DE69616370T2 - Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix - Google Patents

Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix

Info

Publication number
DE69616370T2
DE69616370T2 DE69616370T DE69616370T DE69616370T2 DE 69616370 T2 DE69616370 T2 DE 69616370T2 DE 69616370 T DE69616370 T DE 69616370T DE 69616370 T DE69616370 T DE 69616370T DE 69616370 T2 DE69616370 T2 DE 69616370T2
Authority
DE
Germany
Prior art keywords
liquid
preventing
improved method
matrix
crystalization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69616370T
Other languages
English (en)
Other versions
DE69616370D1 (de
Inventor
W Dohner
A Bura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE69616370D1 publication Critical patent/DE69616370D1/de
Publication of DE69616370T2 publication Critical patent/DE69616370T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive plasters or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
DE69616370T 1995-12-01 1996-11-15 Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix Expired - Lifetime DE69616370T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56622895A 1995-12-01 1995-12-01
PCT/US1996/018397 WO1997020550A2 (en) 1995-12-01 1996-11-15 Improved method for preventing crystal formation in a dispersion of a liquid in a matrix

Publications (2)

Publication Number Publication Date
DE69616370D1 DE69616370D1 (de) 2001-11-29
DE69616370T2 true DE69616370T2 (de) 2002-07-11

Family

ID=24262030

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616370T Expired - Lifetime DE69616370T2 (de) 1995-12-01 1996-11-15 Verbessertes verfahren zur verhinderung der kristallbildung in einer dispersion eines flüssigen stoffes in einer matrix

Country Status (8)

Country Link
US (3) US6569448B1 (de)
EP (1) EP0863751B1 (de)
JP (1) JP4166276B2 (de)
AT (1) ATE207348T1 (de)
AU (1) AU1120097A (de)
DE (1) DE69616370T2 (de)
ES (1) ES2162124T3 (de)
WO (1) WO1997020550A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5662928A (en) * 1995-04-21 1997-09-02 Ciba-Geigy Corporation Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system
AU721267B2 (en) * 1996-07-03 2000-06-29 Alza Corporation Drug delivery devices and process of manufacture
US6007837A (en) * 1996-07-03 1999-12-28 Alza Corporation Drug delivery devices and process of manufacture
US6174545B1 (en) 1997-07-01 2001-01-16 Alza Corporation Drug delivery devices and process of manufacture
DE19738643C2 (de) 1997-09-04 2001-10-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung
AU1623099A (en) * 1997-12-22 1999-07-12 Alza Corporation Rate controlling membranes for controlled drug delivery devices
US20080226698A1 (en) * 2007-03-16 2008-09-18 Mylan Technologies, Inc. Amorphous drug transdermal systems, manufacturing methods, and stabilization
NZ589542A (en) * 2008-05-30 2012-10-26 Mylan Inc Transdermal drug delivery system comprising an active agent in amorphous form and polyvinylpyrrolidone
EP2349230A2 (de) * 2008-10-06 2011-08-03 Mylan Technologies, Inc. Amorphes transdermales system von rotigotin
DE102009052972A1 (de) 2009-11-12 2011-09-15 Lts Lohmann Therapie-Systeme Ag Verfahren zur Verhinderung der Kristallisation von Arzneistoffen in einem Polymerfilm
JP5766475B2 (ja) 2010-03-30 2015-08-19 日東電工株式会社 貼付製剤およびその製造方法
DE102011090178A1 (de) 2011-12-30 2013-07-04 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit geringer Neigung zur Spontankristallisation
JP5270035B1 (ja) 2012-12-06 2013-08-21 久光製薬株式会社 貼付剤及びその製造方法
JP5307931B1 (ja) 2012-12-27 2013-10-02 久光製薬株式会社 貼付剤及びその製造方法
JP5415645B1 (ja) 2013-06-28 2014-02-12 久光製薬株式会社 貼付剤の製造方法、貼付剤及び包装体
DE102018120505A1 (de) 2017-10-20 2019-04-25 Amw Gmbh Verhinderung der Kristallisation von Wirkstoffen in transdermalen Darreichungssystemen

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3797494A (en) 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3598122A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US4144317A (en) 1975-05-30 1979-03-13 Alza Corporation Device consisting of copolymer having acetoxy groups for delivering drugs
US4436741A (en) 1975-12-08 1984-03-13 Alza Corporation Method for administering scopolamine transdermally
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4262003A (en) 1975-12-08 1981-04-14 Alza Corporation Method and therapeutic system for administering scopolamine transdermally
US4060084A (en) 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
US4201211A (en) 1977-07-12 1980-05-06 Alza Corporation Therapeutic system for administering clonidine transdermally
US4308621A (en) * 1978-09-01 1981-12-29 Mendelson Jerry M Radio interference bucker apparatus
US4379454A (en) 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4832953A (en) * 1987-08-13 1989-05-23 Alza Corporation Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix
US5350581A (en) * 1989-12-14 1994-09-27 Pharmetrix Corporation Method for manufacturing transdermal devices
DE4223360C1 (de) * 1992-07-16 1993-04-08 Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
US5662928A (en) * 1995-04-21 1997-09-02 Ciba-Geigy Corporation Method for the prevention or removal of crystalline scopolamine in a non-aqueous matrix of a transdermal system

Also Published As

Publication number Publication date
JP4166276B2 (ja) 2008-10-15
DE69616370D1 (de) 2001-11-29
ES2162124T3 (es) 2001-12-16
JP2000505061A (ja) 2000-04-25
US20040047893A1 (en) 2004-03-11
US6569448B1 (en) 2003-05-27
WO1997020550A2 (en) 1997-06-12
WO1997020550A3 (en) 1997-08-14
EP0863751B1 (de) 2001-10-24
EP0863751A2 (de) 1998-09-16
ATE207348T1 (de) 2001-11-15
AU1120097A (en) 1997-06-27
US20010038850A1 (en) 2001-11-08
US7169409B2 (en) 2007-01-30

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