JPH0210382B2 - - Google Patents
Info
- Publication number
- JPH0210382B2 JPH0210382B2 JP55003148A JP314880A JPH0210382B2 JP H0210382 B2 JPH0210382 B2 JP H0210382B2 JP 55003148 A JP55003148 A JP 55003148A JP 314880 A JP314880 A JP 314880A JP H0210382 B2 JPH0210382 B2 JP H0210382B2
- Authority
- JP
- Japan
- Prior art keywords
- bis
- ligand
- oxalate
- binding
- fluorescent label
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003446 ligand Substances 0.000 claims description 86
- 238000009739 binding Methods 0.000 claims description 74
- 239000003153 chemical reaction reagent Substances 0.000 claims description 50
- 230000027455 binding Effects 0.000 claims description 49
- 238000004458 analytical method Methods 0.000 claims description 47
- 230000009870 specific binding Effects 0.000 claims description 47
- 239000007788 liquid Substances 0.000 claims description 43
- 239000000126 substance Substances 0.000 claims description 41
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 38
- 239000000203 mixture Substances 0.000 claims description 33
- 239000007850 fluorescent dye Substances 0.000 claims description 25
- 238000006243 chemical reaction Methods 0.000 claims description 22
- 238000000159 protein binding assay Methods 0.000 claims description 15
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims description 15
- 229940043267 rhodamine b Drugs 0.000 claims description 15
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
- YIKSCQDJHCMVMK-UHFFFAOYSA-N Oxamide Chemical compound NC(=O)C(N)=O YIKSCQDJHCMVMK-UHFFFAOYSA-N 0.000 claims description 7
- CBZOGAWUNMFXFQ-UHFFFAOYSA-N bis(2,4-dinitrophenyl) oxalate Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC=C1OC(=O)C(=O)OC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O CBZOGAWUNMFXFQ-UHFFFAOYSA-N 0.000 claims description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims description 6
- BBEAQIROQSPTKN-UHFFFAOYSA-N pyrene Chemical compound C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 BBEAQIROQSPTKN-UHFFFAOYSA-N 0.000 claims description 6
- 239000007795 chemical reaction product Substances 0.000 claims description 5
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 4
- -1 dinitrophenyl Chemical group 0.000 claims description 4
- ORBDCTQGJHNJHB-UHFFFAOYSA-N 1,2-bis(benzimidazol-1-yl)ethane-1,2-dione Chemical compound C1=NC2=CC=CC=C2N1C(=O)C(=O)N1C2=CC=CC=C2N=C1 ORBDCTQGJHNJHB-UHFFFAOYSA-N 0.000 claims description 3
- FCNCGHJSNVOIKE-UHFFFAOYSA-N 9,10-diphenylanthracene Chemical compound C1=CC=CC=C1C(C1=CC=CC=C11)=C(C=CC=C2)C2=C1C1=CC=CC=C1 FCNCGHJSNVOIKE-UHFFFAOYSA-N 0.000 claims description 3
- OXTSSJOQCJZYLA-UHFFFAOYSA-N bis(2,3,4,5,6-pentachlorophenyl) oxalate Chemical compound ClC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1OC(=O)C(=O)OC1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1Cl OXTSSJOQCJZYLA-UHFFFAOYSA-N 0.000 claims description 3
- YMTUYHWOWDFXOX-UHFFFAOYSA-N bis(2,3,4,5,6-pentafluorophenyl) oxalate Chemical compound FC1=C(F)C(F)=C(F)C(F)=C1OC(=O)C(=O)OC1=C(F)C(F)=C(F)C(F)=C1F YMTUYHWOWDFXOX-UHFFFAOYSA-N 0.000 claims description 3
- WPPBAMKIQZZXHL-UHFFFAOYSA-N bis[4-nitro-3-(trifluoromethyl)phenyl] oxalate Chemical compound C1=C(C(F)(F)F)C([N+](=O)[O-])=CC=C1OC(=O)C(=O)OC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 WPPBAMKIQZZXHL-UHFFFAOYSA-N 0.000 claims description 3
- GVEPBJHOBDJJJI-UHFFFAOYSA-N fluoranthrene Natural products C1=CC(C2=CC=CC=C22)=C3C2=CC=CC3=C1 GVEPBJHOBDJJJI-UHFFFAOYSA-N 0.000 claims description 3
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims description 3
- 229940088597 hormone Drugs 0.000 claims description 3
- 239000005556 hormone Substances 0.000 claims description 3
- 125000002080 perylenyl group Chemical group C1(=CC=C2C=CC=C3C4=CC=CC5=CC=CC(C1=C23)=C45)* 0.000 claims description 3
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- YYMBJDOZVAITBP-UHFFFAOYSA-N rubrene Chemical compound C1=CC=CC=C1C(C1=C(C=2C=CC=CC=2)C2=CC=CC=C2C(C=2C=CC=CC=2)=C11)=C(C=CC=C2)C2=C1C1=CC=CC=C1 YYMBJDOZVAITBP-UHFFFAOYSA-N 0.000 claims description 3
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- 229960002143 fluorescein Drugs 0.000 claims description 2
- 238000002372 labelling Methods 0.000 claims description 2
- DHNCWGKMISNJQG-UHFFFAOYSA-N n,n'-dimethyl-n,n'-dinitrooxamide Chemical compound [O-][N+](=O)N(C)C(=O)C(=O)N(C)[N+]([O-])=O DHNCWGKMISNJQG-UHFFFAOYSA-N 0.000 claims description 2
- 239000012070 reactive reagent Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000003722 vitamin derivatives Chemical class 0.000 claims 2
- JZHRPUKVLTYRAT-UHFFFAOYSA-N N,N'-dinitrooxamide Chemical compound [N+](=O)([O-])NC(=O)C(=O)N[N+](=O)[O-] JZHRPUKVLTYRAT-UHFFFAOYSA-N 0.000 claims 1
- 238000001215 fluorescent labelling Methods 0.000 claims 1
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 description 4
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- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
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- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
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Classifications
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Landscapes
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- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/004,580 US4238195A (en) | 1979-01-18 | 1979-01-18 | Fluorescer-labeled specific binding assays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5596458A JPS5596458A (en) | 1980-07-22 |
| JPH0210382B2 true JPH0210382B2 (en, 2012) | 1990-03-07 |
Family
ID=21711472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP314880A Granted JPS5596458A (en) | 1979-01-18 | 1980-01-17 | Method of analyzing specific linkage by fluorescent substance label |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4238195A (en, 2012) |
| JP (1) | JPS5596458A (en, 2012) |
| CA (1) | CA1133392A (en, 2012) |
| DE (1) | DE2952498C2 (en, 2012) |
| GB (1) | GB2044449B (en, 2012) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4383031A (en) * | 1975-04-28 | 1983-05-10 | Miles Laboratories, Inc. | Homogeneous chemiluminescent specific binding assay |
| US4318707A (en) * | 1978-11-24 | 1982-03-09 | Syva Company | Macromolecular fluorescent quencher particle in specific receptor assays |
| US4375972A (en) * | 1979-10-17 | 1983-03-08 | Allied Corporation | Heterogeneous chemiluminescent immunoassays utilizing metallo porphyrin tag |
| WO1981001883A1 (en) * | 1979-12-19 | 1981-07-09 | Electro Nucleonics | Chemical luminescence amplification substrate system for immunochemistry |
| US4372745A (en) * | 1979-12-19 | 1983-02-08 | Electro-Nucleonics, Inc. | Chemical luminescence amplification substrate system for immunochemistry involving microencapsulated fluorescer |
| NL8000173A (nl) * | 1980-01-11 | 1981-08-03 | Akzo Nv | Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen. |
| US4318981A (en) * | 1980-04-24 | 1982-03-09 | Miles Laboratories, Inc. | Homogeneous specific binding assay employing an intramolecularly modulated photogenic enzyme substrate label |
| DE3132491A1 (de) * | 1980-08-22 | 1982-07-01 | Laboratorium Prof. Dr. Rudolf Berthold, 7547 Wildbad | Verfahren zur durchfuehrung analytischer bestimmungen mittels der chemilumineszenzmethode und anwendung des verfahrens fuer immunassays |
| EP0054952B1 (de) * | 1980-12-22 | 1984-10-10 | Seromed medizinische Vertriebs GmbH | Verfahren zur Bestimmung von Antigenen, Antikörpern und deren Komplexen |
| US4433060A (en) * | 1980-12-22 | 1984-02-21 | Bernd Frenzel | Chemiluminescent immunoassays with triphenylmethane dyes activated by H.sub. O2 and a chloramine |
| DE3143423C2 (de) * | 1980-12-22 | 1984-08-30 | Bernd Dr. 8000 München Frenzel | Verfahren zur Bestimmung von Antigenen, Antikörpern und deren Komplexen |
| DE3152832C2 (de) * | 1980-12-22 | 1985-02-14 | Bernd Dr. 8000 München Frenzel | Verfahren zur Bestimmung von Antigenen, Antikörpern und deren Komplexen |
| JPS57502137A (en, 2012) * | 1980-12-22 | 1982-12-02 | ||
| GB2112779B (en) * | 1981-12-11 | 1986-10-15 | Welsh Nat School Med | Aryl acridinium esters as luminescent labelling materials |
| US4472301A (en) * | 1982-05-27 | 1984-09-18 | Miles Laboratories, Inc. | Propranolol immunogen and antibodies |
| EP0103469B1 (en) * | 1982-09-10 | 1989-02-08 | The Welsh National School of Medicine | Immunological procedure for quantifying substances |
| US4614712A (en) * | 1983-02-25 | 1986-09-30 | The Upjohn Company | Immunoassays with luciferase labeled ligands or receptors |
| US4542104A (en) * | 1983-04-06 | 1985-09-17 | The Board Of Trustees Of The Leland Stanford Jr. Univ. | Phycobiliprotein fluorescent conjugates |
| NL8401213A (nl) * | 1984-04-16 | 1985-11-18 | Rijksuniversiteit | Chemiluminescerende verbindingen en tussenprodukten, de bereiding daarvan en hun toepassing bij het aantonen of bepalen van organische verbindingen. |
| US4699880A (en) * | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
| US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5221605A (en) * | 1984-10-31 | 1993-06-22 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US5310687A (en) * | 1984-10-31 | 1994-05-10 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
| US4886744A (en) * | 1985-04-25 | 1989-12-12 | Polaroid Corporation | Fluorescent conjugates and biological diagnostic assay system |
| US5279943A (en) * | 1985-08-02 | 1994-01-18 | Compagnie Oris Industrie | Homogeneous process for the detection and/or determination by luminescence of an analyte in a medium in which it may be present |
| JPS62132173A (ja) * | 1985-12-04 | 1987-06-15 | Toyobo Co Ltd | 免疫学的物質の定量法 |
| US4855225A (en) * | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
| US6316607B1 (en) | 1986-04-30 | 2001-11-13 | Igen International, Inc. | Electrochemiluminescent assays |
| US6451225B1 (en) | 1986-04-30 | 2002-09-17 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US6165729A (en) * | 1986-04-30 | 2000-12-26 | Hyperion Catalysis International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| US4777128A (en) * | 1986-05-27 | 1988-10-11 | Ethigen Corporation | Fluorescence immunoassay involving energy transfer between two fluorophores |
| US4863876A (en) * | 1987-01-15 | 1989-09-05 | Hevey Richard C | Method of detecting and quantifying ligands in liquids via biotin-avidin-medicated fluorescence polarization |
| US5384241A (en) * | 1987-09-11 | 1995-01-24 | Enzo Diagnostics, Inc. | Specific binding assay compound with inhibitive self-quenching characteristics |
| US4876190A (en) * | 1987-10-21 | 1989-10-24 | Becton Dickinson & Company | Peridinin-chlorophyll complex as fluorescent label |
| US6702986B1 (en) | 1988-04-29 | 2004-03-09 | Igen International, Inc. | Electrochemiluminescent reaction utilizing amine-derived reductant |
| GB2233451B (en) * | 1989-06-27 | 1993-09-15 | Tropix Inc | Chemiluminescence enhancement |
| JP3184894B2 (ja) * | 1989-10-05 | 2001-07-09 | エックスオックスエミス， インコーポレイテッド | ハロペルオキシターゼ酸至適化学的発光分析系 |
| US5108899A (en) * | 1989-10-31 | 1992-04-28 | Exoxemis, Inc. | Chemiluminescence assay of in vivo inflammation |
| US7119182B1 (en) | 1991-02-19 | 2006-10-10 | The Regents Of The University Of California | Recombinant thrombin receptor and related pharmaceuticals |
| EP0595806A1 (en) * | 1991-07-22 | 1994-05-11 | Astroscan Limited | Analysis of carbohydrates and kits therefore |
| ATE340866T1 (de) * | 1994-10-28 | 2006-10-15 | Gen Probe Inc | Zusammensetzungen und verfahren für die gleichzeitige detektion und quantifizierung von einer mehrheit spezifischer nuklein säure sequenzen |
| US5643713A (en) * | 1995-06-07 | 1997-07-01 | Liang; Pam | Electrochemiluminescent monitoring of compounds |
| US6316180B1 (en) | 1995-01-04 | 2001-11-13 | Igen International, Inc. | Electrochemiluminescent monitoring of compounds/electrochemiluminescence assays |
| US20010003647A1 (en) * | 1995-06-07 | 2001-06-14 | Ji Sun | Coreatant-including electrochemiluminescent compounds, methods, systems and kits utilizing same |
| US5856194A (en) | 1996-09-19 | 1999-01-05 | Abbott Laboratories | Method for determination of item of interest in a sample |
| US5795784A (en) | 1996-09-19 | 1998-08-18 | Abbott Laboratories | Method of performing a process for determining an item of interest in a sample |
| DE19703025C2 (de) * | 1997-01-28 | 1999-04-29 | Bernd Dr Lorenz | Verfahren zur Messung von Konzentrationen sowie zur kontinuierlichen oder diskontinuierlichen Messung des Umsatzes und der Geschwindigkeit enzymatischer oder nichtenzymatischer Reaktionen von Pyrophosphaten und/oder linearen Polyphosphaten unter Ausschluß von zyklischen Polyphosphaten als auch von Orthophosphaten in einer Probe sowie Anwendung des Verfahrens |
| DE19731990A1 (de) * | 1997-07-25 | 1999-01-28 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung und Identifizierung von neuen Hydrolasen mit verbesserten Eigenschaften |
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US7745142B2 (en) | 1997-09-15 | 2010-06-29 | Molecular Devices Corporation | Molecular modification assays |
| US7070921B2 (en) | 2000-04-28 | 2006-07-04 | Molecular Devices Corporation | Molecular modification assays |
| DE19745001A1 (de) * | 1997-10-11 | 1999-05-06 | Evotec Biosystems Ag | Verfahren zur Affinitätsmarkierung von Oligo- oder Polymeren |
| US6607829B1 (en) | 1997-11-13 | 2003-08-19 | Massachusetts Institute Of Technology | Tellurium-containing nanocrystalline materials |
| US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US20090298048A1 (en) * | 2003-11-03 | 2009-12-03 | Integrigen, Inc. | Non-fluorescent, non-enzymatic, chemiluminescent aqueous assay |
| US7514223B2 (en) * | 2004-05-15 | 2009-04-07 | Genentech, Inc. | Cross-screening system and methods for detecting a molecule having binding affinity for a target molecule |
| US8765488B2 (en) | 2004-07-22 | 2014-07-01 | The Board Of Trustees Of The University Of Illinois | Sensors employing single-walled carbon nanotubes |
| CN112782136A (zh) * | 2020-12-24 | 2021-05-11 | 湖南博奥瑞康生物科技有限公司 | 一种基于过氧草酸酯类化学发光体系的生物标志物联合检测方法及试剂盒 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3720760A (en) * | 1968-09-06 | 1973-03-13 | Pharmacia Ab | Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples |
| US3689391A (en) * | 1970-05-13 | 1972-09-05 | Synvar Ass | Method for chemically initiating photochemical reactions |
| US4161515A (en) * | 1973-10-02 | 1979-07-17 | Syva Company | Double receptor fluorescent immunoassay |
| US3996345A (en) * | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US3992631A (en) * | 1975-02-27 | 1976-11-16 | International Diagnostic Technology, Inc. | Fluorometric system, method and test article |
| US4014745A (en) * | 1975-04-30 | 1977-03-29 | Nasa | Application of luciferase assay for ATP to antimicrobial drug susceptibility |
| US4058732A (en) * | 1975-06-30 | 1977-11-15 | Analytical Radiation Corporation | Method and apparatus for improved analytical fluorescent spectroscopy |
| US4181650A (en) * | 1975-08-25 | 1980-01-01 | Maier Charles L Jr | Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids |
| US4036946A (en) * | 1975-10-20 | 1977-07-19 | Marcos Kleinerman | Immunofluorometric method for measuring minute quantities of antigens, antibodies and other substances |
| US3999948A (en) * | 1975-11-03 | 1976-12-28 | International Diagnostic Technology | Diagnostic reagent holder and method |
| US4020151A (en) * | 1976-02-17 | 1977-04-26 | International Diagnostic Technology, Inc. | Method for quantitation of antigens or antibodies on a solid surface |
| GB1573212A (en) | 1976-04-15 | 1980-08-20 | Technicon Instr | Immunoassay for gentamicin |
| US4160818A (en) | 1976-04-15 | 1979-07-10 | Technicon Instruments Corporation | Fluorimetric immunoassay for diphenylhydantoin |
| US4025310A (en) * | 1976-05-28 | 1977-05-24 | International Diagnostic Technology, Inc. | Method for reading a wet fluorescent surface |
| GB1583869A (en) | 1977-08-19 | 1981-02-04 | Technicon Instr | Competitive binding analysis by fluorescence |
| US4115699A (en) * | 1977-06-16 | 1978-09-19 | Kabushiki Kaisha Nihon Kotai Kenkyujo | Apparatus for sensitive detection and quantitative analysis of biological and biochemical substances |
| US4220450A (en) * | 1978-04-05 | 1980-09-02 | Syva Company | Chemically induced fluorescence immunoassay |
-
1979
- 1979-01-18 US US06/004,580 patent/US4238195A/en not_active Expired - Lifetime
- 1979-12-10 CA CA341,540A patent/CA1133392A/en not_active Expired
- 1979-12-27 DE DE2952498A patent/DE2952498C2/de not_active Expired
-
1980
- 1980-01-02 GB GB8000086A patent/GB2044449B/en not_active Expired
- 1980-01-17 JP JP314880A patent/JPS5596458A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE2952498C2 (de) | 1983-11-10 |
| CA1133392A (en) | 1982-10-12 |
| JPS5596458A (en) | 1980-07-22 |
| GB2044449B (en) | 1983-04-20 |
| US4238195A (en) | 1980-12-09 |
| GB2044449A (en) | 1980-10-15 |
| DE2952498A1 (de) | 1980-07-24 |
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