JPH033669B2 - - Google Patents

Info

Publication number
JPH033669B2
JPH033669B2 JP57040904A JP4090482A JPH033669B2 JP H033669 B2 JPH033669 B2 JP H033669B2 JP 57040904 A JP57040904 A JP 57040904A JP 4090482 A JP4090482 A JP 4090482A JP H033669 B2 JPH033669 B2 JP H033669B2
Authority
JP
Japan
Prior art keywords
group
formula
methoxyphenyl
hydrogen atom
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57040904A
Other languages
English (en)
Japanese (ja)
Other versions
JPS58159480A (ja
Inventor
Hiroyuki Nagano
Michiro Takagi
Noboru Kubodera
Isao Matsunaga
Hiroyuki Nahata
Yasuhiro Ooba
Kazunari Sakai
Shunichi Hata
Yasuyoshi Uchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP57040904A priority Critical patent/JPS58159480A/ja
Priority to CA000423221A priority patent/CA1248102A/en
Priority to ZA831674A priority patent/ZA831674B/xx
Priority to DK120483A priority patent/DK156064C/da
Priority to KR1019830001046A priority patent/KR900004125B1/ko
Priority to DE198383102601T priority patent/DE89065T1/de
Priority to EP83102601A priority patent/EP0089065B1/en
Priority to AT83102601T priority patent/ATE27817T1/de
Priority to DE8383102601T priority patent/DE3372095D1/de
Priority to ES520693A priority patent/ES520693A0/es
Priority to FI830893A priority patent/FI77456C/fi
Priority to MX8310535U priority patent/MX7157E/es
Publication of JPS58159480A publication Critical patent/JPS58159480A/ja
Priority to ES527319A priority patent/ES8504778A1/es
Priority to ES527318A priority patent/ES527318A0/es
Priority to US06/604,415 priority patent/US4578465A/en
Publication of JPH033669B2 publication Critical patent/JPH033669B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • C07D239/96—Two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Paper (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
JP57040904A 1982-03-17 1982-03-17 新規なフエニルピペラジン誘導体 Granted JPS58159480A (ja)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP57040904A JPS58159480A (ja) 1982-03-17 1982-03-17 新規なフエニルピペラジン誘導体
CA000423221A CA1248102A (en) 1982-03-17 1983-03-09 Phenylpiperazine derivatives and process for producing the same
ZA831674A ZA831674B (en) 1982-03-17 1983-03-11 Phenylpiperazine derivatives and process for producing the same
DK120483A DK156064C (da) 1982-03-17 1983-03-15 Analogifremgangsmaade til fremstilling af 2,4-(1h,3h)-quinazolindionderivater eller farmaceutisk acceptable syreadditionssalte deraf
AT83102601T ATE27817T1 (de) 1982-03-17 1983-03-16 Phenylpiperazin-derivate und verfahren zu deren herstellung.
DE198383102601T DE89065T1 (de) 1982-03-17 1983-03-16 Phenylpiperazin-derivate und verfahren zu deren herstellung.
EP83102601A EP0089065B1 (en) 1982-03-17 1983-03-16 Novel phenylpiperazine derivatives and process for producing the same
KR1019830001046A KR900004125B1 (ko) 1982-03-17 1983-03-16 페닐 피페라진 유도체의 제조방법
DE8383102601T DE3372095D1 (en) 1982-03-17 1983-03-16 Novel phenylpiperazine derivatives and process for producing the same
ES520693A ES520693A0 (es) 1982-03-17 1983-03-16 Un procedimiento para la preparacion de derivados de fenilpiperazina.
MX8310535U MX7157E (es) 1982-03-17 1983-03-17 Procedimiento para preparar derivados de fenilpiperazina
FI830893A FI77456C (fi) 1982-03-17 1983-03-17 Foerfarande foer framstaellning av terapeutiskt anvaendbara 3-/2-/4-(2-metoxifenyl) -1-piperazinyl/etyl/-2,4-(1h,3h)-kinazolindionderivat.
ES527319A ES8504778A1 (es) 1982-03-17 1983-11-16 Un procedimiento para la preparacion de derivados de fenil-piperazina
ES527318A ES527318A0 (es) 1982-03-17 1983-11-16 Un procedimiento para la preparacion de derivados de fenilpiperazina
US06/604,415 US4578465A (en) 1982-03-17 1984-04-30 Phenyliperazine derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57040904A JPS58159480A (ja) 1982-03-17 1982-03-17 新規なフエニルピペラジン誘導体

Publications (2)

Publication Number Publication Date
JPS58159480A JPS58159480A (ja) 1983-09-21
JPH033669B2 true JPH033669B2 (enExample) 1991-01-21

Family

ID=12593492

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57040904A Granted JPS58159480A (ja) 1982-03-17 1982-03-17 新規なフエニルピペラジン誘導体

Country Status (12)

Country Link
US (1) US4578465A (enExample)
EP (1) EP0089065B1 (enExample)
JP (1) JPS58159480A (enExample)
KR (1) KR900004125B1 (enExample)
AT (1) ATE27817T1 (enExample)
CA (1) CA1248102A (enExample)
DE (2) DE89065T1 (enExample)
DK (1) DK156064C (enExample)
ES (3) ES520693A0 (enExample)
FI (1) FI77456C (enExample)
MX (1) MX7157E (enExample)
ZA (1) ZA831674B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
JPS60169467A (ja) * 1984-02-10 1985-09-02 Chugai Pharmaceut Co Ltd 新規なフエニルピペラジン誘導体
US4711883A (en) * 1985-09-30 1987-12-08 Ortho Pharmaceutical Corporation Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use
GB8524663D0 (en) * 1985-10-07 1985-11-13 Fujisawa Pharmaceutical Co Quinazoline derivatives
JPS62135464A (ja) * 1985-12-10 1987-06-18 Nippon Kayaku Co Ltd フエニルピペラジン誘導体
US4670560A (en) * 1986-04-28 1987-06-02 Ortho Pharmaceutical Corporation Thienopyrimidine-2,4-dione derivatives and intermediates thereof
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
US5160727A (en) * 1990-02-13 1992-11-03 Warner-Lambert Company Tumor cell sensitization method using quinazolinedione derivatives
CA2753599C (en) * 2009-02-26 2017-03-14 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of utilizing arylpiperazine derivatives
BRPI1003506B1 (pt) * 2010-09-24 2019-12-03 Ache Int Bvi Ltd composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a
KR102132078B1 (ko) * 2018-09-20 2020-07-08 원광대학교산학협력단 방향족 화합물, 아민 및 친핵체를 이용한 3가지 성분 반응으로 1-에틸-4-페닐피페라진 유도체를 제조하는 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3274194A (en) * 1963-03-29 1966-09-20 Miles Lab Quinazolinedione derivatives
US3322766A (en) * 1964-11-13 1967-05-30 Shulton Inc 3-beta-(4-pyridyl) ethyl-2, 3-dihydro-4(1h)-quinazolinones
AT269143B (de) * 1966-06-30 1969-03-10 Miles Lab Verfahren zur Herstellung von neuen Chinazolindionderivaten und ihrer Säureadditionssalze bzw. ihrer entsprechenden Piperaziniumverbindungen
GB1227936A (enExample) * 1968-02-29 1971-04-15
DE1934037A1 (de) * 1969-07-04 1971-01-07 Cassella Farbwerke Mainkur Ag Basisch substituierte Derivate des 2,4-(1H,3H)-Chinazolindions
US3726979A (en) * 1971-04-09 1973-04-10 E Hong Method of producing serotonin antagonism
US3819630A (en) * 1972-08-21 1974-06-25 R Parcell 3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
US3879393A (en) * 1973-06-18 1975-04-22 Miles Lab Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
DE3172006D1 (en) * 1980-05-22 1985-10-03 Masayuki Ishikawa Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof

Also Published As

Publication number Publication date
DK120483D0 (da) 1983-03-15
ES8504777A1 (es) 1985-05-01
EP0089065A2 (en) 1983-09-21
DE3372095D1 (en) 1987-07-23
MX7157E (es) 1987-11-27
KR900004125B1 (ko) 1990-06-16
ES8404347A1 (es) 1984-05-01
EP0089065A3 (en) 1984-05-23
JPS58159480A (ja) 1983-09-21
ES520693A0 (es) 1984-05-01
ES527318A0 (es) 1985-05-01
EP0089065B1 (en) 1987-06-16
FI830893L (fi) 1983-09-18
ES527319A0 (es) 1985-05-01
DK156064C (da) 1989-11-06
ES8504778A1 (es) 1985-05-01
DK156064B (da) 1989-06-19
ZA831674B (en) 1984-04-25
FI830893A0 (fi) 1983-03-17
KR840004104A (ko) 1984-10-06
DE89065T1 (de) 1985-04-11
ATE27817T1 (de) 1987-07-15
FI77456B (fi) 1988-11-30
CA1248102A (en) 1989-01-03
DK120483A (da) 1983-09-18
FI77456C (fi) 1989-03-10
US4578465A (en) 1986-03-25

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