JP7510413B2 - B細胞成熟抗原に特異的なキメラ抗原受容体を使用する処置方法 - Google Patents
B細胞成熟抗原に特異的なキメラ抗原受容体を使用する処置方法 Download PDFInfo
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- JP7510413B2 JP7510413B2 JP2021524037A JP2021524037A JP7510413B2 JP 7510413 B2 JP7510413 B2 JP 7510413B2 JP 2021524037 A JP2021524037 A JP 2021524037A JP 2021524037 A JP2021524037 A JP 2021524037A JP 7510413 B2 JP7510413 B2 JP 7510413B2
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862754577P | 2018-11-01 | 2018-11-01 | |
| US62/754,577 | 2018-11-01 | ||
| US201862774167P | 2018-11-30 | 2018-11-30 | |
| US62/774,167 | 2018-11-30 | ||
| US201862774856P | 2018-12-03 | 2018-12-03 | |
| US62/774,856 | 2018-12-03 | ||
| US201862777066P | 2018-12-07 | 2018-12-07 | |
| US62/777,066 | 2018-12-07 | ||
| US201962845817P | 2019-05-09 | 2019-05-09 | |
| US62/845,817 | 2019-05-09 | ||
| PCT/US2019/059271 WO2020092848A2 (en) | 2018-11-01 | 2019-10-31 | Methods for treatment using chimeric antigen receptors specific for b-cell maturation antigen |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022512917A JP2022512917A (ja) | 2022-02-07 |
| JPWO2020092848A5 JPWO2020092848A5 (https=) | 2022-11-08 |
| JP2022512917A5 JP2022512917A5 (https=) | 2022-11-08 |
| JP7510413B2 true JP7510413B2 (ja) | 2024-07-03 |
Family
ID=68655689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021524037A Active JP7510413B2 (ja) | 2018-11-01 | 2019-10-31 | B細胞成熟抗原に特異的なキメラ抗原受容体を使用する処置方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12473345B2 (https=) |
| EP (1) | EP3873943A2 (https=) |
| JP (1) | JP7510413B2 (https=) |
| KR (1) | KR20210113169A (https=) |
| CN (1) | CN113646335A (https=) |
| AU (1) | AU2019372331A1 (https=) |
| BR (1) | BR112021008289A2 (https=) |
| CA (1) | CA3117419A1 (https=) |
| IL (1) | IL282667A (https=) |
| MA (1) | MA54078A (https=) |
| MX (1) | MX2021005024A (https=) |
| SG (1) | SG11202104188VA (https=) |
| WO (1) | WO2020092848A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20240135036A (ko) | 2014-12-05 | 2024-09-10 | 메모리얼 슬로안 케터링 캔서 센터 | B-세포 성숙화 항원을 표적화하는 항체 및 사용 방법 |
| IL268349B2 (en) | 2017-02-17 | 2024-08-01 | Hutchinson Fred Cancer Res | Combination therapies for treatment of bcma-related cancers and autoimmune disorders |
| JP7447006B2 (ja) | 2017-11-01 | 2024-03-11 | ジュノー セラピューティクス インコーポレイテッド | B細胞成熟抗原(bcma)に特異的なキメラ抗原受容体 |
| SG11202003427XA (en) | 2017-11-06 | 2020-05-28 | Juno Therapeutics Inc | Combination of a cell therapy and a gamma secretase inhibitor |
| WO2019113557A1 (en) | 2017-12-08 | 2019-06-13 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
| KR20210113169A (ko) | 2018-11-01 | 2021-09-15 | 주노 쎄러퓨티크스 인코퍼레이티드 | Β세포 성숙 항원에 특이적인 키메라 항원 수용체를 이용한 치료 방법 |
| WO2020097403A1 (en) | 2018-11-08 | 2020-05-14 | Juno Therapeutics, Inc. | Methods and combinations for treatment and t cell modulation |
| CA3140102A1 (en) | 2019-05-30 | 2020-12-03 | Dina SCHNEIDER | Compositions and methods for treating cancer with anti-bcma immunotherapy |
| CN116157125A (zh) * | 2020-04-28 | 2023-05-23 | 朱诺治疗学股份有限公司 | 针对bcma的t细胞疗法与免疫调节化合物的组合 |
| US20230348854A1 (en) * | 2020-05-08 | 2023-11-02 | Seattle Children's Hospital D/B/A Seattle Children's Research Institute | Chimeric antigen receptors (cars) targeting natural killer cells |
| JP7727662B2 (ja) | 2020-05-13 | 2025-08-21 | ジュノー セラピューティクス インコーポレイテッド | 臨床応答に関連する特徴量の特定方法およびその使用 |
| AU2022301978A1 (en) * | 2021-06-28 | 2024-01-25 | Meridian Therapeutics, Inc. | Compositions and methods of treating plasma cell disorders including multiple myeloma with a vaccine composition and myeloma-specific car-t cells |
| CA3230245A1 (en) | 2021-09-01 | 2023-03-09 | Springworks Therapeutics, Inc. | Synthesis of nirogacestat |
| WO2023230548A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Method for predicting response to a t cell therapy |
| WO2026074086A1 (en) * | 2024-10-02 | 2026-04-09 | Fundación Para La Investigación Médica Aplicada | Cells expressing chimeric antigen receptors and a glutamine transporter, uses and methods thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017527271A (ja) | 2014-07-21 | 2017-09-21 | ノバルティス アーゲー | ヒト化抗bcmaキメラ抗原受容体を使用した癌の処置 |
| JP2017537925A (ja) | 2014-12-05 | 2017-12-21 | メモリアル スローン−ケタリング キャンサー センター | B細胞成熟抗原を標的化するキメラ抗原受容体およびその使用 |
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| JP2017527271A (ja) | 2014-07-21 | 2017-09-21 | ノバルティス アーゲー | ヒト化抗bcmaキメラ抗原受容体を使用した癌の処置 |
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| US12473345B2 (en) | 2025-11-18 |
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| US20210393690A1 (en) | 2021-12-23 |
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