JPH0121128B2 - - Google Patents
Info
- Publication number
- JPH0121128B2 JPH0121128B2 JP54103495A JP10349579A JPH0121128B2 JP H0121128 B2 JPH0121128 B2 JP H0121128B2 JP 54103495 A JP54103495 A JP 54103495A JP 10349579 A JP10349579 A JP 10349579A JP H0121128 B2 JPH0121128 B2 JP H0121128B2
- Authority
- JP
- Japan
- Prior art keywords
- diffusion matrix
- water
- matrix according
- soluble polymer
- diffusion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000011159 matrix material Substances 0.000 claims description 59
- 238000009792 diffusion process Methods 0.000 claims description 55
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 claims description 34
- 229960003711 glyceryl trinitrate Drugs 0.000 claims description 34
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 26
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 19
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 19
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 16
- 239000008101 lactose Substances 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 235000011187 glycerol Nutrition 0.000 claims description 13
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 12
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 12
- 229920003169 water-soluble polymer Polymers 0.000 claims description 12
- 239000003814 drug Substances 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 6
- 229920001817 Agar Polymers 0.000 claims description 5
- 239000008272 agar Substances 0.000 claims description 5
- 230000036571 hydration Effects 0.000 claims description 5
- 238000006703 hydration reaction Methods 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 229920000936 Agarose Polymers 0.000 claims description 4
- 239000001913 cellulose Substances 0.000 claims description 4
- 229920002678 cellulose Polymers 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 description 19
- 239000000006 Nitroglycerin Substances 0.000 description 16
- 239000008280 blood Substances 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 241001465754 Metazoa Species 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 4
- 229960000201 isosorbide dinitrate Drugs 0.000 description 4
- MOYKHGMNXAOIAT-JGWLITMVSA-N isosorbide dinitrate Chemical compound [O-][N+](=O)O[C@H]1CO[C@@H]2[C@H](O[N+](=O)[O-])CO[C@@H]21 MOYKHGMNXAOIAT-JGWLITMVSA-N 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 241000282472 Canis lupus familiaris Species 0.000 description 3
- 206010052428 Wound Diseases 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000008240 homogeneous mixture Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- -1 polyethylene Polymers 0.000 description 3
- 210000005245 right atrium Anatomy 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical compound O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 210000000702 aorta abdominal Anatomy 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 210000003191 femoral vein Anatomy 0.000 description 2
- 229960002479 isosorbide Drugs 0.000 description 2
- 210000003141 lower extremity Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 206010002383 Angina Pectoris Diseases 0.000 description 1
- GUBGYTABKSRVRQ-DCSYEGIMSA-N Beta-Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-DCSYEGIMSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- BNUHAJGCKIQFGE-UHFFFAOYSA-N Nitroanisol Chemical compound COC1=CC=C([N+]([O-])=O)C=C1 BNUHAJGCKIQFGE-UHFFFAOYSA-N 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000012790 adhesive layer Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 230000002146 bilateral effect Effects 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- LIKFHECYJZWXFJ-UHFFFAOYSA-N dimethyldichlorosilane Chemical compound C[Si](C)(Cl)Cl LIKFHECYJZWXFJ-UHFFFAOYSA-N 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 230000005264 electron capture Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 210000003090 iliac artery Anatomy 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- CMDGQTVYVAKDNA-UHFFFAOYSA-N propane-1,2,3-triol;hydrate Chemical compound O.OCC(O)CO CMDGQTVYVAKDNA-UHFFFAOYSA-N 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- AWLILQARPMWUHA-UHFFFAOYSA-M thiopental sodium Chemical compound [Na+].CCCC(C)C1(CC)C(=O)NC([S-])=NC1=O AWLILQARPMWUHA-UHFFFAOYSA-M 0.000 description 1
- 210000000779 thoracic wall Anatomy 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
- 229930195724 β-lactose Natural products 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
Priority Applications (34)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL59063A IL59063A (en) | 1979-01-11 | 1980-01-01 | Polymeric diffusion matrix for release of pharmaceutical dosage |
| EP81104585A EP0040861B1 (fr) | 1979-01-11 | 1980-01-04 | Matrice polymère à diffusion et méthode pour sa préparation |
| AT80300038T ATE7266T1 (de) | 1979-01-11 | 1980-01-04 | Wirkstoffabgabevorrichtung und verfahren zu deren herstellung. |
| AT81104585T ATE12731T1 (de) | 1979-01-11 | 1980-01-04 | Polymere diffusionsmatrix und verfahren zu deren herstellung. |
| DE8080300038T DE3067659D1 (en) | 1979-01-11 | 1980-01-04 | Drug delivery device and method for its preparation |
| EP81104586A EP0040862A1 (fr) | 1979-01-11 | 1980-01-04 | Matrice pour brûlures, procédé pour sa préparation et appareil de dosage comprenant cette matrice |
| DE8181104585T DE3070538D1 (en) | 1979-01-11 | 1980-01-04 | Polymeric diffusion matrix and method of its preparation |
| EP80300038A EP0013606B1 (fr) | 1979-01-11 | 1980-01-04 | Dispositif pour la libération d'un composé actif et procédé pour sa préparation |
| ZA00800073A ZA8073B (en) | 1979-01-11 | 1980-01-07 | Polymeric diffusion matrix |
| DK6380A DK6380A (da) | 1979-01-11 | 1980-01-07 | Polymer diffusionsmatrice fremgangsmaade til dens fremstilling og dens anvendelse |
| DK006380A DK155776C (da) | 1979-01-11 | 1980-01-07 | Laegemiddelafgivningsorgan med forlaenget frigoering af laegemiddel, og fremgangsmaade til dets fremstilling |
| NZ192532A NZ192532A (en) | 1979-01-11 | 1980-01-07 | Polymeric diffusion matrix and a transdermal drug delivery device |
| CA000343184A CA1135625A (fr) | 1979-01-11 | 1980-01-07 | Matrice de diffusion polymerique |
| GR60911A GR74069B (fr) | 1979-01-11 | 1980-01-08 | |
| AU54452/80A AU532530B2 (en) | 1979-01-11 | 1980-01-08 | Polymeric diffusion matrix |
| FI800064A FI76690C (fi) | 1979-01-11 | 1980-01-09 | Polymer diffusionsmatris och foerfarande foer framstaellning daerav. |
| ES487583A ES487583A0 (es) | 1979-01-11 | 1980-01-10 | Procedimiento de obtencion de una matriz polimerica de difu-sion |
| NO800054A NO156234C (no) | 1979-01-11 | 1980-01-10 | Fremgangsmaate for fremstilling av en selvbaerende, polymer diffusjonsmatriks for protrahert frigivelse av en systematisk aktiv droge. |
| PT70679A PT70679A (en) | 1979-01-11 | 1980-01-10 | Process for preparing a polymeric diffusion |
| IE59/80A IE50567B1 (en) | 1979-01-11 | 1980-01-11 | Polymeric diffusion matrix |
| US06/163,262 US4291015A (en) | 1979-08-14 | 1980-06-26 | Polymeric diffusion matrix containing a vasodilator |
| US06/167,010 US4292301A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing ephedrine |
| US06/167,009 US4289749A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing phenylpropanolamine |
| US06/167,106 US4292303A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing clonidine |
| US06/167,101 US4294820A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing phenylephrine |
| US06/167,104 US4292302A (en) | 1979-08-14 | 1980-07-09 | Polymeric diffusion matrix containing terbutaline |
| US06/217,400 US4321252A (en) | 1979-08-14 | 1980-12-17 | Polymeric diffusion matrix containing ester derivatives of estradiol |
| US06/258,456 US4470962A (en) | 1979-08-14 | 1981-04-28 | Polymeric diffusion matrix |
| US06/439,023 US4438139A (en) | 1979-08-14 | 1982-01-04 | Polymeric diffusion matrix containing estrogens |
| US06/425,274 US4472372A (en) | 1979-08-14 | 1982-09-28 | Polymeric diffusion matrix containing chlorpheniramine maleate |
| US06/431,735 US4466953A (en) | 1979-08-14 | 1982-09-30 | Polymeric diffusion matrix |
| US06/574,844 US4492685A (en) | 1979-08-14 | 1984-01-30 | Protective skin matrix |
| NO841160A NO166688C (no) | 1979-01-11 | 1984-03-23 | Polymer diffusjonsmatriks. |
| DK190087A DK190087D0 (da) | 1979-01-11 | 1987-04-13 | Polymer-diffusionsmatrice og fremgangsmaade til dens fremstilling |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US256579A | 1979-01-11 | 1979-01-11 | |
| US4708479A | 1979-06-11 | 1979-06-11 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5594316A JPS5594316A (en) | 1980-07-17 |
| JPH0121128B2 true JPH0121128B2 (fr) | 1989-04-19 |
Family
ID=26670554
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10349579A Granted JPS5594316A (en) | 1979-01-11 | 1979-08-14 | Diffusion matrix for medicine release |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5594316A (fr) |
| KR (1) | KR830001816B1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002007499A3 (fr) * | 2000-07-20 | 2002-06-20 | Smartec Engineering Co Ltd | Dispositif et structure de raccordement entre la tete d'un pieu en acier et un socle en beton |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5714522A (en) * | 1980-06-09 | 1982-01-25 | Key Pharma | Polymer diffused matrix |
| JPS57116011A (en) * | 1981-01-08 | 1982-07-19 | Nitto Electric Ind Co Ltd | Pharmaceutical preparation |
| JPS57183714A (en) * | 1981-05-01 | 1982-11-12 | Nitto Electric Ind Co Ltd | Medicinal pharmaceutical |
| JPS58913A (ja) * | 1981-06-26 | 1983-01-06 | Nitto Electric Ind Co Ltd | 局所系医薬製剤 |
| US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
| JP2610142B2 (ja) * | 1987-10-19 | 1997-05-14 | ニチバン株式会社 | ケトチフェン貼付剤 |
| JPH07116032B2 (ja) * | 1990-04-06 | 1995-12-13 | 積水化学工業株式会社 | ニトログリセリン貼付剤 |
| ES2408007T3 (es) * | 2004-04-28 | 2013-06-17 | Hisamitsu Pharmaceutical Co., Inc. | Material adhesivo |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4915764A (fr) * | 1972-06-01 | 1974-02-12 | ||
| JPS4930525A (fr) * | 1972-07-17 | 1974-03-19 | ||
| JPS4971132A (fr) * | 1972-11-11 | 1974-07-10 |
-
1979
- 1979-08-14 JP JP10349579A patent/JPS5594316A/ja active Granted
-
1980
- 1980-01-11 KR KR1019800000095A patent/KR830001816B1/ko active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4915764A (fr) * | 1972-06-01 | 1974-02-12 | ||
| JPS4930525A (fr) * | 1972-07-17 | 1974-03-19 | ||
| JPS4971132A (fr) * | 1972-11-11 | 1974-07-10 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002007499A3 (fr) * | 2000-07-20 | 2002-06-20 | Smartec Engineering Co Ltd | Dispositif et structure de raccordement entre la tete d'un pieu en acier et un socle en beton |
Also Published As
| Publication number | Publication date |
|---|---|
| KR830001650A (ko) | 1983-05-18 |
| KR830001816B1 (ko) | 1983-09-12 |
| JPS5594316A (en) | 1980-07-17 |
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