CN109843923B - 针对ctla-4的单结构域抗体及其变体 - Google Patents

针对ctla-4的单结构域抗体及其变体 Download PDF

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CN109843923B
CN109843923B CN201780063159.XA CN201780063159A CN109843923B CN 109843923 B CN109843923 B CN 109843923B CN 201780063159 A CN201780063159 A CN 201780063159A CN 109843923 B CN109843923 B CN 109843923B
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amino acid
ctla
acid sequence
sequence seq
seq
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CN109843923A (zh
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张亚峰
武术
杨帅
周传初
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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CN201780063159.XA 2016-10-11 2017-10-10 针对ctla-4的单结构域抗体及其变体 Active CN109843923B (zh)

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CN202310715290.7A CN116535506A (zh) 2016-10-11 2017-10-10 针对ctla-4的单结构域抗体及其变体
CN202310715291.1A CN116535507A (zh) 2016-10-11 2017-10-10 针对ctla-4的单结构域抗体及其变体

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PCT/CN2016/101777 WO2018068201A1 (en) 2016-10-11 2016-10-11 Single-domain antibodies and variants thereof against ctla-4
CNPCT/CN2016/101777 2016-10-11
CNPCT/CN2017/093644 2017-07-20
PCT/CN2017/093644 WO2018014855A1 (en) 2016-07-20 2017-07-20 Multispecific antigen binding proteins and methods of use thereof
PCT/CN2017/105506 WO2018068695A1 (en) 2016-10-11 2017-10-10 Single-domain antibodies and variants thereof against ctla-4

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EP (1) EP3526258A4 (enExample)
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KR (1) KR102587496B1 (enExample)
CN (3) CN109843923B (enExample)
AU (1) AU2017343422C1 (enExample)
CA (1) CA3039084A1 (enExample)
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WO2018068201A1 (en) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against ctla-4
KR20200104333A (ko) 2017-12-28 2020-09-03 난징 레전드 바이오테크 씨오., 엘티디. Tigit에 대한 단일-도메인 항체 및 이의 변이체
WO2019136405A1 (en) * 2018-01-05 2019-07-11 City Of Hope Multi-specific ligand binders
TWI802633B (zh) 2018-01-15 2023-05-21 大陸商南京傳奇生物科技有限公司 針對pd-1之單域抗體及其變異體
WO2019179388A1 (en) * 2018-03-19 2019-09-26 Wuxi Biologics (Shanghai) Co., Ltd. Novel anti-ctla-4 antibody polypeptide
JP7346790B2 (ja) * 2018-03-30 2023-09-20 ナンジン レジェンド バイオテック カンパニー，リミテッド Ｌａｇ‐３に対する単一ドメイン抗体およびその使用
AU2019269628A1 (en) * 2018-05-17 2020-12-03 The Board Of Trustees Of The Leland Stanford Junior University Receptor inhibition by phosphatase recruitment
JP7359785B2 (ja) 2018-06-05 2023-10-11 江蘇康寧杰瑞生物制薬有限公司 二量体及びその使用
TW202035451A (zh) 2018-07-24 2020-10-01 美商英伊布里克斯公司 含有受限cd3結合域及受體結合區之多重特異性多肽構築體及其使用方法
CN112789293B (zh) * 2018-09-10 2024-05-10 南京传奇生物科技有限公司 针对cll1的单结构域抗体及其构建体
US20210340273A1 (en) 2018-10-11 2021-11-04 Inhlbrx, inc. 5t4 single domain antibodies and therapeutic compositions thereof
CN113166263A (zh) 2018-10-11 2021-07-23 印希比股份有限公司 Dll3单域抗体及其治疗性组合物
US20230124851A1 (en) 2018-10-11 2023-04-20 Inhibrx, lnc. B7h3 single domain antibodies and therapeutic compositions thereof
EP3941581A2 (en) * 2019-03-22 2022-01-26 Reflexion Pharmaceuticals, Inc. Multivalent d-peptidic compounds for target proteins
JP7557521B2 (ja) * 2019-07-04 2024-09-27 江蘇康寧杰瑞生物制薬有限公司 腫瘍を治療するための物質および方法
CN114096564A (zh) * 2019-07-16 2022-02-25 南京金斯瑞生物科技有限公司 抗cd47/抗ctla-4双特异抗体及其制备方法和应用
WO2021057978A1 (zh) * 2019-09-27 2021-04-01 南京金斯瑞生物科技有限公司 抗vhh域抗体及其用途
US20230017515A1 (en) * 2019-12-04 2023-01-19 Jiangsu Alphamab Biopharmaceuticals Co., Ltd. COMBINATION OF BISPECIFIC FUSION PROTEIN AND ANTI-Her2 ANTIBODY FOR TUMOR TREATMENT
CN114746448A (zh) * 2019-12-04 2022-07-12 江苏康宁杰瑞生物制药有限公司 用于肿瘤治疗的双特异性融合蛋白
CN113121689B (zh) * 2020-01-16 2022-08-19 三优生物医药(上海)有限公司 Ctla-4结合分子及其用途
CN114605539B (zh) * 2020-12-09 2024-01-02 南京融捷康生物科技有限公司 人源化的抗IL-4Rα单域抗体及其应用
US20230357406A1 (en) * 2022-03-08 2023-11-09 Molecular Templates, Inc. Ctla-4 binding molecules comprising shiga toxin a subunit scaffolds and uses thereof
WO2024041650A1 (en) * 2022-08-25 2024-02-29 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors targeting interleukin 13 receptor subunit alpha 2 and methods of use thereof
JP2025529279A (ja) * 2022-09-02 2025-09-04 シクリッド インコーポレイテッド 抗ｃｔｌａ－４モノクローナル抗体及びその使用

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