
KR20110071064A (ko) * 2008-08-19 2011-06-28 크놉 뉴로사이언시스 인코포레이티드 (ｒ)-프라미펙솔을 사용하는 조성물 및 방법
US8715715B2 (en) 2008-11-03 2014-05-06 Nal Pharmaceuticals Ltd. Dosage form for insertion into the mouth
US20100209484A1 (en) * 2009-02-13 2010-08-19 Hoo-Kyun Choi Transdermal Triptan Delivery System
HRP20150110T1 (hr) 2009-05-18 2015-05-08 Sigmoid Pharma Limited Kompozicija koja sadrži uljne kapljice
EP2437753B1 (en) 2009-06-05 2016-08-31 Infectious Disease Research Institute Synthetic glucopyranosyl lipid adjuvants and vaccine compositions containing them
CA2765876A1 (en) * 2009-06-19 2010-12-23 Knopp Neurosciences, Inc. Compositions and methods for treating amyotrophic lateral sclerosis
GB2485327A (en) 2009-08-12 2012-05-09 Sigmoid Pharma Ltd Immunomodulatory compositions comprising a polymer matrix and an oil phase
EP2523952B1 (en) 2010-01-12 2015-03-04 AB Science Oxazole kinase inhibitors
US20120302577A1 (en) 2010-01-28 2012-11-29 Ab Science Treatment of gist with masitinib
ES2726451T3 (es) 2010-04-28 2019-10-04 Sorrento Therapeutics Inc Matriz de microagujas composite que incluye nanoestructuras sobre la misma
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
AU2011246879C1 (en) 2010-04-28 2016-03-24 Sorrento Therapeutics, Inc. Device for delivery of rheumatoid arthritis medication
RU2585138C2 (ru) 2010-04-28 2016-05-27 Кимберли-Кларк Ворлдвайд, Инк. Медицинские устройства для доставки кирнк
CN103180318B (zh) 2010-05-14 2017-05-10 达那-法伯癌症研究所 雄性避孕组合物以及使用方法
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
WO2012096866A2 (en) 2011-01-10 2012-07-19 Inverseon, Inc. Use of beta-adrenergic inverse agonists for smoking cessation
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
EP2681208B1 (en) 2011-03-03 2016-05-18 Denovamed Inc. Antimicrobial/adjuvant compounds
SG194083A1 (en) 2011-04-08 2013-11-29 Immune Design Corp Immunogenic compositions and methods of using the compositions for inducing humoral and cellular immune responses
CA2841785A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
PH12014500168A1 (en) 2011-07-27 2014-02-24 Ab Science Selective protein kinase inhibitors
EP3824942B1 (en) 2011-10-27 2024-01-24 Sorrento Therapeutics, Inc. Transdermal delivery of high viscosity bioactive agents
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
EP2811981B1 (en) 2012-02-07 2019-05-08 Infectious Disease Research Institute Improved adjuvant formulations comprising tlr4 agonists and methods of using the same
EP3388835B1 (en) 2012-05-16 2020-04-01 Immune Design Corp. Vaccines for hsv-2
US20130315891A1 (en) 2012-05-25 2013-11-28 Matthew Charles Formulations of human tissue kallikrein-1 for parenteral delivery and related methods
DK2854841T3 (en) 2012-06-04 2017-05-22 Diamedica Inc Kallikrein-1-glycosylation isoforms of human tissue
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
ES2927844T3 (es) 2013-01-11 2022-11-11 Corsair Pharma Inc Profármacos de treprostinil
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
WO2014113541A1 (en) 2013-01-16 2014-07-24 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Attenuated chlamydia vaccine
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
IL282202B1 (en) 2013-04-07 2025-07-01 Broad Inst Inc Compositions and methods for personalized vaccines for tumor formation
EP2986303B1 (en) 2013-04-18 2020-02-26 Immune Design Corp. Gla monotherapy for use in cancer treatment
WO2014188329A2 (en) 2013-05-20 2014-11-27 Mylan, Inc. Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
DK3019167T3 (da) 2013-07-12 2021-03-15 Knopp Biosciences Llc Behandling af forhøjede niveauer af eosinophiler og/eller basophiler
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
CA2921381A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating chronic urticaria
CA2921378A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
TN2016000197A1 (en) 2013-11-22 2017-10-06 Genzyme Corp Novel methods for treating neurodegenerative diseases.
US10801070B2 (en) 2013-11-25 2020-10-13 The Broad Institute, Inc. Compositions and methods for diagnosing, evaluating and treating cancer
US11725237B2 (en) 2013-12-05 2023-08-15 The Broad Institute Inc. Polymorphic gene typing and somatic change detection using sequencing data
NZ721908A (en) 2013-12-20 2022-12-23 Massachusetts Gen Hospital Combination therapy with neoantigen vaccine
BR112016016672A2 (pt) 2014-01-21 2017-08-08 Immune Design Corp Uso de uma composição
WO2015138919A1 (en) 2014-03-14 2015-09-17 The University Of North Carolina At Chapel Hill Small molecules for inhibiting male fertility
KR20160127826A (ko) 2014-03-24 2016-11-04 에이비 사이언스 비장 티로신 키나제 억제제로서 치환된 옥사졸 유도체
WO2016010538A1 (en) 2014-07-16 2016-01-21 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
CA2958747C (en) 2014-08-15 2022-08-16 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
AU2015341695B2 (en) 2014-11-07 2021-07-08 Sublimity Therapeutics Limited Compositions comprising cyclosporin
WO2016094669A1 (en) 2014-12-11 2016-06-16 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
EP3234193B1 (en) 2014-12-19 2020-07-15 Massachusetts Institute of Technology Molecular biomarkers for cancer immunotherapy
EP3757211B1 (en) 2014-12-19 2025-07-30 The Broad Institute, Inc. Methods for profiling the t-cell-receptor repertoire
WO2016123406A1 (en) 2015-01-28 2016-08-04 Chrono Therapeutics Inc. Drug delivery methods and systems
EP3053920B1 (en) 2015-02-05 2020-04-08 AB Science Compounds with anti-tumoral activity
HK1248564A1 (zh) 2015-03-02 2018-10-19 阿福金制药有限责任公司 用大麻素的局部区域神经影响性疗法
US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
CA2977814A1 (en) 2015-03-12 2016-09-15 Chrono Therapeutics Inc. Craving input and support system
MX2017014700A (es) 2015-05-20 2018-08-15 Broad Inst Inc Neoantigenos compartidos.
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
EP3144307A1 (en) 2015-09-18 2017-03-22 AB Science Novel oxazole derivatives that inhibit syk
EP3446119A1 (en) 2016-04-18 2019-02-27 The Broad Institute Inc. Improved hla epitope prediction
ES2929054T3 (es) 2016-05-16 2022-11-24 Access To Advanced Health Inst Formulación que contiene un agonista de TLR y métodos de uso
CA3023672A1 (en) 2016-05-16 2017-11-23 Infectious Disease Research Institute Pegylated liposomes and methods of use
KR20250008135A (ko) 2016-06-01 2025-01-14 액세스 투 어드밴스드 헬스 인스티튜트 사이징제를 함유하는 나노명반 입자
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
US20190290597A1 (en) 2016-12-05 2019-09-26 Corsair Pharma, Inc. Dermal and transdermal administration of treprostinil and salts thereof
WO2018129304A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
WO2018140391A1 (en) 2017-01-24 2018-08-02 The Broad Institute, Inc. Compositions and methods for detecting a mutant variant of a polynucleotide
JP2020510023A (ja) 2017-03-09 2020-04-02 ダイアメディカ， インコーポレイテッド 組織カリクレイン１の剤形
SG11201911930SA (en) 2017-06-11 2020-01-30 Molecular Express Inc Methods and compositions for substance use disorder vaccine formulations and uses thereof
ES2942848T3 (es) 2018-03-05 2023-06-07 Denovamed Inc Derivados de tiofeno-2-amida sustituidos con difenilo y composiciones farmacéuticas de los mismos útiles como antimicrobiano
AU2019279884B2 (en) 2018-05-29 2025-01-30 Morningside Venture Investments Limited Drug delivery methods and systems
US20210382068A1 (en) 2018-10-02 2021-12-09 Dana-Farber Cancer Institute, Inc. Hla single allele lines
MA54245A (fr) 2018-11-16 2022-02-23 Morningside Venture Investments Ltd Système d'administration transdermique de médicaments à régulation thermique
US20220062394A1 (en) 2018-12-17 2022-03-03 The Broad Institute, Inc. Methods for identifying neoantigens
US12394502B2 (en) 2019-10-02 2025-08-19 The General Hospital Corporation Method for predicting HLA-binding peptides using protein structural features
WO2022136952A1 (en) 2020-12-23 2022-06-30 Infectious Disease Research Institute Solanesol vaccine adjuvants and methods of preparing same
NL2035417B9 (en) 2022-07-19 2024-10-09 Coty Inc Cosmetic composition
NL2035921B1 (en) 2023-05-05 2025-01-27 Coty Inc Cosmetic composition
NL2037617B1 (en) 2023-05-05 2025-07-18 Coty Inc Cosmetic composition
WO2025101867A1 (en) 2023-11-10 2025-05-15 Albert Einstein College Of Medicine Cell-impermeable akt inhibitors and pdpk1 inhibitors
NL2039435B1 (en) 2023-12-22 2025-08-25 Coty Inc Cosmetic composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1071897B (en:Method) * 1957-12-19 1959-12-24
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3731683A (en) * 1971-06-04 1973-05-08 Alza Corp Bandage for the controlled metering of topical drugs to the skin
CA1076480A (en) * 1975-04-28 1980-04-29 John S. Kent Inert core implant pellet
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4060084A (en) * 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
US4230105A (en) * 1978-11-13 1980-10-28 Merck & Co., Inc. Transdermal delivery of drugs
US4291014A (en) * 1979-01-11 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing estradiol diacetate
US4286592A (en) * 1980-02-04 1981-09-01 Alza Corporation Therapeutic system for administering drugs to the skin

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HK90687A (en) 1987-12-11
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CH657055A5 (de) 1986-08-15
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AU547007B2 (en) 1985-10-03
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