JP7523219B2 - Ctla-4に対する単一ドメイン抗体及びその変異体 - Google Patents

Ctla-4に対する単一ドメイン抗体及びその変異体 Download PDF

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JP7523219B2
JP7523219B2 JP2019540486A JP2019540486A JP7523219B2 JP 7523219 B2 JP7523219 B2 JP 7523219B2 JP 2019540486 A JP2019540486 A JP 2019540486A JP 2019540486 A JP2019540486 A JP 2019540486A JP 7523219 B2 JP7523219 B2 JP 7523219B2
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amino acid
seq
acid sequence
ctla
sdab
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JP2019533719A (ja
JP2019533719A5 (enExample
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ヤフェン ジャン,
シュ ウー,
シュアイ ヤン,
チュアン-チュ チョウ,
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Nanjing Legend Biotechnology Co Ltd
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    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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JP2019540486A 2016-10-11 2017-10-10 Ctla-4に対する単一ドメイン抗体及びその変異体 Active JP7523219B2 (ja)

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JP2022208106A JP2023024743A (ja) 2016-10-11 2022-12-26 Ctla-4に対する単一ドメイン抗体及びその変異体

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CNPCT/CN2016/101777 2016-10-11
PCT/CN2016/101777 WO2018068201A1 (en) 2016-10-11 2016-10-11 Single-domain antibodies and variants thereof against ctla-4
CNPCT/CN2017/093644 2017-07-20
PCT/CN2017/093644 WO2018014855A1 (en) 2016-07-20 2017-07-20 Multispecific antigen binding proteins and methods of use thereof
PCT/CN2017/105506 WO2018068695A1 (en) 2016-10-11 2017-10-10 Single-domain antibodies and variants thereof against ctla-4

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KR (1) KR102587496B1 (enExample)
CN (3) CN116535507A (enExample)
AU (1) AU2017343422C1 (enExample)
CA (1) CA3039084A1 (enExample)
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WO2018068201A1 (en) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4
JP7369127B2 (ja) 2017-12-28 2023-10-25 ナンジン レジェンド バイオテック カンパニー,リミテッド Tigitに対する単一ドメイン抗体及びその変異体
US12060435B2 (en) * 2018-01-05 2024-08-13 City Of Hope Multi-specific ligand binders
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WO2019179388A1 (en) * 2018-03-19 2019-09-26 Wuxi Biologics (Shanghai) Co., Ltd. Novel anti-ctla-4 antibody polypeptide
KR102876940B1 (ko) 2018-03-30 2025-10-24 난징 레전드 바이오테크 씨오., 엘티디. Lag-3에 대한 단일-도메인 항체 및 이의 용도
AU2019269628A1 (en) * 2018-05-17 2020-12-03 The Board Of Trustees Of The Leland Stanford Junior University Receptor inhibition by phosphatase recruitment
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CN112789293B (zh) * 2018-09-10 2024-05-10 南京传奇生物科技有限公司 针对cll1的单结构域抗体及其构建体
JP2022512684A (ja) 2018-10-11 2022-02-07 インヒブルクス インコーポレイテッド B7h3シングルドメイン抗体およびその治療用組成物
JP2022504802A (ja) 2018-10-11 2022-01-13 インヒブルクス インコーポレイテッド 5t4シングルドメイン抗体およびその治療組成物
CA3115089A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. Dll3 single domain antibodies and therapeutic compositions thereof
CN114144433A (zh) * 2019-03-22 2022-03-04 反射制药有限公司 用于目标蛋白的多价d-肽化合物
US12448450B2 (en) 2019-07-04 2025-10-21 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. Method for treating tumor using anti-CTLA4 single-domain antibodies
WO2021008577A1 (zh) * 2019-07-16 2021-01-21 南京金斯瑞生物科技有限公司 抗cd47/抗ctla-4双特异抗体及其制备方法和应用
US20220281997A1 (en) * 2019-09-27 2022-09-08 Nanjing GenScript Biotech Co., Ltd. Anti-VHH Domain Antibodies and Use Thereof
JP7712925B2 (ja) * 2019-12-04 2025-07-24 江蘇康寧杰瑞生物制薬有限公司 腫瘍治療のための二重特異性融合タンパク質と抗Her2抗体の組合せ
CN114746448A (zh) * 2019-12-04 2022-07-12 江苏康宁杰瑞生物制药有限公司 用于肿瘤治疗的双特异性融合蛋白
CN113121689B (zh) * 2020-01-16 2022-08-19 三优生物医药(上海)有限公司 Ctla-4结合分子及其用途
CN114605539B (zh) * 2020-12-09 2024-01-02 南京融捷康生物科技有限公司 人源化的抗IL-4Rα单域抗体及其应用
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