JP7523219B2 - Ctla-4に対する単一ドメイン抗体及びその変異体 - Google Patents

Ctla-4に対する単一ドメイン抗体及びその変異体 Download PDF

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JP7523219B2
JP7523219B2 JP2019540486A JP2019540486A JP7523219B2 JP 7523219 B2 JP7523219 B2 JP 7523219B2 JP 2019540486 A JP2019540486 A JP 2019540486A JP 2019540486 A JP2019540486 A JP 2019540486A JP 7523219 B2 JP7523219 B2 JP 7523219B2
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amino acid
seq
acid sequence
ctla
sdab
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JP2019533719A (ja
JP2019533719A5 (enExample
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ヤフェン ジャン,
シュ ウー,
シュアイ ヤン,
チュアン-チュ チョウ,
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Nanjing Legend Biotechnology Co Ltd
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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JP2019540486A 2016-10-11 2017-10-10 Ctla-4に対する単一ドメイン抗体及びその変異体 Active JP7523219B2 (ja)

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JP2022208106A JP2023024743A (ja) 2016-10-11 2022-12-26 Ctla-4に対する単一ドメイン抗体及びその変異体

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CNPCT/CN2016/101777 2016-10-11
PCT/CN2016/101777 WO2018068201A1 (en) 2016-10-11 2016-10-11 Single-domain antibodies and variants thereof against ctla-4
PCT/CN2017/093644 WO2018014855A1 (en) 2016-07-20 2017-07-20 Multispecific antigen binding proteins and methods of use thereof
CNPCT/CN2017/093644 2017-07-20
PCT/CN2017/105506 WO2018068695A1 (en) 2016-10-11 2017-10-10 Single-domain antibodies and variants thereof against ctla-4

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KR (1) KR102587496B1 (enExample)
CN (3) CN109843923B (enExample)
AU (1) AU2017343422C1 (enExample)
CA (1) CA3039084A1 (enExample)
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EP3735254A4 (en) * 2018-01-05 2021-11-03 City of Hope MULTI-SPECIFIC LIGAND BINDERS
KR20250114571A (ko) 2018-01-15 2025-07-29 난징 레전드 바이오테크 씨오., 엘티디. Pd-1에 대한 단일-도메인 항체 및 이의 변이체
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JP7611820B2 (ja) 2018-10-11 2025-01-10 インヒブルクス バイオサイエンシズ インコーポレイテッド Dll3シングルドメイン抗体およびその治療用組成物
TW202506736A (zh) 2018-10-11 2025-02-16 美商因荷布瑞克斯生物科學公司 5t4單域抗體及其治療性組合物
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US12448450B2 (en) 2019-07-04 2025-10-21 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. Method for treating tumor using anti-CTLA4 single-domain antibodies
US20220332848A1 (en) * 2019-07-16 2022-10-20 Nanjing GenScript Biotech Co., Ltd. Anti-cd47/anti-ctla-4 bispecific antibody and preparation method therefor and application thereof
EP4036116A4 (en) * 2019-09-27 2024-01-24 Nanjing GenScript Biotech Co., Ltd. ANTI-VHH DOMAIN ANTIBODIES AND USE THEREOF
US20230017515A1 (en) * 2019-12-04 2023-01-19 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. COMBINATION OF BISPECIFIC FUSION PROTEIN AND ANTI-Her2 ANTIBODY FOR TUMOR TREATMENT
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CN115626956A (zh) * 2020-01-16 2023-01-20 三优生物医药(上海)有限公司 Ctla-4结合分子及其用途
CN114605539B (zh) * 2020-12-09 2024-01-02 南京融捷康生物科技有限公司 人源化的抗IL-4Rα单域抗体及其应用
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