JP7707189B2 - Ｋｒａｓ ｇ１２ｄ変異に対して阻害活性を有する化合物 - Google Patents
Ｋｒａｓ ｇ１２ｄ変異に対して阻害活性を有する化合物 Download PDFInfo
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- JP7707189B2 JP7707189B2 JP2022558819A JP2022558819A JP7707189B2 JP 7707189 B2 JP7707189 B2 JP 7707189B2 JP 2022558819 A JP2022558819 A JP 2022558819A JP 2022558819 A JP2022558819 A JP 2022558819A JP 7707189 B2 JP7707189 B2 JP 7707189B2
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- diazabicyclo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019216165 | 2019-11-29 | ||
| JP2019216165 | 2019-11-29 | ||
| JPPCT/JP2019/049074 | 2019-12-06 | ||
| PCT/JP2019/049074 WO2021106231A1 (en) | 2019-11-29 | 2019-12-06 | A compound having inhibitory activity against kras g12d mutation |
| PCT/JP2020/045146 WO2021107160A1 (en) | 2019-11-29 | 2020-11-27 | A compound having inhibitory activity against kras g12d mutation |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023512113A JP2023512113A (ja) | 2023-03-23 |
| JPWO2021107160A5 JPWO2021107160A5 (https=) | 2023-12-01 |
| JP2023512113A5 JP2023512113A5 (https=) | 2023-12-01 |
| JP7707189B2 true JP7707189B2 (ja) | 2025-07-14 |
Family
ID=76128832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022558819A Active JP7707189B2 (ja) | 2019-11-29 | 2020-11-27 | Ｋｒａｓ ｇ１２ｄ変異に対して阻害活性を有する化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230348495A1 (https=) |
| EP (1) | EP4065583A1 (https=) |
| JP (1) | JP7707189B2 (https=) |
| CN (1) | CN115003677B (https=) |
| TW (1) | TW202134243A (https=) |
| WO (2) | WO2021106231A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024521979A (ja) * | 2021-05-28 | 2024-06-04 | 大鵬薬品工業株式会社 | Ｋｒａｓ変異タンパク質の小分子阻害剤関連出願の相互参照 |
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| TW202134243A (zh) | 2021-09-16 |
| US20230348495A1 (en) | 2023-11-02 |
| JP2023512113A (ja) | 2023-03-23 |
| CN115003677B (zh) | 2024-08-27 |
| CN115003677A (zh) | 2022-09-02 |
| EP4065583A1 (en) | 2022-10-05 |
| WO2021107160A1 (en) | 2021-06-03 |
| WO2021106231A1 (en) | 2021-06-03 |
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